ENSMUSG00000024142


Mus musculus

Features
Gene ID: ENSMUSG00000024142
  
Biological name :Mlst8
  
Synonyms : Mlst8 / Q9DCJ1 / Target of rapamycin complex subunit LST8
  
Possible biological names infered from orthology : MTOR associated protein, LST8 homolog / Q9BVC4
  
Species: Mus musculus
  
Chr. number: 17
Strand: -1
Band: A3.3
Gene start: 24473550
Gene end: 24479078
  
Corresponding Affymetrix probe sets: 10448582 (MoGene1.0st)   1415842_at (Mouse Genome 430 2.0 Array)   1415843_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000136287
Ensembl peptide - ENSMUSP00000065004
NCBI entrez gene - 56716     See in Manteia.
MGI - MGI:1929514
RefSeq - NM_019988
RefSeq - XM_017317587
RefSeq - NM_001252463
RefSeq - NM_001252464
RefSeq - NM_001252465
RefSeq - XM_006524678
RefSeq - XM_006524679
RefSeq - XM_017317586
RefSeq Peptide - NP_001239392
RefSeq Peptide - NP_001239393
RefSeq Peptide - NP_001239394
RefSeq Peptide - NP_064372
swissprot - Q9DCJ1
Ensembl - ENSMUSG00000024142
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mlst8ENSDARG00000003167Danio rerio
 MLST8ENSGALG00000005878Gallus gallus
 MLST8ENSG00000167965Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001680  WD40 repeat
 IPR011047  Quinoprotein alcohol dehydrogenase-like superfamily
 IPR017986  WD40-repeat-containing domain
 IPR019775  WD40 repeat, conserved site
 IPR020472  G-protein beta WD-40 repeat
 IPR037588  Target of rapamycin complex subunit LST8


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0030838 positive regulation of actin filament polymerization IMP
 biological_processGO:0031929 TOR signaling IBA
 biological_processGO:0032008 positive regulation of TOR signaling ISO
 biological_processGO:0032956 regulation of actin cytoskeleton organization IEA
 biological_processGO:0038202 TORC1 signaling IEA
 biological_processGO:0043087 regulation of GTPase activity IMP
 biological_processGO:0050731 positive regulation of peptidyl-tyrosine phosphorylation IMP
 biological_processGO:0071902 positive regulation of protein serine/threonine kinase activity IEA
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0031931 TORC1 complex IDA
 cellular_componentGO:0031932 TORC2 complex ISO
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0043539 protein serine/threonine kinase activator activity IEA


Pathways (from Reactome)
Pathway description
PIP3 activates AKT signaling
Macroautophagy
mTOR signalling
mTORC1-mediated signalling
HSF1-dependent transactivation
Energy dependent regulation of mTOR by LKB1-AMPK
CD28 dependent PI3K/Akt signaling
VEGFR2 mediated vascular permeability
TP53 Regulates Metabolic Genes
Regulation of TP53 Degradation
Regulation of PTEN gene transcription


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000267 abnormal cardiac development "aberrant formation or incomplete differentiation of the heart" [MGI:cls, J:53370]
Show

Allelic Composition: MtorGt(OST92090)Lex/MtorGt(OST92090)Lex
Genetic Background: involves: 129S5/SvEvBrd

 MP:0000913 abnormal brain development "malformed or incomplete differentiation of the brain" [MGI:cls, J:49840]
Show

Allelic Composition: MtorGt(OST92090)Lex/MtorGt(OST92090)Lex
Genetic Background: involves: 129S5/SvEvBrd

 MP:0000934 abnormal telencephalon development "malformed or incomplete differentiation of the anterior division of the embryonic prosencephalon " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:49840]
Show

Allelic Composition: MtorGt(OST92090)Lex/MtorGt(OST92090)Lex
Genetic Background: involves: 129S5/SvEvBrd

 MP:0001634 internal hemorrhage "blood loss in the interior of the body due to vessel rupture or dysmorphology " [J:23170]
Show

Allelic Composition: MtorGt(OST92090)Lex/MtorGt(OST92090)Lex
Genetic Background: involves: 129S5/SvEvBrd

 MP:0001661 extended life span "persistence of life for a longer period than is the norm for an organism" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Mlst8tm1Lex/Mlst8+,Ptentm1Rps/Pten+
Genetic Background: involves: 129S1/Sv * 129S5/SvEvBrd * C57BL/6

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: MtorGt(OST92090)Lex/MtorGt(OST92090)Lex
Genetic Background: involves: 129S5/SvEvBrd

 MP:0001711 abnormal placenta 
Show

Allelic Composition: MtorGt(OST92090)Lex/MtorGt(OST92090)Lex
Genetic Background: involves: 129S5/SvEvBrd

 MP:0003229 abnormal vitelline vasculature "malformation in the vessels of the yolk sac" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93257]
Show

Allelic Composition: MtorGt(OST92090)Lex/MtorGt(OST92090)Lex
Genetic Background: involves: 129S5/SvEvBrd

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: MtorGt(OST92090)Lex/MtorGt(OST92090)Lex
Genetic Background: involves: 129S5/SvEvBrd

 MP:0004938 dilated vasculature "stretched or widened aperture of the luminal space of the network of tubes that carries blood through the body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: MtorGt(OST92090)Lex/MtorGt(OST92090)Lex
Genetic Background: involves: 129S5/SvEvBrd

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: MtorGt(OST92090)Lex/MtorGt(OST92090)Lex
Genetic Background: involves: 129S5/SvEvBrd

 MP:0011524 thick placenta labyrinth "increase in the width of the structure where embryonic blood vessels are surrounded by trophoblast cells and maternal blood" [MGI:csmith]
Show

Allelic Composition: MtorGt(OST92090)Lex/MtorGt(OST92090)Lex
Genetic Background: involves: 129S5/SvEvBrd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000001729 Akt1 / P31750 / Mus musculus thymoma viral proto-onco 1 (Akt1), transcript variant 3, mRNA. / P31749* / AKT serine/threonine kinase 1*  / reaction
 ENSMUSG00000018326 Ywhab / Q9CQV8 / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide / P31946* / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta*  / complex / reaction
 ENSMUSG00000025907 Q9ESK9 / Rb1cc1 / RB1-inducible coiled-coil protein 1 / Q8TDY2* / RB1 inducible coiled-coil 1*  / reaction / complex
 ENSMUSG00000029513 Prkab1 / Q9R078 / protein kinase, AMP-activated, beta 1 non-catalytic subunit / Q9Y478* / protein kinase AMP-activated non-catalytic subunit beta 1*  / reaction
 ENSMUSG00000028945 Rheb / Q921J2 / Ras homolog enriched in brain / Q15382* / Ras homolog, mTORC1 binding*  / complex / reaction
 ENSMUSG00000028944 Prkag2 / Q91WG5 / protein kinase, AMP-activated, gamma 2 non-catalytic subunit / Q9UGJ0* / protein kinase AMP-activated non-catalytic subunit gamma 2*  / reaction
 ENSMUSG00000028518 Prkaa2 / Q8BRK8 / protein kinase, AMP-activated, alpha 2 catalytic subunit / P54646* / protein kinase AMP-activated catalytic subunit alpha 2*  / reaction
 ENSMUSG00000028278 Rragd / Ras-related GTP binding D / Q9NQL2*  / reaction / complex
 ENSMUSG00000029512 Ulk1 / unc-51 like kinase 1 / O75385* / unc-51 like autophagy activating kinase 1*  / complex / reaction
 ENSMUSG00000028646 Rragc / Q99K70 / Ras-related GTP-binding protein C / Q9HB90* / Ras related GTP binding C*  / complex / reaction
 ENSMUSG00000041658 Rragb / Q6NTA4 / Ras-related GTP-binding protein B / Q5VZM2* / Ras related GTP binding B*  / reaction / complex
 ENSMUSG00000027244 Atg13 / Q91YI1 / Mus musculus autophagy related 13 (Atg13), transcript variant 4, mRNA. / O75143* / autophagy related 13*  / complex / reaction
 ENSMUSG00000050697 Prkaa1 / Q5EG47 / protein kinase, AMP-activated, alpha 1 catalytic subunit / Q13131* / protein kinase AMP-activated catalytic subunit alpha 1*  / reaction
 ENSMUSG00000011096 Akt1s1 / Q9D1F4 / Proline-rich AKT1 substrate 1 / Q96B36* / AKT1 substrate 1*  / complex / reaction
 ENSMUSG00000038205 Prkab2 / Q6PAM0 / protein kinase, AMP-activated, beta 2 non-catalytic subunit / O43741* / protein kinase AMP-activated non-catalytic subunit beta 2*  / reaction
 ENSMUSG00000037204 Atg101 / Q9D8Z6 / Autophagy-related protein 101 / Q9BSB4* / autophagy related 101*  / complex / reaction
 ENSMUSG00000028991 Mtor / Q9JLN9 / Serine/threonine-protein kinase mTOR / P42345* / mechanistic target of rapamycin kinase*  / complex
 ENSMUSG00000047789 Q8BGD6 / Slc38a9 / Sodium-coupled neutral amino acid transporter 9 / Q8NBW4* / solute carrier family 38 member 9*  / reaction / complex
 ENSMUSG00000024142 Mlst8 / Q9DCJ1 / Target of rapamycin complex subunit LST8 / Q9BVC4* / MTOR associated protein, LST8 homolog*  / complex
 ENSMUSG00000022553 Maf1 / Q9D0U6 / Repressor of RNA polymerase III transcription MAF1 homolog / Q9H063* / MAF1 homolog, negative regulator of RNA polymerase III*  / reaction
 ENSMUSG00000006542 Prkag3 / Q8BGM7 / protein kinase, AMP-activated, gamma 3 non-catatlytic subunit / Q9UGI9* / protein kinase AMP-activated non-catalytic subunit gamma 3*  / reaction
 ENSMUSG00000070934 Rraga / Q80X95 / Ras-related GTP-binding protein A / Q7L523* / Ras related GTP binding A*  / complex / reaction
 ENSMUSG00000067713 O54950 / Prkag1 / protein kinase, AMP-activated, gamma 1 non-catalytic subunit / P54619* / protein kinase AMP-activated non-catalytic subunit gamma 1*  / reaction






 

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