ENSMUSG00000015733


Mus musculus

Features
Gene ID: ENSMUSG00000015733
  
Biological name :Capza2
  
Synonyms : Capza2 / F-actin-capping protein subunit alpha-2 / P47754
  
Possible biological names infered from orthology : capping actin protein of muscle Z-line alpha subunit 2 / P47755
  
Species: Mus musculus
  
Chr. number: 6
Strand: 1
Band: A2
Gene start: 17636234
Gene end: 17666972
  
Corresponding Affymetrix probe sets: 10536527 (MoGene1.0st)   1423057_at (Mouse Genome 430 2.0 Array)   1423058_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000015877
Ensembl peptide - ENSMUSP00000145159
Ensembl peptide - ENSMUSP00000123398
NCBI entrez gene - 12343     See in Manteia.
MGI - MGI:106222
RefSeq - NM_007604
RefSeq Peptide - NP_031630
swissprot - A0A0N4SVM0
swissprot - D6RCW7
swissprot - P47754
swissprot - Q5DQJ3
Ensembl - ENSMUSG00000015733
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CAPZA2ENSGALG00000043437Gallus gallus
 CAPZA2ENSG00000198898Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Capza1ENSMUSG0000007037284
4933400A11Rik / RIKEN cDNA 4933400A11 gene / CAPZA1* / P52907* / capping actin protein of muscle Z-line alpha subunit 1*ENSMUSG0000005535760
Capza3 / P70190 / F-actin-capping protein subunit alpha-3 / Q96KX2* / capping actin protein of muscle Z-line alpha subunit 3*ENSMUSG0000004179137


Protein motifs (from Interpro)
Interpro ID Name
 IPR002189  F-actin-capping protein subunit alpha
 IPR017865  F-actin capping protein, alpha subunit, conserved site
 IPR037282  F-actin-capping protein subunit alpha/beta


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0008150 biological_process ND
 biological_processGO:0051016 barbed-end actin filament capping IEA
 biological_processGO:0051693 actin filament capping IEA
 cellular_componentGO:0005903 brush border IDA
 cellular_componentGO:0008290 F-actin capping protein complex IEA
 cellular_componentGO:0016020 membrane IDA
 cellular_componentGO:0030863 cortical cytoskeleton IDA
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
MHC class II antigen presentation
HSP90 chaperone cycle for steroid hormone receptors (SHR)
COPI-mediated anterograde transport
COPI-independent Golgi-to-ER retrograde traffic
Advanced glycosylation endproduct receptor signaling
Factors involved in megakaryocyte development and platelet production


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000602 enlarged sinusoidal spaces "larger than normal sized cavities in the liver " [J:23170]
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Allelic Composition: Arf4tm1b(KOMP)Wtsi/Arf4tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Arf4tm1b(KOMP)Wtsi/Ucd

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Arf4tm1b(KOMP)Wtsi/Arf4tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Arf4tm1b(KOMP)Wtsi/Ucd

 MP:0003266 biliary cysts "the appearance of fluid-filled sacs within the bile ducts" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Arf4tm1b(KOMP)Wtsi/Arf4tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Arf4tm1b(KOMP)Wtsi/Ucd

 MP:0004613 fusion of vertebral arches "improper union of the dorsal part of adjacent vertebra" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Arf4tm1b(KOMP)Wtsi/Arf4tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Arf4tm1b(KOMP)Wtsi/Ucd

 MP:0010420 muscular ventricular septal defect "abnormal communications between the two lower chambers of the heart, involving the muscular septum and often occurring as multiple communications, and includes central muscular or midmuscular, apical, or marginal communications when the defect is along the RV-septal junction; any single defect observed from the LV aspect may have several openings on the RV aspect" [http://emedicine.medscape.com]
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Allelic Composition: Arf4tm1b(KOMP)Wtsi/Arf4tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Arf4tm1b(KOMP)Wtsi/Ucd

 MP:0010484 bicuspid aortic valve "the presence of two cusps in the aortic valve instead of three" [http://emedicine.medscape.com]
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Allelic Composition: Arf4tm1b(KOMP)Wtsi/Arf4tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Arf4tm1b(KOMP)Wtsi/Ucd

 MP:0010602 abnormal pulmonary valve cusp morphology "any structural anomaly of the three fibrous triangular components and associated flap of the pulmonary valve" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Arf4tm1b(KOMP)Wtsi/Arf4tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Arf4tm1b(KOMP)Wtsi/Ucd

 MP:0013834 thin hypoglossal nerve "slender appearance of the motor nerve which innervates all the intrinsic and all but one of the extrinsic muscles of the tongue" [ISBN:0-683-40008-8]
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Allelic Composition: Arf4tm1b(KOMP)Wtsi/Arf4tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Arf4tm1b(KOMP)Wtsi/Ucd

 MP:0013835 absent hypoglossal nerve "absence of the motor nerve which innervates all the intrinsic and all but one of the extrinsic muscles of the tongue" [ISBN:0-683-40008-8]
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Allelic Composition: Arf4tm1b(KOMP)Wtsi/Arf4tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Arf4tm1b(KOMP)Wtsi/Ucd

 MP:0013836 abnormal hypoglossal nerve topology "abnormal position of the hypoglossal nerve " [MGI:csmith]
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Allelic Composition: Arf4tm1b(KOMP)Wtsi/Arf4tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Arf4tm1b(KOMP)Wtsi/Ucd

 MP:0013875 trigeminal neuroma 
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Allelic Composition: Arf4tm1b(KOMP)Wtsi/Arf4tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Arf4tm1b(KOMP)Wtsi/Ucd

 MP:0013877 abnormal ductus venosus valve morphology "any structural anomaly of the valve present on the right side of the ductus venosus at the site of the junction with the inferior vena cava" [PMID:5438957]
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Allelic Composition: Arf4tm1b(KOMP)Wtsi/Arf4tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Arf4tm1b(KOMP)Wtsi/Ucd

 MP:0013968 multiple persisting craniopharyngeal ducts 
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Allelic Composition: Arf4tm1b(KOMP)Wtsi/Arf4tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Arf4tm1b(KOMP)Wtsi/Ucd

 MP:0013971 blood in lymph vessels 
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Allelic Composition: Arf4tm1b(KOMP)Wtsi/Arf4tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Arf4tm1b(KOMP)Wtsi/Ucd

 MP:0013973 abnormal hepatic vein connection 
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Allelic Composition: Arf4tm1b(KOMP)Wtsi/Arf4tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Arf4tm1b(KOMP)Wtsi/Ucd

 MP:0014001 abnormal vertebral artery topology "abnormal position of the first branch of the left and right subclavian arteries that merge to form the single midline basilar artery; branches of the vertebral arteries supply the musculature of the neck" [MGI:csmith]
Show

Allelic Composition: Arf4tm1b(KOMP)Wtsi/Arf4tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Arf4tm1b(KOMP)Wtsi/Ucd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000020745 P63005 / Pafah1b1 / platelet-activating factor acetylhydrolase, isoform 1b, subunit 1 / P43034* / platelet activating factor acetylhydrolase 1b regulatory subunit 1*  / complex
 ENSMUSG00000033208 S100b / P50114 / S100 protein, beta polypeptide, neural / P04271* / S100 calcium binding protein B*  / complex / reaction
 ENSMUSG00000030868 Dctn5 / Q9QZB9 / Dynactin subunit 5 / Q9BTE1*  / complex
 ENSMUSG00000064063 BC048507 / cDNA sequence BC048507 / DYNLL1* / P63167* / dynein light chain LC8-type 1*  / complex
 ENSMUSG00000032435 Q8R1Q8 / Dync1li1 / Cytoplasmic dynein 1 light intermediate chain 1 / Q9Y6G9* / dynein cytoplasmic 1 light intermediate chain 1*  / complex
 ENSMUSG00000092329 Q6PB93 / Gm20388 / predicted gene 20388 / GALNT2* / Q10471* / polypeptide N-acetylgalactosaminyltransferase 2*  / reaction / complex
 ENSMUSG00000020483 Dynll2 / Q9D0M5 / Dynein light chain 2, cytoplasmic / Q96FJ2* / dynein light chain LC8-type 2*  / complex
 ENSMUSG00000025410 Dctn2 / Q99KJ8 / Dynactin subunit 2 / Q13561*  / complex
 ENSMUSG00000025228 Actr1a / P61164 / Alpha-centractin / P61163* / ARP1 actin related protein 1 homolog A*  / complex
 ENSMUSG00000031516 Dctn6 / Q9WUB4 / Dynactin subunit 6 / O00399*  / complex
 ENSMUSG00000028447 Dctn3 / Q9Z0Y1 / Dynactin subunit 3 / O75935*  / complex
 ENSMUSG00000018707 Q9JHU4 / Dync1h1 / Cytoplasmic dynein 1 heavy chain 1 / Q14204* / dynein cytoplasmic 1 heavy chain 1*  / complex
 ENSMUSG00000035770 Q6PDL0 / Dync1li2 / Cytoplasmic dynein 1 light intermediate chain 2 / O43237* / dynein cytoplasmic 1 light intermediate chain 2*  / complex
 ENSMUSG00000031865 Dctn1 / O08788 / Mus musculus dynactin 1 (Dctn1), transcript variant 4, mRNA. / Q14203* / dynactin subunit 1*  / complex
 ENSMUSG00000029757 O88485 / Dync1i1 / Cytoplasmic dynein 1 intermediate chain 1 / O14576* / dynein cytoplasmic 1 intermediate chain 1*  / complex
 ENSMUSG00000000420 Galnt1 / O08912 / Polypeptide N-acetylgalactosaminyltransferase 1 Polypeptide N-acetylgalactosaminyltransferase 1 soluble form / Q10472* / polypeptide N-acetylgalactosaminyltransferase 1*  / complex / reaction
 ENSMUSG00000030704 Rab6a / P35279 / RAB6A, member RAS oncogene family / RAB6C* / RAB6D* / Q9H0N0* / P20340* / RAB6C, member RAS oncogene family* / RAB6D, member RAS oncogene family*  / complex / reaction
 ENSMUSG00000021076 Actr10 / Q9QZB7 / Actin-related protein 10 / Q9NZ32* / actin related protein 10 homolog*  / complex
 ENSMUSG00000021338 Q6EDY6 / Carmil1 / F-actin-uncapping protein LRRC16A / Q5VZK9* / capping protein regulator and myosin 1 linker 1*  / complex / reaction
 ENSMUSG00000027012 O88487 / Dync1i2 / Mus musculus dynein cytoplasmic 1 intermediate chain 2 (Dync1i2), transcript variant 9, mRNA. / Q13409* / dynein cytoplasmic 1 intermediate chain 2*  / complex
 ENSMUSG00000003452 Bicd1 / Q8BR07 / Protein bicaudal D homolog 1 / Q96G01* / BICD cargo adaptor 1*  / reaction / complex
 ENSMUSG00000028745 Capzb / P47757 / F-actin-capping protein subunit beta / P47756* / capping actin protein of muscle Z-line beta subunit*  / complex / reaction
 ENSMUSG00000024603 Dctn4 / Q8CBY8 / Mus musculus dynactin 4 (Dctn4), transcript variant 2, mRNA. / Q9UJW0* / dynactin subunit 4*  / complex






 

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