ENSG00000107185


Homo sapiens

Features
Gene ID: ENSG00000107185
  
Biological name :RGP1
  
Synonyms : Q92546 / RGP1 / RGP1 homolog, RAB6A GEF complex partner 1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 9
Strand: 1
Band: p13.3
Gene start: 35749287
Gene end: 35758575
  
Corresponding Affymetrix probe sets: 203169_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000367318
NCBI entrez gene - 9827     See in Manteia.
OMIM - 615742
RefSeq - NM_001080496
RefSeq Peptide - NP_001073965
swissprot - Q92546
Ensembl - ENSG00000107185
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rgp1ENSDARG00000006545Danio rerio
 RGP1ENSGALG00000002394Gallus gallus
 Rgp1ENSMUSG00000028468Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR014848  Reduced growth phenotype protein 1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0042147 retrograde transport, endosome to Golgi IMP
 biological_processGO:0043547 positive regulation of GTPase activity IDA
 biological_processGO:1903363 negative regulation of cellular protein catabolic process IMP
 cellular_componentGO:0000139 Golgi membrane IBA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0032588 trans-Golgi network membrane TAS
 cellular_componentGO:0032991 protein-containing complex IDA
 cellular_componentGO:0034066 RIC1-RGP1 guanyl-nucleotide exchange factor complex IDA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0017112 Rab guanyl-nucleotide exchange factor activity IDA
 molecular_functionGO:0017137 Rab GTPase binding IDA


Pathways (from Reactome)
Pathway description
Intra-Golgi traffic
Retrograde transport at the Trans-Golgi-Network
RAB GEFs exchange GTP for GDP on RABs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000107036 RIC1 / Q4ADV7 / RIC1 homolog, RAB6A GEF complex partner 1  / complex
 ENSG00000172007 Q9H082 / RAB33B / RAB33B, member RAS oncogene family  / complex / reaction
 ENSG00000175582 RAB6A / P20340 / RAB6A, member RAS oncogene family  / complex / reaction
 ENSG00000057608 GDI2 / P50395 / GDP dissociation inhibitor 2  / reaction
 ENSG00000203879 GDI1 / P31150 / GDP dissociation inhibitor 1  / reaction
 ENSG00000188419 CHM / P24386 / CHM, Rab escort protein 1  / reaction
 ENSG00000203668 CHML / P26374 / CHM like, Rab escort protein 2  / reaction






 

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