ENSMUSG00000050357


Mus musculus

Features
Gene ID: ENSMUSG00000050357
  
Biological name :Carmil2
  
Synonyms : Carmil2 / Mus musculus capping protein regulator and myosin 1 linker 2 (Carmil2), mRNA. / Q3V3V9
  
Possible biological names infered from orthology : capping protein regulator and myosin 1 linker 2 / Q6F5E8
  
Species: Mus musculus
  
Chr. number: 8
Strand: 1
Band: D3
Gene start: 105686274
Gene end: 105698187
  
Corresponding Affymetrix probe sets: 10574825 (MoGene1.0st)   1439583_x_at (Mouse Genome 430 2.0 Array)   1440526_at (Mouse Genome 430 2.0 Array)   1456800_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000052322
Ensembl peptide - ENSMUSP00000148422
NCBI entrez gene - 234695     See in Manteia.
MGI - MGI:2685431
RefSeq - XM_017312742
RefSeq - NM_001033320
RefSeq - NM_001357333
RefSeq - XM_011248358
RefSeq - XM_017312739
RefSeq - XM_017312740
RefSeq - XM_017312741
RefSeq - XM_006530898
RefSeq - XM_006530899
RefSeq - XM_006530900
RefSeq Peptide - NP_001344262
RefSeq Peptide - NP_001028492
swissprot - Q3V3V9
swissprot - S0DHL8
Ensembl - ENSMUSG00000050357
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 carmil2ENSDARG00000056639Danio rerio
 CARMIL2ENSGALG00000021442Gallus gallus
 Q6F5E8ENSG00000159753Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q3UFQ8 / Carmil3 / Capping protein, Arp2/3 and myosin-I linker protein 3 / Q8ND23* / capping protein regulator and myosin 1 linker 3*ENSMUSG0000002221127
Q6EDY6 / Carmil1 / F-actin-uncapping protein LRRC16A / Q5VZK9* / capping protein regulator and myosin 1 linker 1*ENSMUSG0000002133821


Protein motifs (from Interpro)
Interpro ID Name
 IPR001611  Leucine-rich repeat
 IPR029763  F-actin-uncapping protein RLTPR
 IPR031943  CARMIL, C-terminal domain
 IPR032675  Leucine-rich repeat domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007163 establishment or maintenance of cell polarity ISS
 biological_processGO:0010592 positive regulation of lamellipodium assembly ISO
 biological_processGO:0016477 cell migration IEA
 biological_processGO:0030011 maintenance of cell polarity IEA
 biological_processGO:0030335 positive regulation of cell migration ISS
 biological_processGO:0032729 positive regulation of interferon-gamma production IMP
 biological_processGO:0042102 positive regulation of T cell proliferation IMP
 biological_processGO:0044319 wound healing, spreading of cells ISS
 biological_processGO:0045184 establishment of protein localization IMP
 biological_processGO:0045591 positive regulation of regulatory T cell differentiation IMP
 biological_processGO:0048538 thymus development IMP
 biological_processGO:0048872 homeostasis of number of cells IMP
 biological_processGO:0050852 T cell receptor signaling pathway IMP
 biological_processGO:0051639 actin filament network formation ISO
 biological_processGO:0061339 establishment or maintenance of monopolar cell polarity ISO
 biological_processGO:0090091 positive regulation of extracellular matrix disassembly ISO
 biological_processGO:1900029 positive regulation of ruffle assembly ISS
 biological_processGO:1900042 positive regulation of interleukin-2 secretion IMP
 biological_processGO:1902715 positive regulation of interferon-gamma secretion IMP
 biological_processGO:1902745 positive regulation of lamellipodium organization ISO
 biological_processGO:2000813 negative regulation of barbed-end actin filament capping ISO
 cellular_componentGO:0001726 ruffle ISS
 cellular_componentGO:0001772 immunological synapse IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005911 cell-cell junction IDA
 cellular_componentGO:0008290 F-actin capping protein complex IDA
 cellular_componentGO:0015629 actin cytoskeleton ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030027 lamellipodium ISS
 cellular_componentGO:0031252 cell leading edge ISO
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0044354 macropinosome ISS
 cellular_componentGO:0045111 intermediate filament cytoskeleton ISS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005543 phospholipid binding ISS
 molecular_functionGO:0044877 protein-containing complex binding ISS


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000709 enlarged thymus "increased size of thymus" [J:50053]
Show

Allelic Composition: Lattm8Mal/Lattm8Mal
Genetic Background: involves: C57BL/6

 MP:0002075 abnormal coat color "irregular or unusual pigmentation pattern of the hair in relation to control animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Psphtm1.1(KOMP)Vlcg/Psphtm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Psphtm1.1(KOMP)Vlcg/Ucd

 MP:0003382 straub tail "condition in which an animal carries its tail in an erect (vertical or nearly vertical) position; often seen upon opioid and other drug treatment" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Psphtm1.1(KOMP)Vlcg/Psphtm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Psphtm1.1(KOMP)Vlcg/Ucd

 MP:0004974 decreased regulatory T cell number "reduced number of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lattm8Mal/Lattm8Mal
Genetic Background: involves: C57BL/6

Allelic Composition: Carmil2bas/Carmil2bas
Genetic Background: involves: C3HeB/FeJ * C57BL/6

 MP:0005095 decreased T cell proliferation "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Lattm8Mal/Lattm8Mal
Genetic Background: involves: C57BL/6

Allelic Composition: Carmil2bas/Carmil2bas
Genetic Background: involves: C3HeB/FeJ * C57BL/6

 MP:0005559 increased circulating glucose level "greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
Show

Allelic Composition: Psphtm1.1(KOMP)Vlcg/Psphtm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Psphtm1.1(KOMP)Vlcg/Ucd

 MP:0008567 decreased interferon-gamma secretion "reduction in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
Show

Allelic Composition: Carmil2bas/Carmil2bas
Genetic Background: involves: C3HeB/FeJ * C57BL/6

 MP:0008688 decreased interleukin-2 secretion "reduction in the production or release of a soluble substance elaborated by antigen- or mitogen-stimulated T-cells which induces DNA synthesis in naive lymphocytes" [MESH:D12.644.276.374.465.502]
Show

Allelic Composition: Lattm8Mal/Lattm8Mal
Genetic Background: involves: C57BL/6

Allelic Composition: Carmil2bas/Carmil2bas
Genetic Background: involves: C3HeB/FeJ * C57BL/6

 MP:0011964 increased total retina thickness "increased width of the retina through the center plane" [MGI:csmith]
Show

Allelic Composition: Psphtm1.1(KOMP)Vlcg/Psphtm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Psphtm1.1(KOMP)Vlcg/Ucd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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