ENSMUSG00000028646


Mus musculus

Features
Gene ID: ENSMUSG00000028646
  
Biological name :Rragc
  
Synonyms : Q99K70 / Ras-related GTP-binding protein C / Rragc
  
Possible biological names infered from orthology : Q9HB90 / Ras related GTP binding C
  
Species: Mus musculus
  
Chr. number: 4
Strand: 1
Band: D2.2
Gene start: 123917446
Gene end: 123936997
  
Corresponding Affymetrix probe sets: 10507894 (MoGene1.0st)   10338085 (MoGene1.0st)   10339348 (MoGene1.0st)   10339707 (MoGene1.0st)   10339956 (MoGene1.0st)   10340306 (MoGene1.0st)   10340993 (MoGene1.0st)   10341939 (MoGene1.0st)   10342263 (MoGene1.0st)   10343887 (MoGene1.0st)   10343942 (MoGene1.0st)   10344505 (MoGene1.0st)   10344512 (MoGene1.0st)   10339004 (MoGene1.0st)   10341244 (MoGene1.0st)   10341362 (MoGene1.0st)   10341931 (MoGene1.0st)   10342334 (MoGene1.0st)   10343338 (MoGene1.0st)   1415749_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000030399
Ensembl peptide - ENSMUSP00000115232
NCBI entrez gene - 54170     See in Manteia.
MGI - MGI:1858751
RefSeq - NM_017475
RefSeq Peptide - NP_059503
swissprot - Q99K70
Ensembl - ENSMUSG00000028646
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rragcaENSDARG00000069829Danio rerio
 RRAGCENSGALG00000033079Gallus gallus
 RRAGCENSG00000116954Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Rragd / Ras-related GTP binding D / Q9NQL2*ENSMUSG0000002827875


Protein motifs (from Interpro)
Interpro ID Name
 IPR006762  Gtr1/RagA G protein
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0009267 cellular response to starvation IBA
 biological_processGO:0010506 regulation of autophagy IBA
 biological_processGO:0032006 regulation of TOR signaling ISO
 biological_processGO:0032008 positive regulation of TOR signaling IBA
 biological_processGO:0034198 cellular response to amino acid starvation ISO
 biological_processGO:0043200 response to amino acid ISO
 biological_processGO:0071230 cellular response to amino acid stimulus IBA
 biological_processGO:1903432 regulation of TORC1 signaling ISO
 cellular_componentGO:0005634 nucleus ISS
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005764 lysosome IBA
 cellular_componentGO:0034448 EGO complex IBA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle ISO
 cellular_componentGO:1990131 Gtr1-Gtr2 GTPase complex IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003924 GTPase activity IBA
 molecular_functionGO:0005525 GTP binding ISS
 molecular_functionGO:0019003 GDP binding ISO
 molecular_functionGO:0046982 protein heterodimerization activity ISS
 molecular_functionGO:0051020 GTPase binding ISO


Pathways (from Reactome)
Pathway description
Macroautophagy
mTOR signalling
mTORC1-mediated signalling
Energy dependent regulation of mTOR by LKB1-AMPK
TP53 Regulates Metabolic Genes
Regulation of PTEN gene transcription


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000001729 Akt1 / P31750 / Mus musculus thymoma viral proto-onco 1 (Akt1), transcript variant 3, mRNA. / P31749* / AKT serine/threonine kinase 1*  / reaction
 ENSMUSG00000018326 Ywhab / Q9CQV8 / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide / P31946* / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta*  / complex / reaction
 ENSMUSG00000025907 Q9ESK9 / Rb1cc1 / RB1-inducible coiled-coil protein 1 / Q8TDY2* / RB1 inducible coiled-coil 1*  / reaction / complex
 ENSMUSG00000029513 Prkab1 / Q9R078 / protein kinase, AMP-activated, beta 1 non-catalytic subunit / Q9Y478* / protein kinase AMP-activated non-catalytic subunit beta 1*  / reaction
 ENSMUSG00000028945 Rheb / Q921J2 / Ras homolog enriched in brain / Q15382* / Ras homolog, mTORC1 binding*  / reaction / complex
 ENSMUSG00000028944 Prkag2 / Q91WG5 / protein kinase, AMP-activated, gamma 2 non-catalytic subunit / Q9UGJ0* / protein kinase AMP-activated non-catalytic subunit gamma 2*  / reaction
 ENSMUSG00000028518 Prkaa2 / Q8BRK8 / protein kinase, AMP-activated, alpha 2 catalytic subunit / P54646* / protein kinase AMP-activated catalytic subunit alpha 2*  / reaction
 ENSMUSG00000029512 Ulk1 / unc-51 like kinase 1 / O75385* / unc-51 like autophagy activating kinase 1*  / reaction / complex
 ENSMUSG00000028991 Mtor / Q9JLN9 / Serine/threonine-protein kinase mTOR / P42345* / mechanistic target of rapamycin kinase*  / complex / reaction
 ENSMUSG00000070934 Rraga / Q80X95 / Ras-related GTP-binding protein A / Q7L523* / Ras related GTP binding A*  / reaction / complex
 ENSMUSG00000011096 Akt1s1 / Q9D1F4 / Proline-rich AKT1 substrate 1 / Q96B36* / AKT1 substrate 1*  / complex / reaction
 ENSMUSG00000037204 Atg101 / Q9D8Z6 / Autophagy-related protein 101 / Q9BSB4* / autophagy related 101*  / complex / reaction
 ENSMUSG00000047789 Q8BGD6 / Slc38a9 / Sodium-coupled neutral amino acid transporter 9 / Q8NBW4* / solute carrier family 38 member 9*  / complex / reaction
 ENSMUSG00000024142 Mlst8 / Q9DCJ1 / Target of rapamycin complex subunit LST8 / Q9BVC4* / MTOR associated protein, LST8 homolog*  / complex / reaction
 ENSMUSG00000027244 Atg13 / Q91YI1 / Mus musculus autophagy related 13 (Atg13), transcript variant 4, mRNA. / O75143* / autophagy related 13*  / complex / reaction
 ENSMUSG00000041658 Rragb / Q6NTA4 / Ras-related GTP-binding protein B / Q5VZM2* / Ras related GTP binding B*  / reaction / complex
 ENSMUSG00000022553 Maf1 / Q9D0U6 / Repressor of RNA polymerase III transcription MAF1 homolog / Q9H063* / MAF1 homolog, negative regulator of RNA polymerase III*  / reaction
 ENSMUSG00000050697 Prkaa1 / Q5EG47 / protein kinase, AMP-activated, alpha 1 catalytic subunit / Q13131* / protein kinase AMP-activated catalytic subunit alpha 1*  / reaction
 ENSMUSG00000038205 Prkab2 / Q6PAM0 / protein kinase, AMP-activated, beta 2 non-catalytic subunit / O43741* / protein kinase AMP-activated non-catalytic subunit beta 2*  / reaction
 ENSMUSG00000006542 Prkag3 / Q8BGM7 / protein kinase, AMP-activated, gamma 3 non-catatlytic subunit / Q9UGI9* / protein kinase AMP-activated non-catalytic subunit gamma 3*  / reaction
 ENSMUSG00000067713 O54950 / Prkag1 / protein kinase, AMP-activated, gamma 1 non-catalytic subunit / P54619* / protein kinase AMP-activated non-catalytic subunit gamma 1*  / reaction






 

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