ENSG00000158560


Homo sapiens

Features
Gene ID: ENSG00000158560
  
Biological name :DYNC1I1
  
Synonyms : DYNC1I1 / dynein cytoplasmic 1 intermediate chain 1 / O14576
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 7
Strand: 1
Band: q21.3
Gene start: 95772506
Gene end: 96110322
  
Corresponding Affymetrix probe sets: 1569843_at (Human Genome U133 Plus 2.0 Array)   205348_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000411957
Ensembl peptide - ENSP00000398118
Ensembl peptide - ENSP00000412444
Ensembl peptide - ENSP00000486363
Ensembl peptide - ENSP00000438377
Ensembl peptide - ENSP00000428934
Ensembl peptide - ENSP00000428273
Ensembl peptide - ENSP00000320130
Ensembl peptide - ENSP00000352348
Ensembl peptide - ENSP00000392337
NCBI entrez gene - 1780     See in Manteia.
OMIM - 603772
RefSeq - XM_017011806
RefSeq - NM_001135556
RefSeq - NM_001135557
RefSeq - NM_001278421
RefSeq - NM_001278422
RefSeq - NM_004411
RefSeq - XM_011515861
RefSeq - XM_011515862
RefSeq - XM_011515863
RefSeq - XM_017011804
RefSeq - XM_017011805
RefSeq Peptide - NP_001129028
RefSeq Peptide - NP_001265350
RefSeq Peptide - NP_001265351
RefSeq Peptide - NP_004402
RefSeq Peptide - NP_001129029
swissprot - A0A0A0MTG2
swissprot - O14576
swissprot - E5RJ75
swissprot - E5RFE1
swissprot - C9J3E7
swissprot - A4D1I7
Ensembl - ENSG00000158560
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dync1i1ENSDARG00000060948Danio rerio
 DYNC1I1ENSGALG00000009722Gallus gallus
 O88485ENSMUSG00000029757Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q13409 / DYNC1I2 / dynein cytoplasmic 1 intermediate chain 2ENSG0000007738076
WDR78 / Q5VTH9 / WD repeat domain 78ENSG0000015276321
DNAI1 / Q9UI46 / dynein axonemal intermediate chain 1ENSG0000012273520
WDR34 / Q96EX3 / WD repeat domain 34ENSG0000011933315
DNAI2 / Q9GZS0 / dynein axonemal intermediate chain 2ENSG0000017159514


Protein motifs (from Interpro)
Interpro ID Name
 IPR001680  WD40 repeat
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR017986  WD40-repeat-containing domain
 IPR025956  Cytoplasmic dynein 1 intermediate chain 1/2
 IPR036322  WD40-repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006888 ER to Golgi vesicle-mediated transport TAS
 biological_processGO:0007018 microtubule-based movement IEA
 biological_processGO:0007062 sister chromatid cohesion TAS
 biological_processGO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II TAS
 biological_processGO:0047496 vesicle transport along microtubule IMP
 biological_processGO:2000582 positive regulation of ATP-dependent microtubule motor activity, plus-end-directed IBA
 cellular_componentGO:0000775 chromosome, centromeric region IEA
 cellular_componentGO:0000776 kinetochore IEA
 cellular_componentGO:0000777 condensed chromosome kinetochore IEA
 cellular_componentGO:0000922 spindle pole IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005868 cytoplasmic dynein complex IEA
 cellular_componentGO:0005874 microtubule IEA
 cellular_componentGO:0030286 dynein complex IEA
 cellular_componentGO:0031982 vesicle IDA
 cellular_componentGO:0036464 cytoplasmic ribonucleoprotein granule IDA
 cellular_componentGO:0048471 perinuclear region of cytoplasm ISS
 cellular_componentGO:0055037 recycling endosome IDA
 molecular_functionGO:0003774 motor activity TAS
 molecular_functionGO:0003777 microtubule motor activity ISS
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008017 microtubule binding ISS
 molecular_functionGO:0008574 ATP-dependent microtubule motor activity, plus-end-directed IBA
 molecular_functionGO:0030507 spectrin binding IDA
 molecular_functionGO:0045503 dynein light chain binding IBA
 molecular_functionGO:0045504 dynein heavy chain binding IBA


Pathways (from Reactome)
Pathway description
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
MHC class II antigen presentation
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
HSP90 chaperone cycle for steroid hormone receptors (SHR)
RHO GTPases Activate Formins
COPI-mediated anterograde transport
COPI-independent Golgi-to-ER retrograde traffic
Mitotic Prometaphase


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000088986 DYNLL1 / P63167 / dynein light chain LC8-type 1  / complex
 ENSG00000135720 O43237 / DYNC1LI2 / dynein cytoplasmic 1 light intermediate chain 2  / complex
 ENSG00000144635 Q9Y6G9 / DYNC1LI1 / dynein cytoplasmic 1 light intermediate chain 1  / complex
 ENSG00000077380 Q13409 / DYNC1I2 / dynein cytoplasmic 1 intermediate chain 2  / complex
 ENSG00000141429 GALNT1 / Q10472 / polypeptide N-acetylgalactosaminyltransferase 1  / reaction / complex
 ENSG00000104671 DCTN6 / O00399 / dynactin subunit 6  / complex
 ENSG00000077549 CAPZB / P47756 / capping actin protein of muscle Z-line beta subunit  / complex
 ENSG00000166847 DCTN5 / Q9BTE1 / dynactin subunit 5  / complex
 ENSG00000138107 ACTR1A / P61163 / ARP1 actin related protein 1 homolog A  / complex
 ENSG00000131966 ACTR10 / Q9NZ32 / actin related protein 10 homolog  / complex
 ENSG00000204843 DCTN1 / Q14203 / dynactin subunit 1  / complex
 ENSG00000143641 GALNT2 / Q10471 / polypeptide N-acetylgalactosaminyltransferase 2  / complex / reaction
 ENSG00000197102 Q14204 / DYNC1H1 / dynein cytoplasmic 1 heavy chain 1  / complex
 ENSG00000177938 CAPZA3 / Q96KX2 / capping actin protein of muscle Z-line alpha subunit 3  / complex
 ENSG00000151746 BICD1 / Q96G01 / BICD cargo adaptor 1  / reaction / complex
 ENSG00000007168 P43034 / PAFAH1B1 / platelet activating factor acetylhydrolase 1b regulatory subunit 1  / complex
 ENSG00000175203 DCTN2 / Q13561 / dynactin subunit 2  / complex
 ENSG00000132912 DCTN4 / Q9UJW0 / dynactin subunit 4  / complex
 ENSG00000198898 CAPZA2 / P47755 / capping actin protein of muscle Z-line alpha subunit 2  / complex
 ENSG00000137100 DCTN3 / O75935 / dynactin subunit 3  / complex
 ENSG00000158560 O14576 / DYNC1I1 / dynein cytoplasmic 1 intermediate chain 1  / complex
 ENSG00000116489 CAPZA1 / P52907 / capping actin protein of muscle Z-line alpha subunit 1  / complex
 ENSG00000175582 RAB6A / P20340 / RAB6A, member RAS oncogene family  / complex / reaction
 ENSG00000264364 DYNLL2 / Q96FJ2 / dynein light chain LC8-type 2  / complex






 

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