ENSMUSG00000028991


Mus musculus

Features
Gene ID: ENSMUSG00000028991
  
Biological name :Mtor
  
Synonyms : Mtor / Q9JLN9 / Serine/threonine-protein kinase mTOR
  
Possible biological names infered from orthology : mechanistic target of rapamycin kinase / P42345
  
Species: Mus musculus
  
Chr. number: 4
Strand: 1
Band: E2
Gene start: 148448611
Gene end: 148557683
  
Corresponding Affymetrix probe sets: 10510305 (MoGene1.0st)   1417592_at (Mouse Genome 430 2.0 Array)   1436267_a_at (Mouse Genome 430 2.0 Array)   1446185_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000054164
Ensembl peptide - ENSMUSP00000099510
NCBI entrez gene - 56717     See in Manteia.
MGI - MGI:1928394
RefSeq - XM_006539077
RefSeq - NM_020009
RefSeq Peptide - NP_064393
swissprot - Q9JLN9
Ensembl - ENSMUSG00000028991
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mtorENSDARG00000053196Danio rerio
 MTORENSGALG00000003339Gallus gallus
 MTORENSG00000198793Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Smg1 / Q8BKX6 / Serine/threonine-protein kinase SMG1 / Q96Q15* / SMG1, nonsense mediated mRNA decay associated PI3K related kinase*ENSMUSG0000003065517


Protein motifs (from Interpro)
Interpro ID Name
 IPR000403  Phosphatidylinositol 3-/4-kinase, catalytic domain
 IPR003151  PIK-related kinase, FAT
 IPR003152  FATC domain
 IPR009076  FKBP12-rapamycin binding domain
 IPR011009  Protein kinase-like domain superfamily
 IPR011989  Armadillo-like helical
 IPR014009  PIK-related kinase
 IPR016024  Armadillo-type fold
 IPR018936  Phosphatidylinositol 3/4-kinase, conserved site
 IPR024585  Domain of unknown function DUF3385, target of rapamycin protein
 IPR026683  Serine/threonine-protein kinase TOR
 IPR036738  FKBP12-rapamycin binding domain superfamily
 IPR036940  Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001558 regulation of cell growth ISO
 biological_processGO:0001932 regulation of protein phosphorylation IDA
 biological_processGO:0001933 negative regulation of protein phosphorylation IEA
 biological_processGO:0001934 positive regulation of protein phosphorylation ISO
 biological_processGO:0001938 positive regulation of endothelial cell proliferation IEA
 biological_processGO:0003007 heart morphogenesis IMP
 biological_processGO:0003179 heart valve morphogenesis IMP
 biological_processGO:0005979 regulation of glycogen biosynthetic process IEA
 biological_processGO:0006109 regulation of carbohydrate metabolic process IEA
 biological_processGO:0006112 energy reserve metabolic process IMP
 biological_processGO:0006207 "de novo" pyrimidine nucleobase biosynthetic process IDA
 biological_processGO:0006281 DNA repair IBA
 biological_processGO:0006468 protein phosphorylation ISO
 biological_processGO:0007281 germ cell development IDA
 biological_processGO:0007420 brain development IEA
 biological_processGO:0007569 cell aging IEA
 biological_processGO:0007584 response to nutrient ISO
 biological_processGO:0007616 long-term memory IEA
 biological_processGO:0008361 regulation of cell size ISO
 biological_processGO:0008542 visual learning IEA
 biological_processGO:0009267 cellular response to starvation ISO
 biological_processGO:0009791 post-embryonic development IMP
 biological_processGO:0010507 negative regulation of autophagy IMP
 biological_processGO:0010592 positive regulation of lamellipodium assembly IDA
 biological_processGO:0010628 positive regulation of gene expression ISO
 biological_processGO:0010718 positive regulation of epithelial to mesenchymal transition ISO
 biological_processGO:0010831 positive regulation of myotube differentiation IGI
 biological_processGO:0010942 positive regulation of cell death IEA
 biological_processGO:0010976 positive regulation of neuron projection development IEA
 biological_processGO:0014042 positive regulation of neuron maturation IEA
 biological_processGO:0014736 negative regulation of muscle atrophy IEA
 biological_processGO:0016242 negative regulation of macroautophagy ISO
 biological_processGO:0016310 phosphorylation ISO
 biological_processGO:0018105 peptidyl-serine phosphorylation ISO
 biological_processGO:0018107 peptidyl-threonine phosphorylation IDA
 biological_processGO:0021510 spinal cord development IEA
 biological_processGO:0030030 cell projection organization ISO
 biological_processGO:0030838 positive regulation of actin filament polymerization IMP
 biological_processGO:0031397 negative regulation of protein ubiquitination IEA
 biological_processGO:0031529 ruffle organization IDA
 biological_processGO:0031641 regulation of myelination IMP
 biological_processGO:0031669 cellular response to nutrient levels IDA
 biological_processGO:0031929 TOR signaling IGI
 biological_processGO:0031998 regulation of fatty acid beta-oxidation IEA
 biological_processGO:0032095 regulation of response to food IEA
 biological_processGO:0032868 response to insulin IDA
 biological_processGO:0032956 regulation of actin cytoskeleton organization ISO
 biological_processGO:0034198 cellular response to amino acid starvation ISO
 biological_processGO:0035176 social behavior IEA
 biological_processGO:0035264 multicellular organism growth IMP
 biological_processGO:0038202 TORC1 signaling ISO
 biological_processGO:0042060 wound healing IEA
 biological_processGO:0042220 response to cocaine IEA
 biological_processGO:0043087 regulation of GTPase activity IMP
 biological_processGO:0043200 response to amino acid ISO
 biological_processGO:0043278 response to morphine IEA
 biological_processGO:0043610 regulation of carbohydrate utilization IEA
 biological_processGO:0045429 positive regulation of nitric oxide biosynthetic process IEA
 biological_processGO:0045670 regulation of osteoclast differentiation IDA
 biological_processGO:0045727 positive regulation of translation ISO
 biological_processGO:0045792 negative regulation of cell size ISO
 biological_processGO:0045859 regulation of protein kinase activity IGI
 biological_processGO:0045945 positive regulation of transcription by RNA polymerase III ISO
 biological_processGO:0046777 protein autophosphorylation ISO
 biological_processGO:0046889 positive regulation of lipid biosynthetic process ISS
 biological_processGO:0048255 mRNA stabilization IEA
 biological_processGO:0048661 positive regulation of smooth muscle cell proliferation IEA
 biological_processGO:0048714 positive regulation of oligodendrocyte differentiation IMP
 biological_processGO:0048738 cardiac muscle tissue development IMP
 biological_processGO:0050731 positive regulation of peptidyl-tyrosine phosphorylation IMP
 biological_processGO:0050769 positive regulation of neurogenesis IEA
 biological_processGO:0050882 voluntary musculoskeletal movement IMP
 biological_processGO:0051496 positive regulation of stress fiber assembly IDA
 biological_processGO:0051549 positive regulation of keratinocyte migration ISO
 biological_processGO:0051896 regulation of protein kinase B signaling IMP
 biological_processGO:0051897 positive regulation of protein kinase B signaling IEA
 biological_processGO:0055006 cardiac cell development IMP
 biological_processGO:0055013 cardiac muscle cell development IMP
 biological_processGO:0060048 cardiac muscle contraction IMP
 biological_processGO:0060135 maternal process involved in female pregnancy IEA
 biological_processGO:0060252 positive regulation of glial cell proliferation IEA
 biological_processGO:0060999 positive regulation of dendritic spine development IEA
 biological_processGO:0061051 positive regulation of cell growth involved in cardiac muscle cell development IEA
 biological_processGO:0071230 cellular response to amino acid stimulus ISO
 biological_processGO:0071233 cellular response to leucine ISO
 biological_processGO:0071456 cellular response to hypoxia IDA
 biological_processGO:0090335 regulation of brown fat cell differentiation IEA
 biological_processGO:0090559 regulation of membrane permeability IMP
 biological_processGO:1901216 positive regulation of neuron death IEA
 biological_processGO:1901838 positive regulation of transcription of nucleolar large rRNA by RNA polymerase I ISO
 biological_processGO:1903691 positive regulation of wound healing, spreading of epidermal cells ISO
 biological_processGO:1904000 positive regulation of eating behavior IEA
 biological_processGO:1904056 positive regulation of cholangiocyte proliferation IEA
 biological_processGO:1904058 positive regulation of sensory perception of pain IEA
 biological_processGO:1904193 negative regulation of cholangiocyte apoptotic process IEA
 biological_processGO:1904197 positive regulation of granulosa cell proliferation IEA
 biological_processGO:1904206 positive regulation of skeletal muscle hypertrophy IEA
 biological_processGO:1904213 negative regulation of iodide transmembrane transport IEA
 biological_processGO:1990253 cellular response to leucine starvation ISO
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005741 mitochondrial outer membrane IEA
 cellular_componentGO:0005764 lysosome ISO
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0012505 endomembrane system ISO
 cellular_componentGO:0016020 membrane ISO
 cellular_componentGO:0016605 PML body IEA
 cellular_componentGO:0030425 dendrite IDA
 cellular_componentGO:0031931 TORC1 complex IDA
 cellular_componentGO:0031932 TORC2 complex ISO
 cellular_componentGO:0032991 protein-containing complex IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0001030 RNA polymerase III type 1 promoter DNA binding ISO
 molecular_functionGO:0001031 RNA polymerase III type 2 promoter DNA binding ISO
 molecular_functionGO:0001032 RNA polymerase III type 3 promoter DNA binding ISO
 molecular_functionGO:0001156 TFIIIC-class transcription factor binding ISO
 molecular_functionGO:0004672 protein kinase activity ISO
 molecular_functionGO:0004674 protein serine/threonine kinase activity ISO
 molecular_functionGO:0005488 binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity ISO
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0019904 protein domain specific binding IEA
 molecular_functionGO:0042802 identical protein binding ISO
 molecular_functionGO:0043022 ribosome binding IDA
 molecular_functionGO:0044877 protein-containing complex binding IEA
 molecular_functionGO:0051219 phosphoprotein binding ISO


Pathways (from Reactome)
Pathway description
PIP3 activates AKT signaling
Macroautophagy
mTOR signalling
mTORC1-mediated signalling
HSF1-dependent transactivation
Energy dependent regulation of mTOR by LKB1-AMPK
CD28 dependent PI3K/Akt signaling
VEGFR2 mediated vascular permeability
TP53 Regulates Metabolic Genes
Regulation of TP53 Degradation
Regulation of PTEN gene transcription


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000160 kyphosis "forward curvature of the spine, characterized by extensive flexion. " [J:62023, J:66943, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Mtortm1.2Koz/Mtortm1.2Koz,Tg(ACTA1-cre)79Jme/?
Genetic Background: involves: 129S4/SvJae * C57BL/6J * SJL

 MP:0000182 increased circulating LDL cholesterol level "greater than average concentration in the blood of low density lipoprotein, which normally transports cholesterol to tissues other than the liver" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Mta1tm1a(EUCOMM)Wtsi/Mta1tm1a(EUCOMM)Wtsi
Genetic Background: 129S/SvEvBrd-Mta1tm1a(EUCOMM)Wtsi/WtsiH

 MP:0000183 decreased circulating LDL cholesterol level "less than average concentration in the blood of low density lipoprotein, which normally transports cholesterol to tissues other than the liver" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Mta1tm1a(EUCOMM)Wtsi/Mta1tm1a(EUCOMM)Wtsi
Genetic Background: 129S/SvEvBrd-Mta1tm1a(EUCOMM)Wtsi/WtsiH

 MP:0000222 decreased neutrophil count "fewer than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mtortm1Lgm/Mtortm1Lgm
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0000223 decreased monocyte count "fewer than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mtortm1Lgm/Mtortm1Lgm
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
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Allelic Composition: Mtortm1.1Gcon/Mtortm1.1Gcon,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

 MP:0000278 abnormal myocardial fiber morphology "malformed or poorly developed cardiac muscle fibers, the multinucleated muscle cells of the heart" [J:18048]
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Allelic Composition: Mtortm1.1Gcon/Mtortm1.1Gcon,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

 MP:0000280 thin ventricular wall "decreased depth of the cardiac wall of the heart ventricles" [J:45302]
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Allelic Composition: Mtortm1.1Gcon/Mtortm1.1Gcon,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

 MP:0000358 abnormal cell content/ morphology "structural anomalies of the minute protoplasmic masses that make up organized tissues and which are the fundamental structural and functional units of living organisms" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Gli3tm1.1Zllr/Gli3tm1.2Zllr,Hoxa13tm1.1(cre)Makm/Hoxa13+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0000692 small spleen "decreased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mtortm1Lgm/Mtortm1Lgm
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0000715 decreased thymocyte number "fewer than expected number of precursors to T cells; these cells are lymphoid cells found in the thymus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Mtortm1Lgm/Mtortm1Lgm
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0000783 abnormal forebrain morphology "malformed or absent anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:38857]
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Allelic Composition: Mgat1tm2Jxm/Mgat1tm1Pst,Tg(Zp3-cre)1Gwh/0
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

 MP:0000784 forebrain hypoplasia "reduced cell number in the anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Mgat1tm2Jxm/Mgat1tm1Pst,Tg(Zp3-cre)1Gwh/0
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

 MP:0000830 abnormal diencephalon morphology "any malformation or absence of the paired caudal parts of the prosencephalon from which the thalamus, hypothalamus, epithalamus and subthalamus are derived; these regions regulate autonomic, visceral and endocrine function, and process information directed to the cerebral cortex" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Mgat1tm2Jxm/Mgat1tm1Pst,Tg(Zp3-cre)1Gwh/0
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

 MP:0000897 abnormal midbrain "malformation or malfunction associated with the middle of the three cerebral vesicles of the embryo; this region controls sensory and motor functions, including eye movement and coordination of auditory and visual reflexes" [J:23882, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Mgat1tm2Jxm/Mgat1tm1Pst,Tg(Zp3-cre)1Gwh/0
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

 MP:0000920 abnormal myelination "atypical or altered myelination in axon sheaths" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mtortm1Koz/Mtortm1Koz,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001106 abnormal Schwann cell "malformed or absent cells which form the insulating myelin sheaths of peripheral axons" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Mtortm1Koz/Mtortm1Koz,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001107 reduced Schwann cell number "fewer than normal cells that sheath the axons of the peripheral nervous system" [J:29971]
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Allelic Composition: Mtortm1Koz/Mtortm1Koz,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Mtortm1.2Koz/Mtortm1.2Koz,Tg(ACTA1-cre)79Jme/?
Genetic Background: involves: 129S4/SvJae * C57BL/6J * SJL

Allelic Composition: Mtortm1Lgm/Mtortm1Lgm
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Anktm1.1Ejr/Ank+
Genetic Background: B6.129-Anktm1.1Ejr

Allelic Composition: Mtorchino/Mtorchino
Genetic Background: involves: C57BL/6JAnu

 MP:0001516 abnormal motor coordination/ balance "altered ability of an animal to maintain skillful and effective interaction of movements or maintenance of equilibrium" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Slc11a2mk/Slc11a2mk
Genetic Background: SEC.Cg-Slc11a2mk

 MP:0001661 extended life span "persistence of life for a longer period than is the norm for an organism" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: MtorGt(OST92090)Lex/Mtor+,Ptentm1Rps/Pten+
Genetic Background: involves: 129S1/Sv * 129S5/SvEvBrd * C57BL/6

 MP:0001695 abnormal gastrulation "anomalous development and invagination of the embryonic germ layers" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Pdx1tm1Cvw/Pdx1+,Pbx1tm1Mlc/Pbx1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Mgat1tm2Jxm/Mgat1tm1Pst,Tg(Zp3-cre)1Gwh/0
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

Allelic Composition: Mtorflat/Mtorflat
Genetic Background: Not Specified

 MP:0001701 incomplete embryo turning "arrest of the axial rotation of the germ layers of the embryo during the primitive streak/early somite stage (E8.5-E9.5)" [J:62571]
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Allelic Composition: Mgat1tm2Jxm/Mgat1tm1Pst,Tg(Zp3-cre)1Gwh/0
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

Allelic Composition: Mtorflat/Mtorflat
Genetic Background: Not Specified

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
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Allelic Composition: Kif3atm1Noh/Kif3atm1Noh
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Mtorflat/Mtorflat
Genetic Background: Not Specified

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Mtortm1.2Koz/Mtortm1.2Koz,Tg(ACTA1-cre)79Jme/?
Genetic Background: involves: 129S4/SvJae * C57BL/6J * SJL

Allelic Composition: Mtortm1.1Seq/Mtortm1.2Seq,Tg(Nphs2-cre)1Seq/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0001800 abnormal humoral immune response "abnormal immune function mediated by antibodies" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Anktm1.1Ejr/Ank+
Genetic Background: B6.129-Anktm1.1Ejr

 MP:0001805 decreased IgG "less than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mtortm1Lgm/Mtortm1Lgm
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001806 decreased IgM "less than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mtortm1Lgm/Mtortm1Lgm
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001943 abnormal respiration "anomaly in the movement of gases into and out of the lung " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mtortm1.2Koz/Mtortm1.2Koz,Tg(ACTA1-cre)79Jme/?
Genetic Background: involves: 129S4/SvJae * C57BL/6J * SJL

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Atp7aMo-8J/Atp7a+
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

Allelic Composition: Mtortm1.1Gcon/Mtortm1.1Gcon,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

Allelic Composition: Eif4ebp1tm1Nso/Eif4ebp1tm1Nso,Mtortm1.1Gcon/Mtortm1.1Gcon,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N

 MP:0002084 abnormal developmental patterning "abnormal systematic arrangement of the developing body along an axis" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Kif3atm1Noh/Kif3atm1Noh
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0002085 abnormal embryonic tissue morphology "structural abnormality or development of any embryonic tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Kif3atm1Noh/Kif3atm1Noh
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Mtorflat/Mtorflat
Genetic Background: Not Specified

 MP:0002086 abnormal extraembryonic tissue morphology "structural abnormality or development of the membranes involved with embryonic protection and nutrition" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:40594, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Kif3atm1Noh/Kif3atm1Noh
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0002106 abnormal muscle physiology "anomolous function of the muscle, not due to an anatomical defect" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gprasp1tm1.1Jlw/Gprasp1tm1.1Jlw
Genetic Background: involves: C57BL/6

Allelic Composition: Mtortm1.2Koz/Mtortm1.2Koz,Tg(ACTA1-cre)79Jme/?
Genetic Background: involves: 129S4/SvJae * C57BL/6J * SJL

 MP:0002108 abnormal muscle morphology "abnormal development of muscle tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Atp7aMo-8J/Atp7a+
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

 MP:0002144 abnormal B lymphocyte development "atypical production of or inability to produce mature B cells, and/or accumulation of B cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mtortm1Lgm/Mtortm1Lgm
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0002145 abnormal T lymphocyte development "atypical production of or inability to produce mature T cells, and/or accumulation of T cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Acadsdel-J/Acadsdel-J,Otcspf/Otc+
Genetic Background: involves: BALB/cByJ * CD-1

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pou4f1tm1Rsd/Pou4f1tm1Rsd
Genetic Background: Not Specified

 MP:0002279 abnormal diaphragm morphology "structural defect in the thin musculomebraneous barrier that separates the abdominal and thoracic cavities; these muscles often used for breathing control" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mtortm1.2Koz/Mtortm1.2Koz,Tg(ACTA1-cre)79Jme/?
Genetic Background: involves: 129S4/SvJae * C57BL/6J * SJL

 MP:0002444 abnormal T cell physiology "anomalous response of T lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mtortm1Lgm/Mtortm1Lgm
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0002459 abnormal B cell physiology "abnormal function of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mtortm1Lgm/Mtortm1Lgm
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0002584 small ectoplacental cone 
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Allelic Composition: Kif3atm1Noh/Kif3atm1Noh
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0002703 abnormal renal tubules "anomalous structure or development of the loops of Henle and collecting ducts in the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mtortm1.1Seq/Mtortm1.2Seq,Tg(Nphs2-cre)1Seq/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0002795 dilated cardiomyopathy "decreased function of the heart associated with cardiac enlargement and congestive heart failure" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Mtortm1.1Gcon/Mtortm1.1Gcon,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

 MP:0002828 abnormal glomerular capsule "anomalous structure or development of the expanded beginning of a nephron that contains the glomerulus" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Mtortm1.1Seq/Mtortm1.2Seq,Tg(Nphs2-cre)1Seq/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0003081 abnormal soleus morphology "anomaly in the the superficial flat broad muscle of the calf that is responsible for plantar flexion of the foot" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, smb:Susan M. Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Mtortm1.2Koz/Mtortm1.2Koz,Tg(ACTA1-cre)79Jme/?
Genetic Background: involves: 129S4/SvJae * C57BL/6J * SJL

 MP:0003082 abnormal gastrocnemius morphology "anomaly in the the two-headed large muscle of the posterior portion of the lower hindleg, the most superficial of the calf muscles" [smb:Susan M. Bello, Mouse Genome Informatics Curator, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Mtortm1.2Koz/Mtortm1.2Koz,Tg(ACTA1-cre)79Jme/?
Genetic Background: involves: 129S4/SvJae * C57BL/6J * SJL

 MP:0003083 abnormal tibialis anterior morphology "anomaly in the the muscle of the shin that is responsible for dorsiflexion and inversion of the foot" [smb:Susan M. Bello, Mouse Genome Informatics Curator, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Mtortm1.2Koz/Mtortm1.2Koz,Tg(ACTA1-cre)79Jme/?
Genetic Background: involves: 129S4/SvJae * C57BL/6J * SJL

 MP:0003084 abnormal skeletal muscle fiber morphology "anomalous structure of the skeletal muscle fibers, the large multinucleated cells that make up the skeletal muscles" [smb:Susan M. Bello, Mouse Genome Informatics Curator, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Mtortm1.2Koz/Mtortm1.2Koz,Tg(ACTA1-cre)79Jme/?
Genetic Background: involves: 129S4/SvJae * C57BL/6J * SJL

 MP:0003222 increased cardiomyocyte apoptosis "increase in the number of cardiac muscle cells undergoing programmed cell death" [RGD:Rat Genome Database submission]
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Allelic Composition: Mtortm1.1Gcon/Mtortm1.1Gcon,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

 MP:0003223 decreased cardiomyocyte apoptosis "decrease in the number of cardiac muscle cells undergoing programmed cell death" [RGD:Rat Genome Database submission]
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Allelic Composition: Eif4ebp1tm1Nso/Eif4ebp1tm1Nso,Mtortm1.1Gcon/Mtortm1.1Gcon,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N

 MP:0003358 abnormal hypaxial muscle morphology "malformation of the muscles of the limbs" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Mtortm1.2Koz/Mtortm1.2Koz,Tg(ACTA1-cre)79Jme/?
Genetic Background: involves: 129S4/SvJae * C57BL/6J * SJL

 MP:0003646 muscle fatigue "increased muscle exhaustion or increased susceptibility to muscle exhaustion" [J:96306]
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Allelic Composition: Mtortm1.2Koz/Mtortm1.2Koz,Tg(ACTA1-cre)79Jme/?
Genetic Background: involves: 129S4/SvJae * C57BL/6J * SJL

 MP:0003871 abnormal myelin sheath morphology "malformation of the insulating envelope that surrounds nerve fibers or axons" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Mtortm1Koz/Mtortm1Koz,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0003944 abnormal T cell subpopulation ratio "deviation from the standard ratios of T cell subpopulations (e.g. double positive to single positive ratio) compared to control samples" [mberry:Melissa Berry, Genetics Resources Curator]
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Allelic Composition: Acadsdel-J/Acadsdel-J,Otcspf/Otc+
Genetic Background: involves: BALB/cByJ * CD-1

 MP:0003961 decreased lean body mass "less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
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Allelic Composition: Gprasp1tm1.1Jlw/Gprasp1tm1.1Jlw
Genetic Background: involves: C57BL/6

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mtortm1.1Koz/Mtortm1.1Koz
Genetic Background: either: (involves: 129S4/SvJae) or (involves: 129S4/SvJae * C57BL/6)

Allelic Composition: Mtorflat/Mtorflat
Genetic Background: involves: BTBR/J * C57BL/6J

Allelic Composition: Mtorflat/Mtorflat
Genetic Background: Not Specified

 MP:0004036 abnormal muscle relaxation "altered ability of the muscle to lengthen following contractions" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Mtortm1.2Koz/Mtortm1.2Koz,Tg(ACTA1-cre)79Jme/?
Genetic Background: involves: 129S4/SvJae * C57BL/6J * SJL

 MP:0004090 abnormal sarcomere morphology "any structural abnormality in the segment of a myofibril between two Z lines comprised of multi-protein complexes composed of three different filament systems; these systems work together to contract and relax muscle" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Mtortm1.1Gcon/Mtortm1.1Gcon,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

 MP:0004215 abnormal myocardial fiber physiology "anomaly in the function of the multinucleated muscle cells of the heart" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Mtortm1.1Gcon/Mtortm1.1Gcon,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

 MP:0004261 abnormal embryonic neuroepithelium morphology "any structural anomaly in the epithelial cell layer that lines the neural tube and develops into the nervous system and into the neural crest cells" [ISBN:0838580343 "Kandel ER, et al. Principles of Neural Science, 3rd edition", MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Mtorflat/Mtorflat
Genetic Background: involves: BTBR/J * C57BL/6J

 MP:0004263 abnormal limb posture "atypical position of the limbs compared to the normal carriage of the body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mtortm1.2Koz/Mtortm1.2Koz,Tg(ACTA1-cre)79Jme/?
Genetic Background: involves: 129S4/SvJae * C57BL/6J * SJL

 MP:0004485 increased response of heart to induced stress "increase in severity of the physiological response of the heart to induced stress such as cardiac hypertrophy due to mechanical pressure overload from aortic banding" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mtortm1.1Gcon/Mtortm1.1Gcon,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

 MP:0004565 small myocardial fiber "decreased size of the cardiac muscle fibers, the multinucleated muscle cells of the heart" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Mtortm1.1Gcon/Mtortm1.1Gcon,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

 MP:0004701 decreased circulating insulin-like growth factor I level "reduced blood concentration of this polypeptide hormone with growth-regulating, insulin-like, and mitogenic activities" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gprasp1tm1.1Jlw/Gprasp1tm1.1Jlw
Genetic Background: involves: C57BL/6

 MP:0004965 inner cell mass degeneration 
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Allelic Composition: Mtortm1.1Koz/Mtortm1.1Koz
Genetic Background: either: (involves: 129S4/SvJae) or (involves: 129S4/SvJae * C57BL/6)

 MP:0004973 increased regulatory T cell number "greater number of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Acadsdel-J/Acadsdel-J,Otcspf/Otc+
Genetic Background: involves: BALB/cByJ * CD-1

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mtortm1Lgm/Mtortm1Lgm
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0005031 abnormal trophoblast "malformation of the mesectodermal cell layer covering the blastocyst that erodes the uterine mucosa and contributes to the formation of the placenta" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Pdx1tm1Cvw/Pdx1+,Pbx1tm1Mlc/Pbx1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Mtortm1.1Koz/Mtortm1.1Koz
Genetic Background: either: (involves: 129S4/SvJae) or (involves: 129S4/SvJae * C57BL/6)

 MP:0005033 abnormal trophoblast cells "anomaly of the cells covering the blastocyst that erode the uterine mucosa and contribute to the formation of the placenta " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator, J:57761]
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Allelic Composition: RictorGt(RRR347)Byg/RictorGt(RRR347)Byg
Genetic Background: involves: 129P2/OlaHsd

 MP:0005092 decreased double-positive T cell count "less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Mtortm1Lgm/Mtortm1Lgm
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0005093 impaired B cell proliferation "absent or reduced ability of B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mtortm1Lgm/Mtortm1Lgm
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0005095 decreased T cell proliferation "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Acadsdel-J/Acadsdel-J,Otcspf/Otc+
Genetic Background: involves: BALB/cByJ * CD-1

 MP:0005140 decreased cardiac muscle contractility "inability or reduced ability of the heart muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Mtortm1.1Gcon/Mtortm1.1Gcon,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

 MP:0005288 abnormal oxygen consumption "deviation from the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Mtortm1.2Koz/Mtortm1.2Koz,Tg(ACTA1-cre)79Jme/?
Genetic Background: involves: 129S4/SvJae * C57BL/6J * SJL

 MP:0005290 decreased oxygen consumption "less than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Mtortm1.2Koz/Mtortm1.2Koz,Tg(ACTA1-cre)79Jme/?
Genetic Background: involves: 129S4/SvJae * C57BL/6J * SJL

 MP:0005324 ascites "accumulation or retention of fluid within the peritoneal cavity" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Mtortm1.1Gcon/Mtortm1.1Gcon,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

 MP:0005325 abnormal glomerulus "anomalous structure of the capillary loops of the kidney that normally function as a filtration unit" [J:57971, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mtortm1.1Seq/Mtortm1.2Seq,Tg(Nphs2-cre)1Seq/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0005326 abnormal podocytes "anomalous structure of the foot processes of the epithelial cells of the glomerulus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:57971]
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Allelic Composition: Mtortm1.1Seq/Mtortm1.2Seq,Tg(Nphs2-cre)1Seq/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0005404 abnormal axon morphology "anomaly in the structure of the single process of a nerve cell that normally conducts impulses away from the cell body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Mtortm1Koz/Mtortm1Koz,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mtortm1.2Koz/Mtortm1.2Koz,Tg(ACTA1-cre)79Jme/?
Genetic Background: involves: 129S4/SvJae * C57BL/6J * SJL

 MP:0005561 increased mean corpuscular hemoglobin "greater than the average levels of hemoglobin contained in an erythrocyte" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Mta1tm1a(EUCOMM)Wtsi/Mta1tm1a(EUCOMM)Wtsi
Genetic Background: 129S/SvEvBrd-Mta1tm1a(EUCOMM)Wtsi/WtsiH

 MP:0005566 decreased blood urea nitrogen level "low circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Mta1tm1a(EUCOMM)Wtsi/Mta1tm1a(EUCOMM)Wtsi
Genetic Background: 129S/SvEvBrd-Mta1tm1a(EUCOMM)Wtsi/WtsiH

 MP:0005598 decreased ventricle muscle contractility "reduced ability of the heart ventricle muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Mtortm1.1Gcon/Mtortm1.1Gcon,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

 MP:0005608 cardiac interstitial fibrosis "formation of fibrous tissue within the interstices of the heart as a result of repair or a reactive process" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Mtortm1.1Gcon/Mtortm1.1Gcon,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

Allelic Composition: Eif4ebp1tm1Nso/Eif4ebp1tm1Nso,Mtortm1.1Gcon/Mtortm1.1Gcon,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N

 MP:0005620 abnormal muscle contractility "aberrant ability of a muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Mtortm1.2Koz/Mtortm1.2Koz,Tg(ACTA1-cre)79Jme/?
Genetic Background: involves: 129S4/SvJae * C57BL/6J * SJL

 MP:0006036 abnormal mitochondrial physiology 
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Allelic Composition: Mtortm1.1Gcon/Mtortm1.1Gcon,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

Allelic Composition: Eif4ebp1tm1Nso/Eif4ebp1tm1Nso,Mtortm1.1Gcon/Mtortm1.1Gcon,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N

 MP:0006138 congestive heart failure "the heart is unable to adequately pump blood throughout the body" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Mtortm1.1Gcon/Mtortm1.1Gcon,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

 MP:0008037 abnormal T cell morphology "any structural anomaly of lymphocytes that are responsible for cell-mediated immunity and immune system regulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mtortm1Lgm/Mtortm1Lgm
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0008074 increased CD4-positive T cell number "greater number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mtortm1Lgm/Mtortm1Lgm
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mtorchino/Mtorchino
Genetic Background: involves: C57BL/6JAnu

 MP:0008078 increased CD8-positive T cell number "greater number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mtortm1Lgm/Mtortm1Lgm
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0008098 decreased plasma cell number "reduced number of terminally differentiated, post-mitotic, short-lived cells of the B cell lineage devoted to producing large amounts of immunoglobulin" [CL:0000786, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mtortm1Lgm/Mtortm1Lgm
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0008140 podocyte foot process effacement "thinning of the footlike extension of podocytes that interdigitate with one another to form the walls of the glomerular capillaries" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Mtortm1.1Seq/Mtortm1.2Seq,Tg(Nphs2-cre)1Seq/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0008174 decreased follicular B cell number "reduced number of resting mature B cells with distinct phenotypic characteristics (CD23-positive, CD21-positive) found typically in the B cell follicle region of the spleen and lymph nodes" [CL:0000843, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mtortm1Lgm/Mtortm1Lgm
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0008182 decreased marginal zone B cell number "reduced number of CD23-negative, CD21-positive B cells of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL" [CL:0000845, ISBN:0781735149]
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Allelic Composition: Mtortm1Lgm/Mtortm1Lgm
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0008260 abnormal autophagy "abnormal catabolic process involving the degradation of a cell s own components through the lysosomal machinery" [MGI:honda "Hiraoki Onda, Mouse Genome Informatics Curator"]
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Allelic Composition: Mtortm1.1Gcon/Mtortm1.1Gcon,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

Allelic Composition: Eif4ebp1tm1Nso/Eif4ebp1tm1Nso,Mtortm1.1Gcon/Mtortm1.1Gcon,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N

 MP:0008561 decreased tumor necrosis factor secretion "reduction in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
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Allelic Composition: Acadsdel-J/Acadsdel-J,Otcspf/Otc+
Genetic Background: involves: BALB/cByJ * CD-1

 MP:0008567 decreased interferon-gamma secretion "reduction in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Acadsdel-J/Acadsdel-J,Otcspf/Otc+
Genetic Background: involves: BALB/cByJ * CD-1

 MP:0008682 decreased interleukin-17 secretion "reduction in the production or release of a proinflammatory cytokine produced primarily by T-cells or their precursors" [MESH:D12.644.276.374.465.517]
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Allelic Composition: Acadsdel-J/Acadsdel-J,Otcspf/Otc+
Genetic Background: involves: BALB/cByJ * CD-1

 MP:0008688 decreased interleukin-2 secretion "reduction in the production or release of a soluble substance elaborated by antigen- or mitogen-stimulated T-cells which induces DNA synthesis in naive lymphocytes" [MESH:D12.644.276.374.465.502]
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Allelic Composition: Acadsdel-J/Acadsdel-J,Otcspf/Otc+
Genetic Background: involves: BALB/cByJ * CD-1

 MP:0008725 enlarged heart atrium "increased size of one or both of the two upper chambers of the heart, to which the blood returns from the circulation" [MESH:A07.541.358]
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Allelic Composition: Mtortm1.1Gcon/Mtortm1.1Gcon,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

 MP:0008762 embryonic lethality "death of an animal in the embryonic period (Mus: up to E14)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gprasp1tm1.1Jlw/Gprasp1tm1.1Jlw
Genetic Background: involves: C57BL/6

 MP:0008772 enlarged heart ventricle "increased average size of the heart ventricles compared to the average for a particular population" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Mtortm1.1Gcon/Mtortm1.1Gcon,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

 MP:0008814 reduced nerve conduction velocity "decrease in the rate at which an eletrical impulse travels through a nerve" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Mtortm1Koz/Mtortm1Koz,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0008827 abnormal thymus cell ratio "deviation from the standard ratios of thymocyte subpopulations compared to control samples" [MGI:mberry "Melissa Berry, Genetics Resources Curator"]
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Allelic Composition: Acadsdel-J/Acadsdel-J,Otcspf/Otc+
Genetic Background: involves: BALB/cByJ * CD-1

 MP:0009335 decreased splenocyte proliferation "reduction in the expansion rate of a splenocyte cell population by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mtortm1Lgm/Mtortm1Lgm
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0009339 decreased splenocyte number "reduction in the expected number of cells of the spleen" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mtorchino/Mtorchino
Genetic Background: involves: C57BL/6JAnu

 MP:0009341 decreased splenocyte apoptosis "reduction in the number of spleen cells undergoing programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mtortm1Lgm/Mtortm1Lgm
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0009404 centrally nucleated skeletal muscle fibers "cell nuclei are located at a position in the center of the skeletal myofiber, instead of their normal location at the periphery of the fiber; may be indicative of centronuclear myopathy" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mtortm1.2Koz/Mtortm1.2Koz,Tg(ACTA1-cre)79Jme/?
Genetic Background: involves: 129S4/SvJae * C57BL/6J * SJL

 MP:0009412 skeletal muscle fiber degeneration "pathological deterioration of skeletal muscle fiber tissue, often accompanied by loss of function" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mtortm1.2Koz/Mtortm1.2Koz,Tg(ACTA1-cre)79Jme/?
Genetic Background: involves: 129S4/SvJae * C57BL/6J * SJL

 MP:0009415 skeletal muscle degeneration "pathological deterioration of skeletal muscle tissue, often accompanied by loss of function" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mtortm1.2Koz/Mtortm1.2Koz,Tg(ACTA1-cre)79Jme/?
Genetic Background: involves: 129S4/SvJae * C57BL/6J * SJL

 MP:0009643 abnormal urine homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of various functions and chemical or protein composition of the urine" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mtortm1.1Seq/Mtortm1.2Seq,Tg(Nphs2-cre)1Seq/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0009923 decreased transitional stage T1 B cell number "reduced number of a type of transitional stage B cell that migrates from the bone marrow into the peripheral circulation, and finally to the spleen; this cell type has the phenotype surface IgM-positive, surface IgD-negative, CD21-negative, CD23-negative, and CD62L-negative" [PMID:12810111]
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Allelic Composition: Mtortm1Lgm/Mtortm1Lgm
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0010024 increased total body fat amount "greater than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gprasp1tm1.1Jlw/Gprasp1tm1.1Jlw
Genetic Background: involves: C57BL/6

 MP:0010239 decreased skeletal muscle weight "less than average skeletal muscle weight" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gprasp1tm1.1Jlw/Gprasp1tm1.1Jlw
Genetic Background: involves: C57BL/6

 MP:0010334 pleural effusion "accumulation of excess fluid in the pleural cavity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mtortm1.1Gcon/Mtortm1.1Gcon,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

 MP:0010401 increased skeletal muscle glycogen level "greater than the normal concentration of a readily converted carbohydrate reserve in skeletal muscle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mtortm1.2Koz/Mtortm1.2Koz,Tg(ACTA1-cre)79Jme/?
Genetic Background: involves: 129S4/SvJae * C57BL/6J * SJL

 MP:0010725 thin interventricular septum "decreased thickness of the wall between the two lower chambers of the heart" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mtortm1.1Gcon/Mtortm1.1Gcon,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

 MP:0010738 abnormal internode morphology "any structrual anomaly of the intervening axon segment that is located between the juxtaparanodes and is surrounded by a single compact myelin sheath" [PMID:18929652]
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Allelic Composition: Mtortm1Koz/Mtortm1Koz,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0010739 abnormal axolemma morphology "any structural anomaly of the plasma membrane of an axon" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Mtortm1Koz/Mtortm1Koz,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Gli3tm1.1Zllr/Gli3tm1.2Zllr,Hoxa13tm1.1(cre)Makm/Hoxa13+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
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Allelic Composition: Mtorflat/Mtorflat
Genetic Background: involves: BTBR/J * C57BL/6J

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
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Allelic Composition: Pdx1tm1Cvw/Pdx1+,Pbx1tm1Mlc/Pbx1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Mtortm1.1Koz/Mtortm1.1Koz
Genetic Background: either: (involves: 129S4/SvJae) or (involves: 129S4/SvJae * C57BL/6)

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Mtortm1Lgm/Mtortm1Lgm
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0011501 increased glomerular capsule space "increased volume of the luminal region between the glomerular capsule visceral and parietal layers, into which filtrate enters after passing through the filtration barrier from the glomerular capillaries" [MGI:csmith]
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Allelic Composition: Mtortm1.1Seq/Mtortm1.2Seq,Tg(Nphs2-cre)1Seq/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0011629 decreased mitochondria number "fewer than normal number of the cellular organelles responsible for energy production" [MGI:csmith]
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Allelic Composition: Mtortm1.2Koz/Mtortm1.2Koz,Tg(ACTA1-cre)79Jme/?
Genetic Background: involves: 129S4/SvJae * C57BL/6J * SJL

 MP:0011632 dilated mitochondria "the luminal space of the mitochondria is increased in volume or area, usually with an increase of contained fluid" [MGI:csmith]
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Allelic Composition: Mtortm1.1Gcon/Mtortm1.1Gcon,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

 MP:0012114 absent inner cell mass proliferation 
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Allelic Composition: Pdx1tm1Cvw/Pdx1+,Pbx1tm1Mlc/Pbx1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: MtorGt(OST92090)Lex/MtorGt(OST92090)Lex
Genetic Background: involves: 129S5/SvEvBrd

 MP:0013272 abnormal translation "any anomaly in the cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain; translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA; translation ends with the release of a polypeptide chain from the ribosome" [GO:0006412]
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Allelic Composition: Mtortm1.1Gcon/Mtortm1.1Gcon,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

 MP:0013906 absent embryonic telencephalon "absence of the paired diverticula of the embryonic telencephalon, from which the forebrain develops" [MGI:Anna]
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Allelic Composition: Mtorflat/Mtorflat
Genetic Background: involves: BTBR/J * C57BL/6J

Allelic Composition: Mtorflat/Mtorflat
Genetic Background: Not Specified

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000001729 Akt1 / P31750 / Mus musculus thymoma viral proto-onco 1 (Akt1), transcript variant 3, mRNA. / P31749* / AKT serine/threonine kinase 1*  / reaction
 ENSMUSG00000018326 Ywhab / Q9CQV8 / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide / P31946* / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta*  / reaction / complex
 ENSMUSG00000025907 Q9ESK9 / Rb1cc1 / RB1-inducible coiled-coil protein 1 / Q8TDY2* / RB1 inducible coiled-coil 1*  / reaction / complex
 ENSMUSG00000029513 Prkab1 / Q9R078 / protein kinase, AMP-activated, beta 1 non-catalytic subunit / Q9Y478* / protein kinase AMP-activated non-catalytic subunit beta 1*  / reaction
 ENSMUSG00000028945 Rheb / Q921J2 / Ras homolog enriched in brain / Q15382* / Ras homolog, mTORC1 binding*  / complex / reaction
 ENSMUSG00000028944 Prkag2 / Q91WG5 / protein kinase, AMP-activated, gamma 2 non-catalytic subunit / Q9UGJ0* / protein kinase AMP-activated non-catalytic subunit gamma 2*  / reaction
 ENSMUSG00000028518 Prkaa2 / Q8BRK8 / protein kinase, AMP-activated, alpha 2 catalytic subunit / P54646* / protein kinase AMP-activated catalytic subunit alpha 2*  / reaction
 ENSMUSG00000028278 Rragd / Ras-related GTP binding D / Q9NQL2*  / reaction / complex
 ENSMUSG00000029512 Ulk1 / unc-51 like kinase 1 / O75385* / unc-51 like autophagy activating kinase 1*  / complex / reaction
 ENSMUSG00000028646 Rragc / Q99K70 / Ras-related GTP-binding protein C / Q9HB90* / Ras related GTP binding C*  / complex / reaction
 ENSMUSG00000041658 Rragb / Q6NTA4 / Ras-related GTP-binding protein B / Q5VZM2* / Ras related GTP binding B*  / reaction / complex
 ENSMUSG00000027244 Atg13 / Q91YI1 / Mus musculus autophagy related 13 (Atg13), transcript variant 4, mRNA. / O75143* / autophagy related 13*  / complex / reaction
 ENSMUSG00000050697 Prkaa1 / Q5EG47 / protein kinase, AMP-activated, alpha 1 catalytic subunit / Q13131* / protein kinase AMP-activated catalytic subunit alpha 1*  / reaction
 ENSMUSG00000011096 Akt1s1 / Q9D1F4 / Proline-rich AKT1 substrate 1 / Q96B36* / AKT1 substrate 1*  / complex / reaction
 ENSMUSG00000038205 Prkab2 / Q6PAM0 / protein kinase, AMP-activated, beta 2 non-catalytic subunit / O43741* / protein kinase AMP-activated non-catalytic subunit beta 2*  / reaction
 ENSMUSG00000037204 Atg101 / Q9D8Z6 / Autophagy-related protein 101 / Q9BSB4* / autophagy related 101*  / reaction / complex
 ENSMUSG00000020516 Q8BSK8 / Rps6kb1 / ribosomal protein S6 kinase, polypeptide 1 / P23443* / ribosomal protein S6 kinase B1*  / reaction
 ENSMUSG00000019970 Sgk1 / Q9WVC6 / Serine/threonine-protein kinase Sgk1 / O00141* / serum/glucocorticoid regulated kinase 1*  / reaction
 ENSMUSG00000022553 Maf1 / Q9D0U6 / Repressor of RNA polymerase III transcription MAF1 homolog / Q9H063* / MAF1 homolog, negative regulator of RNA polymerase III*  / reaction
 ENSMUSG00000024142 Mlst8 / Q9DCJ1 / Target of rapamycin complex subunit LST8 / Q9BVC4* / MTOR associated protein, LST8 homolog*  / complex
 ENSMUSG00000028991 Mtor / Q9JLN9 / Serine/threonine-protein kinase mTOR / P42345* / mechanistic target of rapamycin kinase*  / complex
 ENSMUSG00000022556 Hsf1 / P38532 / heat shock factor 1 / Q00613* / heat shock transcription factor 1*  / reaction
 ENSMUSG00000047789 Q8BGD6 / Slc38a9 / Sodium-coupled neutral amino acid transporter 9 / Q8NBW4* / solute carrier family 38 member 9*  / reaction / complex
 ENSMUSG00000006542 Prkag3 / Q8BGM7 / protein kinase, AMP-activated, gamma 3 non-catatlytic subunit / Q9UGI9* / protein kinase AMP-activated non-catalytic subunit gamma 3*  / reaction
 ENSMUSG00000070934 Rraga / Q80X95 / Ras-related GTP-binding protein A / Q7L523* / Ras related GTP binding A*  / complex / reaction
 ENSMUSG00000067713 O54950 / Prkag1 / protein kinase, AMP-activated, gamma 1 non-catalytic subunit / P54619* / protein kinase AMP-activated non-catalytic subunit gamma 1*  / reaction






 

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