ENSMUSG00000061322


Mus musculus

Features
Gene ID: ENSMUSG00000061322
  
Biological name :Dnaic1
  
Synonyms : Dnaic1 / Dynein intermediate chain 1, axonemal / Q8C0M8
  
Possible biological names infered from orthology : DNAI1 / dynein axonemal intermediate chain 1 / Q9UI46
  
Species: Mus musculus
  
Chr. number: 4
Strand: 1
Band: A5
Gene start: 41569775
Gene end: 41638158
  
Corresponding Affymetrix probe sets: 10504072 (MoGene1.0st)   1437093_at (Mouse Genome 430 2.0 Array)   1437094_x_at (Mouse Genome 430 2.0 Array)   1454585_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000113929
Ensembl peptide - ENSMUSP00000100028
NCBI entrez gene - 68922     See in Manteia.
MGI - MGI:1916172
RefSeq - NM_175138
RefSeq Peptide - NP_780347
swissprot - A2ANP4
swissprot - Q8BMY8
swissprot - Q8C0M8
Ensembl - ENSMUSG00000061322
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dnai1.1ENSDARG00000100081Danio rerio
 dnai1.2ENSDARG00000038788Danio rerio
 DNAI1ENSGALG00000005831Gallus gallus
 DNAI1ENSG00000122735Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Wdr78 / E9PYY5 / WD repeat domain 78 / Q5VTH9*ENSMUSG0000003512627
O88485 / Dync1i1 / Cytoplasmic dynein 1 intermediate chain 1 / O14576* / dynein cytoplasmic 1 intermediate chain 1*ENSMUSG0000002975718
O88487 / Dync1i2 / Mus musculus dynein cytoplasmic 1 intermediate chain 2 (Dync1i2), transcript variant 9, mRNA. / Q13409* / dynein cytoplasmic 1 intermediate chain 2*ENSMUSG0000002701217
Wdr34 / WD repeat domain 34 / Q96EX3*ENSMUSG0000003971515
Dnaic2 / A2AC93 / Dynein intermediate chain 2, axonemal / DNAI2* / Q9GZS0* / dynein axonemal intermediate chain 2*ENSMUSG0000003470614


Protein motifs (from Interpro)
Interpro ID Name
 IPR001680  WD40 repeat
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR017986  WD40-repeat-containing domain
 IPR036322  WD40-repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003341 cilium movement ISO
 biological_processGO:0003351 epithelial cilium movement IMP
 biological_processGO:0007368 determination of left/right symmetry ISO
 biological_processGO:0007507 heart development IMP
 biological_processGO:0008286 insulin receptor signaling pathway IDA
 biological_processGO:0030317 flagellated sperm motility ISO
 biological_processGO:0036158 outer dynein arm assembly ISO
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005813 centrosome IDA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005874 microtubule IEA
 cellular_componentGO:0005929 cilium IEA
 cellular_componentGO:0030286 dynein complex IEA
 cellular_componentGO:0036157 outer dynein arm ISO
 cellular_componentGO:0042995 cell projection IEA
 molecular_functionGO:0003774 motor activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008574 ATP-dependent microtubule motor activity, plus-end-directed IBA
 molecular_functionGO:0045503 dynein light chain binding IBA
 molecular_functionGO:0045504 dynein heavy chain binding IBA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000284 double outlet right ventricle "both the aorta and the pulmonary trunk originate from the right ventricle, usually in conjunction with a ventricular septal defect" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:67826]
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Allelic Composition: Dnaic1b2b284Clo/Dnaic1b2b284Clo
Genetic Background: C57BL/6J-Dnaic1b2b284Clo

 MP:0000445 short snout "reduced length of the anterior facial part of the muzzle" [J:53370]
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Allelic Composition: Ifngtm3.1Lky/Ifngtm3.1Lky
Genetic Background: B6.129S4-Ifngtm3.1Lky

 MP:0000644 dextrocardia "cardiac apex pointing to the right as opposed to the normal levocardia" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Dnaic1b2b284Clo/Dnaic1b2b284Clo
Genetic Background: C57BL/6J-Dnaic1b2b284Clo

Allelic Composition: Dnaic1b2b1526Clo/Dnaic1b2b1526Clo
Genetic Background: C57BL/6J-Dnaic1b2b1526Clo

 MP:0000694 spleen hypoplasia "small size due to reduced cell number in the spleen" [J:43971]
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Allelic Composition: Ifngtm3.1Lky/Ifngtm3.1Lky
Genetic Background: B6.129S4-Ifngtm3.1Lky

 MP:0001872 sinus inflammation "increase in susceptibility of the hollow cavities in bone (usually but not exclusively those in the skull) to allergens and/or pathogens" [MGI:tc, J:60896]
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Allelic Composition: Etv4tm1Arbr/Etv4tm1Arbr,Etv5tm1Hass/Etv5+,Tg(Hoxb7-Venus*)17Cos/0
Genetic Background: involves: 129S1/Sv * C57BL/6J * CBA/J

 MP:0001891 hydroencephaly "excessive accumulation of cerebrospinal fluid in the brain, especially the cerebral ventricles, often leading to increased brain size and other brain trauma" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Etv4tm1Arbr/Etv4tm1Arbr,Etv5tm1Hass/Etv5+,Tg(Hoxb7-Venus*)17Cos/0
Genetic Background: involves: 129S1/Sv * C57BL/6J * CBA/J

Allelic Composition: Dnaic1b2b284Clo/Dnaic1b2b284Clo
Genetic Background: C57BL/6J-Dnaic1b2b284Clo

 MP:0001947 abnormal mucociliary clearance "anomaly in the rate of ciliary and secretory activity of the respiratory submucosal glands" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Etv4tm1Arbr/Etv4tm1Arbr,Etv5tm1Hass/Etv5+,Tg(Hoxb7-Venus*)17Cos/0
Genetic Background: involves: 129S1/Sv * C57BL/6J * CBA/J

 MP:0001950 abnormal respiratory sounds "anomalous noises heard over any part of the respiratory tract" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Slc2a10G128E/Slc2a10G128E
Genetic Background: C3HeB/FeJ-Slc2a10G128E

 MP:0002082 postnatal lethality "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Epotm1.2Mym/Epotm1.2Mym
Genetic Background: Not Specified

 MP:0002127 abnormal cardiovascular system morphology "abnormal development of the heart or vascular tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Epotm1.2Mym/Epotm1.2Mym
Genetic Background: Not Specified

 MP:0002133 abnormal respiratory system physiology "anomalous function of the pulmonary system; inability or reduced ability to intake and exchange oxygen and carbon dioxide with the environment" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Etv4tm1Arbr/Etv4tm1Arbr,Etv5tm1Hass/Etv5+,Tg(Hoxb7-Venus*)17Cos/0
Genetic Background: involves: 129S1/Sv * C57BL/6J * CBA/J

 MP:0002639 micrognathia "abnormally reduced size of the jaws, especially of the mandible" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Ifngtm3.1Lky/Ifngtm3.1Lky
Genetic Background: B6.129S4-Ifngtm3.1Lky

 MP:0003178 left pulmonary isomerism "bilaterally symmetric left lung pattern (or altered asymmetric patterning of the lung)" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93051]
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Allelic Composition: Dnaic1b2b1526Clo/Dnaic1b2b1526Clo
Genetic Background: C57BL/6J-Dnaic1b2b1526Clo

 MP:0003354 astrocytosis "a proliferation or spread of astrocytes in the area of a degenerative lesion or damaged tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Etv4tm1Arbr/Etv4tm1Arbr,Etv5tm1Hass/Etv5+,Tg(Hoxb7-Venus*)17Cos/0
Genetic Background: involves: 129S1/Sv * C57BL/6J * CBA/J

 MP:0004113 abnormal aortic arch morphology "structural anomoly of the portion of the descending aorta proceeding from the arch of the aorta and extending to the diaphragm " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Dnaic1b2b284Clo/Dnaic1b2b284Clo
Genetic Background: C57BL/6J-Dnaic1b2b284Clo

 MP:0004133 heterotaxia "abnormal arrangement of organs or parts of the body in relation to each other" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Dnaic1b2b284Clo/Dnaic1b2b284Clo
Genetic Background: C57BL/6J-Dnaic1b2b284Clo

Allelic Composition: Dnaic1b2b1526Clo/Dnaic1b2b1526Clo
Genetic Background: C57BL/6J-Dnaic1b2b1526Clo

 MP:0010402 ventricular septal defect "abnormal communications between the two lower chambers of the heart, including such defects in the perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular regions" [MESH:C14.240.400.560.540]
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Allelic Composition: Dnaic1b2b284Clo/Dnaic1b2b284Clo
Genetic Background: C57BL/6J-Dnaic1b2b284Clo

 MP:0010412 atrioventricular septal defect "defects in the thin membranous structure between the right atrium and left ventricle that arise from faulty development of the embryonic endocardial cushions; the spectrum ranges from a primum atrial septal defect and cleft mitral valve, known as a partial atrioventricular septal defect (partial AVSD), to defects of both the primum atrial septum and inlet ventricular septum and the presence of a common atrioventricular valve, referred to as complete atrioventricular septal defect (complete AVSD)" [http://emedicine.medscape.com]
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Allelic Composition: Dnaic1b2b284Clo/Dnaic1b2b284Clo
Genetic Background: C57BL/6J-Dnaic1b2b284Clo

 MP:0010463 aorta stenosis "diffuse constriction or narrowing of the aorta" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Dnaic1b2b1526Clo/Dnaic1b2b1526Clo
Genetic Background: C57BL/6J-Dnaic1b2b1526Clo

 MP:0011050 abnormal respiratory motile cilium morphology "any structural anomaly of the multiple epithelial tiny, motile hair-like projections, which have a variable arrangement of axonemal microtubules, contains molecular motors, and beat with a characteristic whip-like pattern that promote transport of fluids and other cells across the epithelium of the respiratory tract" [GO:0031514, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Dnaic1b2b284Clo/Dnaic1b2b284Clo
Genetic Background: C57BL/6J-Dnaic1b2b284Clo

 MP:0011249 abdominal situs inversus "lateral transposition or mirroring of the viscera of the abdomen, sometimes incomplete, with all organs maintaining the normal relative position with respect to each other" [MGI:csmith]
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Allelic Composition: Dnaic1b2b1526Clo/Dnaic1b2b1526Clo
Genetic Background: C57BL/6J-Dnaic1b2b1526Clo

 MP:0011250 abdominal situs ambiguus "an abnormality in which the abdominal organs are positioned in such a way with respect to each other and the left-right axis as to be not clearly lateralised and thus have neither the usual, or normal (situs solitus), nor the mirror-imaged (situs inversus) arrangements" [MGI:csmith, PMID:18039396]
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Allelic Composition: Dnaic1b2b284Clo/Dnaic1b2b284Clo
Genetic Background: C57BL/6J-Dnaic1b2b284Clo

Allelic Composition: Dnaic1b2b1526Clo/Dnaic1b2b1526Clo
Genetic Background: C57BL/6J-Dnaic1b2b1526Clo

 MP:0011251 bronchial situs inversus "anomaly in the asymmetry of the bronchi of the lung such that these structures on both the left and right side have the morphology normally seen on the opposite side of the body" [MGI:csmith]
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Allelic Composition: Dnaic1b2b284Clo/Dnaic1b2b284Clo
Genetic Background: C57BL/6J-Dnaic1b2b284Clo

 MP:0011252 situs inversus totalis "the complete right to left reversal (transposition) of the thoracic and abdominal organs, including the heart (dextrocardia)" [MGI:csmith]
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Allelic Composition: Dnaic1b2b284Clo/Dnaic1b2b284Clo
Genetic Background: C57BL/6J-Dnaic1b2b284Clo

Allelic Composition: Dnaic1b2b1526Clo/Dnaic1b2b1526Clo
Genetic Background: C57BL/6J-Dnaic1b2b1526Clo

 MP:0011649 immotile respiratory cilia "failure of the multiple epithelial tiny, motile hair-like projections of the repiratory tract epithelium to beat with a characteristic whip-like pattern in order to promote transport of fluids and other cells across the epithelium of the respiratory tract" [MGI:csmith]
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Allelic Composition: Dnaic1b2b1526Clo/Dnaic1b2b1526Clo
Genetic Background: C57BL/6J-Dnaic1b2b1526Clo

 MP:0011683 dual inferior vena cava "presence of two inferior vena cavae, often resulting from the persistence of both supracardinal veins during development; the two structures may be symmetric or asymmetric but typically join together at the renal vein" [MGI:csmith, PMID:10835118]
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Allelic Composition: Dnaic1b2b1526Clo/Dnaic1b2b1526Clo
Genetic Background: C57BL/6J-Dnaic1b2b1526Clo

 MP:0012676 dilated brain ventricles "the luminal space of one or more of the four communicating cavities within the brain that are continuous with the central canal of the spinal cord is increased in volume or area, usually with an increase in contained fluid" [MGI:anna]
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Allelic Composition: Etv4tm1Arbr/Etv4tm1Arbr,Etv5tm1Hass/Etv5+,Tg(Hoxb7-Venus*)17Cos/0
Genetic Background: involves: 129S1/Sv * C57BL/6J * CBA/J

 MP:0013206 abnormal motile cilium morphology "any structural anomaly of a cilium which has a variable arrangement of axonemal microtubules, contains molecular motors, and beats with a characteristic whip-like pattern that promotes cell motility or transport of fluids and other cells across a cell surface; motile cilia are typically found in multiple copies on epithelial cells that line the lumenal ducts of various tissues and may also function as sensory organelles" [GO:0031514]
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Allelic Composition: Dnaic1b2b284Clo/Dnaic1b2b284Clo
Genetic Background: C57BL/6J-Dnaic1b2b284Clo

 MP:0013209 abnormal motile cilium physiology "any structural anomaly of a cilium which has a variable arrangement of axonemal microtubules, contains molecular motors, and beats with a characteristic whip-like pattern that promotes cell motility or transport of fluids and other cells across a cell surface; motile cilia are typically found in multiple copies on epithelial cells that line the lumenal ducts of various tissues and may also function as sensory organelles" [GO:0031514]
Show

Allelic Composition: Dnaic1b2b284Clo/Dnaic1b2b284Clo
Genetic Background: C57BL/6J-Dnaic1b2b284Clo

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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