ENSG00000138107


Homo sapiens

Features
Gene ID: ENSG00000138107
  
Biological name :ACTR1A
  
Synonyms : ACTR1A / ARP1 actin related protein 1 homolog A / P61163
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 10
Strand: -1
Band: q24.32
Gene start: 102461881
Gene end: 102502711
  
Corresponding Affymetrix probe sets: 200720_s_at (Human Genome U133 Plus 2.0 Array)   200721_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000358921
Ensembl peptide - ENSP00000490634
Ensembl peptide - ENSP00000473334
NCBI entrez gene - 10121     See in Manteia.
OMIM - 605143
RefSeq - NM_005736
RefSeq Peptide - NP_005727
swissprot - A0A1B0GVS3
swissprot - P61163
swissprot - R4GMT0
Ensembl - ENSG00000138107
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ACTR1AENSGALG00000008086Gallus gallus
 Actr1aENSMUSG00000025228Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ACTR1B / P42025 / ARP1 actin related protein 1 homolog BENSG0000011507390
ACTC1 / P68032 / actin, alpha, cardiac muscle 1ENSG0000015925153
ACTB / P60709 / actin betaENSG0000007562453
ACTA2 / P62736 / actin, alpha 2, smooth muscle, aortaENSG0000010779653
ACTG1 / P63261 / actin gamma 1ENSG0000018400953
ACTG2 / P63267 / actin, gamma 2, smooth muscle, entericENSG0000016301753
ACTA1 / P68133 / actin, alpha 1, skeletal muscleENSG0000014363252
ACTBL2 / Q562R1 / actin, beta like 2ENSG0000016906750
POTEJ / P0CG39 / POTE ankyrin domain family member JENSG0000022203849
ACTRT2 / Q8TDY3 / actin related protein T2ENSG0000016971741
ACTRT3 / Q9BYD9 / actin related protein T3ENSG0000018437841
ACTRT1 / Q8TDG2 / actin related protein T1ENSG0000012316538
ACTL7A / Q9Y615 / actin like 7AENSG0000018700337
ACTL7B / Q9Y614 / actin like 7BENSG0000014815636
ACTL9 / Q8TC94 / actin like 9ENSG0000018178635


Protein motifs (from Interpro)
Interpro ID Name
 IPR004000  Actin family
 IPR004001  Actin, conserved site
 IPR020902  Actin/actin-like conserved site
 IPR029909  Actin-related protein 1 family


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000086 G2/M transition of mitotic cell cycle TAS
 biological_processGO:0006888 ER to Golgi vesicle-mediated transport TAS
 biological_processGO:0007283 spermatogenesis IEA
 biological_processGO:0010389 regulation of G2/M transition of mitotic cell cycle TAS
 biological_processGO:0016192 vesicle-mediated transport TAS
 biological_processGO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II TAS
 biological_processGO:0097711 ciliary basal body-plasma membrane docking TAS
 cellular_componentGO:0002177 manchette IEA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005813 centrosome IDA
 cellular_componentGO:0005814 centriole IEA
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005869 dynactin complex IEA
 cellular_componentGO:0005875 microtubule associated complex TAS
 cellular_componentGO:0005938 cell cortex IEA
 cellular_componentGO:0015630 microtubule cytoskeleton IDA
 cellular_componentGO:0030137 COPI-coated vesicle IEA
 cellular_componentGO:0043209 myelin sheath IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:0099738 cell cortex region IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA


Pathways (from Reactome)
Pathway description
MHC class II antigen presentation
Regulation of PLK1 Activity at G2/M Transition
HSP90 chaperone cycle for steroid hormone receptors (SHR)
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization from the centrosome
Recruitment of NuMA to mitotic centrosomes
Anchoring of the basal body to the plasma membrane
COPI-mediated anterograde transport
COPI-independent Golgi-to-ER retrograde traffic
AURKA Activation by TPX2


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000104671 DCTN6 / O00399 / dynactin subunit 6  / complex
 ENSG00000131966 ACTR10 / Q9NZ32 / actin related protein 10 homolog  / complex
 ENSG00000088986 DYNLL1 / P63167 / dynein light chain LC8-type 1  / complex
 ENSG00000135720 O43237 / DYNC1LI2 / dynein cytoplasmic 1 light intermediate chain 2  / complex
 ENSG00000077549 CAPZB / P47756 / capping actin protein of muscle Z-line beta subunit  / complex
 ENSG00000116489 CAPZA1 / P52907 / capping actin protein of muscle Z-line alpha subunit 1  / complex
 ENSG00000144635 Q9Y6G9 / DYNC1LI1 / dynein cytoplasmic 1 light intermediate chain 1  / complex
 ENSG00000166847 DCTN5 / Q9BTE1 / dynactin subunit 5  / complex
 ENSG00000177938 CAPZA3 / Q96KX2 / capping actin protein of muscle Z-line alpha subunit 3  / complex
 ENSG00000077380 Q13409 / DYNC1I2 / dynein cytoplasmic 1 intermediate chain 2  / complex
 ENSG00000158560 O14576 / DYNC1I1 / dynein cytoplasmic 1 intermediate chain 1  / complex
 ENSG00000197102 Q14204 / DYNC1H1 / dynein cytoplasmic 1 heavy chain 1  / complex
 ENSG00000198898 CAPZA2 / P47755 / capping actin protein of muscle Z-line alpha subunit 2  / complex
 ENSG00000175203 DCTN2 / Q13561 / dynactin subunit 2  / complex
 ENSG00000141429 GALNT1 / Q10472 / polypeptide N-acetylgalactosaminyltransferase 1  / complex / reaction
 ENSG00000175582 RAB6A / P20340 / RAB6A, member RAS oncogene family  / complex / reaction
 ENSG00000151746 BICD1 / Q96G01 / BICD cargo adaptor 1  / reaction / complex
 ENSG00000007168 P43034 / PAFAH1B1 / platelet activating factor acetylhydrolase 1b regulatory subunit 1  / complex
 ENSG00000138107 ACTR1A / P61163 / ARP1 actin related protein 1 homolog A  / complex
 ENSG00000143641 GALNT2 / Q10471 / polypeptide N-acetylgalactosaminyltransferase 2  / complex / reaction
 ENSG00000137100 DCTN3 / O75935 / dynactin subunit 3  / complex
 ENSG00000204843 DCTN1 / Q14203 / dynactin subunit 1  / complex
 ENSG00000132912 DCTN4 / Q9UJW0 / dynactin subunit 4  / complex
 ENSG00000264364 DYNLL2 / Q96FJ2 / dynein light chain LC8-type 2  / complex






 

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