ENSMUSG00000030559


Mus musculus

Features
Gene ID: ENSMUSG00000030559
  
Biological name :Rab38
  
Synonyms : Q8QZZ8 / Rab38 / RAB38, member RAS oncogene family
  
Possible biological names infered from orthology : P57729
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: D3
Gene start: 88430273
Gene end: 88491572
  
Corresponding Affymetrix probe sets: 10554800 (MoGene1.0st)   1417700_at (Mouse Genome 430 2.0 Array)   1439628_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000146448
Ensembl peptide - ENSMUSP00000102877
NCBI entrez gene - 72433     See in Manteia.
MGI - MGI:1919683
RefSeq - NM_028238
RefSeq Peptide - NP_082514
swissprot - A0A140LHK2
swissprot - Q5FW76
swissprot - Q8QZZ8
Ensembl - ENSMUSG00000030559
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rab38bENSDARG00000112889Danio rerio
 RAB38ENSGALG00000028018Gallus gallus
 RAB38ENSG00000123892Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Rab32 / Q9CZE3 / RAB32, member RAS oncogene family / Q13637*ENSMUSG0000001983265
Rab29 / RAB29, member RAS oncogene family / O14966*ENSMUSG0000002643349
Rab7 / P51150 / RAB7, member RAS oncogene family / RAB7A* / P51149* / RAB7A, member RAS oncogene family*ENSMUSG0000007947731
Rab7b / Q8VEA8 / RAB7B, member RAS oncogene family / Q96AH8*ENSMUSG0000005268831
Rab9b / Q8BHH2 / RAB9B, member RAS oncogene family / Q9NP90*ENSMUSG0000004346330
Rab9 / Q9R0M6 / RAB9, member RAS oncogene family / RAB9A* / P51151* / RAB9A, member RAS oncogene family*ENSMUSG0000007931630
Rab23 / RAB23, member RAS oncogene family / Q9ULC3*ENSMUSG0000000476829


Protein motifs (from Interpro)
Interpro ID Name
 IPR001806  Small GTPase superfamily
 IPR005225  Small GTP-binding protein domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR030697  Ras-related protein Rab29/Rab38/Rab32


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006996 organelle organization IEA
 biological_processGO:0007005 mitochondrion organization IEA
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016192 vesicle-mediated transport IEA
 biological_processGO:0035646 endosome to melanosome transport IEA
 biological_processGO:0060155 platelet dense granule organization IEA
 biological_processGO:0072657 protein localization to membrane IEA
 biological_processGO:0090383 phagosome acidification IEA
 biological_processGO:1903232 melanosome assembly ISS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005764 lysosome IEA
 cellular_componentGO:0005769 early endosome IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005802 trans-Golgi network IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane ISO
 cellular_componentGO:0030670 phagocytic vesicle membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0031982 vesicle IEA
 cellular_componentGO:0033162 melanosome membrane ISO
 cellular_componentGO:0042470 melanosome ISO
 cellular_componentGO:0044233 ER-mitochondrion membrane contact site IEA
 cellular_componentGO:0045335 phagocytic vesicle ISS
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003924 GTPase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005525 GTP binding IEA
 molecular_functionGO:0030742 GTP-dependent protein binding IEA
 molecular_functionGO:0035650 AP-1 adaptor complex binding IEA
 molecular_functionGO:0035651 AP-3 adaptor complex binding IEA
 molecular_functionGO:0036461 BLOC-2 complex binding ISO


Pathways (from Reactome)
Pathway description
RAB geranylgeranylation
RAB GEFs exchange GTP for GDP on RABs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000371 diluted coat color "a coat color that appears lighter in intensity or paler than normal" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Card11M2Btlr/Card11M2Btlr
Genetic Background: involves: C57BL/6J

 MP:0001324 abnormal eye pigmentation "change in the normal black pigmentation of the eye to another color, or lack of color" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ighmtm1Cgn/Ighmtm1Cgn
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001942 abnormal lung volume "anomaly in the amount of air that the lungs contain at various points of the respiratory cycle" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ighmtm1Cgn/Ighmtm1Cgn
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002075 abnormal coat color "irregular or unusual pigmentation pattern of the hair in relation to control animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ighmtm1Cgn/Ighmtm1Cgn
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Rab38em1Rkuhn/Rab38em1Rkuhn
Genetic Background: involves: C57BL/6JCrl * FVB/NCrl

Allelic Composition: Rab38em4Rkuhn/Rab38em4Rkuhn
Genetic Background: involves: C57BL/6NCrl * FVB/NCrl

 MP:0002095 abnormal skin pigmentation "variation of skin color or complexion" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ighmtm1Cgn/Ighmtm1Cgn
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002275 abnormal type II pneumocyte morphology "any structural anomaly of the epithelial cells lining the alveoli that produce surfactant " [Pathology , 2nd edition:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ighmtm1Cgn/Ighmtm1Cgn
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0004382 abnormal hair follicle melanogenesis "failure of or anomaly in the biosynthetic pathway of melanin formation in hair follicles" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ighmtm1Cgn/Ighmtm1Cgn
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0004780 abnormal surfactant secretion "anomaly in the production or release from pneumocytes of surfactant, a phospholipid present in the lungs that controls surface tension in the alveoli" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ighmtm1Cgn/Ighmtm1Cgn
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0005075 abnormal melanosome morphology "anomalous structure of these tissue-specific cytoplasmic organelles within which melanin pigments are synthesized and stored" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:5346]
Show

Allelic Composition: Ighmtm1Cgn/Ighmtm1Cgn
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0005102 abnormal iris pigmentation "anomalous coloring of the adjustable membrane, composed of the stroma and pigmented epithelium, located just in front of the crystalline lens within the eye" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ighmtm1Cgn/Ighmtm1Cgn
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0005172 lack of eye pigmentation "visual organs are devoid of coloring pigment in relation to control animals, usually resulting in a red or pink color" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:83500]
Show

Allelic Composition: Ighmtm1Cgn/Ighmtm1Cgn
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0010815 enlarged alveolar lamellar bodies "increased size of the specialized secretory organelles found in the cytoplasm of type II pneumocytes and involved in the synthesis, secretion, and reutilization of pulmonary surfactant" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ighmtm1Cgn/Ighmtm1Cgn
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0010856 dilated respiratory conducting tubes "expansion or widening of the lumens of the tubes of the respiratory system that allow passage of air from the trachea to the alveoli of the lungs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ighmtm1Cgn/Ighmtm1Cgn
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0010891 increased alveolar lamellar body number "greater number of the specialized secretory organelles found in the cytoplasm of type II pneumocytes and involved in the synthesis, secretion, and reutilization of pulmonary surfactant" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ighmtm1Cgn/Ighmtm1Cgn
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0010895 increased lung compliance "increased ability of the lung to distend in response to pressure without disruption, usually expressed as the unit volume of change in the lung per unit of pressure" [ISBN:070202788 "Saunders Comprehensive Veterinary Dictionary, 3rd edition"]
Show

Allelic Composition: Ighmtm1Cgn/Ighmtm1Cgn
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0010903 abnormal pulmonary alveolus wall morphology 
Show

Allelic Composition: Ighmtm1Cgn/Ighmtm1Cgn
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0010908 dilated pulmonary alveolar ducts "expansion or widening of the lumens of the respiratory conducting tubes distal to the respiratory bronchiole that lead to the alveolar sacs and the alveoli" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ighmtm1Cgn/Ighmtm1Cgn
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0010911 abnormal pulmonary acinus morphology "any structural anomaly of the part of the airway consisting of a respiratory bronchiole and all of its branches" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Ighmtm1Cgn/Ighmtm1Cgn
Genetic Background: involves: 129S2/SvPas * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000042328 Hps4 / Q99KG7 / Hermansky-Pudlak syndrome 4 protein homolog / Q9NQG7* / HPS4, biogenesis of lysosomal organelles complex 3 subunit 2*  / reaction
 ENSMUSG00000078185 Chml / choroideremia-like / P26374* / CHM like, Rab escort protein 2*  / complex
 ENSMUSG00000021218 Gdi2 / Q61598 / Rab GDP dissociation inhibitor beta / P50395* / GDP dissociation inhibitor 2*  / complex
 ENSMUSG00000015291 Gdi1 / P50396 / Rab GDP dissociation inhibitor alpha / P31150* / GDP dissociation inhibitor 1*  / complex
 ENSMUSG00000025531 Chm / choroidermia (RAB escort protein 1) / P24386* / CHM, Rab escort protein 1*  / complex






 

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