ENSG00000177938


Homo sapiens

Features
Gene ID: ENSG00000177938
  
Biological name :CAPZA3
  
Synonyms : capping actin protein of muscle Z-line alpha subunit 3 / CAPZA3 / Q96KX2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: 1
Band: p12.3
Gene start: 18738101
Gene end: 18739187
  
Corresponding Affymetrix probe sets: 236888_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000326238
NCBI entrez gene - 93661     See in Manteia.
OMIM - 608722
RefSeq - NM_033328
RefSeq Peptide - NP_201585
swissprot - A0A140VKF6
swissprot - Q96KX2
Ensembl - ENSG00000177938
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CAPZA3ENSGALG00000013125Gallus gallus
 Capza3ENSMUSG00000041791Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CAPZA1 / P52907 / capping actin protein of muscle Z-line alpha subunit 1ENSG0000011648933
CAPZA2 / P47755 / capping actin protein of muscle Z-line alpha subunit 2ENSG0000019889833


Protein motifs (from Interpro)
Interpro ID Name
 IPR002189  F-actin-capping protein subunit alpha
 IPR017865  F-actin capping protein, alpha subunit, conserved site
 IPR037282  F-actin-capping protein subunit alpha/beta


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006888 ER to Golgi vesicle-mediated transport TAS
 biological_processGO:0007286 spermatid development IEA
 biological_processGO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II TAS
 biological_processGO:0051016 barbed-end actin filament capping IEA
 biological_processGO:0051693 actin filament capping IEA
 cellular_componentGO:0001669 acrosomal vesicle IEA
 cellular_componentGO:0005634 nucleus HDA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0008290 F-actin capping protein complex IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030863 cortical cytoskeleton IEA
 molecular_functionGO:0003779 actin binding IEA


Pathways (from Reactome)
Pathway description
MHC class II antigen presentation
HSP90 chaperone cycle for steroid hormone receptors (SHR)
COPI-mediated anterograde transport
COPI-independent Golgi-to-ER retrograde traffic


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000088986 DYNLL1 / P63167 / dynein light chain LC8-type 1  / complex
 ENSG00000135720 O43237 / DYNC1LI2 / dynein cytoplasmic 1 light intermediate chain 2  / complex
 ENSG00000144635 Q9Y6G9 / DYNC1LI1 / dynein cytoplasmic 1 light intermediate chain 1  / complex
 ENSG00000007168 P43034 / PAFAH1B1 / platelet activating factor acetylhydrolase 1b regulatory subunit 1  / complex
 ENSG00000151746 BICD1 / Q96G01 / BICD cargo adaptor 1  / complex / reaction
 ENSG00000143641 GALNT2 / Q10471 / polypeptide N-acetylgalactosaminyltransferase 2  / complex / reaction
 ENSG00000138107 ACTR1A / P61163 / ARP1 actin related protein 1 homolog A  / complex
 ENSG00000137100 DCTN3 / O75935 / dynactin subunit 3  / complex
 ENSG00000141429 GALNT1 / Q10472 / polypeptide N-acetylgalactosaminyltransferase 1  / complex / reaction
 ENSG00000077549 CAPZB / P47756 / capping actin protein of muscle Z-line beta subunit  / complex
 ENSG00000166847 DCTN5 / Q9BTE1 / dynactin subunit 5  / complex
 ENSG00000104671 DCTN6 / O00399 / dynactin subunit 6  / complex
 ENSG00000131966 ACTR10 / Q9NZ32 / actin related protein 10 homolog  / complex
 ENSG00000175203 DCTN2 / Q13561 / dynactin subunit 2  / complex
 ENSG00000175582 RAB6A / P20340 / RAB6A, member RAS oncogene family  / complex / reaction
 ENSG00000204843 DCTN1 / Q14203 / dynactin subunit 1  / complex
 ENSG00000132912 DCTN4 / Q9UJW0 / dynactin subunit 4  / complex
 ENSG00000077380 Q13409 / DYNC1I2 / dynein cytoplasmic 1 intermediate chain 2  / complex
 ENSG00000158560 O14576 / DYNC1I1 / dynein cytoplasmic 1 intermediate chain 1  / complex
 ENSG00000197102 Q14204 / DYNC1H1 / dynein cytoplasmic 1 heavy chain 1  / complex
 ENSG00000264364 DYNLL2 / Q96FJ2 / dynein light chain LC8-type 2  / complex






 

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