ENSMUSG00000029757


Mus musculus

Features
Gene ID: ENSMUSG00000029757
  
Biological name :Dync1i1
  
Synonyms : Cytoplasmic dynein 1 intermediate chain 1 / Dync1i1 / O88485
  
Possible biological names infered from orthology : dynein cytoplasmic 1 intermediate chain 1 / O14576
  
Species: Mus musculus
  
Chr. number: 6
Strand: 1
Band: A1
Gene start: 5725639
Gene end: 6028039
  
Corresponding Affymetrix probe sets: 10536334 (MoGene1.0st)   1416361_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000111221
Ensembl peptide - ENSMUSP00000111218
Ensembl peptide - ENSMUSP00000121787
Ensembl peptide - ENSMUSP00000145221
Ensembl peptide - ENSMUSP00000111216
Ensembl peptide - ENSMUSP00000111217
NCBI entrez gene - 13426     See in Manteia.
MGI - MGI:107743
RefSeq - XM_017321380
RefSeq - NM_001191023
RefSeq - NM_001191025
RefSeq - NM_001191026
RefSeq - NM_001191027
RefSeq - NM_010063
RefSeq - XM_006504982
RefSeq Peptide - NP_001177954
RefSeq Peptide - NP_001177956
RefSeq Peptide - NP_034193
RefSeq Peptide - NP_001177955
RefSeq Peptide - NP_001177952
swissprot - Q3TYJ3
swissprot - D3Z258
swissprot - D3Z0M6
swissprot - O88485
swissprot - A0A0N4SVS1
Ensembl - ENSMUSG00000029757
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dync1i1ENSDARG00000060948Danio rerio
 DYNC1I1ENSGALG00000009722Gallus gallus
 O14576ENSG00000158560Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
O88487 / Dync1i2 / Mus musculus dynein cytoplasmic 1 intermediate chain 2 (Dync1i2), transcript variant 9, mRNA. / Q13409* / dynein cytoplasmic 1 intermediate chain 2*ENSMUSG0000002701277
Wdr78 / E9PYY5 / WD repeat domain 78 / Q5VTH9*ENSMUSG0000003512621
Dnaic1 / Q8C0M8 / Dynein intermediate chain 1, axonemal / DNAI1* / Q9UI46* / dynein axonemal intermediate chain 1*ENSMUSG0000006132220
Wdr34 / WD repeat domain 34 / Q96EX3*ENSMUSG0000003971515
Dnaic2 / A2AC93 / Dynein intermediate chain 2, axonemal / DNAI2* / Q9GZS0* / dynein axonemal intermediate chain 2*ENSMUSG0000003470615


Protein motifs (from Interpro)
Interpro ID Name
 IPR001680  WD40 repeat
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR017986  WD40-repeat-containing domain
 IPR025956  Cytoplasmic dynein 1 intermediate chain 1/2
 IPR036322  WD40-repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007018 microtubule-based movement IEA
 biological_processGO:0010970 transport along microtubule IBA
 biological_processGO:0047496 vesicle transport along microtubule ISS
 biological_processGO:2000582 positive regulation of ATP-dependent microtubule motor activity, plus-end-directed IBA
 cellular_componentGO:0000775 chromosome, centromeric region IEA
 cellular_componentGO:0000776 kinetochore ISO
 cellular_componentGO:0000777 condensed chromosome kinetochore IEA
 cellular_componentGO:0000922 spindle pole ISO
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005868 cytoplasmic dynein complex IBA
 cellular_componentGO:0005874 microtubule IEA
 cellular_componentGO:0030286 dynein complex IEA
 cellular_componentGO:0031982 vesicle ISO
 cellular_componentGO:0036464 cytoplasmic ribonucleoprotein granule ISO
 cellular_componentGO:0048471 perinuclear region of cytoplasm ISS
 cellular_componentGO:0055037 recycling endosome ISO
 molecular_functionGO:0003774 motor activity IEA
 molecular_functionGO:0003777 microtubule motor activity ISS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008017 microtubule binding ISS
 molecular_functionGO:0008574 ATP-dependent microtubule motor activity, plus-end-directed IBA
 molecular_functionGO:0030507 spectrin binding ISO
 molecular_functionGO:0045503 dynein light chain binding IPI
 molecular_functionGO:0045504 dynein heavy chain binding IBA


Pathways (from Reactome)
Pathway description
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
MHC class II antigen presentation
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
HSP90 chaperone cycle for steroid hormone receptors (SHR)
RHO GTPases Activate Formins
COPI-mediated anterograde transport
COPI-independent Golgi-to-ER retrograde traffic
Mitotic Prometaphase


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000020483 Dynll2 / Q9D0M5 / Dynein light chain 2, cytoplasmic / Q96FJ2* / dynein light chain LC8-type 2*  / complex
 ENSMUSG00000020745 P63005 / Pafah1b1 / platelet-activating factor acetylhydrolase, isoform 1b, subunit 1 / P43034* / platelet activating factor acetylhydrolase 1b regulatory subunit 1*  / complex
 ENSMUSG00000018707 Q9JHU4 / Dync1h1 / Cytoplasmic dynein 1 heavy chain 1 / Q14204* / dynein cytoplasmic 1 heavy chain 1*  / complex
 ENSMUSG00000015733 Capza2 / P47754 / F-actin-capping protein subunit alpha-2 / P47755* / capping actin protein of muscle Z-line alpha subunit 2*  / complex
 ENSMUSG00000021076 Actr10 / Q9QZB7 / Actin-related protein 10 / Q9NZ32* / actin related protein 10 homolog*  / complex
 ENSMUSG00000025410 Dctn2 / Q99KJ8 / Dynactin subunit 2 / Q13561*  / complex
 ENSMUSG00000024603 Dctn4 / Q8CBY8 / Mus musculus dynactin 4 (Dctn4), transcript variant 2, mRNA. / Q9UJW0* / dynactin subunit 4*  / complex
 ENSMUSG00000028745 Capzb / P47757 / F-actin-capping protein subunit beta / P47756* / capping actin protein of muscle Z-line beta subunit*  / complex
 ENSMUSG00000041791 Capza3 / P70190 / F-actin-capping protein subunit alpha-3 / Q96KX2* / capping actin protein of muscle Z-line alpha subunit 3*  / complex
 ENSMUSG00000031516 Dctn6 / Q9WUB4 / Dynactin subunit 6 / O00399*  / complex
 ENSMUSG00000030868 Dctn5 / Q9QZB9 / Dynactin subunit 5 / Q9BTE1*  / complex
 ENSMUSG00000035770 Q6PDL0 / Dync1li2 / Cytoplasmic dynein 1 light intermediate chain 2 / O43237* / dynein cytoplasmic 1 light intermediate chain 2*  / complex
 ENSMUSG00000025228 Actr1a / P61164 / Alpha-centractin / P61163* / ARP1 actin related protein 1 homolog A*  / complex
 ENSMUSG00000028447 Dctn3 / Q9Z0Y1 / Dynactin subunit 3 / O75935*  / complex
 ENSMUSG00000032435 Q8R1Q8 / Dync1li1 / Cytoplasmic dynein 1 light intermediate chain 1 / Q9Y6G9* / dynein cytoplasmic 1 light intermediate chain 1*  / complex
 ENSMUSG00000027012 O88487 / Dync1i2 / Mus musculus dynein cytoplasmic 1 intermediate chain 2 (Dync1i2), transcript variant 9, mRNA. / Q13409* / dynein cytoplasmic 1 intermediate chain 2*  / complex
 ENSMUSG00000031865 Dctn1 / O08788 / Mus musculus dynactin 1 (Dctn1), transcript variant 4, mRNA. / Q14203* / dynactin subunit 1*  / complex
 ENSMUSG00000064063 BC048507 / cDNA sequence BC048507 / DYNLL1* / P63167* / dynein light chain LC8-type 1*  / complex
 ENSMUSG00000092329 Q6PB93 / Gm20388 / predicted gene 20388 / GALNT2* / Q10471* / polypeptide N-acetylgalactosaminyltransferase 2*  / reaction / complex
 ENSMUSG00000003452 Bicd1 / Q8BR07 / Protein bicaudal D homolog 1 / Q96G01* / BICD cargo adaptor 1*  / reaction / complex
 ENSMUSG00000000420 Galnt1 / O08912 / Polypeptide N-acetylgalactosaminyltransferase 1 Polypeptide N-acetylgalactosaminyltransferase 1 soluble form / Q10472* / polypeptide N-acetylgalactosaminyltransferase 1*  / complex / reaction
 ENSMUSG00000029757 O88485 / Dync1i1 / Cytoplasmic dynein 1 intermediate chain 1 / O14576* / dynein cytoplasmic 1 intermediate chain 1*  / complex
 ENSMUSG00000030704 Rab6a / P35279 / RAB6A, member RAS oncogene family / RAB6C* / RAB6D* / Q9H0N0* / P20340* / RAB6C, member RAS oncogene family* / RAB6D, member RAS oncogene family*  / complex / reaction






 

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