ENSG00000160307


Homo sapiens

Features
Gene ID: ENSG00000160307
  
Biological name :S100B
  
Synonyms : P04271 / S100B / S100 calcium binding protein B
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 21
Strand: -1
Band: q22.3
Gene start: 46598962
Gene end: 46605208
  
Corresponding Affymetrix probe sets: 1561521_at (Human Genome U133 Plus 2.0 Array)   209686_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000291700
Ensembl peptide - ENSP00000380769
Ensembl peptide - ENSP00000356038
NCBI entrez gene - 6285     See in Manteia.
OMIM - 176990
RefSeq - NM_006272
RefSeq - XM_017028424
RefSeq Peptide - NP_006263
swissprot - A8MRB1
swissprot - A0A0S2Z4C5
swissprot - P04271
Ensembl - ENSG00000160307
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 s100bENSDARG00000057598Danio rerio
 S100BENSGALG00000006217Gallus gallus
 S100bENSMUSG00000033208Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P23297 / S100A1 / S100 calcium binding protein A1ENSG0000016067859
S100P / P25815 / S100 calcium binding protein PENSG0000016399349
S100Z / Q8WXG8 / S100 calcium binding protein ZENSG0000017164346
P26447 / S100A4 / S100 calcium binding protein A4ENSG0000019615445
P29034 / S100A2 / S100 calcium binding protein A2ENSG0000019675443
P33763 / S100A5 / S100 calcium binding protein A5ENSG0000019642042
P06703 / S100A6 / S100 calcium binding protein A6ENSG0000019795638
P33764 / S100A3 / S100 calcium binding protein A3ENSG0000018801537
P60903 / S100A10 / S100 calcium binding protein A10ENSG0000019774737
P31949 / S100A11 / S100 calcium binding protein A11ENSG0000016319135


Protein motifs (from Interpro)
Interpro ID Name
 IPR001751  S100/Calbindin-D9k, conserved site
 IPR002048  EF-hand domain
 IPR011992  EF-hand domain pair
 IPR013787  S100/CaBP-9k-type, calcium binding, subdomain
 IPR018247  EF-Hand 1, calcium-binding site
 IPR028481  Protein S100-B


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007409 axonogenesis TAS
 biological_processGO:0007417 central nervous system development TAS
 biological_processGO:0007611 learning or memory ISS
 biological_processGO:0007613 memory IEA
 biological_processGO:0008283 cell proliferation TAS
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0008360 regulation of cell shape IEA
 biological_processGO:0031643 positive regulation of myelination IEA
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IDA
 biological_processGO:0045087 innate immune response TAS
 biological_processGO:0048168 regulation of neuronal synaptic plasticity IEA
 biological_processGO:0048708 astrocyte differentiation IEA
 biological_processGO:0050806 positive regulation of synaptic transmission IEA
 biological_processGO:0051384 response to glucocorticoid IEA
 biological_processGO:0051597 response to methylmercury IEA
 biological_processGO:0060291 long-term synaptic potentiation IEA
 biological_processGO:0071456 cellular response to hypoxia IEA
 biological_processGO:2001015 negative regulation of skeletal muscle cell differentiation IEA
 cellular_componentGO:0001726 ruffle IDA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IDA
 molecular_functionGO:0005102 signaling receptor binding IEA
 molecular_functionGO:0005509 calcium ion binding TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008270 zinc ion binding ISS
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0042803 protein homodimerization activity IPI
 molecular_functionGO:0044548 S100 protein binding IPI
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0048156 tau protein binding ISS
 molecular_functionGO:0048306 calcium-dependent protein binding IDA
 molecular_functionGO:0050786 RAGE receptor binding IPI


Pathways (from Reactome)
Pathway description
Nuclear signaling by ERBB4
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
Advanced glycosylation endproduct receptor signaling
TRAF6 mediated NF-kB activation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000116489 CAPZA1 / P52907 / capping actin protein of muscle Z-line alpha subunit 1  / reaction / complex
 ENSG00000160307 S100B / P04271 / S100 calcium binding protein B  / complex
 ENSG00000198898 CAPZA2 / P47755 / capping actin protein of muscle Z-line alpha subunit 2  / reaction / complex






 

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