ENSG00000116489


Homo sapiens

Features
Gene ID: ENSG00000116489
  
Biological name :CAPZA1
  
Synonyms : capping actin protein of muscle Z-line alpha subunit 1 / CAPZA1 / P52907
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: p13.2
Gene start: 112619173
Gene end: 112671619
  
Corresponding Affymetrix probe sets: 208374_s_at (Human Genome U133 Plus 2.0 Array)   241275_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000263168
NCBI entrez gene - 829     See in Manteia.
OMIM - 601580
RefSeq - XM_017002424
RefSeq - NM_006135
RefSeq - XM_011542225
RefSeq Peptide - NP_006126
swissprot - P52907
swissprot - A0A024R0E5
Ensembl - ENSG00000116489
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 capza1aENSDARG00000034240Danio rerio
 capza1bENSDARG00000056090Danio rerio
 CAPZA1ENSGALG00000001547Gallus gallus
 4933400A11RikENSMUSG00000055357Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CAPZA2 / P47755 / capping actin protein of muscle Z-line alpha subunit 2ENSG0000019889885
CAPZA3 / Q96KX2 / capping actin protein of muscle Z-line alpha subunit 3ENSG0000017793835


Protein motifs (from Interpro)
Interpro ID Name
 IPR002189  F-actin-capping protein subunit alpha
 IPR017865  F-actin capping protein, alpha subunit, conserved site
 IPR037282  F-actin-capping protein subunit alpha/beta


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006888 ER to Golgi vesicle-mediated transport TAS
 biological_processGO:0007596 blood coagulation TAS
 biological_processGO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II TAS
 biological_processGO:0034329 cell junction assembly IMP
 biological_processGO:0035722 interleukin-12-mediated signaling pathway TAS
 biological_processGO:0045087 innate immune response TAS
 biological_processGO:0051016 barbed-end actin filament capping IEA
 biological_processGO:0051693 actin filament capping IEA
 biological_processGO:0065003 protein-containing complex assembly TAS
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005856 cytoskeleton TAS
 cellular_componentGO:0008290 F-actin capping protein complex TAS
 cellular_componentGO:0015629 actin cytoskeleton TAS
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:0071203 WASH complex IDA
 molecular_functionGO:0003779 actin binding TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0045296 cadherin binding IDA


Pathways (from Reactome)
Pathway description
MHC class II antigen presentation
HSP90 chaperone cycle for steroid hormone receptors (SHR)
COPI-mediated anterograde transport
COPI-independent Golgi-to-ER retrograde traffic
Advanced glycosylation endproduct receptor signaling
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
Factors involved in megakaryocyte development and platelet production


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000088986 DYNLL1 / P63167 / dynein light chain LC8-type 1  / complex
 ENSG00000135720 O43237 / DYNC1LI2 / dynein cytoplasmic 1 light intermediate chain 2  / complex
 ENSG00000077549 CAPZB / P47756 / capping actin protein of muscle Z-line beta subunit  / reaction / complex
 ENSG00000166847 DCTN5 / Q9BTE1 / dynactin subunit 5  / complex
 ENSG00000104671 DCTN6 / O00399 / dynactin subunit 6  / complex
 ENSG00000141429 GALNT1 / Q10472 / polypeptide N-acetylgalactosaminyltransferase 1  / reaction / complex
 ENSG00000204843 DCTN1 / Q14203 / dynactin subunit 1  / complex
 ENSG00000131966 ACTR10 / Q9NZ32 / actin related protein 10 homolog  / complex
 ENSG00000079691 Q5VZK9 / CARMIL1 / capping protein regulator and myosin 1 linker 1  / complex / reaction
 ENSG00000175582 RAB6A / P20340 / RAB6A, member RAS oncogene family  / complex / reaction
 ENSG00000137100 DCTN3 / O75935 / dynactin subunit 3  / complex
 ENSG00000143641 GALNT2 / Q10471 / polypeptide N-acetylgalactosaminyltransferase 2  / complex / reaction
 ENSG00000138107 ACTR1A / P61163 / ARP1 actin related protein 1 homolog A  / complex
 ENSG00000151746 BICD1 / Q96G01 / BICD cargo adaptor 1  / reaction / complex
 ENSG00000007168 P43034 / PAFAH1B1 / platelet activating factor acetylhydrolase 1b regulatory subunit 1  / complex
 ENSG00000132912 DCTN4 / Q9UJW0 / dynactin subunit 4  / complex
 ENSG00000175203 DCTN2 / Q13561 / dynactin subunit 2  / complex
 ENSG00000144635 Q9Y6G9 / DYNC1LI1 / dynein cytoplasmic 1 light intermediate chain 1  / complex
 ENSG00000160307 S100B / P04271 / S100 calcium binding protein B  / reaction / complex
 ENSG00000077380 Q13409 / DYNC1I2 / dynein cytoplasmic 1 intermediate chain 2  / complex
 ENSG00000075624 ACTB / P60709 / actin beta  / complex / reaction
 ENSG00000158560 O14576 / DYNC1I1 / dynein cytoplasmic 1 intermediate chain 1  / complex
 ENSG00000197102 Q14204 / DYNC1H1 / dynein cytoplasmic 1 heavy chain 1  / complex
 ENSG00000264364 DYNLL2 / Q96FJ2 / dynein light chain LC8-type 2  / complex






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr