Manteia

ENSMUSG00000028468

Mus musculus

Features

Gene ID:	ENSMUSG00000028468

Biological name :	Rgp1

Synonyms :	Q8BHT7 / RAB6A-GEF complex partner protein 2 / Rgp1

Possible biological names infered from orthology :	Q92546 / RGP1 homolog, RAB6A GEF complex partner 1

Species:	Mus musculus

Chr. number:	4
Strand:	1
Band:	A5
Gene start:	43578715
Gene end:	43587487

Corresponding Affymetrix probe sets:	10504362 (MoGene1.0st) 1434338_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000030190 Ensembl peptide - ENSMUSP00000103518 Ensembl peptide - ENSMUSP00000113476 NCBI entrez gene - 242406 See in Manteia. MGI - MGI:1915956 RefSeq - XM_006537909 RefSeq - NM_172866 RefSeq Peptide - NP_766454 swissprot - Q3TDM6 swissprot - Q8BHT7 Ensembl - ENSMUSG00000028468

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Paralog prediction (from Ensembl)

Paralog name

Similarity(%)

No match

Protein motifs (from Interpro)

Interpro ID	Name
IPR014848	Reduced growth phenotype protein 1

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0042147	retrograde transport, endosome to Golgi	ISS
biological_process	GO:0043547	positive regulation of GTPase activity	ISS
biological_process	GO:1903363	negative regulation of cellular protein catabolic process	ISO
cellular_component	GO:0000139	Golgi membrane	IBA
cellular_component	GO:0005737	cytoplasm	IEA
cellular_component	GO:0005829	cytosol	ISS
cellular_component	GO:0005886	plasma membrane	ISO
cellular_component	GO:0016020	membrane	ISO
cellular_component	GO:0032991	protein-containing complex	ISS
cellular_component	GO:0034066	RIC1-RGP1 guanyl-nucleotide exchange factor complex	ISO
molecular_function	GO:0005085	guanyl-nucleotide exchange factor activity	IEA
molecular_function	GO:0017112	Rab guanyl-nucleotide exchange factor activity	IBA
molecular_function	GO:0017137	Rab GTPase binding	ISO

Pathways (from Reactome)

Pathway description

Intra-Golgi traffic

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0011100	complete preweaning lethality	"death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]	Show Allelic Composition: Rad21l^{tm1b(KOMP)Wtsi}/Rad21l^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Rad21l^{tm1b(KOMP)Wtsi}/J
MP:0013292	embryonic lethality prior to organogenesis	"death prior to the completion of embryo turning (Mus: E9-9.5)" [MGI:smb]	Show Allelic Composition: Rad21l^{tm1b(KOMP)Wtsi}/Rad21l^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Rad21l^{tm1b(KOMP)Wtsi}/J
MP:0013293	embryonic lethality prior to tooth bud stage	"death prior to the appearance of tooth buds (Mus: E12-E12.5)" [MGI:smb]	Show Allelic Composition: Rad21l^{tm1b(KOMP)Wtsi}/Rad21l^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Rad21l^{tm1b(KOMP)Wtsi}/J

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000025531	Chm / choroidermia (RAB escort protein 1) / P24386* / CHM, Rab escort protein 1*	/ reaction
ENSMUSG00000027739	O35963 / Rab33b / RAB33B, member RAS oncogene family / Q9H082*	/ reaction / complex
ENSMUSG00000030704	Rab6a / P35279 / RAB6A, member RAS oncogene family / RAB6C* / RAB6D* / Q9H0N0* / P20340* / RAB6C, member RAS oncogene family* / RAB6D, member RAS oncogene family*	/ reaction / complex
ENSMUSG00000078185	Chml / choroideremia-like / P26374* / CHM like, Rab escort protein 2*	/ reaction
ENSMUSG00000021218	Gdi2 / Q61598 / Rab GDP dissociation inhibitor beta / P50395* / GDP dissociation inhibitor 2*	/ reaction
ENSMUSG00000015291	Gdi1 / P50396 / Rab GDP dissociation inhibitor alpha / P31150* / GDP dissociation inhibitor 1*	/ reaction
ENSMUSG00000038658	Ric1 / Q69ZJ7 / RAB6A-GEF complex partner protein 1 / Q4ADV7* / RIC1 homolog, RAB6A GEF complex partner 1*	/ complex

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr