ENSMUSG00000033208


Mus musculus

Features
Gene ID: ENSMUSG00000033208
  
Biological name :S100b
  
Synonyms : P50114 / S100b / S100 protein, beta polypeptide, neural
  
Possible biological names infered from orthology : P04271 / S100 calcium binding protein B
  
Species: Mus musculus
  
Chr. number: 10
Strand: 1
Band: C1
Gene start: 76253853
Gene end: 76261159
  
Corresponding Affymetrix probe sets: 10364149 (MoGene1.0st)   1419383_at (Mouse Genome 430 2.0 Array)   1434342_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000047968
NCBI entrez gene - 20203     See in Manteia.
MGI - MGI:98217
RefSeq - NM_009115
RefSeq Peptide - NP_033141
swissprot - P50114
swissprot - Q3UY00
Ensembl - ENSMUSG00000033208
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 s100bENSDARG00000057598Danio rerio
 S100BENSGALG00000006217Gallus gallus
 S100BENSG00000160307Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
S100a1 / S100 calcium binding protein A1 / P23297*ENSMUSG0000004408058
S100z / S100 calcium binding protein, zeta / Q8WXG8* / S100 calcium binding protein Z*ENSMUSG0000002167947
P07091 / S100a4 / S100 calcium binding protein A4 / P26447*ENSMUSG0000000102043
P63084 / S100a5 / S100 calcium binding protein A5 / P33763*ENSMUSG0000000102341
P62818 / S100a3 / S100 calcium binding protein A3ENSMUSG0000000102138
P08207 / S100a10 / S100 calcium binding protein A10 (calpactin) / P60903* / S100 calcium binding protein A10*ENSMUSG0000004195938
P50543 / S100a11 / Protein S100-A11 / P31949* / S100 calcium binding protein A11*ENSMUSG0000002790737
P14069 / S100a6 / S100 calcium binding protein A6 (calcyclin) / P06703* / S100 calcium binding protein A6*ENSMUSG0000000102537
Gm42674 / P33764* / S100A3* / S100 calcium binding protein A3*ENSMUSG0000010551816


Protein motifs (from Interpro)
Interpro ID Name
 IPR001751  S100/Calbindin-D9k, conserved site
 IPR002048  EF-hand domain
 IPR011992  EF-hand domain pair
 IPR013787  S100/CaBP-9k-type, calcium binding, subdomain
 IPR018247  EF-Hand 1, calcium-binding site
 IPR028481  Protein S100-B


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006112 energy reserve metabolic process NAS
 biological_processGO:0006874 cellular calcium ion homeostasis NAS
 biological_processGO:0007611 learning or memory IMP
 biological_processGO:0007613 memory IMP
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0008360 regulation of cell shape IEA
 biological_processGO:0031643 positive regulation of myelination IEA
 biological_processGO:0042035 regulation of cytokine biosynthetic process NAS
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IEA
 biological_processGO:0048168 regulation of neuronal synaptic plasticity IMP
 biological_processGO:0048169 regulation of long-term neuronal synaptic plasticity NAS
 biological_processGO:0048708 astrocyte differentiation IEA
 biological_processGO:0050806 positive regulation of synaptic transmission IEA
 biological_processGO:0051384 response to glucocorticoid IEA
 biological_processGO:0051597 response to methylmercury IEA
 biological_processGO:0060291 long-term synaptic potentiation IEA
 biological_processGO:0071456 cellular response to hypoxia IEA
 biological_processGO:2001015 negative regulation of skeletal muscle cell differentiation IEA
 cellular_componentGO:0001726 ruffle IEA
 cellular_componentGO:0005576 extracellular region NAS
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005737 cytoplasm NAS
 cellular_componentGO:0043025 neuronal cell body IDA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0005102 signaling receptor binding IEA
 molecular_functionGO:0005509 calcium ion binding NAS
 molecular_functionGO:0008270 zinc ion binding ISS
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0044548 S100 protein binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0048156 tau protein binding ISS
 molecular_functionGO:0048306 calcium-dependent protein binding IEA
 molecular_functionGO:0050786 RAGE receptor binding IEA


Pathways (from Reactome)
Pathway description
RIP-mediated NFkB activation via ZBP1
DEx/H-box helicases activate type I IFN and inflammatory cytokines production
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
Advanced glycosylation endproduct receptor signaling
TRAF6 mediated NF-kB activation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: ApcMin/Apc+,Dnmt3btm1Jae/Dnmt3btm1Jae,Tg(Fabp1-cre)1Jig/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * FVB/N

Allelic Composition: S100btm1a(EUCOMM)Wtsi/S100btm1a(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0003177 decreased pain threshold "ordinarily painless stimuli, once perceived, are experienced as being painful" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:81734]
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Allelic Composition: Mostm1Gvw/Mostm1Gvw
Genetic Background: involves: 129S1/Sv

 MP:0010092 increased circulating magnesium level "an elevation in the blood concentration of magnesium" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Rnf10tm1a(KOMP)Wtsi/Rnf10tm1a(KOMP)Wtsi
Genetic Background: C57BL/6N-Rnf10tm1a(KOMP)Wtsi/Wtsi

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000015733 Capza2 / P47754 / F-actin-capping protein subunit alpha-2 / P47755* / capping actin protein of muscle Z-line alpha subunit 2*  / complex / reaction
 ENSMUSG00000033208 S100b / P50114 / S100 protein, beta polypeptide, neural / P04271* / S100 calcium binding protein B*  / complex






 

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