ENSG00000077549


Homo sapiens

Features
Gene ID: ENSG00000077549
  
Biological name :CAPZB
  
Synonyms : capping actin protein of muscle Z-line beta subunit / CAPZB / P47756
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: -1
Band: p36.13
Gene start: 19338776
Gene end: 19485539
  
Corresponding Affymetrix probe sets: 201949_x_at (Human Genome U133 Plus 2.0 Array)   201950_x_at (Human Genome U133 Plus 2.0 Array)   215097_at (Human Genome U133 Plus 2.0 Array)   37012_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000401010
Ensembl peptide - ENSP00000264202
Ensembl peptide - ENSP00000264203
Ensembl peptide - ENSP00000364284
Ensembl peptide - ENSP00000364286
NCBI entrez gene - 832     See in Manteia.
OMIM - 601572
RefSeq - XM_017002428
RefSeq - NM_001206540
RefSeq - NM_001206541
RefSeq - NM_001282162
RefSeq - NM_004930
RefSeq - XM_006710938
RefSeq - XM_011542228
RefSeq - XM_011542229
RefSeq - XM_011542230
RefSeq Peptide - NP_001269091
RefSeq Peptide - NP_004921
RefSeq Peptide - NP_001193469
RefSeq Peptide - NP_001193470
swissprot - P47756
swissprot - B1AK87
swissprot - B1AK88
swissprot - B1AK85
Ensembl - ENSG00000077549
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 capzbENSDARG00000100252Danio rerio
 CAPZBENSGALG00000004034Gallus gallus
 CapzbENSMUSG00000028745Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001698  F-actin-capping protein subunit beta
 IPR019771  F-actin capping protein, beta subunit, conserved site
 IPR037282  F-actin-capping protein subunit alpha/beta


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006888 ER to Golgi vesicle-mediated transport TAS
 biological_processGO:0007010 cytoskeleton organization IMP
 biological_processGO:0007596 blood coagulation TAS
 biological_processGO:0010591 regulation of lamellipodium assembly IBA
 biological_processGO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II TAS
 biological_processGO:0022604 regulation of cell morphogenesis IMP
 biological_processGO:0030030 cell projection organization IEA
 biological_processGO:0030032 lamellipodium assembly IEA
 biological_processGO:0030036 actin cytoskeleton organization IEA
 biological_processGO:0031115 negative regulation of microtubule polymerization IEA
 biological_processGO:0031175 neuron projection development IEA
 biological_processGO:0048747 muscle fiber development IEA
 biological_processGO:0051016 barbed-end actin filament capping IBA
 biological_processGO:0051490 negative regulation of filopodium assembly IBA
 biological_processGO:0051693 actin filament capping IEA
 biological_processGO:0090036 regulation of protein kinase C signaling IEA
 cellular_componentGO:0001669 acrosomal vesicle IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005856 cytoskeleton TAS
 cellular_componentGO:0005884 actin filament IBA
 cellular_componentGO:0005903 brush border IEA
 cellular_componentGO:0008290 F-actin capping protein complex IBA
 cellular_componentGO:0014704 intercalated disc IEA
 cellular_componentGO:0015629 actin cytoskeleton TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030017 sarcomere IEA
 cellular_componentGO:0030018 Z disc IEA
 cellular_componentGO:0030027 lamellipodium IEA
 cellular_componentGO:0030863 cortical cytoskeleton IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:0071203 WASH complex IDA
 molecular_functionGO:0003779 actin binding TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0045296 cadherin binding IDA
 molecular_functionGO:0048487 beta-tubulin binding IEA
 molecular_functionGO:0051015 actin filament binding IBA


Pathways (from Reactome)
Pathway description
MHC class II antigen presentation
HSP90 chaperone cycle for steroid hormone receptors (SHR)
COPI-mediated anterograde transport
COPI-independent Golgi-to-ER retrograde traffic
Factors involved in megakaryocyte development and platelet production


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000088986 DYNLL1 / P63167 / dynein light chain LC8-type 1  / complex
 ENSG00000135720 O43237 / DYNC1LI2 / dynein cytoplasmic 1 light intermediate chain 2  / complex
 ENSG00000175582 RAB6A / P20340 / RAB6A, member RAS oncogene family  / reaction / complex
 ENSG00000143641 GALNT2 / Q10471 / polypeptide N-acetylgalactosaminyltransferase 2  / complex / reaction
 ENSG00000079691 Q5VZK9 / CARMIL1 / capping protein regulator and myosin 1 linker 1  / reaction / complex
 ENSG00000104671 DCTN6 / O00399 / dynactin subunit 6  / complex
 ENSG00000141429 GALNT1 / Q10472 / polypeptide N-acetylgalactosaminyltransferase 1  / complex / reaction
 ENSG00000204843 DCTN1 / Q14203 / dynactin subunit 1  / complex
 ENSG00000131966 ACTR10 / Q9NZ32 / actin related protein 10 homolog  / complex
 ENSG00000007168 P43034 / PAFAH1B1 / platelet activating factor acetylhydrolase 1b regulatory subunit 1  / complex
 ENSG00000151746 BICD1 / Q96G01 / BICD cargo adaptor 1  / complex / reaction
 ENSG00000175203 DCTN2 / Q13561 / dynactin subunit 2  / complex
 ENSG00000132912 DCTN4 / Q9UJW0 / dynactin subunit 4  / complex
 ENSG00000137100 DCTN3 / O75935 / dynactin subunit 3  / complex
 ENSG00000138107 ACTR1A / P61163 / ARP1 actin related protein 1 homolog A  / complex
 ENSG00000166847 DCTN5 / Q9BTE1 / dynactin subunit 5  / complex
 ENSG00000116489 CAPZA1 / P52907 / capping actin protein of muscle Z-line alpha subunit 1  / complex / reaction
 ENSG00000144635 Q9Y6G9 / DYNC1LI1 / dynein cytoplasmic 1 light intermediate chain 1  / complex
 ENSG00000177938 CAPZA3 / Q96KX2 / capping actin protein of muscle Z-line alpha subunit 3  / complex
 ENSG00000077380 Q13409 / DYNC1I2 / dynein cytoplasmic 1 intermediate chain 2  / complex
 ENSG00000075624 ACTB / P60709 / actin beta  / reaction / complex
 ENSG00000158560 O14576 / DYNC1I1 / dynein cytoplasmic 1 intermediate chain 1  / complex
 ENSG00000197102 Q14204 / DYNC1H1 / dynein cytoplasmic 1 heavy chain 1  / complex
 ENSG00000198898 CAPZA2 / P47755 / capping actin protein of muscle Z-line alpha subunit 2  / complex / reaction
 ENSG00000264364 DYNLL2 / Q96FJ2 / dynein light chain LC8-type 2  / complex






 

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