ENSG00000079691


Homo sapiens

Features
Gene ID: ENSG00000079691
  
Biological name :CARMIL1
  
Synonyms : capping protein regulator and myosin 1 linker 1 / CARMIL1 / Q5VZK9
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 6
Strand: 1
Band: p22.2
Gene start: 25279078
Gene end: 25620530
  
Corresponding Affymetrix probe sets: 1558931_at (Human Genome U133 Plus 2.0 Array)   1562939_at (Human Genome U133 Plus 2.0 Array)   219573_at (Human Genome U133 Plus 2.0 Array)   230793_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000489114
Ensembl peptide - ENSP00000489403
Ensembl peptide - ENSP00000331983
NCBI entrez gene - 55604     See in Manteia.
OMIM - 609593
RefSeq - XM_017011017
RefSeq - XM_017011012
RefSeq - XM_017011013
RefSeq - XM_017011014
RefSeq - XM_017011015
RefSeq - XM_017011016
RefSeq - NM_001173977
RefSeq - NM_017640
RefSeq - XM_005249218
RefSeq - XM_017011008
RefSeq - XM_017011009
RefSeq - XM_017011010
RefSeq - XM_017011011
RefSeq Peptide - NP_001167448
RefSeq Peptide - NP_060110
swissprot - A0A0U1RR91
swissprot - Q5VZK9
swissprot - A0A0U1RQQ1
Ensembl - ENSG00000079691
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 carmil1ENSDARG00000103887Danio rerio
 CARMIL1ENSGALG00000013605Gallus gallus
 Q6EDY6ENSMUSG00000021338Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q8ND23 / CARMIL3 / capping protein regulator and myosin 1 linker 3ENSG0000018664838
Q6F5E8 / CARMIL2 / capping protein regulator and myosin 1 linker 2ENSG0000015975331


Protein motifs (from Interpro)
Interpro ID Name
 IPR001611  Leucine-rich repeat
 IPR029764  Leucine-rich repeat-containing protein 16A
 IPR031943  CARMIL, C-terminal domain
 IPR032675  Leucine-rich repeat domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007015 actin filament organization NAS
 biological_processGO:0007596 blood coagulation TAS
 biological_processGO:0016477 cell migration IMP
 biological_processGO:0030032 lamellipodium assembly IMP
 biological_processGO:0030335 positive regulation of cell migration IEA
 biological_processGO:0030838 positive regulation of actin filament polymerization IEA
 biological_processGO:0031529 ruffle organization IMP
 biological_processGO:0044351 macropinocytosis IDA
 biological_processGO:0046415 urate metabolic process IMP
 biological_processGO:0051496 positive regulation of stress fiber assembly IEA
 biological_processGO:0051638 barbed-end actin filament uncapping IEA
 biological_processGO:0051639 actin filament network formation IDA
 biological_processGO:1900026 positive regulation of substrate adhesion-dependent cell spreading IEA
 biological_processGO:1902745 positive regulation of lamellipodium organization IEA
 biological_processGO:2000813 negative regulation of barbed-end actin filament capping IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016607 nuclear speck IDA
 cellular_componentGO:0030027 lamellipodium IEA
 cellular_componentGO:0031252 cell leading edge IDA
 cellular_componentGO:0031941 filamentous actin IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0044354 macropinosome IDA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0044877 protein-containing complex binding IEA


Pathways (from Reactome)
Pathway description
Factors involved in megakaryocyte development and platelet production


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000077549 CAPZB / P47756 / capping actin protein of muscle Z-line beta subunit  / complex / reaction
 ENSG00000116489 CAPZA1 / P52907 / capping actin protein of muscle Z-line alpha subunit 1  / reaction / complex
 ENSG00000198898 CAPZA2 / P47755 / capping actin protein of muscle Z-line alpha subunit 2  / complex / reaction






 

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