ENSMUSG00000028945


Mus musculus

Features
Gene ID: ENSMUSG00000028945
  
Biological name :Rheb
  
Synonyms : Q921J2 / Ras homolog enriched in brain / Rheb
  
Possible biological names infered from orthology : Q15382 / Ras homolog, mTORC1 binding
  
Species: Mus musculus
  
Chr. number: 5
Strand: -1
Band: A3
Gene start: 24802823
Gene end: 24842624
  
Corresponding Affymetrix probe sets: 10528691 (MoGene1.0st)   1416636_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000030787
NCBI entrez gene - 19744     See in Manteia.
MGI - MGI:97912
RefSeq - NM_053075
RefSeq Peptide - NP_444305
swissprot - Q540E6
swissprot - Q921J2
Ensembl - ENSMUSG00000028945
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rhebENSDARG00000090213Danio rerio
 RHEBENSGALG00000039880Gallus gallus
 RHEBENSG00000106615Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9D8T3 / Rhebl1 / GTPase RhebL1 / Q8TAI7* / RHEB like 1*ENSMUSG0000002375552


Protein motifs (from Interpro)
Interpro ID Name
 IPR001806  Small GTPase superfamily
 IPR005225  Small GTP-binding protein domain
 IPR020849  Small GTPase superfamily, Ras-type
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR037586  GTP-binding protein Rheb


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0032006 regulation of TOR signaling IMP
 biological_processGO:0032008 positive regulation of TOR signaling ISO
 biological_processGO:0048714 positive regulation of oligodendrocyte differentiation IMP
 biological_processGO:2000074 regulation of type B pancreatic cell development ISO
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0005681 spliceosomal complex IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0012505 endomembrane system IEA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000287 magnesium ion binding IEA
 molecular_functionGO:0003924 GTPase activity IEA
 molecular_functionGO:0005525 GTP binding ISO
 molecular_functionGO:0019003 GDP binding IEA
 molecular_functionGO:0019901 protein kinase binding IPI
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Macroautophagy
mTOR signalling
mTORC1-mediated signalling
Energy dependent regulation of mTOR by LKB1-AMPK
TP53 Regulates Metabolic Genes
Regulation of PTEN gene transcription


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000267 abnormal cardiac development "aberrant formation or incomplete differentiation of the heart" [MGI:cls, J:53370]
Show

Allelic Composition: Gpd2tm1Lbr/Gpd2tm1Lbr,Slc25a25tm1.1Kz/Slc25a25tm1.1Kz
Genetic Background: involves: 129X1/SvJ * C57BL/6J * FVB/N

 MP:0000280 thin ventricular wall "decreased depth of the cardiac wall of the heart ventricles" [J:45302]
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Allelic Composition: Gpd2tm1Lbr/Gpd2tm1Lbr,Slc25a25tm1.1Kz/Slc25a25tm1.1Kz
Genetic Background: involves: 129X1/SvJ * C57BL/6J * FVB/N

 MP:0000913 abnormal brain development "malformed or incomplete differentiation of the brain" [MGI:cls, J:49840]
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Allelic Composition: Rhebtm1.1Pfw/Rhebtm1.1Pfw,Rhebl1tm1.1Pfw/Rhebl1tm1.1Pfw
Genetic Background: involves: C57BL/6

 MP:0000921 demyelination "loss of the myelin sheath without loss of axons or fiber tracts" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rhebtm1.1Pfw/Rhebtm1.1Pfw,Rhebl1tm1.1Pfw/Rhebl1tm1.1Pfw
Genetic Background: involves: C57BL/6

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Gpd2tm1Lbr/Gpd2tm1Lbr,Slc25a25tm1.1Kz/Slc25a25tm1.1Kz
Genetic Background: involves: 129X1/SvJ * C57BL/6J * FVB/N

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Rhebtm1.1Pfw/Rhebtm1.1Pfw,Rhebl1tm1.1Pfw/Rhebl1tm1.1Pfw
Genetic Background: involves: C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rhebtm1.1Pfw/Rhebtm1.1Pfw,Rhebl1tm1.1Pfw/Rhebl1tm1.1Pfw
Genetic Background: involves: C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Fcer2atm1Max/Fcer2atm1Max,Ighg1tm1.1Pyu/Ighg1+
Genetic Background: involves: 129 * BALB/cJ * C57BL/6 * C57BL/6J

 MP:0002175 low brain weight "lower than average weight of the brain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rhebtm1.1Pfw/Rhebtm1.1Pfw,Rhebl1tm1.1Pfw/Rhebl1tm1.1Pfw
Genetic Background: involves: C57BL/6

 MP:0002834 decreased heart weight "less than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
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Allelic Composition: Fcer2atm1Max/Fcer2atm1Max,Ighg1tm1.1Pyu/Ighg1+
Genetic Background: involves: 129 * BALB/cJ * C57BL/6 * C57BL/6J

 MP:0003871 abnormal myelin sheath morphology "malformation of the insulating envelope that surrounds nerve fibers or axons" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Rhebtm1.1Pfw/Rhebtm1.1Pfw,Rhebl1tm1.1Pfw/Rhebl1tm1.1Pfw
Genetic Background: involves: C57BL/6

 MP:0003921 abnormal left ventricle morphology "structural anomaly of the left lower chamber of the heart " [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Fcer2atm1Max/Fcer2atm1Max,Ighg1tm1.1Pyu/Ighg1+
Genetic Background: involves: 129 * BALB/cJ * C57BL/6 * C57BL/6J

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gpd2tm1Lbr/Gpd2tm1Lbr,Slc25a25tm1.1Kz/Slc25a25tm1.1Kz
Genetic Background: involves: 129X1/SvJ * C57BL/6J * FVB/N

 MP:0004090 abnormal sarcomere morphology "any structural abnormality in the segment of a myofibril between two Z lines comprised of multi-protein complexes composed of three different filament systems; these systems work together to contract and relax muscle" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Fcer2atm1Max/Fcer2atm1Max,Ighg1tm1.1Pyu/Ighg1+
Genetic Background: involves: 129 * BALB/cJ * C57BL/6 * C57BL/6J

 MP:0004200 reduced fetal size "smaller proportions of a fetus compared to littermates (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rhebtm1.1Yelg/Rhebtm1.1Yelg
Genetic Background: B6.129P2-Rhebtm1.1Yelg

 MP:0004201 fetal growth retardation "slow or limited development during the fetal period (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rhebtm1.1Yelg/Rhebtm1.1Yelg
Genetic Background: B6.129P2-Rhebtm1.1Yelg

 MP:0004565 small myocardial fiber "decreased size of the cardiac muscle fibers, the multinucleated muscle cells of the heart" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Fcer2atm1Max/Fcer2atm1Max,Ighg1tm1.1Pyu/Ighg1+
Genetic Background: involves: 129 * BALB/cJ * C57BL/6 * C57BL/6J

 MP:0005140 decreased cardiac muscle contractility "inability or reduced ability of the heart muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Fcer2atm1Max/Fcer2atm1Max,Ighg1tm1.1Pyu/Ighg1+
Genetic Background: involves: 129 * BALB/cJ * C57BL/6 * C57BL/6J

 MP:0005244 hemopericardium "bleeding into the pericardial space" [Pathology:ISBN 0-397-51047-0]
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Allelic Composition: Gpd2tm1Lbr/Gpd2tm1Lbr,Slc25a25tm1.1Kz/Slc25a25tm1.1Kz
Genetic Background: involves: 129X1/SvJ * C57BL/6J * FVB/N

 MP:0005330 cardiomyopathy "diseases of the heart (myocardium); may result from many causes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:80681]
Show

Allelic Composition: Fcer2atm1Max/Fcer2atm1Max,Ighg1tm1.1Pyu/Ighg1+
Genetic Background: involves: 129 * BALB/cJ * C57BL/6 * C57BL/6J

 MP:0006254 thin cerebral cortex "decreased depth of the mantle covering the surface of the cerebral hemispheres" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:84683]
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Allelic Composition: Rhebtm1.1Pfw/Rhebtm1.1Pfw,Rhebl1tm1.1Pfw/Rhebl1tm1.1Pfw
Genetic Background: involves: C57BL/6

 MP:0009808 reduced oligodendrocyte number "significantly fewer than the expected number of cells of the central nervous system that form the insulating myelin sheath of axons in the CNS are present" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Rhebtm1.1Pfw/Rhebtm1.1Pfw,Rhebl1tm1.1Pfw/Rhebl1tm1.1Pfw
Genetic Background: involves: C57BL/6

 MP:0010725 thin interventricular septum "decreased thickness of the wall between the two lower chambers of the heart" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fcer2atm1Max/Fcer2atm1Max,Ighg1tm1.1Pyu/Ighg1+
Genetic Background: involves: 129 * BALB/cJ * C57BL/6 * C57BL/6J

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Fcer2atm1Max/Fcer2atm1Max,Ighg1tm1.1Pyu/Ighg1+
Genetic Background: involves: 129 * BALB/cJ * C57BL/6 * C57BL/6J

Allelic Composition: Atg5tm1Myok/Atg5tm1Myok,Rhebtm1.1Otsu/Rhebtm1.1Otsu,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Fcer2atm1Max/Fcer2atm1Max,Ighg1tm1.1Pyu/Ighg1+
Genetic Background: involves: 129 * BALB/cJ * C57BL/6 * C57BL/6J

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Il1r1tm1Imx/Il1r1tm1Imx
Genetic Background: B6.129-Il1r1tm1Imx Apoetm1Unc

Allelic Composition: Rhebtm1.1Pfw/Rhebtm1.1Pfw,Rhebl1tm1.1Pfw/Rhebl1tm1.1Pfw
Genetic Background: involves: C57BL/6

Allelic Composition: Rhebtm1.1Yelg/Rhebtm1.1Yelg
Genetic Background: B6.129P2-Rhebtm1.1Yelg

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Rhebtm1.1Yelg/Rhebtm1.1Yelg
Genetic Background: B6.129P2-Rhebtm1.1Yelg

 MP:0011704 decreased fibroblast proliferation "reduction in the expansion rate of a fibroblast cell population by cell division" [MGI:csmith]
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Allelic Composition: Rhebtm1.1Yelg/Rhebtm1.1Yelg
Genetic Background: B6.129P2-Rhebtm1.1Yelg

 MP:0013241 embryo tissue necrosis "morphological changes resulting from pathological death of some or all embryo tissue; usually due to irreversible damage" [MGI:csmith]
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Allelic Composition: Rhebtm1.1Yelg/Rhebtm1.1Yelg
Genetic Background: B6.129P2-Rhebtm1.1Yelg

 MP:0013504 increased embryonic tissue cell apoptosis "increase in the timing or the number of cells in embryonic tissue undergoing programmed cell death" [MGI:csmith]
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Allelic Composition: Rhebtm1.1Yelg/Rhebtm1.1Yelg
Genetic Background: B6.129P2-Rhebtm1.1Yelg

Allelic Composition: Rhebtm1.1Yelg/Rheb+,Tsc1tm1Chdl/Tsc1tm1Chdl
Genetic Background: B6.129P2-Tsc1tm1Chdl Rhebtm1.1Yelg

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000001729 Akt1 / P31750 / Mus musculus thymoma viral proto-onco 1 (Akt1), transcript variant 3, mRNA. / P31749* / AKT serine/threonine kinase 1*  / reaction
 ENSMUSG00000018326 Ywhab / Q9CQV8 / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide / P31946* / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta*  / complex / reaction
 ENSMUSG00000025907 Q9ESK9 / Rb1cc1 / RB1-inducible coiled-coil protein 1 / Q8TDY2* / RB1 inducible coiled-coil 1*  / reaction / complex
 ENSMUSG00000029513 Prkab1 / Q9R078 / protein kinase, AMP-activated, beta 1 non-catalytic subunit / Q9Y478* / protein kinase AMP-activated non-catalytic subunit beta 1*  / reaction
 ENSMUSG00000028646 Rragc / Q99K70 / Ras-related GTP-binding protein C / Q9HB90* / Ras related GTP binding C*  / reaction / complex
 ENSMUSG00000024142 Mlst8 / Q9DCJ1 / Target of rapamycin complex subunit LST8 / Q9BVC4* / MTOR associated protein, LST8 homolog*  / complex / reaction
 ENSMUSG00000070934 Rraga / Q80X95 / Ras-related GTP-binding protein A / Q7L523* / Ras related GTP binding A*  / reaction / complex
 ENSMUSG00000029512 Ulk1 / unc-51 like kinase 1 / O75385* / unc-51 like autophagy activating kinase 1*  / complex / reaction
 ENSMUSG00000037204 Atg101 / Q9D8Z6 / Autophagy-related protein 101 / Q9BSB4* / autophagy related 101*  / complex / reaction
 ENSMUSG00000041658 Rragb / Q6NTA4 / Ras-related GTP-binding protein B / Q5VZM2* / Ras related GTP binding B*  / reaction / complex
 ENSMUSG00000028991 Mtor / Q9JLN9 / Serine/threonine-protein kinase mTOR / P42345* / mechanistic target of rapamycin kinase*  / complex / reaction
 ENSMUSG00000047789 Q8BGD6 / Slc38a9 / Sodium-coupled neutral amino acid transporter 9 / Q8NBW4* / solute carrier family 38 member 9*  / reaction / complex
 ENSMUSG00000027244 Atg13 / Q91YI1 / Mus musculus autophagy related 13 (Atg13), transcript variant 4, mRNA. / O75143* / autophagy related 13*  / complex / reaction
 ENSMUSG00000028278 Rragd / Ras-related GTP binding D / Q9NQL2*  / reaction / complex
 ENSMUSG00000011096 Akt1s1 / Q9D1F4 / Proline-rich AKT1 substrate 1 / Q96B36* / AKT1 substrate 1*  / reaction / complex
 ENSMUSG00000022553 Maf1 / Q9D0U6 / Repressor of RNA polymerase III transcription MAF1 homolog / Q9H063* / MAF1 homolog, negative regulator of RNA polymerase III*  / reaction
 ENSMUSG00000028944 Prkag2 / Q91WG5 / protein kinase, AMP-activated, gamma 2 non-catalytic subunit / Q9UGJ0* / protein kinase AMP-activated non-catalytic subunit gamma 2*  / reaction
 ENSMUSG00000028518 Prkaa2 / Q8BRK8 / protein kinase, AMP-activated, alpha 2 catalytic subunit / P54646* / protein kinase AMP-activated catalytic subunit alpha 2*  / reaction
 ENSMUSG00000050697 Prkaa1 / Q5EG47 / protein kinase, AMP-activated, alpha 1 catalytic subunit / Q13131* / protein kinase AMP-activated catalytic subunit alpha 1*  / reaction
 ENSMUSG00000038205 Prkab2 / Q6PAM0 / protein kinase, AMP-activated, beta 2 non-catalytic subunit / O43741* / protein kinase AMP-activated non-catalytic subunit beta 2*  / reaction
 ENSMUSG00000006542 Prkag3 / Q8BGM7 / protein kinase, AMP-activated, gamma 3 non-catatlytic subunit / Q9UGI9* / protein kinase AMP-activated non-catalytic subunit gamma 3*  / reaction
 ENSMUSG00000067713 O54950 / Prkag1 / protein kinase, AMP-activated, gamma 1 non-catalytic subunit / P54619* / protein kinase AMP-activated non-catalytic subunit gamma 1*  / reaction






 

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