ENSMUSG00000028745


Mus musculus

Features
Gene ID: ENSMUSG00000028745
  
Biological name :Capzb
  
Synonyms : Capzb / F-actin-capping protein subunit beta / P47757
  
Possible biological names infered from orthology : capping actin protein of muscle Z-line beta subunit / P47756
  
Species: Mus musculus
  
Chr. number: 4
Strand: 1
Band: D3
Gene start: 139192899
Gene end: 139291818
  
Corresponding Affymetrix probe sets: 10509620 (MoGene1.0st)   1417259_a_at (Mouse Genome 430 2.0 Array)   1424168_a_at (Mouse Genome 430 2.0 Array)   1431668_at (Mouse Genome 430 2.0 Array)   1453960_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000119252
Ensembl peptide - ENSMUSP00000114973
Ensembl peptide - ENSMUSP00000122077
Ensembl peptide - ENSMUSP00000030518
Ensembl peptide - ENSMUSP00000038011
Ensembl peptide - ENSMUSP00000099565
Ensembl peptide - ENSMUSP00000099566
NCBI entrez gene - 12345     See in Manteia.
MGI - MGI:104652
RefSeq - XM_006538504
RefSeq - NM_001037761
RefSeq - NM_001271405
RefSeq - NM_009798
RefSeq Peptide - NP_001032850
RefSeq Peptide - NP_001258334
RefSeq Peptide - NP_033928
swissprot - F6YHZ8
swissprot - F7CAZ6
swissprot - P47757
swissprot - A2AMW0
swissprot - Q923G3
swissprot - A0A0A0MQI9
Ensembl - ENSMUSG00000028745
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 capzbENSDARG00000100252Danio rerio
 CAPZBENSGALG00000004034Gallus gallus
 CAPZBENSG00000077549Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001698  F-actin-capping protein subunit beta
 IPR019771  F-actin capping protein, beta subunit, conserved site
 IPR037282  F-actin-capping protein subunit alpha/beta


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000902 cell morphogenesis IBA
 biological_processGO:0007010 cytoskeleton organization ISO
 biological_processGO:0010591 regulation of lamellipodium assembly IBA
 biological_processGO:0022604 regulation of cell morphogenesis ISO
 biological_processGO:0030030 cell projection organization IMP
 biological_processGO:0030032 lamellipodium assembly IMP
 biological_processGO:0030036 actin cytoskeleton organization IEA
 biological_processGO:0031115 negative regulation of microtubule polymerization IDA
 biological_processGO:0031175 neuron projection development IMP
 biological_processGO:0048747 muscle fiber development IMP
 biological_processGO:0051016 barbed-end actin filament capping IEA
 biological_processGO:0051490 negative regulation of filopodium assembly IBA
 biological_processGO:0051693 actin filament capping IEA
 biological_processGO:0090036 regulation of protein kinase C signaling IMP
 cellular_componentGO:0001669 acrosomal vesicle IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005884 actin filament IBA
 cellular_componentGO:0005903 brush border IDA
 cellular_componentGO:0008290 F-actin capping protein complex IEA
 cellular_componentGO:0014704 intercalated disc ISA
 cellular_componentGO:0016020 membrane IDA
 cellular_componentGO:0030017 sarcomere IEA
 cellular_componentGO:0030018 Z disc IEA
 cellular_componentGO:0030027 lamellipodium IDA
 cellular_componentGO:0030863 cortical cytoskeleton IDA
 cellular_componentGO:0033150 cytoskeletal calyx IEA
 cellular_componentGO:0071203 WASH complex ISS
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0045296 cadherin binding ISO
 molecular_functionGO:0048487 beta-tubulin binding IPI
 molecular_functionGO:0051015 actin filament binding IDA


Pathways (from Reactome)
Pathway description
MHC class II antigen presentation
HSP90 chaperone cycle for steroid hormone receptors (SHR)
COPI-mediated anterograde transport
COPI-independent Golgi-to-ER retrograde traffic
Factors involved in megakaryocyte development and platelet production


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000031 abnormal cochlea morphology "any anomaly, deformity, malformation, impairment or dysfunction of the cochlea" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator, J:21484]
Show

Allelic Composition: Kif20bmagoo/Kif20bmagoo
Genetic Background: involves: BALB/c * C57BL/6

 MP:0002730 head shaking "compulsive movement of the head in the horizontal plane" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:274]
Show

Allelic Composition: Kif20bmagoo/Kif20bmagoo
Genetic Background: involves: BALB/c * C57BL/6

 MP:0004362 cochlear hair cell degeneration "degeneration or loss of the sensory epithelial cells of the cochlea; these cells are in synaptic contact with the auditory nerve" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Capzbtm1c(EUCOMM)Wtsi/Capzbtm1c(EUCOMM)Wtsi,Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+,Tg(Atoh1-cre)1Bfri/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6N * CBA * SJL

 MP:0004515 abnormal vestibular hair cell stereociliary bundle morphology "any structural anomaly or disruption of the typical staircase-like arrangement of the mechanosensitive hair bundles which are composed of thick long microvilli (stereocilia) and are located at the apical end of vestibular hair cells of the utricle and saccule" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Capzbtm1c(EUCOMM)Wtsi/Capzbtm1c(EUCOMM)Wtsi,Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+,Tg(Atoh1-cre)1Bfri/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6N * CBA * SJL

 MP:0004520 short vestibular hair cell stereocilia "reduced length of the nonmotile, actin-filled specialized microvilli (stereocilia) which are normally arrayed on vestibular hair cells in a staircase-like pattern" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Capzbtm1c(EUCOMM)Wtsi/Capzbtm1c(EUCOMM)Wtsi,Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+,Tg(Atoh1-cre)1Bfri/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6N * CBA * SJL

 MP:0004523 decreased cochlear hair cell stereocilia number "decreased number (or less than the expected 100 or so) of the nonmotile, actin-filled specialized microvilli (stereocilia) normally arrayed on cochlear inner and outer hair cells" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Capzbtm1c(EUCOMM)Wtsi/Capzbtm1c(EUCOMM)Wtsi,Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+,Tg(Atoh1-cre)1Bfri/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6N * CBA * SJL

 MP:0004737 absent distortion product otoacoustic emissions "failure to create mechanical distortions in the inner ear when two primary tones are presented, indicating failure of outer hair cells to amplify basilar membrane motion" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Kif20bmagoo/Kif20bmagoo
Genetic Background: involves: BALB/c * C57BL/6

 MP:0004742 abnormal vestibular system physiology "any functional anomaly of the sensory system responsible for the sense of head position and movement of the body through space; such anomalies may include impaired balance, dizziness, poor regulation of postural muscle tone and inability to detect quick movements of the head " [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Kif20bmagoo/Kif20bmagoo
Genetic Background: involves: BALB/c * C57BL/6

 MP:0004813 absent linear vestibular evoked potential "absence of the biphasic response elicited by linear acceleration transients (usually jerk pulses to an animal s head)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Kif20bmagoo/Kif20bmagoo
Genetic Background: involves: BALB/c * C57BL/6

 MP:0010015 abnormal cuticular plate morphology "any structural anomaly of the firm laminar network of actin filaments in the organ of Corti to which the apical ends of the cochlear hair cells attach and through which their stereocilia project" [PMID:12324381]
Show

Allelic Composition: Capzbtm1c(EUCOMM)Wtsi/Capzbtm1c(EUCOMM)Wtsi,Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+,Tg(Atoh1-cre)1Bfri/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6N * CBA * SJL

 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
Show

Allelic Composition: Kif20bmagoo/Kif20bmagoo
Genetic Background: involves: BALB/c * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000020745 P63005 / Pafah1b1 / platelet-activating factor acetylhydrolase, isoform 1b, subunit 1 / P43034* / platelet activating factor acetylhydrolase 1b regulatory subunit 1*  / complex
 ENSMUSG00000015733 Capza2 / P47754 / F-actin-capping protein subunit alpha-2 / P47755* / capping actin protein of muscle Z-line alpha subunit 2*  / complex / reaction
 ENSMUSG00000064063 BC048507 / cDNA sequence BC048507 / DYNLL1* / P63167* / dynein light chain LC8-type 1*  / complex
 ENSMUSG00000027012 O88487 / Dync1i2 / Mus musculus dynein cytoplasmic 1 intermediate chain 2 (Dync1i2), transcript variant 9, mRNA. / Q13409* / dynein cytoplasmic 1 intermediate chain 2*  / complex
 ENSMUSG00000035770 Q6PDL0 / Dync1li2 / Cytoplasmic dynein 1 light intermediate chain 2 / O43237* / dynein cytoplasmic 1 light intermediate chain 2*  / complex
 ENSMUSG00000028447 Dctn3 / Q9Z0Y1 / Dynactin subunit 3 / O75935*  / complex
 ENSMUSG00000031516 Dctn6 / Q9WUB4 / Dynactin subunit 6 / O00399*  / complex
 ENSMUSG00000025228 Actr1a / P61164 / Alpha-centractin / P61163* / ARP1 actin related protein 1 homolog A*  / complex
 ENSMUSG00000025410 Dctn2 / Q99KJ8 / Dynactin subunit 2 / Q13561*  / complex
 ENSMUSG00000092329 Q6PB93 / Gm20388 / predicted gene 20388 / GALNT2* / Q10471* / polypeptide N-acetylgalactosaminyltransferase 2*  / complex / reaction
 ENSMUSG00000020483 Dynll2 / Q9D0M5 / Dynein light chain 2, cytoplasmic / Q96FJ2* / dynein light chain LC8-type 2*  / complex
 ENSMUSG00000041791 Capza3 / P70190 / F-actin-capping protein subunit alpha-3 / Q96KX2* / capping actin protein of muscle Z-line alpha subunit 3*  / complex
 ENSMUSG00000021338 Q6EDY6 / Carmil1 / F-actin-uncapping protein LRRC16A / Q5VZK9* / capping protein regulator and myosin 1 linker 1*  / reaction / complex
 ENSMUSG00000021076 Actr10 / Q9QZB7 / Actin-related protein 10 / Q9NZ32* / actin related protein 10 homolog*  / complex
 ENSMUSG00000000420 Galnt1 / O08912 / Polypeptide N-acetylgalactosaminyltransferase 1 Polypeptide N-acetylgalactosaminyltransferase 1 soluble form / Q10472* / polypeptide N-acetylgalactosaminyltransferase 1*  / reaction / complex
 ENSMUSG00000030704 Rab6a / P35279 / RAB6A, member RAS oncogene family / RAB6C* / RAB6D* / Q9H0N0* / P20340* / RAB6C, member RAS oncogene family* / RAB6D, member RAS oncogene family*  / reaction / complex
 ENSMUSG00000031865 Dctn1 / O08788 / Mus musculus dynactin 1 (Dctn1), transcript variant 4, mRNA. / Q14203* / dynactin subunit 1*  / complex
 ENSMUSG00000029757 O88485 / Dync1i1 / Cytoplasmic dynein 1 intermediate chain 1 / O14576* / dynein cytoplasmic 1 intermediate chain 1*  / complex
 ENSMUSG00000018707 Q9JHU4 / Dync1h1 / Cytoplasmic dynein 1 heavy chain 1 / Q14204* / dynein cytoplasmic 1 heavy chain 1*  / complex
 ENSMUSG00000003452 Bicd1 / Q8BR07 / Protein bicaudal D homolog 1 / Q96G01* / BICD cargo adaptor 1*  / complex / reaction
 ENSMUSG00000024603 Dctn4 / Q8CBY8 / Mus musculus dynactin 4 (Dctn4), transcript variant 2, mRNA. / Q9UJW0* / dynactin subunit 4*  / complex
 ENSMUSG00000032435 Q8R1Q8 / Dync1li1 / Cytoplasmic dynein 1 light intermediate chain 1 / Q9Y6G9* / dynein cytoplasmic 1 light intermediate chain 1*  / complex
 ENSMUSG00000030868 Dctn5 / Q9QZB9 / Dynactin subunit 5 / Q9BTE1*  / complex






 

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