ENSMUSG00000019832


Mus musculus

Features
Gene ID: ENSMUSG00000019832
  
Biological name :Rab32
  
Synonyms : Q9CZE3 / Rab32 / RAB32, member RAS oncogene family
  
Possible biological names infered from orthology : Q13637
  
Species: Mus musculus
  
Chr. number: 10
Strand: -1
Band: A1
Gene start: 10545002
Gene end: 10558265
  
Corresponding Affymetrix probe sets: 10367822 (MoGene1.0st)   1416527_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000152210
Ensembl peptide - ENSMUSP00000019974
NCBI entrez gene - 67844     See in Manteia.
MGI - MGI:1915094
RefSeq - NM_026405
RefSeq Peptide - NP_080681
swissprot - A0A1Y7VIZ0
swissprot - Q0PD23
swissprot - Q9CZE3
Ensembl - ENSMUSG00000019832
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rab32aENSDARG00000029036Danio rerio
 RAB32ENSGALG00000012300Gallus gallus
 RAB32ENSG00000118508Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Rab38 / Q8QZZ8 / RAB38, member RAS oncogene family / P57729*ENSMUSG0000003055962
Rab29 / RAB29, member RAS oncogene family / O14966*ENSMUSG0000002643347
Rab9 / Q9R0M6 / RAB9, member RAS oncogene family / RAB9A* / P51151* / RAB9A, member RAS oncogene family*ENSMUSG0000007931631
Rab7b / Q8VEA8 / RAB7B, member RAS oncogene family / Q96AH8*ENSMUSG0000005268830
Rab7 / P51150 / RAB7, member RAS oncogene family / RAB7A* / P51149* / RAB7A, member RAS oncogene family*ENSMUSG0000007947730
Rab23 / RAB23, member RAS oncogene family / Q9ULC3*ENSMUSG0000000476829
Rab9b / Q8BHH2 / RAB9B, member RAS oncogene family / Q9NP90*ENSMUSG0000004346328


Protein motifs (from Interpro)
Interpro ID Name
 IPR001806  Small GTPase superfamily
 IPR005225  Small GTP-binding protein domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR030697  Ras-related protein Rab29/Rab38/Rab32


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007005 mitochondrion organization IEA
 biological_processGO:0016192 vesicle-mediated transport IEA
 biological_processGO:0019882 antigen processing and presentation IEA
 biological_processGO:0032438 melanosome organization IBA
 biological_processGO:0035646 endosome to melanosome transport IEA
 biological_processGO:0072657 protein localization to membrane IEA
 biological_processGO:0090382 phagosome maturation ISO
 biological_processGO:1903232 melanosome assembly ISS
 cellular_componentGO:0005739 mitochondrion ISO
 cellular_componentGO:0005741 mitochondrial outer membrane ISO
 cellular_componentGO:0005769 early endosome IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005802 trans-Golgi network IBA
 cellular_componentGO:0016020 membrane ISO
 cellular_componentGO:0030670 phagocytic vesicle membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0031982 vesicle IEA
 cellular_componentGO:0033162 melanosome membrane ISO
 cellular_componentGO:0042470 melanosome ISO
 cellular_componentGO:0044233 ER-mitochondrion membrane contact site IEA
 cellular_componentGO:0045335 phagocytic vesicle ISS
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003924 GTPase activity ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005525 GTP binding IEA
 molecular_functionGO:0030742 GTP-dependent protein binding IEA
 molecular_functionGO:0035650 AP-1 adaptor complex binding IEA
 molecular_functionGO:0035651 AP-3 adaptor complex binding ISO
 molecular_functionGO:0036461 BLOC-2 complex binding ISO


Pathways (from Reactome)
Pathway description
RAB geranylgeranylation
RAB GEFs exchange GTP for GDP on RABs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
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Allelic Composition: Psphtm1.1(KOMP)Vlcg/Psphtm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Psphtm1.1(KOMP)Vlcg/Ucd

 MP:0009709 hydrometra "an accumulation in the uterine lumen of normal secretions that ordinarily drain from the body but are retained when the cervix or vagina is significantly or completely closed" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Psphtm1.1(KOMP)Vlcg/Psphtm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Psphtm1.1(KOMP)Vlcg/Ucd

 MP:0010052 increased grip strength "greater ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
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Allelic Composition: Ptpn12tm1b(NCOM)Mfgc/Ptpn12tm1b(NCOM)Mfgc
Genetic Background: C57BL/6N-Ptpn12tm1b(NCOM)Mfgc/Tcp

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Psphtm1.1(KOMP)Vlcg/Psphtm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Psphtm1.1(KOMP)Vlcg/Ucd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000078185 Chml / choroideremia-like / P26374* / CHM like, Rab escort protein 2*  / complex
 ENSMUSG00000015291 Gdi1 / P50396 / Rab GDP dissociation inhibitor alpha / P31150* / GDP dissociation inhibitor 1*  / complex
 ENSMUSG00000021218 Gdi2 / Q61598 / Rab GDP dissociation inhibitor beta / P50395* / GDP dissociation inhibitor 2*  / complex
 ENSMUSG00000025531 Chm / choroidermia (RAB escort protein 1) / P24386* / CHM, Rab escort protein 1*  / complex
 ENSMUSG00000042328 Hps4 / Q99KG7 / Hermansky-Pudlak syndrome 4 protein homolog / Q9NQG7* / HPS4, biogenesis of lysosomal organelles complex 3 subunit 2*  / reaction






 

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