ENSG00000159753


Homo sapiens

Features
Gene ID: ENSG00000159753
  
Biological name :CARMIL2
  
Synonyms : capping protein regulator and myosin 1 linker 2 / CARMIL2 / Q6F5E8
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 16
Strand: 1
Band: q22.1
Gene start: 67644919
Gene end: 67657569
  
Corresponding Affymetrix probe sets: 227216_at (Human Genome U133 Plus 2.0 Array)   227218_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000334958
Ensembl peptide - ENSP00000441481
Ensembl peptide - ENSP00000473419
Ensembl peptide - ENSP00000473580
NCBI entrez gene - 146206     See in Manteia.
OMIM - 610859
RefSeq - XM_017022953
RefSeq - NM_001013838
RefSeq - NM_001317026
RefSeq - XM_011522874
RefSeq - XM_011522875
RefSeq Peptide - NP_001013860
RefSeq Peptide - NP_001303955
swissprot - R4GMZ7
swissprot - R4GNC4
swissprot - Q6F5E8
Ensembl - ENSG00000159753
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 carmil2ENSDARG00000056639Danio rerio
 CARMIL2ENSGALG00000021442Gallus gallus
 Q3V3V9ENSMUSG00000050357Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q8ND23 / CARMIL3 / capping protein regulator and myosin 1 linker 3ENSG0000018664836
Q5VZK9 / CARMIL1 / capping protein regulator and myosin 1 linker 1ENSG0000007969130


Protein motifs (from Interpro)
Interpro ID Name
 IPR001611  Leucine-rich repeat
 IPR029763  F-actin-uncapping protein RLTPR
 IPR031943  CARMIL, C-terminal domain
 IPR032675  Leucine-rich repeat domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007163 establishment or maintenance of cell polarity IDA
 biological_processGO:0010592 positive regulation of lamellipodium assembly IDA
 biological_processGO:0016477 cell migration IEA
 biological_processGO:0030011 maintenance of cell polarity IEA
 biological_processGO:0030335 positive regulation of cell migration IDA
 biological_processGO:0044319 wound healing, spreading of cells IDA
 biological_processGO:0051639 actin filament network formation IDA
 biological_processGO:0061339 establishment or maintenance of monopolar cell polarity IDA
 biological_processGO:0090091 positive regulation of extracellular matrix disassembly IDA
 biological_processGO:1900029 positive regulation of ruffle assembly IDA
 biological_processGO:1902745 positive regulation of lamellipodium organization IDA
 biological_processGO:2000813 negative regulation of barbed-end actin filament capping IDA
 cellular_componentGO:0001726 ruffle IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0015629 actin cytoskeleton IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030027 lamellipodium IEA
 cellular_componentGO:0031234 extrinsic component of cytoplasmic side of plasma membrane NAS
 cellular_componentGO:0031252 cell leading edge IDA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0044354 macropinosome IDA
 cellular_componentGO:0045111 intermediate filament cytoskeleton IDA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005543 phospholipid binding IDA
 molecular_functionGO:0044877 protein-containing complex binding IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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