MP:0000208 | decreased hematocrit | "less than the average percentage of a volume of a blood sample occupied by red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Rb1cc1tm1.1Guan/Rb1cc1tm1.1Guan,Tg(Tek-cre)12Flv/0 Genetic Background: B6.Cg-Rb1cc1tm1.1Guan Tg(Tek-cre)12Flv
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MP:0000219 | increased neutrophil count | "greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Rb1cc1tm1.1Guan/Rb1cc1tm1.1Guan,Tg(Tek-cre)12Flv/0 Genetic Background: B6.Cg-Rb1cc1tm1.1Guan Tg(Tek-cre)12Flv
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MP:0000245 | abnormal erythropoiesis | "atypical process of red blood cell formation" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator] |
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Allelic Composition: Rb1cc1tm1.1Guan/Rb1cc1tm1.1Guan,Tg(Tek-cre)12Flv/0 Genetic Background: B6.Cg-Rb1cc1tm1.1Guan Tg(Tek-cre)12Flv
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MP:0000266 | abnormal cardiac morphology | "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Erbb3tm1Squ/Erbb3tm1Squ,Tg(EIIa-cre)C5379Lmgd/0 Genetic Background: involves: 129S6/SvEvTac * FVB/N
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MP:0000280 | thin ventricular wall | "decreased depth of the cardiac wall of the heart ventricles" [J:45302] |
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Allelic Composition: Erbb3tm1Squ/Erbb3tm1Squ,Tg(EIIa-cre)C5379Lmgd/0 Genetic Background: involves: 129S6/SvEvTac * FVB/N
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MP:0000479 | abnormal intestinal cell | "anomalous structure or development of the cells comprising the intestine" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Dcbld2tm1Mhms/Dcbld2tm1.1Mhms,Tg(Cdh5-cre)7Mlia/0 Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * FVB/N
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MP:0000598 | abnormal liver morphology | "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170] |
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Allelic Composition: Erbb3tm1Squ/Erbb3tm1Squ,Tg(EIIa-cre)C5379Lmgd/0 Genetic Background: involves: 129S6/SvEvTac * FVB/N
Allelic Composition: Rb1cc1tm1.1Guan/Rb1cc1tm1.1Guan,Tg(Tek-cre)12Flv/0 Genetic Background: B6.Cg-Rb1cc1tm1.1Guan Tg(Tek-cre)12Flv
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MP:0000603 | pale liver | "liver lacking normal coloration, often refers to bloodless condition" [J:18048] |
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Allelic Composition: Rb1cc1tm1.1Guan/Rb1cc1tm1.1Guan,Tg(Tek-cre)12Flv/0 Genetic Background: B6.Cg-Rb1cc1tm1.1Guan Tg(Tek-cre)12Flv
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MP:0000606 | decreased hepatocyte number | "fewer than normal number of parenchymal liver cells" [J:23170] |
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Allelic Composition: Erbb3tm1Squ/Erbb3tm1Squ,Tg(EIIa-cre)C5379Lmgd/0 Genetic Background: involves: 129S6/SvEvTac * FVB/N
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MP:0000607 | abnormal hepatocyte morphology | "malformation of the main structural component of the liver; these are specialized epithelial cells normally organize into interconnected plates called lobules" [J:23170, MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Erbb3tm1Squ/Erbb3tm1Squ,Tg(EIIa-cre)C5379Lmgd/0 Genetic Background: involves: 129S6/SvEvTac * FVB/N
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MP:0000608 | dissociated hepatocytes | "disorganization of cohesive hepatocyte structure" [J:23170] |
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Allelic Composition: Erbb3tm1Squ/Erbb3tm1Squ,Tg(EIIa-cre)C5379Lmgd/0 Genetic Background: involves: 129S6/SvEvTac * FVB/N
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MP:0001577 | anemia | "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370] |
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Allelic Composition: Rb1cc1tm1.1Guan/Rb1cc1tm1.1Guan,Tg(Tek-cre)12Flv/0 Genetic Background: B6.Cg-Rb1cc1tm1.1Guan Tg(Tek-cre)12Flv
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MP:0001601 | abnormal myelopoiesis | "atypical process of bone marrow cell formation and/or bone marrow-derived blood cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc] |
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Allelic Composition: Rb1cc1tm1.1Guan/Rb1cc1tm1.1Guan,Tg(Tek-cre)12Flv/0 Genetic Background: B6.Cg-Rb1cc1tm1.1Guan Tg(Tek-cre)12Flv
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MP:0001785 | edema | "an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065] |
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Allelic Composition: Erbb3tm1Squ/Erbb3tm1Squ,Tg(EIIa-cre)C5379Lmgd/0 Genetic Background: involves: 129S6/SvEvTac * FVB/N
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MP:0002169 | no phenotype detected | "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Erbb3tm1Squ/Erbb3tm1Squ,Tg(EIIa-cre)C5379Lmgd/0 Genetic Background: involves: 129S6/SvEvTac * FVB/N
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MP:0002189 | abnormal myocardial trabeculae morphology | "malformation of the supporting bundles of muscular fibers lining the walls of the heart" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Erbb3tm1Squ/Erbb3tm1Squ,Tg(EIIa-cre)C5379Lmgd/0 Genetic Background: involves: 129S6/SvEvTac * FVB/N
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MP:0002652 | thin myocardial wall | "thinly developed cardiac muscle layers" [il:Ira Lu , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Erbb3tm1Squ/Erbb3tm1Squ,Tg(EIIa-cre)C5379Lmgd/0 Genetic Background: involves: 129S6/SvEvTac * FVB/N
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MP:0002753 | dilated left ventricle | "an expansion in the volume of the lower left chamber of the heart" [J:82859, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
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Allelic Composition: Erbb3tm1Squ/Erbb3tm1Squ,Tg(EIIa-cre)C5379Lmgd/0 Genetic Background: involves: 129S6/SvEvTac * FVB/N
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MP:0002874 | decreased hemoglobin content | "decrease in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Rb1cc1tm1.1Guan/Rb1cc1tm1.1Guan,Tg(Tek-cre)12Flv/0 Genetic Background: B6.Cg-Rb1cc1tm1.1Guan Tg(Tek-cre)12Flv
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MP:0002875 | decreased erythrocyte count | "reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Rb1cc1tm1.1Guan/Rb1cc1tm1.1Guan,Tg(Tek-cre)12Flv/0 Genetic Background: B6.Cg-Rb1cc1tm1.1Guan Tg(Tek-cre)12Flv
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MP:0003103 | liver degeneration | "deterioration of the liver due to injury or disease, often accompanied by loss of function" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91653] |
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Allelic Composition: Erbb3tm1Squ/Erbb3tm1Squ,Tg(EIIa-cre)C5379Lmgd/0 Genetic Background: involves: 129S6/SvEvTac * FVB/N
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MP:0003717 | pallor | "an unnatural paleness to the skin, generally attributable to anemia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Erbb3tm1Squ/Erbb3tm1Squ,Tg(EIIa-cre)C5379Lmgd/0 Genetic Background: involves: 129S6/SvEvTac * FVB/N
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MP:0003887 | increased hepatocyte apoptosis | "increase in the number of hepatocytes undergoing programmed cell death" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator] |
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Allelic Composition: Erbb3tm1Squ/Erbb3tm1Squ,Tg(EIIa-cre)C5379Lmgd/0 Genetic Background: involves: 129S6/SvEvTac * FVB/N
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MP:0003888 | liver hemorrhage | "bleeding within the liver" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator] |
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Allelic Composition: Erbb3tm1Squ/Erbb3tm1Squ,Tg(EIIa-cre)C5379Lmgd/0 Genetic Background: involves: 129S6/SvEvTac * FVB/N
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MP:0003904 | decreased cell mass | "reduction in the total physical bulk or volume of a cell compared to the normal state" [RGD:Rat Genome Database submission] |
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Allelic Composition: Erbb3tm1Squ/Erbb3tm1Squ,Tg(EIIa-cre)C5379Lmgd/0 Genetic Background: involves: 129S6/SvEvTac * FVB/N
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MP:0004056 | abnormal myocardial compact layer morphology | "malformation of the outer, dense layer of the myocardium " [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator] |
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Allelic Composition: Erbb3tm1Squ/Erbb3tm1Squ,Tg(EIIa-cre)C5379Lmgd/0 Genetic Background: involves: 129S6/SvEvTac * FVB/N
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MP:0004067 | abnormal ventricular trabeculae morphology | "aberrant structure of the supporting bundles of muscular fibers lining the walls of the ventricles of the heart" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator] |
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Allelic Composition: Erbb3tm1Squ/Erbb3tm1Squ,Tg(EIIa-cre)C5379Lmgd/0 Genetic Background: involves: 129S6/SvEvTac * FVB/N
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MP:0004808 | abnormal hematopoietic stem cell morphology | "any structural anomaly of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Rb1cc1tm1.1Guan/Rb1cc1tm1.1Guan,Tg(Tek-cre)12Flv/0 Genetic Background: B6.Cg-Rb1cc1tm1.1Guan Tg(Tek-cre)12Flv
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MP:0004810 | decreased hematopoietic stem cell number | "reduced cell count of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Rb1cc1tm1.1Guan/Rb1cc1tm1.1Guan,Tg(Tek-cre)12Flv/0 Genetic Background: B6.Cg-Rb1cc1tm1.1Guan Tg(Tek-cre)12Flv
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MP:0005294 | abnormal heart ventricle morphology | "structural anomaly of one or both of the two lower chambers of the heart " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Erbb3tm1Squ/Erbb3tm1Squ,Tg(EIIa-cre)C5379Lmgd/0 Genetic Background: involves: 129S6/SvEvTac * FVB/N
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MP:0005329 | abnormal cardiac muscle morphology | "anomalous structure of the involuntary muscle comprising the myocardium " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
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Allelic Composition: Erbb3tm1Squ/Erbb3tm1Squ,Tg(EIIa-cre)C5379Lmgd/0 Genetic Background: involves: 129S6/SvEvTac * FVB/N
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MP:0006035 | abnormal mitochondrial morphology | "anomalous structure of the mitochondria" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Rb1cc1tm1.1Guan/Rb1cc1tm1.1Guan,Tg(Tek-cre)12Flv/0 Genetic Background: B6.Cg-Rb1cc1tm1.1Guan Tg(Tek-cre)12Flv
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MP:0006138 | congestive heart failure | "the heart is unable to adequately pump blood throughout the body" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Erbb3tm1Squ/Erbb3tm1Squ,Tg(EIIa-cre)C5379Lmgd/0 Genetic Background: involves: 129S6/SvEvTac * FVB/N
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MP:0008260 | abnormal autophagy | "abnormal catabolic process involving the degradation of a cell s own components through the lysosomal machinery" [MGI:honda "Hiraoki Onda, Mouse Genome Informatics Curator"] |
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Allelic Composition: Rb1cc1tm1.1Guan/Rb1cc1tm1.1Guan,Tg(Tek-cre)12Flv/0 Genetic Background: B6.Cg-Rb1cc1tm1.1Guan Tg(Tek-cre)12Flv
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MP:0010067 | increased red blood cell distribution width | "higher than normal coefficient of variance (reference range) of the red blood cell volume for an organism" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", NCI:C64800 "NCI Thesaurus (Code C64800)"] |
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Allelic Composition: Rb1cc1tm1.1Guan/Rb1cc1tm1.1Guan,Tg(Tek-cre)12Flv/0 Genetic Background: B6.Cg-Rb1cc1tm1.1Guan Tg(Tek-cre)12Flv
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MP:0011085 | complete postnatal lethality | "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith] |
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Allelic Composition: Rb1cc1tm1.1Guan/Rb1cc1tm1.1Guan,Tg(Tek-cre)12Flv/0 Genetic Background: B6.Cg-Rb1cc1tm1.1Guan Tg(Tek-cre)12Flv
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MP:0011099 | complete lethality throughout fetal growth and development | "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith] |
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Allelic Composition: Erbb3tm1Squ/Erbb3tm1Squ,Tg(EIIa-cre)C5379Lmgd/0 Genetic Background: involves: 129S6/SvEvTac * FVB/N
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MP:0011109 | partial lethality throughout fetal growth and development | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith] |
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Allelic Composition: Rb1cc1tm1.1Guan/Rb1cc1tm1.1Guan,Tg(Tek-cre)12Flv/0 Genetic Background: B6.Cg-Rb1cc1tm1.1Guan Tg(Tek-cre)12Flv
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MP:0011178 | increased erythroblast number | "greater number of the nucleated precursor of erythrocytes" [MGI:csmith] |
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Allelic Composition: Rb1cc1tm1.1Guan/Rb1cc1tm1.1Guan,Tg(Tek-cre)12Flv/0 Genetic Background: B6.Cg-Rb1cc1tm1.1Guan Tg(Tek-cre)12Flv
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MP:0011902 | increased hematopoietic stem cell proliferation | "increase in the expansion rate of a hematopoietic stem cell population by cell division" [MGI:csmith] |
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Allelic Composition: Rb1cc1tm1.1Guan/Rb1cc1tm1.1Guan,Tg(Tek-cre)12Flv/0 Genetic Background: B6.Cg-Rb1cc1tm1.1Guan Tg(Tek-cre)12Flv
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MP:0013501 | increased fibroblast apoptosis | "increase in the timing or the number of fibroblast cells undergoing programmed cell death" [MGI:csmith] |
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Allelic Composition: Erbb3tm1Squ/Erbb3tm1Squ,Tg(EIIa-cre)C5379Lmgd/0 Genetic Background: involves: 129S6/SvEvTac * FVB/N
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