ENSMUSG00000032571


Mus musculus

Features
Gene ID: ENSMUSG00000032571
  
Biological name :Pik3r4
  
Synonyms : Phosphoinositide 3-kinase regulatory subunit 4 / Pik3r4 / Q8VD65
  
Possible biological names infered from orthology : Q99570
  
Species: Mus musculus
  
Chr. number: 9
Strand: 1
Band: F1
Gene start: 105642978
Gene end: 105687657
  
Corresponding Affymetrix probe sets: 10588429 (MoGene1.0st)   1460352_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000139427
Ensembl peptide - ENSMUSP00000140988
Ensembl peptide - ENSMUSP00000140311
Ensembl peptide - ENSMUSP00000139643
Ensembl peptide - ENSMUSP00000067400
NCBI entrez gene - 75669     See in Manteia.
MGI - MGI:1922919
RefSeq - NM_001081309
RefSeq Peptide - NP_001074778
swissprot - A0A087WQR4
swissprot - A0A087WP62
swissprot - A0A0R4J2C7
swissprot - Q8VD65
Ensembl - ENSMUSG00000032571
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pik3r4ENSDARG00000060469Danio rerio
 PIK3R4ENSGALG00000040917Gallus gallus
 PIK3R4ENSG00000196455Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR001680  WD40 repeat
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR011042  Six-bladed beta-propeller, TolB-like
 IPR011989  Armadillo-like helical
 IPR016024  Armadillo-type fold
 IPR017986  WD40-repeat-containing domain
 IPR019775  WD40 repeat, conserved site
 IPR021133  HEAT, type 2
 IPR036322  WD40-repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006623 protein targeting to vacuole IBA
 biological_processGO:0016236 macroautophagy IBA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0030242 autophagy of peroxisome IBA
 biological_processGO:0032465 regulation of cytokinesis ISO
 biological_processGO:0032801 receptor catabolic process ISO
 biological_processGO:0042149 cellular response to glucose starvation IDA
 biological_processGO:0043552 positive regulation of phosphatidylinositol 3-kinase activity ISO
 biological_processGO:0045324 late endosome to vacuole transport IBA
 cellular_componentGO:0005643 nuclear pore IBA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005770 late endosome IBA
 cellular_componentGO:0005776 autophagosome IEA
 cellular_componentGO:0005930 axoneme IDA
 cellular_componentGO:0015630 microtubule cytoskeleton ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0034271 phosphatidylinositol 3-kinase complex, class III, type I IBA
 cellular_componentGO:0034272 phosphatidylinositol 3-kinase complex, class III, type II IBA
 cellular_componentGO:0035032 phosphatidylinositol 3-kinase complex, class III IDA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle ISO
 cellular_componentGO:0071561 nucleus-vacuole junction IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IBA
 molecular_functionGO:0005488 binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
PI3K Cascade
Macroautophagy
Synthesis of PIPs at the Golgi membrane
Synthesis of PIPs at the early endosome membrane
Synthesis of PIPs at the late endosome membrane
Toll Like Receptor 9 (TLR9) Cascade
RHO GTPases Activate NADPH Oxidases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000747 muscle weakness "loss of muscle strength" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Pros1tm1Grl/Pros1tm1Grl,Tg(Tagln-cre)1Her/0
Genetic Background: involves: 129S1/SvImJ * C57BL/6 * SJL

 MP:0000751 myopathy "any abnormal condition or disease of the skeletal muscle" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:42574]
Show

Allelic Composition: Pros1tm1Grl/Pros1tm1Grl,Tg(Tagln-cre)1Her/0
Genetic Background: involves: 129S1/SvImJ * C57BL/6 * SJL

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pros1tm1Grl/Pros1tm1Grl,Tg(Tagln-cre)1Her/0
Genetic Background: involves: 129S1/SvImJ * C57BL/6 * SJL

 MP:0004121 abnormal sarcolemma morphology "structural anomaly in the plasma membrane of a muscle fiber that is cabable of conducting electrical impuses" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Pros1tm1Grl/Pros1tm1Grl,Tg(Tagln-cre)1Her/0
Genetic Background: involves: 129S1/SvImJ * C57BL/6 * SJL

 MP:0004510 myositis "inflammation of skeletal muscle; local accumulation of fluid, plasma proteins, and leukocytes in the striated muscle" [MESH:C05.651.594]
Show

Allelic Composition: Pros1tm1Grl/Pros1tm1Grl,Tg(Tagln-cre)1Her/0
Genetic Background: involves: 129S1/SvImJ * C57BL/6 * SJL

 MP:0008260 abnormal autophagy "abnormal catabolic process involving the degradation of a cell s own components through the lysosomal machinery" [MGI:honda "Hiraoki Onda, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pros1tm1Grl/Pros1tm1Grl,Tg(Tagln-cre)1Her/0
Genetic Background: involves: 129S1/SvImJ * C57BL/6 * SJL

Allelic Composition: Pik3r4tm1.1Mpnd/Pik3r4tm1.1Mpnd,Tg(ACTA1-cre)79Jme/0
Genetic Background: involves: 129S2/SvPas * C57BL/6J * C57BL/6N * SJL

 MP:0009404 centrally nucleated skeletal muscle fibers "cell nuclei are located at a position in the center of the skeletal myofiber, instead of their normal location at the periphery of the fiber; may be indicative of centronuclear myopathy" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pik3r4tm1.1Mpnd/Pik3r4tm1.1Mpnd,Tg(ACTA1-cre)79Jme/0
Genetic Background: involves: 129S2/SvPas * C57BL/6J * C57BL/6N * SJL

 MP:0009414 skeletal muscle fiber necrosis "pathological cell death in the skeletal muscle fibers, usually due to irreversible damage" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pik3r4tm1.1Mpnd/Pik3r4tm1.1Mpnd,Tg(ACTA1-cre)79Jme/0
Genetic Background: involves: 129S2/SvPas * C57BL/6J * C57BL/6N * SJL

 MP:0009415 skeletal muscle degeneration "pathological deterioration of skeletal muscle tissue, often accompanied by loss of function" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pik3r4tm1.1Mpnd/Pik3r4tm1.1Mpnd,Tg(ACTA1-cre)79Jme/0
Genetic Background: involves: 129S2/SvPas * C57BL/6J * C57BL/6N * SJL

 MP:0010090 increased circulating creatine kinase level "an elevation in the concentration in the blood of an enzyme that catalyzes the reversible transfer of creatine to phosphocreatine" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pik3r4tm1.1Mpnd/Pik3r4tm1.1Mpnd,Tg(ACTA1-cre)79Jme/0
Genetic Background: involves: 129S2/SvPas * C57BL/6J * C57BL/6N * SJL

 MP:0010401 increased skeletal muscle glycogen level "greater than the normal concentration of a readily converted carbohydrate reserve in skeletal muscle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pik3r4tm1.1Mpnd/Pik3r4tm1.1Mpnd,Tg(ACTA1-cre)79Jme/0
Genetic Background: involves: 129S2/SvPas * C57BL/6J * C57BL/6N * SJL

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
Show

Allelic Composition: Pik3r4tm1.1Mpnd/Pik3r4tm1.1Mpnd,Tg(ACTA1-cre)79Jme/0
Genetic Background: involves: 129S2/SvPas * C57BL/6J * C57BL/6N * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000025907 Q9ESK9 / Rb1cc1 / RB1-inducible coiled-coil protein 1 / Q8TDY2* / RB1 inducible coiled-coil 1*  / reaction
 ENSMUSG00000035354 Uvrag / Q8K245 / UV radiation resistance associated gene / Q9P2Y5* / UV radiation resistance associated*  / complex
 ENSMUSG00000029513 Prkab1 / Q9R078 / protein kinase, AMP-activated, beta 1 non-catalytic subunit / Q9Y478* / protein kinase AMP-activated non-catalytic subunit beta 1*  / reaction
 ENSMUSG00000028944 Prkag2 / Q91WG5 / protein kinase, AMP-activated, gamma 2 non-catalytic subunit / Q9UGJ0* / protein kinase AMP-activated non-catalytic subunit gamma 2*  / reaction
 ENSMUSG00000028518 Prkaa2 / Q8BRK8 / protein kinase, AMP-activated, alpha 2 catalytic subunit / P54646* / protein kinase AMP-activated catalytic subunit alpha 2*  / reaction
 ENSMUSG00000029512 Ulk1 / unc-51 like kinase 1 / O75385* / unc-51 like autophagy activating kinase 1*  / reaction
 ENSMUSG00000037526 Atg14 / Q8CDJ3 / Beclin 1-associated autophagy-related key regulator / Q6ZNE5* / autophagy related 14*  / complex
 ENSMUSG00000027244 Atg13 / Q91YI1 / Mus musculus autophagy related 13 (Atg13), transcript variant 4, mRNA. / O75143* / autophagy related 13*  / reaction
 ENSMUSG00000050697 Prkaa1 / Q5EG47 / protein kinase, AMP-activated, alpha 1 catalytic subunit / Q13131* / protein kinase AMP-activated catalytic subunit alpha 1*  / reaction
 ENSMUSG00000038205 Prkab2 / Q6PAM0 / protein kinase, AMP-activated, beta 2 non-catalytic subunit / O43741* / protein kinase AMP-activated non-catalytic subunit beta 2*  / reaction
 ENSMUSG00000037204 Atg101 / Q9D8Z6 / Autophagy-related protein 101 / Q9BSB4* / autophagy related 101*  / reaction
 ENSMUSG00000045322 Tlr9 / Q9EQU3 / Toll-like receptor 9 / Q9NR96* / AC097637.1*  / reaction / complex
 ENSMUSG00000020483 Dynll2 / Q9D0M5 / Dynein light chain 2, cytoplasmic / Q96FJ2* / dynein light chain LC8-type 2*  / reaction / complex
 ENSMUSG00000040506 A2AH22 / Ambra1 / Activating molecule in BECN1-regulated autophagy protein 1 / Q9C0C7* / autophagy and beclin 1 regulator 1*  / reaction / complex
 ENSMUSG00000033628 Pik3c3 / Q6PF93 / Phosphatidylinositol 3-kinase catalytic subunit type 3 / Q8NEB9*  / complex
 ENSMUSG00000035086 Becn1 / O88597 / Beclin-1 Beclin-1-C 35 kDa Beclin-1-C 37 kDa / Q14457* / beclin 1*  / complex
 ENSMUSG00000064063 BC048507 / cDNA sequence BC048507 / DYNLL1* / P63167* / dynein light chain LC8-type 1*  / complex / reaction
 ENSMUSG00000006542 Prkag3 / Q8BGM7 / protein kinase, AMP-activated, gamma 3 non-catatlytic subunit / Q9UGI9* / protein kinase AMP-activated non-catalytic subunit gamma 3*  / reaction
 ENSMUSG00000067713 O54950 / Prkag1 / protein kinase, AMP-activated, gamma 1 non-catalytic subunit / P54619* / protein kinase AMP-activated non-catalytic subunit gamma 1*  / reaction






 

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