ENSMUSG00000027012


Mus musculus

Features
Gene ID: ENSMUSG00000027012
  
Biological name :Dync1i2
  
Synonyms : Dync1i2 / Mus musculus dynein cytoplasmic 1 intermediate chain 2 (Dync1i2), transcript variant 9, mRNA. / O88487
  
Possible biological names infered from orthology : dynein cytoplasmic 1 intermediate chain 2 / Q13409
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: C2
Gene start: 71211706
Gene end: 71263303
  
Corresponding Affymetrix probe sets: 10472764 (MoGene1.0st)   1415841_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000107767
Ensembl peptide - ENSMUSP00000107766
Ensembl peptide - ENSMUSP00000107768
Ensembl peptide - ENSMUSP00000107772
Ensembl peptide - ENSMUSP00000107770
Ensembl peptide - ENSMUSP00000080410
Ensembl peptide - ENSMUSP00000097605
Ensembl peptide - ENSMUSP00000107764
NCBI entrez gene - 13427     See in Manteia.
MGI - MGI:107750
RefSeq - XM_017315326
RefSeq - NM_001198874
RefSeq - NM_001198875
RefSeq - NM_001198876
RefSeq - NM_001198877
RefSeq - NM_001198878
RefSeq - NM_001347173
RefSeq - NM_010064
RefSeq - XM_006498674
RefSeq - XM_006498676
RefSeq - XM_006498677
RefSeq - XM_006498678
RefSeq - XM_006498679
RefSeq - XM_006498680
RefSeq - XM_017315319
RefSeq - XM_017315324
RefSeq - NM_001198872
RefSeq - NM_001198873
RefSeq Peptide - NP_001185803
RefSeq Peptide - NP_001185806
RefSeq Peptide - NP_001185807
RefSeq Peptide - NP_001334102
RefSeq Peptide - NP_034194
RefSeq Peptide - NP_001185801
RefSeq Peptide - NP_001185802
RefSeq Peptide - NP_001185804
RefSeq Peptide - NP_001185805
swissprot - A2BFF8
swissprot - A2BFF7
swissprot - A2BFF5
swissprot - A2BFF9
swissprot - O88487
swissprot - Q3TPJ8
Ensembl - ENSMUSG00000027012
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dync1i2aENSDARG00000078386Danio rerio
 dync1i2bENSDARG00000103195Danio rerio
 DYNC1I2ENSGALG00000009551Gallus gallus
 Q13409ENSG00000077380Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
O88485 / Dync1i1 / Cytoplasmic dynein 1 intermediate chain 1 / O14576* / dynein cytoplasmic 1 intermediate chain 1*ENSMUSG0000002975775
Wdr78 / E9PYY5 / WD repeat domain 78 / Q5VTH9*ENSMUSG0000003512622
Dnaic1 / Q8C0M8 / Dynein intermediate chain 1, axonemal / DNAI1* / Q9UI46* / dynein axonemal intermediate chain 1*ENSMUSG0000006132219
Wdr34 / WD repeat domain 34 / Q96EX3*ENSMUSG0000003971516
Dnaic2 / A2AC93 / Dynein intermediate chain 2, axonemal / DNAI2* / Q9GZS0* / dynein axonemal intermediate chain 2*ENSMUSG0000003470615


Protein motifs (from Interpro)
Interpro ID Name
 IPR001680  WD40 repeat
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR017986  WD40-repeat-containing domain
 IPR025956  Cytoplasmic dynein 1 intermediate chain 1/2
 IPR036322  WD40-repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007018 microtubule-based movement IEA
 biological_processGO:0010970 transport along microtubule IBA
 biological_processGO:2000582 positive regulation of ATP-dependent microtubule motor activity, plus-end-directed IBA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005813 centrosome IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005868 cytoplasmic dynein complex IEA
 cellular_componentGO:0005874 microtubule IEA
 cellular_componentGO:0030286 dynein complex IEA
 cellular_componentGO:0031982 vesicle ISS
 molecular_functionGO:0003774 motor activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008574 ATP-dependent microtubule motor activity, plus-end-directed IBA
 molecular_functionGO:0045503 dynein light chain binding IBA
 molecular_functionGO:0045504 dynein heavy chain binding IBA


Pathways (from Reactome)
Pathway description
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
MHC class II antigen presentation
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
Regulation of PLK1 Activity at G2/M Transition
HSP90 chaperone cycle for steroid hormone receptors (SHR)
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization from the centrosome
Recruitment of NuMA to mitotic centrosomes
Anchoring of the basal body to the plasma membrane
RHO GTPases Activate Formins
COPI-mediated anterograde transport
COPI-independent Golgi-to-ER retrograde traffic
Mitotic Prometaphase
AURKA Activation by TPX2


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001392 abnormal locomotor activity "altered ability or inability to move from place to place" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Sgpl1Gt(ROSA)78Sor/Sgpl1Gt(ROSA)78Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0005179 decreased total circulating cholesterol level "less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Dusp1tm1(KOMP)Wtsi/Dusp1tm1(KOMP)Wtsi
Genetic Background: C57BL/6N-Dusp1tm1(KOMP)Wtsi/Wtsi

 MP:0005634 decreased circulating sodium level "less than the normal concentration in the blood of this metallic element, the most plentiful extracellular ion in the body and the principal determinant of extracellular fluid volume" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Dusp1tm1(KOMP)Wtsi/Dusp1tm1(KOMP)Wtsi
Genetic Background: C57BL/6N-Dusp1tm1(KOMP)Wtsi/Wtsi

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Dusp1tm1(KOMP)Wtsi/Dusp1tm1(KOMP)Wtsi
Genetic Background: C57BL/6N-Dusp1tm1(KOMP)Wtsi/Wtsi

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000020483 Dynll2 / Q9D0M5 / Dynein light chain 2, cytoplasmic / Q96FJ2* / dynein light chain LC8-type 2*  / complex
 ENSMUSG00000020745 P63005 / Pafah1b1 / platelet-activating factor acetylhydrolase, isoform 1b, subunit 1 / P43034* / platelet activating factor acetylhydrolase 1b regulatory subunit 1*  / complex
 ENSMUSG00000018707 Q9JHU4 / Dync1h1 / Cytoplasmic dynein 1 heavy chain 1 / Q14204* / dynein cytoplasmic 1 heavy chain 1*  / complex
 ENSMUSG00000015733 Capza2 / P47754 / F-actin-capping protein subunit alpha-2 / P47755* / capping actin protein of muscle Z-line alpha subunit 2*  / complex
 ENSMUSG00000021076 Actr10 / Q9QZB7 / Actin-related protein 10 / Q9NZ32* / actin related protein 10 homolog*  / complex
 ENSMUSG00000025410 Dctn2 / Q99KJ8 / Dynactin subunit 2 / Q13561*  / complex
 ENSMUSG00000024603 Dctn4 / Q8CBY8 / Mus musculus dynactin 4 (Dctn4), transcript variant 2, mRNA. / Q9UJW0* / dynactin subunit 4*  / complex
 ENSMUSG00000028745 Capzb / P47757 / F-actin-capping protein subunit beta / P47756* / capping actin protein of muscle Z-line beta subunit*  / complex
 ENSMUSG00000041791 Capza3 / P70190 / F-actin-capping protein subunit alpha-3 / Q96KX2* / capping actin protein of muscle Z-line alpha subunit 3*  / complex
 ENSMUSG00000031516 Dctn6 / Q9WUB4 / Dynactin subunit 6 / O00399*  / complex
 ENSMUSG00000030868 Dctn5 / Q9QZB9 / Dynactin subunit 5 / Q9BTE1*  / complex
 ENSMUSG00000035770 Q6PDL0 / Dync1li2 / Cytoplasmic dynein 1 light intermediate chain 2 / O43237* / dynein cytoplasmic 1 light intermediate chain 2*  / complex
 ENSMUSG00000025228 Actr1a / P61164 / Alpha-centractin / P61163* / ARP1 actin related protein 1 homolog A*  / complex
 ENSMUSG00000028447 Dctn3 / Q9Z0Y1 / Dynactin subunit 3 / O75935*  / complex
 ENSMUSG00000032435 Q8R1Q8 / Dync1li1 / Cytoplasmic dynein 1 light intermediate chain 1 / Q9Y6G9* / dynein cytoplasmic 1 light intermediate chain 1*  / complex
 ENSMUSG00000092329 Q6PB93 / Gm20388 / predicted gene 20388 / GALNT2* / Q10471* / polypeptide N-acetylgalactosaminyltransferase 2*  / complex / reaction
 ENSMUSG00000029757 O88485 / Dync1i1 / Cytoplasmic dynein 1 intermediate chain 1 / O14576* / dynein cytoplasmic 1 intermediate chain 1*  / complex
 ENSMUSG00000030704 Rab6a / P35279 / RAB6A, member RAS oncogene family / RAB6C* / RAB6D* / Q9H0N0* / P20340* / RAB6C, member RAS oncogene family* / RAB6D, member RAS oncogene family*  / complex / reaction
 ENSMUSG00000000420 Galnt1 / O08912 / Polypeptide N-acetylgalactosaminyltransferase 1 Polypeptide N-acetylgalactosaminyltransferase 1 soluble form / Q10472* / polypeptide N-acetylgalactosaminyltransferase 1*  / reaction / complex
 ENSMUSG00000003452 Bicd1 / Q8BR07 / Protein bicaudal D homolog 1 / Q96G01* / BICD cargo adaptor 1*  / reaction / complex
 ENSMUSG00000027012 O88487 / Dync1i2 / Mus musculus dynein cytoplasmic 1 intermediate chain 2 (Dync1i2), transcript variant 9, mRNA. / Q13409* / dynein cytoplasmic 1 intermediate chain 2*  / complex
 ENSMUSG00000031865 Dctn1 / O08788 / Mus musculus dynactin 1 (Dctn1), transcript variant 4, mRNA. / Q14203* / dynactin subunit 1*  / complex
 ENSMUSG00000064063 BC048507 / cDNA sequence BC048507 / DYNLL1* / P63167* / dynein light chain LC8-type 1*  / complex






 

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