ENSMUSG00000021218


Mus musculus

Features
Gene ID: ENSMUSG00000021218
  
Biological name :Gdi2
  
Synonyms : Gdi2 / Q61598 / Rab GDP dissociation inhibitor beta
  
Possible biological names infered from orthology : GDP dissociation inhibitor 2 / P50395
  
Species: Mus musculus
  
Chr. number: 13
Strand: 1
Band: A1
Gene start: 3538063
Gene end: 3567871
  
Corresponding Affymetrix probe sets: 10403258 (MoGene1.0st)   1420814_at (Mouse Genome 430 2.0 Array)   1420815_at (Mouse Genome 430 2.0 Array)   1431645_a_at (Mouse Genome 430 2.0 Array)   1435898_x_at (Mouse Genome 430 2.0 Array)   1436016_x_at (Mouse Genome 430 2.0 Array)   1456581_x_at (Mouse Genome 430 2.0 Array)   1457398_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000152075
Ensembl peptide - ENSMUSP00000152454
Ensembl peptide - ENSMUSP00000152175
Ensembl peptide - ENSMUSP00000062996
NCBI entrez gene - 14569     See in Manteia.
MGI - MGI:99845
RefSeq - NM_008112
RefSeq Peptide - NP_032138
swissprot - A0A1Y7VLG4
swissprot - A0A1Y7VL99
swissprot - Q61598
Ensembl - ENSMUSG00000021218
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gdi2ENSDARG00000005451Danio rerio
 GDI2ENSGALG00000008169Gallus gallus
 GDI2ENSG00000057608Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gdi1 / P50396 / Rab GDP dissociation inhibitor alpha / P31150* / GDP dissociation inhibitor 1*ENSMUSG0000001529185
Chml / choroideremia-like / P26374* / CHM like, Rab escort protein 2*ENSMUSG0000007818525
Chm / choroidermia (RAB escort protein 1) / P24386* / CHM, Rab escort protein 1*ENSMUSG0000002553124


Protein motifs (from Interpro)
Interpro ID Name
 IPR000806  Rab GDI protein
 IPR018203  GDP dissociation inhibitor
 IPR036188  FAD/NAD(P)-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007264 small GTPase mediated signal transduction IEA
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016192 vesicle-mediated transport IEA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0050790 regulation of catalytic activity IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005794 Golgi apparatus IPI
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0043209 myelin sheath IDA
 molecular_functionGO:0005092 GDP-dissociation inhibitor activity IEA
 molecular_functionGO:0005093 Rab GDP-dissociation inhibitor activity IEA
 molecular_functionGO:0005096 GTPase activator activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0031267 small GTPase binding IEA


Pathways (from Reactome)
Pathway description
Rho GTPase cycle
Neutrophil degranulation
RAB GEFs exchange GTP for GDP on RABs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
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Allelic Composition: Enhotm1.1Butl/Enho+
Genetic Background: B6.Cg-Enhotm1.1Butl

 MP:0008167 increased B-1a cell number "greater number of the B-1 B cell subset bearing the CD5 surface marker" [CL:0000820, PMID:11861604]
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Allelic Composition: Enhotm1.1Butl/Enho+
Genetic Background: B6.Cg-Enhotm1.1Butl

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Gbx1tm1b(KOMP)Wtsi/Gbx1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Gbx1tm1b(KOMP)Wtsi/H

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000019832 Rab32 / Q9CZE3 / RAB32, member RAS oncogene family / Q13637*  / complex
 ENSMUSG00000002668 Q8CFK6 / Dennd1c / DENN domain-containing protein 1C / Q8IV53* / DENN domain containing 1C*  / reaction
 ENSMUSG00000026867 Gapvd1 / Q6PAR5 / GTPase-activating protein and VPS9 domain-containing protein 1 / Q14C86* / GTPase activating protein and VPS9 domains 1*  / reaction
 ENSMUSG00000028468 Rgp1 / Q8BHT7 / RAB6A-GEF complex partner protein 2 / Q92546* / RGP1 homolog, RAB6A GEF complex partner 1*  / reaction
 ENSMUSG00000036104 Q80UJ7 / Rab3gap1 / Rab3 GTPase-activating protein catalytic subunit / Q15042* / RAB3 GTPase activating protein catalytic subunit 1*  / reaction
 ENSMUSG00000038456 Q8C4S8 / Dennd2a / DENN domain-containing protein 2A / Q9ULE3* / DENN domain containing 2A*  / reaction
 ENSMUSG00000036661 A2RT67 / Dennd3 / DENN domain-containing protein 3 / A2RUS2* / DENN domain containing 3*  / reaction
 ENSMUSG00000042328 Hps4 / Q99KG7 / Hermansky-Pudlak syndrome 4 protein homolog / Q9NQG7* / HPS4, biogenesis of lysosomal organelles complex 3 subunit 2*  / reaction
 ENSMUSG00000053641 Dennd4a / DENN domain containing 4A / Q7Z401*  / reaction
 ENSMUSG00000034867 Q3UMR0 / Ankrd27 / Ankyrin repeat domain-containing protein 27 / Q96NW4* / ankyrin repeat domain 27*  / reaction
 ENSMUSG00000029617 Ccz1 / Q8C1Y8 / Vacuolar fusion / CCZ1B* / P86790* / P86791* / CCZ1 homolog, vacuolar protein trafficking and biogenesis associated* / CCZ1 homolog B, vacuolar protein trafficking and bio...  / reaction
 ENSMUSG00000032583 Mon1a / MON1 homolog A, secretory trafficking associated / Q86VX9*  / reaction
 ENSMUSG00000040818 Q8BH65 / Dennd6a / Protein DENND6A / Q8IWF6* / DENN domain containing 6A*  / reaction
 ENSMUSG00000038658 Ric1 / Q69ZJ7 / RAB6A-GEF complex partner protein 1 / Q4ADV7* / RIC1 homolog, RAB6A GEF complex partner 1*  / reaction
 ENSMUSG00000079316 Rab9 / Q9R0M6 / RAB9, member RAS oncogene family / RAB9A* / P51151* / RAB9A, member RAS oncogene family*  / complex
 ENSMUSG00000020849 Ywhae / P62259 / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide / P62258* / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation prote...  / reaction
 ENSMUSG00000044456 Rin3 / P59729 / Ras and Rab interactor 3 / Q8TB24*  / reaction
 ENSMUSG00000020149 Rab1 / P62821 / Ras-related protein Rab-1A / RAB1A* / P62820* / RAB1A, member RAS oncogene family*  / complex
 ENSMUSG00000079477 Rab7 / P51150 / RAB7, member RAS oncogene family / RAB7A* / P51149* / RAB7A, member RAS oncogene family*  / complex
 ENSMUSG00000031840 Rab3a / P63011 / RAB3A, member RAS oncogene family / P20336*  / complex
 ENSMUSG00000056515 Rab31 / RAB31, member RAS oncogene family / Q13636*  / complex
 ENSMUSG00000032202 Q9ERI2 / Rab27a / RAB27A, member RAS oncogene family / P51159*  / complex
 ENSMUSG00000020671 Rab10 / P61027 / RAB10, member RAS oncogene family / P61026*  / complex
 ENSMUSG00000026878 Rab14 / Q91V41 / RAB14, member RAS oncogene family / P61106*  / complex
 ENSMUSG00000029518 Rab35 / Q6PHN9 / RAB35, member RAS oncogene family / Q15286*  / complex
 ENSMUSG00000027935 Rab13 / Q9DD03 / Ras-related protein Rab-13 / P51153* / RAB13, member RAS oncogene family*  / complex
 ENSMUSG00000020132 Rab21 / P35282 / RAB21, member RAS oncogene family / Q9UL25*  / complex
 ENSMUSG00000073639 Rab18 / P35293 / RAB18, member RAS oncogene family / Q9NP72*  / complex
 ENSMUSG00000030704 Rab6a / P35279 / RAB6A, member RAS oncogene family / RAB6C* / RAB6D* / Q9H0N0* / P20340* / RAB6C, member RAS oncogene family* / RAB6D, member RAS oncogene family*  / complex
 ENSMUSG00000003037 Rab8a / P55258 / RAB8A, member RAS oncogene family / P61006*  / complex
 ENSMUSG00000023460 Rab12 / P35283 / Ras-related protein Rab-12 / Q6IQ22* / RAB12, member RAS oncogene family*  / complex
 ENSMUSG00000017831 Rab5a / Q9CQD1 / Ras-related protein Rab-5A / P20339* / RAB5A, member RAS oncogene family*  / complex
 ENSMUSG00000038024 A6H8H2 / Dennd4c / DENN domain-containing protein 4C / Q5VZ89* / DENN domain containing 4C*  / reaction
 ENSMUSG00000039318 Rab3gap2 / RAB3 GTPase activating non-catalytic protein subunit 2 / Q9H2M9*  / reaction
 ENSMUSG00000055069 Rab39 / Q8BHD0 / RAB39, member RAS oncogene family / Q14964* / RAB39A* / RAB39A, member RAS oncogene family*  / complex
 ENSMUSG00000035901 Q6PAL8 / Dennd5a / DENN domain-containing protein 5A / Q6IQ26* / DENN domain containing 5A*  / reaction
 ENSMUSG00000015377 Q9D9V7 / Dennd6b / Protein DENND6B / Q8NEG7* / DENN domain containing 6B*  / reaction
 ENSMUSG00000056268 Q3U1T9 / Dennd1b / DENN domain-containing protein 1B / Q6P3S1* / DENN domain containing 1B*  / reaction
 ENSMUSG00000035392 Q8K382 / Dennd1a / DENN domain-containing protein 1A / Q8TEH3* / DENN domain containing 1A*  / reaction
 ENSMUSG00000030559 Rab38 / Q8QZZ8 / RAB38, member RAS oncogene family / P57729*  / complex
 ENSMUSG00000042404 Q3U1Y4 / Dennd4b / Mus musculus DENN/MADD domain containing 4B (Dennd4b), transcript variant 2, mRNA. / O75064* / DENN domain containing 4B*  / reaction
 ENSMUSG00000024663 Q8VDV3 / Rab3il1 / Mus musculus RAB3A interacting protein (rabin3)-like 1 (Rab3il1), transcript variant 2, mRNA. / Q8TBN0* / RAB3A interacting protein like 1*  / reaction
 ENSMUSG00000030313 A2RSQ0 / Dennd5b / DENN domain-containing protein 5B / Q6ZUT9* / DENN domain containing 5B*  / reaction
 ENSMUSG00000036529 Sbf1 / Q6ZPE2 / SET binding factor 1 / O95248*  / reaction






 

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