Manteia - Molecule gene

ENSMUSG00000029513

Mus musculus

Features

Gene ID:	ENSMUSG00000029513

Biological name :	Prkab1

Synonyms :	Prkab1 / protein kinase, AMP-activated, beta 1 non-catalytic subunit / Q9R078

Possible biological names infered from orthology :	protein kinase AMP-activated non-catalytic subunit beta 1 / Q9Y478

Species:	Mus musculus

Chr. number:	5
Strand:	-1
Band:	F
Gene start:	116013586
Gene end:	116024508

Corresponding Affymetrix probe sets:	10533026 (MoGene1.0st) 1424119_at (Mouse Genome 430 2.0 Array) 1452457_a_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000031486 Ensembl peptide - ENSMUSP00000107630 Ensembl peptide - ENSMUSP00000138221 Ensembl peptide - ENSMUSP00000138749 NCBI entrez gene - 19079 See in Manteia. MGI - MGI:1336167 RefSeq - XM_006530201 RefSeq - NM_031869 RefSeq Peptide - NP_114075 swissprot - Q542K0 swissprot - Q9R078 swissprot - S4R2R1 Ensembl - ENSMUSG00000029513

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
prkab1a	ENSDARG00000044183	Danio rerio
prkab1b	ENSDARG00000046143	Danio rerio
PRKAB1	ENSGALG00000007373	Gallus gallus
PRKAB1	ENSG00000111725	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Prkab2 / Q6PAM0 / protein kinase, AMP-activated, beta 2 non-catalytic subunit / O43741* / protein kinase AMP-activated non-catalytic subunit beta 2*	ENSMUSG00000038205	70

Protein motifs (from Interpro)

Interpro ID	Name
IPR006828	Association with the SNF1 complex (ASC) domain
IPR013783	Immunoglobulin-like fold
IPR014756	Immunoglobulin E-set
IPR032640	AMP-activated protein kinase, glycogen-binding domain
IPR037256	ASC domain superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0006468	protein phosphorylation	ISO
biological_process	GO:0006629	lipid metabolic process	IEA
biological_process	GO:0006631	fatty acid metabolic process	IEA
biological_process	GO:0006633	fatty acid biosynthetic process	IEA
biological_process	GO:0010628	positive regulation of gene expression	ISO
biological_process	GO:0016310	phosphorylation	IEA
biological_process	GO:0035878	nail development	IMP
biological_process	GO:0050790	regulation of catalytic activity	IEA
biological_process	GO:0051291	protein heterooligomerization	IEA
cellular_component	GO:0005634	nucleus	IDA
cellular_component	GO:0005829	cytosol	TAS
cellular_component	GO:0031588	nucleotide-activated protein kinase complex	IEA
molecular_function	GO:0004672	protein kinase activity	ISO
molecular_function	GO:0004679	AMP-activated protein kinase activity	TAS
molecular_function	GO:0005515	protein binding	IPI
molecular_function	GO:0016301	kinase activity	IEA
molecular_function	GO:0019901	protein kinase binding	IEA

Pathways (from Reactome)

Pathway description

Energy dependent regulation of mTOR by LKB1-AMPK

TP53 Regulates Metabolic Genes

Regulation of TP53 Activity through Phosphorylation

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000062	increased bone density	"increased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61295]	Show Allelic Composition: Ppp3r2^{tm1.1(KOMP)Vlcg}/Ppp3r2^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Ppp3r2^{tm1.1(KOMP)Vlcg}/Ucd
MP:0000183	decreased circulating LDL cholesterol level	"less than average concentration in the blood of low density lipoprotein, which normally transports cholesterol to tissues other than the liver" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Pparg^{tm1b(KOMP)Wtsi}/Pparg^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Pparg^{tm1b(KOMP)Wtsi}/H
MP:0000186	decreased circulating HDL cholesterol level	"lower than average level of high density lipoprotein in blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Pparg^{tm1b(KOMP)Wtsi}/Pparg^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Pparg^{tm1b(KOMP)Wtsi}/H Allelic Composition: Prkab1^{tm1b(KOMP)Wtsi}/Prkab1^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Prkab1^{tm1b(KOMP)Wtsi}/Rbrc Allelic Composition: Prkab1^{tm1b(KOMP)Wtsi}/Prkab1^{tm1b(KOMP)Wtsi} Genetic Background: B6N(Cg)-Prkab1^{tm1b(KOMP)Wtsi}/J
MP:0000208	decreased hematocrit	"less than the average percentage of a volume of a blood sample occupied by red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Pparg^{tm1b(KOMP)Wtsi}/Pparg^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Pparg^{tm1b(KOMP)Wtsi}/H Allelic Composition: Prkab1^{tm1b(KOMP)Wtsi}/Prkab1^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Prkab1^{tm1b(KOMP)Wtsi}/H Allelic Composition: Prkab1^{tm1b(KOMP)Wtsi}/Prkab1^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Prkab1^{tm1b(KOMP)Wtsi}/Rbrc Allelic Composition: Prkab1^{tm1a(KOMP)Wtsi}/Prkab1^{tm1a(KOMP)Wtsi} Genetic Background: C57BL/6N-Prkab1^{tm1a(KOMP)Wtsi}/Wtsi Allelic Composition: Prkab1^{tm1b(KOMP)Wtsi}/Prkab1^{tm1b(KOMP)Wtsi} Genetic Background: involves: C57BL/6N
MP:0000240	extramedullary hematopoiesis	"formation and development of blood cells outside the bone marrow, e.g., in the spleen, liver, or lymph nodes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Prkab1^{tm1b(KOMP)Wtsi}/Prkab1^{tm1b(KOMP)Wtsi} Genetic Background: involves: C57BL/6N
MP:0000245	abnormal erythropoiesis	"atypical process of red blood cell formation" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]	Show Allelic Composition: Prkab1^{tm1b(KOMP)Wtsi}/Prkab1^{tm1b(KOMP)Wtsi} Genetic Background: involves: C57BL/6N
MP:0000256	echinocytosis	"a state in which the red blood cells have multiple small projections appearing over the cell circumference resembling a small burr or a sea urchin" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, J:82330, ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator]	Show Allelic Composition: Prkab1^{tm1b(KOMP)Wtsi}/Prkab1^{tm1b(KOMP)Wtsi} Genetic Background: involves: C57BL/6N
MP:0000274	enlarged heart	"increase over normal size of the heart" [J:29971]	Show Allelic Composition: Pitx2^{tm1b(EUCOMM)Wtsi}/Pitx2⁺ Genetic Background: C57BL/6N-Pitx2^{tm1b(EUCOMM)Wtsi}/H
MP:0000314	schistocytosis	"the appearance of poikilocytes in the blood that owe their abnormal shape to fragmentation occurring as the cells flow through damaged small vessels" [J:82330, ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator]	Show Allelic Composition: Prkab1^{tm1b(KOMP)Wtsi}/Prkab1^{tm1b(KOMP)Wtsi} Genetic Background: involves: C57BL/6N
MP:0000689	abnormal spleen morphology	"atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]	Show Allelic Composition: Pparg^{tm1b(KOMP)Wtsi}/Pparg^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Pparg^{tm1b(KOMP)Wtsi}/H
MP:0000691	enlarged spleen	"increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Pparg^{tm1b(KOMP)Wtsi}/Pparg^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Pparg^{tm1b(KOMP)Wtsi}/H Allelic Composition: Prkab1^{tm1b(KOMP)Wtsi}/Prkab1^{tm1b(KOMP)Wtsi} Genetic Background: involves: C57BL/6N
MP:0000745	tremors	"repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Lmx1a^dr-sst/Lmx1a^dr-sst Genetic Background: involves: BALB/cCf * C57BL/6J * DBA/2J
MP:0000759	abnormal skeletal muscle morphology	"anomalous structure of any of the striated muscle fibers connected at either or both extremeties with the bony framework of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Egr2^tm2(cre)Pch/Egr2⁺,Phox2b^tm4Jbr/Phox2b⁺ Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2
MP:0000774	reduced brain size	"smaller appearance of the brain" [J:35802]	Show Allelic Composition: Lmx1a^dr-sst/Lmx1a^dr-sst Genetic Background: involves: BALB/cCf * C57BL/6J * DBA/2J
MP:0000788	abnormal cerebral cortex morphology	"malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857]	Show Allelic Composition: Lmx1a^dr-sst/Lmx1a^dr-sst Genetic Background: involves: BALB/cCf * C57BL/6J * DBA/2J
MP:0000812	abnormal dentate gyrus morphology	"absence or malformation of one of two interlocking gyri of the hippocampus that contains granule cells, which project to the pyramidal cells and interneurons of the CA3 region of the ammon gyrus" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:38857]	Show Allelic Composition: Lmx1a^dr-sst/Lmx1a^dr-sst Genetic Background: involves: BALB/cCf * C57BL/6J * DBA/2J
MP:0000849	abnormal cerebellum morphology	"any malformation or absence of the part of the metencephalon that lies in the posterior cranial fossa dorsal to the pons and medulla that is concerned with the coordination of movement and learning of motor skills" [J:50311, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]	Show Allelic Composition: Lmx1a^dr-sst/Lmx1a^dr-sst Genetic Background: involves: BALB/cCf * C57BL/6J * DBA/2J
MP:0000888	absent cerebellar granule layer	"missing innermost cortical layer of the cerebellum" [J:46854]	Show Allelic Composition: Lmx1a^dr-sst/Lmx1a^dr-sst Genetic Background: involves: BALB/cCf * C57BL/6J * DBA/2J
MP:0000920	abnormal myelination	"atypical or altered myelination in axon sheaths" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Lmx1a^dr-sst/Lmx1a^dr-sst Genetic Background: involves: BALB/cCf * C57BL/6J * DBA/2J
MP:0001262	decreased body weight	"lower than normal average weight " [J:61295]	Show Allelic Composition: Lmx1a^dr-sst/Lmx1a^dr-sst Genetic Background: involves: BALB/cCf * C57BL/6J * DBA/2J Allelic Composition: Prkab1^tm1Eihl/Prkab1^tm1Eihl Genetic Background: involves: C57BL/6
MP:0001293	anophthalmia	"congenital absence of all tissues of the eyes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CML, J:71979]	Show Allelic Composition: Pitx2^{tm1b(EUCOMM)Wtsi}/Pitx2⁺ Genetic Background: C57BL/6N-Pitx2^{tm1b(EUCOMM)Wtsi}/H
MP:0001303	abnormal lens morphology	"malformed transparent structure of the eye responsible for focusing light rays" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:40203]	Show Allelic Composition: Pparg^{tm1b(KOMP)Wtsi}/Pparg^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Pparg^{tm1b(KOMP)Wtsi}/H
MP:0001330	abnormal optic nerve morphology	"malformation, misprojection or atrophy in the second cranial nerve which is responsible for conveying visual information from the retina to the brain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Lmx1a^dr-sst/Lmx1a^dr-sst Genetic Background: involves: BALB/cCf * C57BL/6J * DBA/2J
MP:0001393	ataxia	"inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]	Show Allelic Composition: Lmx1a^dr-sst/Lmx1a^dr-sst Genetic Background: involves: BALB/cCf * C57BL/6J * DBA/2J
MP:0001402	hypoactivity	"reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]	Show Allelic Composition: Egr2^tm2(cre)Pch/Egr2⁺,Phox2b^tm4Jbr/Phox2b⁺ Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2
MP:0001547	abnormal lipid level	"anomalous concentrations of fat-soluble substances (molecules composed of carbon and hydrogen and are characteristically insoluble in water) in the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Prkab1^tm1Eihl/Prkab1^tm1Eihl Genetic Background: involves: C57BL/6
MP:0001585	hemolytic anemia	"an anemic condition resulting from an increased rate of erythrocyte destruction" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Blvra^{tm1c(EUCOMM)Hmgu}/Blvra^{tm1c(EUCOMM)Hmgu},Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ Genetic Background: involves: C57BL/6J * C57BL/6N
MP:0002064	seizures	"sudden and often acute manifestation of epileptic attack, sometimes convulsive" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Lmx1a^dr-sst/Lmx1a^dr-sst Genetic Background: involves: BALB/cCf * C57BL/6J * DBA/2J
MP:0002169	no phenotype detected	"normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Prkab1^{tm1a(KOMP)Wtsi}/Prkab1^{tm1a(KOMP)Wtsi} Genetic Background: C57BL/6N-Prkab1^{tm1a(KOMP)Wtsi}/Wtsi
MP:0002182	abnormal astrocyte morphology	"anomalous structure, number or compostion of one of the large neuroglia cells of nervous tissue" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Lmx1a^dr-sst/Lmx1a^dr-sst Genetic Background: involves: BALB/cCf * C57BL/6J * DBA/2J
MP:0002310	resistance to fatty liver development	"less likely than the norm to to develop hepatic steatosis " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Prkab1^tm1Eihl/Prkab1^tm1Eihl Genetic Background: involves: C57BL/6
MP:0002397	abnormal bone marrow morphology	"structural anomalies in the soft tissue that fills the cavities of bones" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Blvra^{tm1c(EUCOMM)Hmgu}/Blvra^{tm1c(EUCOMM)Hmgu},Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ Genetic Background: involves: C57BL/6J * C57BL/6N
MP:0002447	abnormal erythrocyte morphology	"structural anomaly of the cells in the blood that carry oxygen, red blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Blvra^{tm1c(EUCOMM)Hmgu}/Blvra^{tm1c(EUCOMM)Hmgu},Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ Genetic Background: involves: C57BL/6J * C57BL/6N
MP:0002591	decreased mean corpuscular volume	"less than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Pparg^{tm1b(KOMP)Wtsi}/Pparg^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Pparg^{tm1b(KOMP)Wtsi}/H Allelic Composition: Prkab1^{tm1b(KOMP)Wtsi}/Prkab1^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Prkab1^{tm1b(KOMP)Wtsi}/H Allelic Composition: Prkab1^{tm1b(KOMP)Wtsi}/Prkab1^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Prkab1^{tm1b(KOMP)Wtsi}/Rbrc Allelic Composition: Prkab1^{tm1b(KOMP)Wtsi}/Prkab1^{tm1b(KOMP)Wtsi} Genetic Background: B6N(Cg)-Prkab1^{tm1b(KOMP)Wtsi}/J Allelic Composition: Prkab1^{tm1b(KOMP)Wtsi}/Prkab1^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Prkab1^{tm1b(KOMP)Wtsi}/Orl
MP:0002599	increased mean platelet volume	"increased content of platelet cells over the norm" [cml:Cathleen M. Lutz, Mouse Genome Informatics Curator]	Show Allelic Composition: Pparg^{tm1b(KOMP)Wtsi}/Pparg^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Pparg^{tm1b(KOMP)Wtsi}/H Allelic Composition: Prkab1^{tm1b(KOMP)Wtsi}/Prkab1^{tm1b(KOMP)Wtsi} Genetic Background: involves: C57BL/6N
MP:0002626	increased heart rate	"greater than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Pparg^{tm1b(KOMP)Wtsi}/Pparg^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Pparg^{tm1b(KOMP)Wtsi}/H
MP:0002640	reticulocytosis	"an increase in the number of reticulocytes in the blood" [J:78271, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]	Show Allelic Composition: Prkab1^{tm1b(KOMP)Wtsi}/Prkab1^{tm1b(KOMP)Wtsi} Genetic Background: involves: C57BL/6N
MP:0002642	anisocytosis	"blood cells of variable size on smear" [J:7209, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]	Show Allelic Composition: Prkab1^{tm1b(KOMP)Wtsi}/Prkab1^{tm1b(KOMP)Wtsi} Genetic Background: involves: C57BL/6N
MP:0002727	decreased circulating insulin level	"less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]	Show Allelic Composition: Prkab1^tm1Eihl/Prkab1^tm1Eihl Genetic Background: involves: C57BL/6
MP:0002792	abnormal retinal vascularization	"malformation or disorganization of the blood vessels supplying the retina" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]	Show Allelic Composition: Pparg^{tm1b(KOMP)Wtsi}/Pparg^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Pparg^{tm1b(KOMP)Wtsi}/H
MP:0002810	microcytic anemia	"anemia in which the circulating erythrocyte corpuscular volume is smaller than normal" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Prkab1^{tm1b(KOMP)Wtsi}/Prkab1^{tm1b(KOMP)Wtsi} Genetic Background: involves: C57BL/6N
MP:0002813	microcytosis	"the presence of unusually small erythrocytes in the circulating blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Prkab1^{tm1b(KOMP)Wtsi}/Prkab1^{tm1b(KOMP)Wtsi} Genetic Background: involves: C57BL/6N
MP:0002874	decreased hemoglobin content	"decrease in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Pparg^{tm1b(KOMP)Wtsi}/Pparg^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Pparg^{tm1b(KOMP)Wtsi}/H Allelic Composition: Prkab1^{tm1b(KOMP)Wtsi}/Prkab1^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Prkab1^{tm1b(KOMP)Wtsi}/H Allelic Composition: Prkab1^{tm1b(KOMP)Wtsi}/Prkab1^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Prkab1^{tm1b(KOMP)Wtsi}/Rbrc Allelic Composition: Prkab1^{tm1b(KOMP)Wtsi}/Prkab1^{tm1b(KOMP)Wtsi} Genetic Background: B6N(Cg)-Prkab1^{tm1b(KOMP)Wtsi}/J Allelic Composition: Prkab1^{tm1b(KOMP)Wtsi}/Prkab1^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Prkab1^{tm1b(KOMP)Wtsi}/Orl Allelic Composition: Prkab1^{tm1a(KOMP)Wtsi}/Prkab1^{tm1a(KOMP)Wtsi} Genetic Background: C57BL/6N-Prkab1^{tm1a(KOMP)Wtsi}/Wtsi Allelic Composition: Prkab1^{tm1b(KOMP)Wtsi}/Prkab1^{tm1b(KOMP)Wtsi} Genetic Background: involves: C57BL/6N
MP:0002875	decreased erythrocyte count	"reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Pparg^{tm1b(KOMP)Wtsi}/Pparg^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Pparg^{tm1b(KOMP)Wtsi}/H Allelic Composition: Prkab1^{tm1a(KOMP)Wtsi}/Prkab1^{tm1a(KOMP)Wtsi} Genetic Background: C57BL/6N-Prkab1^{tm1a(KOMP)Wtsi}/Wtsi Allelic Composition: Prkab1^{tm1b(KOMP)Wtsi}/Prkab1^{tm1b(KOMP)Wtsi} Genetic Background: involves: C57BL/6N
MP:0002891	increased insulin sensitivity	"greater ability to clear glucose from the bloodstream when given insulin than normal; can result in hypoglycemia" [RGD:Rat Genome Database submission]	Show Allelic Composition: Prkab1^tm1Eihl/Prkab1^tm1Eihl Genetic Background: involves: C57BL/6
MP:0003135	increased erythrocyte precursors	"greater numbers of progenitors of the erythrocyte lineage" [smb:Susan M. Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Prkab1^{tm1b(KOMP)Wtsi}/Prkab1^{tm1b(KOMP)Wtsi} Genetic Background: involves: C57BL/6N
MP:0003240	loss of hippocampal neurons	"loss of neurons in the hippocampal region of the brain, commonly due to an apoptotic event" [RGD:Rat Genome Database submission]	Show Allelic Composition: Lmx1a^dr-sst/Lmx1a^dr-sst Genetic Background: involves: BALB/cCf * C57BL/6J * DBA/2J
MP:0003313	abnormal locomotor activation	"altered ability or desire of an animal to initiate locomotor activity" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Prkab1^{tm1b(KOMP)Wtsi}/Prkab1^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Prkab1^{tm1b(KOMP)Wtsi}/H
MP:0003354	astrocytosis	"a proliferation or spread of astrocytes in the area of a degenerative lesion or damaged tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Lmx1a^dr-sst/Lmx1a^dr-sst Genetic Background: involves: BALB/cCf * C57BL/6J * DBA/2J
MP:0003646	muscle fatigue	"increased muscle exhaustion or increased susceptibility to muscle exhaustion" [J:96306]	Show Allelic Composition: Egr2^tm2(cre)Pch/Egr2⁺,Phox2b^tm4Jbr/Phox2b⁺ Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2
MP:0003657	abnormal erythrocyte lysis	"increase or decrease in the ability of RBCs to withstand changes in osmolarity" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Prkab1^{tm1b(KOMP)Wtsi}/Prkab1^{tm1b(KOMP)Wtsi} Genetic Background: involves: C57BL/6N
MP:0003961	decreased lean body mass	"less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]	Show Allelic Composition: Prkab1^{tm1b(KOMP)Wtsi}/Prkab1^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Prkab1^{tm1b(KOMP)Wtsi}/Rbrc
MP:0004151	hypoferremia	"less than the normal concentration of this metallic element in the blood" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]	Show Allelic Composition: Pparg^{tm1b(KOMP)Wtsi}/Pparg^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Pparg^{tm1b(KOMP)Wtsi}/H Allelic Composition: Prkab1^{tm1b(KOMP)Wtsi}/Prkab1^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Prkab1^{tm1b(KOMP)Wtsi}/H Allelic Composition: Prkab1^{tm1b(KOMP)Wtsi}/Prkab1^{tm1b(KOMP)Wtsi} Genetic Background: involves: C57BL/6N
MP:0004948	abnormal neuronal precursor proliferation	"any anomaly in the ability of a neuroblast population to undergo rapid expansion by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Lmx1a^dr-sst/Lmx1a^dr-sst Genetic Background: involves: BALB/cCf * C57BL/6J * DBA/2J
MP:0004952	increased spleen weight	"greater than average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Prkab1^{tm1b(KOMP)Wtsi}/Prkab1^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Prkab1^{tm1b(KOMP)Wtsi}/H Allelic Composition: Prkab1^{tm1b(KOMP)Wtsi}/Prkab1^{tm1b(KOMP)Wtsi} Genetic Background: involves: C57BL/6N
MP:0005018	decreased T cell number	"fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Prkab1^{tm1b(KOMP)Wtsi}/Prkab1^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Prkab1^{tm1b(KOMP)Wtsi}/Rbrc
MP:0005179	decreased total circulating cholesterol level	"less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Pparg^{tm1b(KOMP)Wtsi}/Pparg^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Pparg^{tm1b(KOMP)Wtsi}/H Allelic Composition: Prkab1^{tm1b(KOMP)Wtsi}/Prkab1^{tm1b(KOMP)Wtsi} Genetic Background: B6N(Cg)-Prkab1^{tm1b(KOMP)Wtsi}/J
MP:0005293	impaired glucose tolerance	"less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Prkab1^{tm1b(KOMP)Wtsi}/Prkab1^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Prkab1^{tm1b(KOMP)Wtsi}/H
MP:0005344	increased circulating bilirubin level	"greater than the normal concentration in the blood of this yellow heme breakdown product" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85204]	Show Allelic Composition: Pparg^{tm1b(KOMP)Wtsi}/Pparg^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Pparg^{tm1b(KOMP)Wtsi}/H Allelic Composition: Prkab1^{tm1b(KOMP)Wtsi}/Prkab1^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Prkab1^{tm1b(KOMP)Wtsi}/Rbrc Allelic Composition: Prkab1^{tm1b(KOMP)Wtsi}/Prkab1^{tm1b(KOMP)Wtsi} Genetic Background: B6N(Cg)-Prkab1^{tm1b(KOMP)Wtsi}/J Allelic Composition: Prkab1^{tm1a(KOMP)Wtsi}/Prkab1^{tm1a(KOMP)Wtsi} Genetic Background: C57BL/6N-Prkab1^{tm1a(KOMP)Wtsi}/Wtsi
MP:0005387	immune system phenotype		Show Allelic Composition: Prkab1^{tm1b(KOMP)Wtsi}/Prkab1^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Prkab1^{tm1b(KOMP)Wtsi}/Rbrc
MP:0005404	abnormal axon morphology	"anomaly in the structure of the single process of a nerve cell that normally conducts impulses away from the cell body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Lmx1a^dr-sst/Lmx1a^dr-sst Genetic Background: involves: BALB/cCf * C57BL/6J * DBA/2J
MP:0005559	increased circulating glucose level	"greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]	Show Allelic Composition: Egr2^tm2(cre)Pch/Egr2⁺,Phox2b^tm4Jbr/Phox2b⁺ Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2
MP:0005562	decreased mean corpuscular hemoglobin	"less than the average levels of hemoglobin contained in an erythrocyte" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Pparg^{tm1b(KOMP)Wtsi}/Pparg^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Pparg^{tm1b(KOMP)Wtsi}/H Allelic Composition: Prkab1^{tm1b(KOMP)Wtsi}/Prkab1^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Prkab1^{tm1b(KOMP)Wtsi}/H Allelic Composition: Prkab1^{tm1b(KOMP)Wtsi}/Prkab1^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Prkab1^{tm1b(KOMP)Wtsi}/Rbrc Allelic Composition: Prkab1^{tm1b(KOMP)Wtsi}/Prkab1^{tm1b(KOMP)Wtsi} Genetic Background: B6N(Cg)-Prkab1^{tm1b(KOMP)Wtsi}/J Allelic Composition: Prkab1^{tm1b(KOMP)Wtsi}/Prkab1^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Prkab1^{tm1b(KOMP)Wtsi}/Orl Allelic Composition: Prkab1^{tm1a(KOMP)Wtsi}/Prkab1^{tm1a(KOMP)Wtsi} Genetic Background: C57BL/6N-Prkab1^{tm1a(KOMP)Wtsi}/Wtsi
MP:0005584	abnormal enzyme/coenzyme activity	"altered ability of any of these proteins, or their cofactors, to act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Egr2^tm2(cre)Pch/Egr2⁺,Phox2b^tm4Jbr/Phox2b⁺ Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2
MP:0005642	decreased mean corpuscular hemoglobin concentration	"less than the normal Hgb/Hct; the average hemoglobin concentration in a given volume of packed red cells, calculated from the hemoglobin therein and the hematocrit, in erythrocyte indices" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:8936]	Show Allelic Composition: Prkab1^{tm1b(KOMP)Wtsi}/Prkab1^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Prkab1^{tm1b(KOMP)Wtsi}/H Allelic Composition: Prkab1^{tm1b(KOMP)Wtsi}/Prkab1^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Prkab1^{tm1b(KOMP)Wtsi}/Rbrc Allelic Composition: Prkab1^{tm1b(KOMP)Wtsi}/Prkab1^{tm1b(KOMP)Wtsi} Genetic Background: B6N(Cg)-Prkab1^{tm1b(KOMP)Wtsi}/J Allelic Composition: Prkab1^{tm1b(KOMP)Wtsi}/Prkab1^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Prkab1^{tm1b(KOMP)Wtsi}/Orl Allelic Composition: Prkab1^{tm1b(KOMP)Wtsi}/Prkab1^{tm1b(KOMP)Wtsi} Genetic Background: involves: C57BL/6N
MP:0005659	resistance to diet-induced obesity	"less likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]	Show Allelic Composition: Prkab1^tm1Eihl/Prkab1^tm1Eihl Genetic Background: involves: C57BL/6
MP:0005668	decreased circulating leptin level	"less than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]	Show Allelic Composition: Prkab1^tm1Eihl/Prkab1^tm1Eihl Genetic Background: involves: C57BL/6
MP:0006063	abnormal inferior vena cava morphology	"structural malformation in the principal vein draining blood from the lower portion of the body" [smb:Susan M Bello, Mouse Genome Informatics Curator, Taber s Cyclopedic Medical Dictionary:19th edition: ISBN N 0-8036-0655-99]	Show Allelic Composition: Prkab1^{tm1a(KOMP)Wtsi}/Prkab1^{tm1a(KOMP)Wtsi} Genetic Background: C57BL/6N-Prkab1^{tm1a(KOMP)Wtsi}/Wtsi
MP:0006221	optic nerve hypoplasia	"less than the normal number of fibers in the optic nerve" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Lmx1a^dr-sst/Lmx1a^dr-sst Genetic Background: involves: BALB/cCf * C57BL/6J * DBA/2J
MP:0006353	incleased glycosylated hemoglobin level	"greater than normal blood concentration of a modified form of hemoglobin with an attached saccharide molecule " [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator", Riken ENU:Hiroshi Masuya]	Show Allelic Composition: Prkab1^{tm1b(KOMP)Wtsi}/Prkab1^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Prkab1^{tm1b(KOMP)Wtsi}/Rbrc
MP:0008025	brain vacuoles	"the abnormal presence of cavities or fluid-filled vesicles in the soma of brain cells, often indicative of spongiosis or other pathological states" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Lmx1a^dr-sst/Lmx1a^dr-sst Genetic Background: involves: BALB/cCf * C57BL/6J * DBA/2J
MP:0008079	decreased CD8-positive T cell number	"reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Prkab1^{tm1b(KOMP)Wtsi}/Prkab1^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Prkab1^{tm1b(KOMP)Wtsi}/Rbrc
MP:0008143	abnormal dendrite morphology	"any structural anomaly of the highly branched tree-like process of a neuron that serves as a receptive field and conducts impulses toward the cell body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]	Show Allelic Composition: Lmx1a^dr-sst/Lmx1a^dr-sst Genetic Background: involves: BALB/cCf * C57BL/6J * DBA/2J
MP:0008476	increased spleen red pulp amount	"increase in the quantity of the parenchymatous tissue network of the spleen that consists of loose plates or cords (sinuses) infiltrated with red blood cells where most of the blood filtration occurs and degenerate erythrocytes are removed from the circulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Prkab1^{tm1b(KOMP)Wtsi}/Prkab1^{tm1b(KOMP)Wtsi} Genetic Background: involves: C57BL/6N
MP:0008489	postnatal slow weight gain	"the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Lmx1a^dr-sst/Lmx1a^dr-sst Genetic Background: involves: BALB/cCf * C57BL/6J * DBA/2J
MP:0008597	decreased circulating interleukin-6 level	"reduction in the amount in the blood of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]	Show Allelic Composition: Prkab1^tm1Eihl/Prkab1^tm1Eihl Genetic Background: involves: C57BL/6
MP:0008805	decreased circulating amylase level	"reduction in the concentration of a group of amylolytic enzymes that cleave starch, glycogen, and related alpha-1,4-glucans in the blood" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:D08.811.277.450.066, MGI:brs "Beverly Richards-Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Prkab1^{tm1b(KOMP)Wtsi}/Prkab1^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Prkab1^{tm1b(KOMP)Wtsi}/Rbrc
MP:0008809	increased spleen iron level	"increase in the amount of iron present in the spleen tissue" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Prkab1^{tm1b(KOMP)Wtsi}/Prkab1^{tm1b(KOMP)Wtsi} Genetic Background: involves: C57BL/6N
MP:0008924	decreased granule neuron number	"reduction in the number of the small neurons of the granule cell layer that send parallel fibers to the upper molecular layer, where they synapse with Purkinje cell dendrites" [ISBN:0838580343 "Kandel ER, et al. Principles of Neural Science, 3rd edition"]	Show Allelic Composition: Lmx1a^dr-sst/Lmx1a^dr-sst Genetic Background: involves: BALB/cCf * C57BL/6J * DBA/2J
MP:0008948	decreased neuron number	"fewer than normal numbers of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:A08.663]	Show Allelic Composition: Lmx1a^dr-sst/Lmx1a^dr-sst Genetic Background: involves: BALB/cCf * C57BL/6J * DBA/2J
MP:0009289	decreased epididymal fat pad weight		Show Allelic Composition: Prkab1^tm1Eihl/Prkab1^tm1Eihl Genetic Background: involves: C57BL/6
MP:0009356	decreased liver triglyceride level	"lower than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Prkab1^tm1Eihl/Prkab1^tm1Eihl Genetic Background: involves: C57BL/6
MP:0009808	reduced oligodendrocyte number	"significantly fewer than the expected number of cells of the central nervous system that form the insulating myelin sheath of axons in the CNS are present" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Lmx1a^dr-sst/Lmx1a^dr-sst Genetic Background: involves: BALB/cCf * C57BL/6J * DBA/2J
MP:0009937	abnormal neuron differentiation	"abnormal growth or development of the cells of the nervous system that receive, conduct, and transmit impulses" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Lmx1a^dr-sst/Lmx1a^dr-sst Genetic Background: involves: BALB/cCf * C57BL/6J * DBA/2J
MP:0010025	decreased total body fat amount	"less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Prkab1^{tm1b(KOMP)Wtsi}/Prkab1^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Prkab1^{tm1b(KOMP)Wtsi}/Rbrc
MP:0010067	increased red blood cell distribution width	"higher than normal coefficient of variance (reference range) of the red blood cell volume for an organism" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", NCI:C64800 "NCI Thesaurus (Code C64800)"]	Show Allelic Composition: Pparg^{tm1b(KOMP)Wtsi}/Pparg^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Pparg^{tm1b(KOMP)Wtsi}/H Allelic Composition: Prkab1^{tm1b(KOMP)Wtsi}/Prkab1^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Prkab1^{tm1b(KOMP)Wtsi}/Rbrc Allelic Composition: Prkab1^{tm1b(KOMP)Wtsi}/Prkab1^{tm1b(KOMP)Wtsi} Genetic Background: involves: C57BL/6N
MP:0010074	stomatocytosis	"deformation of red blood cells to a cup-like shape, with swelling and with an elongated area of central pallor, instead of the normal biconcave shape" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Prkab1^{tm1b(KOMP)Wtsi}/Prkab1^{tm1b(KOMP)Wtsi} Genetic Background: involves: C57BL/6N
MP:0010080	abnormal hepatocyte physiology	"any functional anomaly of the main structural specialized epithelial cells which normally organize into interconnected plates called lobules" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Prkab1^tm1Eihl/Prkab1^tm1Eihl Genetic Background: involves: C57BL/6
MP:0010093	decreased circulating magnesium level	"a reduction in the blood concentration of magnesium" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Prkab1^{tm1a(KOMP)Wtsi}/Prkab1^{tm1a(KOMP)Wtsi} Genetic Background: C57BL/6N-Prkab1^{tm1a(KOMP)Wtsi}/Wtsi
MP:0010097	abnormal retinal blood vessel morphology	"any structural anomaly of the blood vessels supplying the retina" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pparg^{tm1b(KOMP)Wtsi}/Pparg^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Pparg^{tm1b(KOMP)Wtsi}/H
MP:0010177	acanthocytosis	"presence of erythrocytes characterized by multiple spiny (thorn-like) cytoplasmic projections" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Prkab1^{tm1b(KOMP)Wtsi}/Prkab1^{tm1b(KOMP)Wtsi} Genetic Background: involves: C57BL/6N
MP:0010507	shortened RR interval	"reduction in the length of the interval between an R wave and the next R wave; the RR interval is the inverse of the heart rate" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pparg^{tm1b(KOMP)Wtsi}/Pparg^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Pparg^{tm1b(KOMP)Wtsi}/H
MP:0011085	complete postnatal lethality	"premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]	Show Allelic Composition: Lmx1a^dr-sst/Lmx1a^dr-sst Genetic Background: involves: BALB/cCf * C57BL/6J * DBA/2J
MP:0011110	partial preweaning lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]	Show Allelic Composition: Pparg^{tm1b(KOMP)Wtsi}/Pparg^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Pparg^{tm1b(KOMP)Wtsi}/H Allelic Composition: Prkab1^{tm1b(KOMP)Wtsi}/Prkab1^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Prkab1^{tm1b(KOMP)Wtsi}/Ieg Allelic Composition: Prkab1^{tm1b(KOMP)Wtsi}/Prkab1^{tm1b(KOMP)Wtsi} Genetic Background: B6N(Cg)-Prkab1^{tm1b(KOMP)Wtsi}/J
MP:0011178	increased erythroblast number	"greater number of the nucleated precursor of erythrocytes" [MGI:csmith]	Show Allelic Composition: Prkab1^{tm1b(KOMP)Wtsi}/Prkab1^{tm1b(KOMP)Wtsi} Genetic Background: involves: C57BL/6N
MP:0011285	increased circulating erythropoietin level	"greater blood concentration of a sialic acid-containing glycoprotein hormone that enhances erythropoiesis and participates in wound healing; it is formed in the kidney and liver and can be detected in plasma and urine" [ISBN:0-683-40008-8, MGI:csmith]	Show Allelic Composition: Prkab1^{tm1b(KOMP)Wtsi}/Prkab1^{tm1b(KOMP)Wtsi} Genetic Background: involves: C57BL/6N
MP:0011400	complete lethality	"all individuals of a given genotype in a population die before the end of the normal lifespan but time(s) of death are unspecified" [MGI:llw2]	Show Allelic Composition: Egr2^tm2(cre)Pch/Egr2⁺,Phox2b^tm4Jbr/Phox2b⁺ Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2
MP:0011890	increased circulating ferritin level	"elevated concentration in the blood of ferritin, a ubiquitous intracellular protein that stores iron and releases it in a controlled fashion; some ferritin is also found in the blood and is measured in tests for overall iron levels, anemia and chronic diseases" [MGI:csmith]	Show Allelic Composition: Prkab1^{tm1b(KOMP)Wtsi}/Prkab1^{tm1b(KOMP)Wtsi} Genetic Background: involves: C57BL/6N
MP:0011913	abnormal reticulocyte cell number	"altered number of immature (nucleated) erythrocytes" [MPD:Molly]	Show Allelic Composition: Prkab1^{tm1b(KOMP)Wtsi}/Prkab1^{tm1b(KOMP)Wtsi} Genetic Background: involves: C57BL/6N
MP:0011940	decreased food intake	"reduction in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]	Show Allelic Composition: Prkab1^tm1Eihl/Prkab1^tm1Eihl Genetic Background: involves: C57BL/6
MP:0012106	impaired exercise endurance	"impaired performance during controlled physical activity" [MGI:smb]	Show Allelic Composition: Prkab1^tm1Grst/Prkab1^tm1Grst,Prkab2^tm1Grst/Prkab2^tm1Grst,Tg(Ckmm-cre)5Khn/0 Genetic Background: involves: C57BL/6 * FVB
MP:0013418	increased memory-marker gamma-delta T cell number	"increase in the number of memory-marker gamma-delta T cells with a CD44+ CD62L- phenotype" [IMPC:Saran, PMID:23928962]	Show Allelic Composition: Pparg^{tm1b(KOMP)Wtsi}/Pparg^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Pparg^{tm1b(KOMP)Wtsi}/H
MP:0013435	decreased CD8-positive, naive alpha-beta T cell number	"reduction in the number of the naÃ¯ve regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions with a CD44-low CD62L+ phenotype" [IMPC:Saran]	Show Allelic Composition: Prkab1^{tm1b(KOMP)Wtsi}/Prkab1^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Prkab1^{tm1b(KOMP)Wtsi}/Rbrc
MP:0013691	decreased CD5-positive Ly6C-positive T cell number	"reduction in the number of CD5-positive T cells expressing the memory marker Ly6C" [MGI:Saran]	Show Allelic Composition: Prkab1^{tm1b(KOMP)Wtsi}/Prkab1^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Prkab1^{tm1b(KOMP)Wtsi}/Rbrc
MP:0013772	increased effector memory T-helper cell number	"increase in the number of CD4-positive alpha-beta T-helper cells with a CD44-positive, CD62L-negative memory phenotype" [MGI:Saran]	Show Allelic Composition: Prkab1^{tm1b(KOMP)Wtsi}/Prkab1^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Prkab1^{tm1b(KOMP)Wtsi}/Rbrc
MP:0013873	abnormal ductus venosus morphology	"any structural anomaly of the embryonic connection between the portal vein and inferior vena cava formed by the left umbilical vein that allows oxygenated blood to bypass the developing liver during the time when this connection is normally open; this normally closes during develpment to adulthood" [MGI:csmith]	Show Allelic Composition: Prkab1^{tm1a(KOMP)Wtsi}/Prkab1^{tm1a(KOMP)Wtsi} Genetic Background: C57BL/6N-Prkab1^{tm1a(KOMP)Wtsi}/Wtsi
MP:0014185	cerebellum atrophy	"acquired diminution of the size of the cerebellum associated with wasting as from death and reabsorption of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes" [MGI:Anna]	Show Allelic Composition: Lmx1a^dr-sst/Lmx1a^dr-sst Genetic Background: involves: BALB/cCf * C57BL/6J * DBA/2J
MP:0030022	decreased muscle cell glucose uptake	"reduced ability of muscle cells to take in glucose" [MGI:anna]	Show Allelic Composition: Prkab1^tm1Grst/Prkab1^tm1Grst,Prkab2^tm1Grst/Prkab2^tm1Grst,Tg(Ckmm-cre)5Khn/0 Genetic Background: involves: C57BL/6 * FVB

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000003068	Stk11 / Q9WTK7 / Serine/threonine-protein kinase STK11 / Q15831* / serine/threonine kinase 11*	/ reaction
ENSMUSG00000021096	Ppm1a / P49443 / protein phosphatase 1A, magnesium dependent, alpha isoform / P35813* / protein phosphatase, Mg2+/Mn2+ dependent 1A*	/ reaction
ENSMUSG00000025907	Q9ESK9 / Rb1cc1 / RB1-inducible coiled-coil protein 1 / Q8TDY2* / RB1 inducible coiled-coil 1*	/ reaction / complex
ENSMUSG00000038332	Sesn1 / P58006 / Sestrin-1 / Q9Y6P5*	/ complex / reaction
ENSMUSG00000070934	Rraga / Q80X95 / Ras-related GTP-binding protein A / Q7L523* / Ras related GTP binding A*	/ reaction
ENSMUSG00000020483	Dynll2 / Q9D0M5 / Dynein light chain 2, cytoplasmic / Q96FJ2* / dynein light chain LC8-type 2*	/ reaction
ENSMUSG00000028944	Prkag2 / Q91WG5 / protein kinase, AMP-activated, gamma 2 non-catalytic subunit / Q9UGJ0* / protein kinase AMP-activated non-catalytic subunit gamma 2*	/ complex
ENSMUSG00000029512	Ulk1 / unc-51 like kinase 1 / O75385* / unc-51 like autophagy activating kinase 1*	/ reaction / complex
ENSMUSG00000059552	Trp53 / P02340 / transformation related protein 53 / TP53* / P04637* / tumor protein p53*	/ reaction
ENSMUSG00000033628	Pik3c3 / Q6PF93 / Phosphatidylinositol 3-kinase catalytic subunit type 3 / Q8NEB9*	/ reaction
ENSMUSG00000002496	Tsc2 / tuberous sclerosis 2 / P49815* / TSC complex subunit 2*	/ reaction
ENSMUSG00000028646	Rragc / Q99K70 / Ras-related GTP-binding protein C / Q9HB90* / Ras related GTP binding C*	/ reaction
ENSMUSG00000035086	Becn1 / O88597 / Beclin-1 Beclin-1-C 35 kDa Beclin-1-C 37 kDa / Q14457* / beclin 1*	/ reaction
ENSMUSG00000028518	Prkaa2 / Q8BRK8 / protein kinase, AMP-activated, alpha 2 catalytic subunit / P54646* / protein kinase AMP-activated catalytic subunit alpha 2*	/ complex
ENSMUSG00000037204	Atg101 / Q9D8Z6 / Autophagy-related protein 101 / Q9BSB4* / autophagy related 101*	/ complex / reaction
ENSMUSG00000028945	Rheb / Q921J2 / Ras homolog enriched in brain / Q15382* / Ras homolog, mTORC1 binding*	/ reaction
ENSMUSG00000041658	Rragb / Q6NTA4 / Ras-related GTP-binding protein B / Q5VZM2* / Ras related GTP binding B*	/ reaction
ENSMUSG00000028278	Rragd / Ras-related GTP binding D / Q9NQL2*	/ reaction
ENSMUSG00000032571	Pik3r4 / Q8VD65 / Phosphoinositide 3-kinase regulatory subunit 4 / Q99570*	/ reaction
ENSMUSG00000037526	Atg14 / Q8CDJ3 / Beclin 1-associated autophagy-related key regulator / Q6ZNE5* / autophagy related 14*	/ reaction
ENSMUSG00000040506	A2AH22 / Ambra1 / Activating molecule in BECN1-regulated autophagy protein 1 / Q9C0C7* / autophagy and beclin 1 regulator 1*	/ reaction
ENSMUSG00000026812	Tsc1 / Q9EP53 / Hamartin / Q92574* / TSC complex subunit 1*	/ reaction
ENSMUSG00000050697	Prkaa1 / Q5EG47 / protein kinase, AMP-activated, alpha 1 catalytic subunit / Q13131* / protein kinase AMP-activated catalytic subunit alpha 1*	/ complex
ENSMUSG00000064063	BC048507 / cDNA sequence BC048507 / DYNLL1* / P63167* / dynein light chain LC8-type 1*	/ reaction
ENSMUSG00000027244	Atg13 / Q91YI1 / Mus musculus autophagy related 13 (Atg13), transcript variant 4, mRNA. / O75143* / autophagy related 13*	/ complex / reaction
ENSMUSG00000006542	Prkag3 / Q8BGM7 / protein kinase, AMP-activated, gamma 3 non-catatlytic subunit / Q9UGI9* / protein kinase AMP-activated non-catalytic subunit gamma 3*	/ complex
ENSMUSG00000028893	Sesn2 / P58043 / Sestrin-2 / P58004*	/ reaction / complex
ENSMUSG00000024142	Mlst8 / Q9DCJ1 / Target of rapamycin complex subunit LST8 / Q9BVC4* / MTOR associated protein, LST8 homolog*	/ reaction
ENSMUSG00000067713	O54950 / Prkag1 / protein kinase, AMP-activated, gamma 1 non-catalytic subunit / P54619* / protein kinase AMP-activated non-catalytic subunit gamma 1*	/ complex
ENSMUSG00000028991	Mtor / Q9JLN9 / Serine/threonine-protein kinase mTOR / P42345* / mechanistic target of rapamycin kinase*	/ reaction
ENSMUSG00000047789	Q8BGD6 / Slc38a9 / Sodium-coupled neutral amino acid transporter 9 / Q8NBW4* / solute carrier family 38 member 9*	/ reaction

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