ENSMUSG00000028518


Mus musculus

Features
Gene ID: ENSMUSG00000028518
  
Biological name :Prkaa2
  
Synonyms : Prkaa2 / protein kinase, AMP-activated, alpha 2 catalytic subunit / Q8BRK8
  
Possible biological names infered from orthology : P54646 / protein kinase AMP-activated catalytic subunit alpha 2
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: C6
Gene start: 105029874
Gene end: 105109890
  
Corresponding Affymetrix probe sets: 10514779 (MoGene1.0st)   1429463_at (Mouse Genome 430 2.0 Array)   1429464_at (Mouse Genome 430 2.0 Array)   1434766_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000030243
NCBI entrez gene - 108079     See in Manteia.
MGI - MGI:1336173
RefSeq - XM_006502651
RefSeq - NM_001356568
RefSeq - NM_178143
RefSeq Peptide - NP_835279
RefSeq Peptide - NP_001343497
swissprot - Q8BRK8
Ensembl - ENSMUSG00000028518
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 prkaa2ENSDARG00000060641Danio rerio
 PRKAA2ENSGALG00000010826Gallus gallus
 P54646ENSG00000162409Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Prkaa1 / Q5EG47 / protein kinase, AMP-activated, alpha 1 catalytic subunit / Q13131* / protein kinase AMP-activated catalytic subunit alpha 1*ENSMUSG0000005069776
Nuak2 / Q8BZN4 / NUAK family SNF1-like kinase 2 / Q9H093* / NUAK family kinase 2*ENSMUSG0000000977230
Nuak1 / Q641K5 / NUAK family SNF1-like kinase 1 / O60285* / NUAK family kinase 1*ENSMUSG0000002003230
Stk40 / Q7TNL3 / Serine/threonine-protein kinase 40 / Q8N2I9* / serine/threonine kinase 40*ENSMUSG0000004260814
Trib2 / Q8K4K3 / Tribbles homolog 2 / Q92519* / tribbles pseudokinase 2*ENSMUSG0000002060114
Trib1 / Q8K4K4 / Tribbles homolog 1 / Q96RU8* / tribbles pseudokinase 1*ENSMUSG0000003250114
Trib3 / Q8K4K2 / Tribbles homolog 3 / Q96RU7* / tribbles pseudokinase 3*ENSMUSG0000003271513


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR028375  KA1 domain/Ssp2, C-terminal
 IPR032270  AMPK, C-terminal adenylate sensor domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006468 protein phosphorylation IDA
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006631 fatty acid metabolic process IEA
 biological_processGO:0006633 fatty acid biosynthetic process IEA
 biological_processGO:0006694 steroid biosynthetic process IEA
 biological_processGO:0006695 cholesterol biosynthetic process IEA
 biological_processGO:0006914 autophagy IEA
 biological_processGO:0006950 response to stress IMP
 biological_processGO:0008202 steroid metabolic process IEA
 biological_processGO:0008203 cholesterol metabolic process IEA
 biological_processGO:0008610 lipid biosynthetic process IDA
 biological_processGO:0010468 regulation of gene expression IMP
 biological_processGO:0010508 positive regulation of autophagy IMP
 biological_processGO:0014850 response to muscle activity IMP
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0016126 sterol biosynthetic process IEA
 biological_processGO:0016241 regulation of macroautophagy IDA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0031669 cellular response to nutrient levels IDA
 biological_processGO:0032007 negative regulation of TOR signaling IMP
 biological_processGO:0035404 histone-serine phosphorylation IEA
 biological_processGO:0035690 cellular response to drug IMP
 biological_processGO:0042149 cellular response to glucose starvation IDA
 biological_processGO:0042593 glucose homeostasis IMP
 biological_processGO:0042752 regulation of circadian rhythm IMP
 biological_processGO:0043066 negative regulation of apoptotic process IMP
 biological_processGO:0045821 positive regulation of glycolytic process ISS
 biological_processGO:0048511 rhythmic process IEA
 biological_processGO:0055089 fatty acid homeostasis ISS
 biological_processGO:0071380 cellular response to prostaglandin E stimulus IGI
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0016607 nuclear speck IEA
 cellular_componentGO:0031588 nucleotide-activated protein kinase complex IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003682 chromatin binding IDA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity EXP
 molecular_functionGO:0004679 AMP-activated protein kinase activity IEA
 molecular_functionGO:0004712 protein serine/threonine/tyrosine kinase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0035174 histone serine kinase activity IDA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0047322 [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity IEA
 molecular_functionGO:0050405 [acetyl-CoA carboxylase] kinase activity IEA


Pathways (from Reactome)
Pathway description
Macroautophagy
AMPK inhibits chREBP transcriptional activation activity
Import of palmitoyl-CoA into the mitochondrial matrix
Energy dependent regulation of mTOR by LKB1-AMPK
TP53 Regulates Metabolic Genes
Regulation of TP53 Activity through Phosphorylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ppargtm1b(KOMP)Wtsi/Ppargtm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Ppargtm1b(KOMP)Wtsi/H

 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
Show

Allelic Composition: Prkaa2tm1Vio/Prkaa2tm1Vio,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: 129S2/SvPas * FVB/N

Allelic Composition: Prkaa1tm1Sbj/Prkaa1+,Prkaa2tm1Vio/Prkaa2tm1Vio
Genetic Background: involves: 129S2/SvPas * FVB/N

Allelic Composition: Prkaa1tm1Sbj/Prkaa1tm1Sbj,Prkaa2tm1Vio/Prkaa2tm1Vio,Tg(Pomc1-cre)1Gsb/0
Genetic Background: involves: 129S2/SvPas * FVB/N

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Prkaa1tm1Sbj/Prkaa1tm1Sbj,Prkaa2tm1Vio/Prkaa2tm1Vio,Tg(Pomc1-cre)1Gsb/0
Genetic Background: involves: 129S2/SvPas * FVB/N

 MP:0001554 increased circulating free fatty acid level "higher than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]
Show

Allelic Composition: Srd5a1tm1Mahe/Srd5a1tm1Mahe,Srd5a2tm1Mahe/Srd5a2tm1Mahe
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6J

 MP:0001559 hyperglycemia "abnormally high concentration of glucose in the blood; generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Srd5a1tm1Mahe/Srd5a1tm1Mahe,Srd5a2tm1Mahe/Srd5a2tm1Mahe
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6J

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Srd5a1tm1Mahe/Srd5a1tm1Mahe,Srd5a2tm1Mahe/Srd5a2tm1Mahe
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Prkaa2tm1Vio/Prkaa2tm1Vio,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: 129S2/SvPas * FVB/N

 MP:0002079 increased circulating insulin level "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Prkaa2tm1Vio/Prkaa2tm1Vio,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: 129S2/SvPas * FVB/N

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
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Allelic Composition: Srd5a1tm1Mahe/Srd5a1tm1Mahe,Srd5a2tm1Mahe/Srd5a2tm1Mahe
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Prkaa2tm1.1Vio/Prkaa2tm1.1Vio
Genetic Background: involves: 129S2/SvPas

 MP:0003059 decreased insulin secretion "less than normal release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Srd5a1tm1Mahe/Srd5a1tm1Mahe,Srd5a2tm1Mahe/Srd5a2tm1Mahe
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6J

 MP:0003383 abnormal gluconeogenesis "anomaly in the formation of glucose from noncarbohydrates, such as proteins or fat" [J:93896]
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Allelic Composition: Prkaa2tm1Vio/Prkaa2tm1Vio,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: 129S2/SvPas * FVB/N

 MP:0004130 abnormal muscle cell glucose uptake "anomaly in the ability of muscle cells to take in glucose" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Prkaa2tm1.1Vio/Prkaa2tm1.1Vio
Genetic Background: involves: 129S2/SvPas

 MP:0004183 abnormal sympathetic nervous system physiology "anomaly in the function of the part of the autonomic nervous system that innervates smooth muscle, cardiac muscle and glands and mediates the body s response to stressful situations" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Srd5a1tm1Mahe/Srd5a1tm1Mahe,Srd5a2tm1Mahe/Srd5a2tm1Mahe
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6J

 MP:0004810 decreased hematopoietic stem cell number "reduced cell count of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Myf5tm3(cre)Sor/Myf5+,Stat5btm1Mam/Stat5btm1Mam
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac

 MP:0004811 abnormal neuron physiology "anomalous function of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:National Library of Medicine_Medical Subject Headings]
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Allelic Composition: Prkaa2tm1Vio/Prkaa2tm1Vio,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: 129S2/SvPas * FVB/N

Allelic Composition: Prkaa2tm1Vio/Prkaa2tm1Vio,Tg(Agrp-cre)1Gsb/0
Genetic Background: involves: 129S2/SvPas * FVB/N

 MP:0004892 increased adiponectin level "greater level of a protein hormone that regulates glucose homeostasis and metabolism of lipids; it is normally produced by adipose tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Prkaa2tm1Vio/Prkaa2tm1Vio,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: 129S2/SvPas * FVB/N

 MP:0005266 abnormal metabolism "anomalous chemical and physical changes occurring in tissue " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Prkaa2tm1Vio/Prkaa2tm1Vio,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: 129S2/SvPas * FVB/N

 MP:0005281 increased fatty acid level "higher than normal non-circulating level of organic, monobasic acids derived from hydrocarbons; they are saturated and unsaturated" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Prkaa2tm1Vio/Prkaa2tm1Vio,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: 129S2/SvPas * FVB/N

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Srd5a1tm1Mahe/Srd5a1tm1Mahe,Srd5a2tm1Mahe/Srd5a2tm1Mahe
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Prkaa2tm1.1Vio/Prkaa2tm1.1Vio
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Prkaa2tm1Vio/Prkaa2tm1Vio,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: 129S2/SvPas * FVB/N

 MP:0005317 increased triglyceride level "higher than normal concentration of triacylglycerols " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Prkaa2tm1Vio/Prkaa2tm1Vio,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: 129S2/SvPas * FVB/N

 MP:0005331 insulin resistance "diminished effectiveness of insulin in lowering plasma glucose levels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:84260, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Srd5a1tm1Mahe/Srd5a1tm1Mahe,Srd5a2tm1Mahe/Srd5a2tm1Mahe
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6J

 MP:0005438 abnormal glycogen homeostasis "abnormal processing and or utilization of this readily converted carbohydrate reserve, found in most tissues of the body, especially liver and muscle" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Srd5a1tm1Mahe/Srd5a1tm1Mahe,Srd5a2tm1Mahe/Srd5a2tm1Mahe
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6J

 MP:0005439 decreased glycogen level "less than the normal concentration of this readily converted carbohydrate reserve, found in most tissues of the body, especially liver and muscle" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Srd5a1tm1Mahe/Srd5a1tm1Mahe,Srd5a2tm1Mahe/Srd5a2tm1Mahe
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Prkaa2tm1.1Vio/Prkaa2tm1.1Vio
Genetic Background: involves: 129S2/SvPas

 MP:0005458 increased percent body fat "more fat, relative to the norm, as a percentage of total body weight" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Prkaa2tm1Vio/Prkaa2tm1Vio,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: 129S2/SvPas * FVB/N

 MP:0005559 increased circulating glucose level "greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
Show

Allelic Composition: Prkaa2tm1Vio/Prkaa2tm1Vio,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: 129S2/SvPas * FVB/N

 MP:0005658 susceptibility to diet-induced obesity "more likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]
Show

Allelic Composition: Prkaa2tm1Vio/Prkaa2tm1Vio,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: 129S2/SvPas * FVB/N

Allelic Composition: Prkaa1tm1Sbj/Prkaa1+,Prkaa2tm1Vio/Prkaa2tm1Vio
Genetic Background: involves: 129S2/SvPas * FVB/N

 MP:0005668 decreased circulating leptin level "less than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
Show

Allelic Composition: Srd5a1tm1Mahe/Srd5a1tm1Mahe,Srd5a2tm1Mahe/Srd5a2tm1Mahe
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6J

 MP:0005669 increased circulating leptin level "greater than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
Show

Allelic Composition: Prkaa2tm1Vio/Prkaa2tm1Vio,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: 129S2/SvPas * FVB/N

 MP:0006038 increased mitochondrial proliferation "greater than normal reproduction of mitochondria" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Myf5tm3(cre)Sor/Myf5+,Stat5btm1Mam/Stat5btm1Mam
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac

 MP:0009746 enhanced behavioral response to xenobiotic "increased sensitivity to a foreign compound capable of inducing the appearance of behavioral response, such as consumption preference, induced hyperactivity or stereotypic behavior, or reduced dosage threshold for the appearance of the behavioral response" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Prkaa2tm1Vio/Prkaa2tm1Vio,Tg(Agrp-cre)1Gsb/0
Genetic Background: involves: 129S2/SvPas * FVB/N

 MP:0011478 abnormal urine catecholamine level "any anomaly in the urinary amount of catecholamines, including adrenaline, noradrenaline and L-dopamine; catecholamines are act as hormones or neurotransmitters and are derived from the amino acid tyrosine" [MGI:csmith]
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Allelic Composition: Srd5a1tm1Mahe/Srd5a1tm1Mahe,Srd5a2tm1Mahe/Srd5a2tm1Mahe
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6J

 MP:0011958 increased compensatory feeding amount "increased amount of food consumed after a period of fasting" [MGI:csmith]
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Allelic Composition: Prkaa2tm1Vio/Prkaa2tm1Vio,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: 129S2/SvPas * FVB/N

 MP:0013278 decreased fasted circulating glucose level "reduction in the amount of glucose in the blood at some defined time point after eating compared to controls" [MGI:Armida_Di_Fenza]
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Allelic Composition: Ppargtm1b(KOMP)Wtsi/Ppargtm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Ppargtm1b(KOMP)Wtsi/H

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000003068 Stk11 / Q9WTK7 / Serine/threonine-protein kinase STK11 / Q15831* / serine/threonine kinase 11*  / reaction
 ENSMUSG00000021096 Ppm1a / P49443 / protein phosphatase 1A, magnesium dependent, alpha isoform / P35813* / protein phosphatase, Mg2+/Mn2+ dependent 1A*  / reaction
 ENSMUSG00000025907 Q9ESK9 / Rb1cc1 / RB1-inducible coiled-coil protein 1 / Q8TDY2* / RB1 inducible coiled-coil 1*  / reaction / complex
 ENSMUSG00000029513 Prkab1 / Q9R078 / protein kinase, AMP-activated, beta 1 non-catalytic subunit / Q9Y478* / protein kinase AMP-activated non-catalytic subunit beta 1*  / complex
 ENSMUSG00000028944 Prkag2 / Q91WG5 / protein kinase, AMP-activated, gamma 2 non-catalytic subunit / Q9UGJ0* / protein kinase AMP-activated non-catalytic subunit gamma 2*  / complex
 ENSMUSG00000006542 Prkag3 / Q8BGM7 / protein kinase, AMP-activated, gamma 3 non-catatlytic subunit / Q9UGI9* / protein kinase AMP-activated non-catalytic subunit gamma 3*  / complex
 ENSMUSG00000029174 Q60949 / Tbc1d1 / TBC1 domain family, member 1 / Q86TI0*  / reaction
 ENSMUSG00000028893 Sesn2 / P58043 / Sestrin-2 / P58004*  / complex / reaction
 ENSMUSG00000024142 Mlst8 / Q9DCJ1 / Target of rapamycin complex subunit LST8 / Q9BVC4* / MTOR associated protein, LST8 homolog*  / reaction
 ENSMUSG00000027244 Atg13 / Q91YI1 / Mus musculus autophagy related 13 (Atg13), transcript variant 4, mRNA. / O75143* / autophagy related 13*  / reaction / complex
 ENSMUSG00000032571 Pik3r4 / Q8VD65 / Phosphoinositide 3-kinase regulatory subunit 4 / Q99570*  / reaction
 ENSMUSG00000040506 A2AH22 / Ambra1 / Activating molecule in BECN1-regulated autophagy protein 1 / Q9C0C7* / autophagy and beclin 1 regulator 1*  / reaction
 ENSMUSG00000026812 Tsc1 / Q9EP53 / Hamartin / Q92574* / TSC complex subunit 1*  / reaction
 ENSMUSG00000038205 Prkab2 / Q6PAM0 / protein kinase, AMP-activated, beta 2 non-catalytic subunit / O43741* / protein kinase AMP-activated non-catalytic subunit beta 2*  / complex
 ENSMUSG00000064063 BC048507 / cDNA sequence BC048507 / DYNLL1* / P63167* / dynein light chain LC8-type 1*  / reaction
 ENSMUSG00000035086 Becn1 / O88597 / Beclin-1 Beclin-1-C 35 kDa Beclin-1-C 37 kDa / Q14457* / beclin 1*  / reaction
 ENSMUSG00000059552 Trp53 / P02340 / transformation related protein 53 / TP53* / P04637* / tumor protein p53*  / reaction
 ENSMUSG00000033628 Pik3c3 / Q6PF93 / Phosphatidylinositol 3-kinase catalytic subunit type 3 / Q8NEB9*  / reaction
 ENSMUSG00000067713 O54950 / Prkag1 / protein kinase, AMP-activated, gamma 1 non-catalytic subunit / P54619* / protein kinase AMP-activated non-catalytic subunit gamma 1*  / complex
 ENSMUSG00000028991 Mtor / Q9JLN9 / Serine/threonine-protein kinase mTOR / P42345* / mechanistic target of rapamycin kinase*  / reaction
 ENSMUSG00000047789 Q8BGD6 / Slc38a9 / Sodium-coupled neutral amino acid transporter 9 / Q8NBW4* / solute carrier family 38 member 9*  / reaction
 ENSMUSG00000041658 Rragb / Q6NTA4 / Ras-related GTP-binding protein B / Q5VZM2* / Ras related GTP binding B*  / reaction
 ENSMUSG00000037526 Atg14 / Q8CDJ3 / Beclin 1-associated autophagy-related key regulator / Q6ZNE5* / autophagy related 14*  / reaction
 ENSMUSG00000029167 O70343 / Ppargc1a / Peroxisome proliferator-activated receptor gamma coactivator 1-alpha / Q9UBK2* / PPARG coactivator 1 alpha*  / reaction
 ENSMUSG00000028278 Rragd / Ras-related GTP binding D / Q9NQL2*  / reaction
 ENSMUSG00000029512 Ulk1 / unc-51 like kinase 1 / O75385* / unc-51 like autophagy activating kinase 1*  / complex / reaction
 ENSMUSG00000038332 Sesn1 / P58006 / Sestrin-1 / Q9Y6P5*  / complex / reaction
 ENSMUSG00000070934 Rraga / Q80X95 / Ras-related GTP-binding protein A / Q7L523* / Ras related GTP binding A*  / reaction
 ENSMUSG00000020483 Dynll2 / Q9D0M5 / Dynein light chain 2, cytoplasmic / Q96FJ2* / dynein light chain LC8-type 2*  / reaction
 ENSMUSG00000037204 Atg101 / Q9D8Z6 / Autophagy-related protein 101 / Q9BSB4* / autophagy related 101*  / reaction / complex
 ENSMUSG00000028945 Rheb / Q921J2 / Ras homolog enriched in brain / Q15382* / Ras homolog, mTORC1 binding*  / reaction
 ENSMUSG00000002496 Tsc2 / tuberous sclerosis 2 / P49815* / TSC complex subunit 2*  / reaction
 ENSMUSG00000028646 Rragc / Q99K70 / Ras-related GTP-binding protein C / Q9HB90* / Ras related GTP binding C*  / reaction






 

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The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr