ENSMUSG00000021338


Mus musculus

Features
Gene ID: ENSMUSG00000021338
  
Biological name :Carmil1
  
Synonyms : Carmil1 / F-actin-uncapping protein LRRC16A / Q6EDY6
  
Possible biological names infered from orthology : capping protein regulator and myosin 1 linker 1 / Q5VZK9
  
Species: Mus musculus
  
Chr. number: 13
Strand: -1
Band: A3.1
Gene start: 24012344
Gene end: 24280795
  
Corresponding Affymetrix probe sets: 10408280 (MoGene1.0st)   1451804_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000126522
Ensembl peptide - ENSMUSP00000120971
Ensembl peptide - ENSMUSP00000127121
Ensembl peptide - ENSMUSP00000130100
Ensembl peptide - ENSMUSP00000072662
Ensembl peptide - ENSMUSP00000106028
NCBI entrez gene - 68732     See in Manteia.
MGI - MGI:1915982
RefSeq - XM_017315587
RefSeq - XM_011244336
RefSeq - XM_011244337
RefSeq - XM_011244338
RefSeq - XM_011244340
RefSeq - XM_017315583
RefSeq - XM_017315584
RefSeq - XM_017315585
RefSeq - XM_017315586
RefSeq - NM_001311122
RefSeq - NM_026825
RefSeq - XM_006516739
RefSeq - XM_006516741
RefSeq - XM_006516742
RefSeq - XM_011244333
RefSeq - XM_011244334
RefSeq - XM_011244335
RefSeq Peptide - NP_001298051
RefSeq Peptide - NP_081101
swissprot - F7AI27
swissprot - E9Q4H6
swissprot - E9Q7X4
swissprot - D3Z030
swissprot - Q6EDY6
swissprot - F6XQY1
Ensembl - ENSMUSG00000021338
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 carmil1ENSDARG00000103887Danio rerio
 CARMIL1ENSGALG00000013605Gallus gallus
 Q5VZK9ENSG00000079691Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q3UFQ8 / Carmil3 / Capping protein, Arp2/3 and myosin-I linker protein 3 / Q8ND23* / capping protein regulator and myosin 1 linker 3*ENSMUSG0000002221137
Q3V3V9 / Carmil2 / Mus musculus capping protein regulator and myosin 1 linker 2 (Carmil2), mRNA. / Q6F5E8* / capping protein regulator and myosin 1 linker 2*ENSMUSG0000005035711


Protein motifs (from Interpro)
Interpro ID Name
 IPR001611  Leucine-rich repeat
 IPR029764  Leucine-rich repeat-containing protein 16A
 IPR031943  CARMIL, C-terminal domain
 IPR032675  Leucine-rich repeat domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007163 establishment or maintenance of cell polarity ISS
 biological_processGO:0016477 cell migration IEA
 biological_processGO:0030032 lamellipodium assembly IEA
 biological_processGO:0030335 positive regulation of cell migration IEA
 biological_processGO:0030838 positive regulation of actin filament polymerization IMP
 biological_processGO:0031529 ruffle organization IEA
 biological_processGO:0044351 macropinocytosis IEA
 biological_processGO:0046415 urate metabolic process IEA
 biological_processGO:0051496 positive regulation of stress fiber assembly IEA
 biological_processGO:0051638 barbed-end actin filament uncapping IEA
 biological_processGO:0051639 actin filament network formation IEA
 biological_processGO:1900026 positive regulation of substrate adhesion-dependent cell spreading IEA
 biological_processGO:1902745 positive regulation of lamellipodium organization IEA
 biological_processGO:2000813 negative regulation of barbed-end actin filament capping IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016607 nuclear speck IEA
 cellular_componentGO:0030027 lamellipodium IEA
 cellular_componentGO:0031252 cell leading edge IEA
 cellular_componentGO:0031941 filamentous actin IDA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0044354 macropinosome IEA
 cellular_componentGO:0045111 intermediate filament cytoskeleton ISS
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0044877 protein-containing complex binding IEA


Pathways (from Reactome)
Pathway description
Factors involved in megakaryocyte development and platelet production


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Fundc1tm1a(KOMP)Wtsi/Y
Genetic Background: involves: C57BL/6 * C57BL/6N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000015733 Capza2 / P47754 / F-actin-capping protein subunit alpha-2 / P47755* / capping actin protein of muscle Z-line alpha subunit 2*  / complex / reaction
 ENSMUSG00000028745 Capzb / P47757 / F-actin-capping protein subunit beta / P47756* / capping actin protein of muscle Z-line beta subunit*  / reaction / complex






 

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