ENSMUSG00000064063


Mus musculus

Features
Gene ID: ENSMUSG00000064063
  
Biological name :BC048507
  
Synonyms : BC048507 / cDNA sequence BC048507
  
Possible biological names infered from orthology : dynein light chain LC8-type 1 / DYNLL1 / P63167
  
Species: Mus musculus
  
Chr. number: 13
Strand: 1
Band: B3
Gene start: 67863326
Gene end: 67863925
  
Corresponding Affymetrix probe sets: 10405948 (MoGene1.0st)   1439446_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000077564
NCBI entrez gene - 408058     See in Manteia.
MGI - MGI:3040680
RefSeq - NM_001001185
RefSeq Peptide - NP_001001185
swissprot - Q80ZS7
Ensembl - ENSMUSG00000064063
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dynll1ENSDARG00000058454Danio rerio
 si:dkeyp-51b9.3ENSDARG00000092379Danio rerio
 DYNLL1ENSGALG00000020999Gallus gallus
 DYNLL1ENSG00000088986Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Dynll1 / P63168 / Dynein light chain 1, cytoplasmic ENSMUSG0000000901391
Dynll2 / Q9D0M5 / Dynein light chain 2, cytoplasmic / Q96FJ2* / dynein light chain LC8-type 2*ENSMUSG0000002048385
Dnal4 / Q9DCM4 / Dynein light chain 4, axonemal / O96015* / dynein axonemal light chain 4*ENSMUSG0000002242031


Protein motifs (from Interpro)
Interpro ID Name
 IPR001372  Dynein light chain, type 1/2
 IPR019763  Dynein light chain, type 1/2, conserved site
 IPR037177  Dynein light chain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007017 microtubule-based process IEA
 biological_processGO:0010970 transport along microtubule IBA
 biological_processGO:0060271 cilium assembly IBA
 biological_processGO:2000582 positive regulation of ATP-dependent microtubule motor activity, plus-end-directed IBA
 cellular_componentGO:0005868 cytoplasmic dynein complex IBA
 cellular_componentGO:0005875 microtubule associated complex IEA
 cellular_componentGO:0030286 dynein complex IEA
 molecular_functionGO:0008092 cytoskeletal protein binding IBA
 molecular_functionGO:0008574 ATP-dependent microtubule motor activity, plus-end-directed IBA
 molecular_functionGO:0045505 dynein intermediate chain binding IBA
 molecular_functionGO:0051959 dynein light intermediate chain binding IBA


Pathways (from Reactome)
Pathway description
Activation of BIM and translocation to mitochondria
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Macroautophagy
MHC class II antigen presentation
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
Regulation of PLK1 Activity at G2/M Transition
HSP90 chaperone cycle for steroid hormone receptors (SHR)
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization from the centrosome
Recruitment of NuMA to mitotic centrosomes
Anchoring of the basal body to the plasma membrane
Intraflagellar transport
RHO GTPases Activate Formins
Neutrophil degranulation
COPI-mediated anterograde transport
COPI-independent Golgi-to-ER retrograde traffic
Mitotic Prometaphase
AURKA Activation by TPX2


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000020483 Dynll2 / Q9D0M5 / Dynein light chain 2, cytoplasmic / Q96FJ2* / dynein light chain LC8-type 2*  / complex
 ENSMUSG00000020745 P63005 / Pafah1b1 / platelet-activating factor acetylhydrolase, isoform 1b, subunit 1 / P43034* / platelet activating factor acetylhydrolase 1b regulatory subunit 1*  / complex
 ENSMUSG00000018707 Q9JHU4 / Dync1h1 / Cytoplasmic dynein 1 heavy chain 1 / Q14204* / dynein cytoplasmic 1 heavy chain 1*  / complex
 ENSMUSG00000015733 Capza2 / P47754 / F-actin-capping protein subunit alpha-2 / P47755* / capping actin protein of muscle Z-line alpha subunit 2*  / complex
 ENSMUSG00000021076 Actr10 / Q9QZB7 / Actin-related protein 10 / Q9NZ32* / actin related protein 10 homolog*  / complex
 ENSMUSG00000021936 Mapk8 / Q91Y86 / Mitogen-activated protein kinase 8 / P45983*  / reaction
 ENSMUSG00000025410 Dctn2 / Q99KJ8 / Dynactin subunit 2 / Q13561*  / complex
 ENSMUSG00000025907 Q9ESK9 / Rb1cc1 / RB1-inducible coiled-coil protein 1 / Q8TDY2* / RB1 inducible coiled-coil 1*  / reaction
 ENSMUSG00000024603 Dctn4 / Q8CBY8 / Mus musculus dynactin 4 (Dctn4), transcript variant 2, mRNA. / Q9UJW0* / dynactin subunit 4*  / complex
 ENSMUSG00000029513 Prkab1 / Q9R078 / protein kinase, AMP-activated, beta 1 non-catalytic subunit / Q9Y478* / protein kinase AMP-activated non-catalytic subunit beta 1*  / reaction
 ENSMUSG00000028745 Capzb / P47757 / F-actin-capping protein subunit beta / P47756* / capping actin protein of muscle Z-line beta subunit*  / complex
 ENSMUSG00000028944 Prkag2 / Q91WG5 / protein kinase, AMP-activated, gamma 2 non-catalytic subunit / Q9UGJ0* / protein kinase AMP-activated non-catalytic subunit gamma 2*  / reaction
 ENSMUSG00000041791 Capza3 / P70190 / F-actin-capping protein subunit alpha-3 / Q96KX2* / capping actin protein of muscle Z-line alpha subunit 3*  / complex
 ENSMUSG00000028518 Prkaa2 / Q8BRK8 / protein kinase, AMP-activated, alpha 2 catalytic subunit / P54646* / protein kinase AMP-activated catalytic subunit alpha 2*  / reaction
 ENSMUSG00000029512 Ulk1 / unc-51 like kinase 1 / O75385* / unc-51 like autophagy activating kinase 1*  / reaction
 ENSMUSG00000031516 Dctn6 / Q9WUB4 / Dynactin subunit 6 / O00399*  / complex
 ENSMUSG00000030868 Dctn5 / Q9QZB9 / Dynactin subunit 5 / Q9BTE1*  / complex
 ENSMUSG00000035770 Q6PDL0 / Dync1li2 / Cytoplasmic dynein 1 light intermediate chain 2 / O43237* / dynein cytoplasmic 1 light intermediate chain 2*  / complex
 ENSMUSG00000037526 Atg14 / Q8CDJ3 / Beclin 1-associated autophagy-related key regulator / Q6ZNE5* / autophagy related 14*  / complex / reaction
 ENSMUSG00000025228 Actr1a / P61164 / Alpha-centractin / P61163* / ARP1 actin related protein 1 homolog A*  / complex
 ENSMUSG00000035086 Becn1 / O88597 / Beclin-1 Beclin-1-C 35 kDa Beclin-1-C 37 kDa / Q14457* / beclin 1*  / complex / reaction
 ENSMUSG00000028447 Dctn3 / Q9Z0Y1 / Dynactin subunit 3 / O75935*  / complex
 ENSMUSG00000027244 Atg13 / Q91YI1 / Mus musculus autophagy related 13 (Atg13), transcript variant 4, mRNA. / O75143* / autophagy related 13*  / reaction
 ENSMUSG00000040506 A2AH22 / Ambra1 / Activating molecule in BECN1-regulated autophagy protein 1 / Q9C0C7* / autophagy and beclin 1 regulator 1*  / complex / reaction
 ENSMUSG00000050697 Prkaa1 / Q5EG47 / protein kinase, AMP-activated, alpha 1 catalytic subunit / Q13131* / protein kinase AMP-activated catalytic subunit alpha 1*  / reaction
 ENSMUSG00000038205 Prkab2 / Q6PAM0 / protein kinase, AMP-activated, beta 2 non-catalytic subunit / O43741* / protein kinase AMP-activated non-catalytic subunit beta 2*  / reaction
 ENSMUSG00000037204 Atg101 / Q9D8Z6 / Autophagy-related protein 101 / Q9BSB4* / autophagy related 101*  / reaction
 ENSMUSG00000032435 Q8R1Q8 / Dync1li1 / Cytoplasmic dynein 1 light intermediate chain 1 / Q9Y6G9* / dynein cytoplasmic 1 light intermediate chain 1*  / complex
 ENSMUSG00000032571 Pik3r4 / Q8VD65 / Phosphoinositide 3-kinase regulatory subunit 4 / Q99570*  / complex / reaction
 ENSMUSG00000006542 Prkag3 / Q8BGM7 / protein kinase, AMP-activated, gamma 3 non-catatlytic subunit / Q9UGI9* / protein kinase AMP-activated non-catalytic subunit gamma 3*  / reaction
 ENSMUSG00000033628 Pik3c3 / Q6PF93 / Phosphatidylinositol 3-kinase catalytic subunit type 3 / Q8NEB9*  / complex / reaction
 ENSMUSG00000031865 Dctn1 / O08788 / Mus musculus dynactin 1 (Dctn1), transcript variant 4, mRNA. / Q14203* / dynactin subunit 1*  / complex
 ENSMUSG00000003452 Bicd1 / Q8BR07 / Protein bicaudal D homolog 1 / Q96G01* / BICD cargo adaptor 1*  / complex / reaction
 ENSMUSG00000027012 O88487 / Dync1i2 / Mus musculus dynein cytoplasmic 1 intermediate chain 2 (Dync1i2), transcript variant 9, mRNA. / Q13409* / dynein cytoplasmic 1 intermediate chain 2*  / complex
 ENSMUSG00000092329 Q6PB93 / Gm20388 / predicted gene 20388 / GALNT2* / Q10471* / polypeptide N-acetylgalactosaminyltransferase 2*  / complex / reaction
 ENSMUSG00000064063 BC048507 / cDNA sequence BC048507 / DYNLL1* / P63167* / dynein light chain LC8-type 1*  / complex
 ENSMUSG00000029757 O88485 / Dync1i1 / Cytoplasmic dynein 1 intermediate chain 1 / O14576* / dynein cytoplasmic 1 intermediate chain 1*  / complex
 ENSMUSG00000000420 Galnt1 / O08912 / Polypeptide N-acetylgalactosaminyltransferase 1 Polypeptide N-acetylgalactosaminyltransferase 1 soluble form / Q10472* / polypeptide N-acetylgalactosaminyltransferase 1*  / complex / reaction
 ENSMUSG00000030704 Rab6a / P35279 / RAB6A, member RAS oncogene family / RAB6C* / RAB6D* / Q9H0N0* / P20340* / RAB6C, member RAS oncogene family* / RAB6D, member RAS oncogene family*  / complex / reaction
 ENSMUSG00000027381 O54918 / Bcl2l11 / Bcl-2-like protein 11 / O43521* / BCL2 like 11*  / complex
 ENSMUSG00000067713 O54950 / Prkag1 / protein kinase, AMP-activated, gamma 1 non-catalytic subunit / P54619* / protein kinase AMP-activated non-catalytic subunit gamma 1*  / reaction






 

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