ENSG00000175582


Homo sapiens

Features
Gene ID: ENSG00000175582
  
Biological name :RAB6A
  
Synonyms : P20340 / RAB6A / RAB6A, member RAS oncogene family
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: -1
Band: q13.4
Gene start: 73675638
Gene end: 73761137
  
Corresponding Affymetrix probe sets: 1559174_at (Human Genome U133 Plus 2.0 Array)   201045_s_at (Human Genome U133 Plus 2.0 Array)   201047_x_at (Human Genome U133 Plus 2.0 Array)   201048_x_at (Human Genome U133 Plus 2.0 Array)   210406_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000440469
Ensembl peptide - ENSP00000443470
Ensembl peptide - ENSP00000445350
Ensembl peptide - ENSP00000443782
Ensembl peptide - ENSP00000311449
Ensembl peptide - ENSP00000336850
Ensembl peptide - ENSP00000437863
Ensembl peptide - ENSP00000438842
NCBI entrez gene - 5870     See in Manteia.
OMIM - 179513
RefSeq - NM_198896
RefSeq - NM_001243718
RefSeq - NM_001243719
RefSeq - NM_002869
RefSeq Peptide - NP_001230647
RefSeq Peptide - NP_001230648
RefSeq Peptide - NP_002860
RefSeq Peptide - NP_942599
swissprot - P20340
swissprot - A0A024R5H8
swissprot - F5GX61
swissprot - F5H3K7
swissprot - A0A024R5J5
Ensembl - ENSG00000175582
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rab6aENSDARG00000103714Danio rerio
 RAB6AENSGALG00000017320Gallus gallus
 Rab6aENSMUSG00000030704Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
RAB6D / RAB6D, member RAS oncogene familyENSG0000023308792
RAB6C / Q9H0N0 / RAB6C, member RAS oncogene familyENSG0000022201491
RAB6B / Q9NRW1 / RAB6B, member RAS oncogene familyENSG0000015491789
RAB41 / Q5JT25 / RAB41, member RAS oncogene familyENSG0000014712765
RAB36 / O95755 / RAB36, member RAS oncogene familyENSG0000010022835
RAB34 / P0DI83 / Q9BZG1 / RAB34, member RAS oncogene familyENSG0000010911328


Protein motifs (from Interpro)
Interpro ID Name
 IPR001806  Small GTPase superfamily
 IPR005225  Small GTP-binding protein domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006890 retrograde vesicle-mediated transport, Golgi to ER TAS
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016032 viral process IEA
 biological_processGO:0016192 vesicle-mediated transport IEA
 biological_processGO:0018125 peptidyl-cysteine methylation IDA
 biological_processGO:0019882 antigen processing and presentation IMP
 biological_processGO:0034067 protein localization to Golgi apparatus IDA
 biological_processGO:0034498 early endosome to Golgi transport IMP
 biological_processGO:0043312 neutrophil degranulation TAS
 biological_processGO:0072385 minus-end-directed organelle transport along microtubule TAS
 cellular_componentGO:0000139 Golgi membrane TAS
 cellular_componentGO:0005789 endoplasmic reticulum membrane TAS
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005802 trans-Golgi network IDA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0016020 membrane IDA
 cellular_componentGO:0030667 secretory granule membrane TAS
 cellular_componentGO:0031410 cytoplasmic vesicle IDA
 cellular_componentGO:0032588 trans-Golgi network membrane TAS
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:0070381 endosome to plasma membrane transport vesicle IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003924 GTPase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005525 GTP binding IEA
 molecular_functionGO:0019904 protein domain specific binding IPI
 molecular_functionGO:0031489 myosin V binding IPI


Pathways (from Reactome)
Pathway description
Pre-NOTCH Processing in Golgi
Neutrophil degranulation
COPI-independent Golgi-to-ER retrograde traffic
Retrograde transport at the Trans-Golgi-Network
TBC/RABGAPs
RAB geranylgeranylation
RAB GEFs exchange GTP for GDP on RABs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000104671 DCTN6 / O00399 / dynactin subunit 6  / complex / reaction
 ENSG00000131966 ACTR10 / Q9NZ32 / actin related protein 10 homolog  / complex / reaction
 ENSG00000107036 RIC1 / Q4ADV7 / RIC1 homolog, RAB6A GEF complex partner 1  / reaction / complex
 ENSG00000088986 DYNLL1 / P63167 / dynein light chain LC8-type 1  / reaction / complex
 ENSG00000137100 DCTN3 / O75935 / dynactin subunit 3  / reaction / complex
 ENSG00000135720 O43237 / DYNC1LI2 / dynein cytoplasmic 1 light intermediate chain 2  / complex / reaction
 ENSG00000077549 CAPZB / P47756 / capping actin protein of muscle Z-line beta subunit  / complex / reaction
 ENSG00000116489 CAPZA1 / P52907 / capping actin protein of muscle Z-line alpha subunit 1  / reaction / complex
 ENSG00000144635 Q9Y6G9 / DYNC1LI1 / dynein cytoplasmic 1 light intermediate chain 1  / reaction / complex
 ENSG00000151746 BICD1 / Q96G01 / BICD cargo adaptor 1  / reaction / complex
 ENSG00000057608 GDI2 / P50395 / GDP dissociation inhibitor 2  / complex
 ENSG00000203879 GDI1 / P31150 / GDP dissociation inhibitor 1  / complex
 ENSG00000011454 Q9Y3P9 / RABGAP1 / RAB GTPase activating protein 1  / reaction / complex
 ENSG00000203668 CHML / P26374 / CHM like, Rab escort protein 2  / complex
 ENSG00000188419 CHM / P24386 / CHM, Rab escort protein 1  / complex
 ENSG00000107185 RGP1 / Q92546 / RGP1 homolog, RAB6A GEF complex partner 1  / complex / reaction
 ENSG00000166847 DCTN5 / Q9BTE1 / dynactin subunit 5  / complex / reaction
 ENSG00000141429 GALNT1 / Q10472 / polypeptide N-acetylgalactosaminyltransferase 1  / complex / reaction
 ENSG00000177938 CAPZA3 / Q96KX2 / capping actin protein of muscle Z-line alpha subunit 3  / complex / reaction
 ENSG00000077380 Q13409 / DYNC1I2 / dynein cytoplasmic 1 intermediate chain 2  / reaction / complex
 ENSG00000158560 O14576 / DYNC1I1 / dynein cytoplasmic 1 intermediate chain 1  / reaction / complex
 ENSG00000204843 DCTN1 / Q14203 / dynactin subunit 1  / complex / reaction
 ENSG00000197102 Q14204 / DYNC1H1 / dynein cytoplasmic 1 heavy chain 1  / reaction / complex
 ENSG00000198898 CAPZA2 / P47755 / capping actin protein of muscle Z-line alpha subunit 2  / complex / reaction
 ENSG00000143641 GALNT2 / Q10471 / polypeptide N-acetylgalactosaminyltransferase 2  / complex / reaction
 ENSG00000138107 ACTR1A / P61163 / ARP1 actin related protein 1 homolog A  / reaction / complex
 ENSG00000007168 P43034 / PAFAH1B1 / platelet activating factor acetylhydrolase 1b regulatory subunit 1  / reaction
 ENSG00000132912 DCTN4 / Q9UJW0 / dynactin subunit 4  / complex / reaction
 ENSG00000175203 DCTN2 / Q13561 / dynactin subunit 2  / complex / reaction
 ENSG00000264364 DYNLL2 / Q96FJ2 / dynein light chain LC8-type 2  / reaction / complex






 

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