ENSMUSG00000037526


Mus musculus

Features
Gene ID: ENSMUSG00000037526
  
Biological name :Atg14
  
Synonyms : Atg14 / Beclin 1-associated autophagy-related key regulator / Q8CDJ3
  
Possible biological names infered from orthology : autophagy related 14 / Q6ZNE5
  
Species: Mus musculus
  
Chr. number: 14
Strand: -1
Band: C1
Gene start: 47540893
Gene end: 47570649
  
Corresponding Affymetrix probe sets: 10419343 (MoGene1.0st)   1426780_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000039047
Ensembl peptide - ENSMUSP00000153718
Ensembl peptide - ENSMUSP00000154124
NCBI entrez gene - 100504663     See in Manteia.
MGI - MGI:1261775
RefSeq - NM_172599
RefSeq Peptide - NP_766187
swissprot - Q8CDJ3
Ensembl - ENSMUSG00000037526
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ATG14ENSDARG00000002670Danio rerio
 ATG14ENSGALG00000012148Gallus gallus
 ATG14ENSG00000126775Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR018791  UV radiation resistance protein/autophagy-related protein 14


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000045 autophagosome assembly ISO
 biological_processGO:0000423 mitophagy ISO
 biological_processGO:0001932 regulation of protein phosphorylation ISO
 biological_processGO:0001933 negative regulation of protein phosphorylation IDA
 biological_processGO:0001934 positive regulation of protein phosphorylation IDA
 biological_processGO:0006914 autophagy IMP
 biological_processGO:0008333 endosome to lysosome transport ISO
 biological_processGO:0009267 cellular response to starvation ISO
 biological_processGO:0010608 posttranscriptional regulation of gene expression ISO
 biological_processGO:0016236 macroautophagy ISO
 biological_processGO:0016240 autophagosome membrane docking ISO
 biological_processGO:0042149 cellular response to glucose starvation IDA
 biological_processGO:0043552 positive regulation of phosphatidylinositol 3-kinase activity ISO
 biological_processGO:0090207 regulation of triglyceride metabolic process IMP
 biological_processGO:0098780 response to mitochondrial depolarisation ISO
 cellular_componentGO:0000421 autophagosome membrane IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005776 autophagosome ISO
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005930 axoneme IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0034045 phagophore assembly site membrane ISO
 cellular_componentGO:0035032 phosphatidylinositol 3-kinase complex, class III IDA
 cellular_componentGO:0044233 ER-mitochondrion membrane contact site IDA
 cellular_componentGO:0045335 phagocytic vesicle IDA
 cellular_componentGO:0097629 extrinsic component of omegasome membrane ISO
 cellular_componentGO:0097632 extrinsic component of phagophore assembly site membrane ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0051020 GTPase binding ISO


Pathways (from Reactome)
Pathway description
Macroautophagy


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000479 abnormal intestinal cell "anomalous structure or development of the cells comprising the intestine" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Dcbld2tm1Mhms/Dcbld2tm1.1Mhms,Tg(Cdh5-cre)7Mlia/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000025907 Q9ESK9 / Rb1cc1 / RB1-inducible coiled-coil protein 1 / Q8TDY2* / RB1 inducible coiled-coil 1*  / reaction
 ENSMUSG00000029513 Prkab1 / Q9R078 / protein kinase, AMP-activated, beta 1 non-catalytic subunit / Q9Y478* / protein kinase AMP-activated non-catalytic subunit beta 1*  / reaction
 ENSMUSG00000028944 Prkag2 / Q91WG5 / protein kinase, AMP-activated, gamma 2 non-catalytic subunit / Q9UGJ0* / protein kinase AMP-activated non-catalytic subunit gamma 2*  / reaction
 ENSMUSG00000028518 Prkaa2 / Q8BRK8 / protein kinase, AMP-activated, alpha 2 catalytic subunit / P54646* / protein kinase AMP-activated catalytic subunit alpha 2*  / reaction
 ENSMUSG00000029512 Ulk1 / unc-51 like kinase 1 / O75385* / unc-51 like autophagy activating kinase 1*  / reaction
 ENSMUSG00000020483 Dynll2 / Q9D0M5 / Dynein light chain 2, cytoplasmic / Q96FJ2* / dynein light chain LC8-type 2*  / reaction / complex
 ENSMUSG00000033628 Pik3c3 / Q6PF93 / Phosphatidylinositol 3-kinase catalytic subunit type 3 / Q8NEB9*  / complex
 ENSMUSG00000040506 A2AH22 / Ambra1 / Activating molecule in BECN1-regulated autophagy protein 1 / Q9C0C7* / autophagy and beclin 1 regulator 1*  / complex / reaction
 ENSMUSG00000032571 Pik3r4 / Q8VD65 / Phosphoinositide 3-kinase regulatory subunit 4 / Q99570*  / complex
 ENSMUSG00000064063 BC048507 / cDNA sequence BC048507 / DYNLL1* / P63167* / dynein light chain LC8-type 1*  / complex / reaction
 ENSMUSG00000035086 Becn1 / O88597 / Beclin-1 Beclin-1-C 35 kDa Beclin-1-C 37 kDa / Q14457* / beclin 1*  / complex
 ENSMUSG00000027244 Atg13 / Q91YI1 / Mus musculus autophagy related 13 (Atg13), transcript variant 4, mRNA. / O75143* / autophagy related 13*  / reaction
 ENSMUSG00000050697 Prkaa1 / Q5EG47 / protein kinase, AMP-activated, alpha 1 catalytic subunit / Q13131* / protein kinase AMP-activated catalytic subunit alpha 1*  / reaction
 ENSMUSG00000038205 Prkab2 / Q6PAM0 / protein kinase, AMP-activated, beta 2 non-catalytic subunit / O43741* / protein kinase AMP-activated non-catalytic subunit beta 2*  / reaction
 ENSMUSG00000037204 Atg101 / Q9D8Z6 / Autophagy-related protein 101 / Q9BSB4* / autophagy related 101*  / reaction
 ENSMUSG00000006542 Prkag3 / Q8BGM7 / protein kinase, AMP-activated, gamma 3 non-catatlytic subunit / Q9UGI9* / protein kinase AMP-activated non-catalytic subunit gamma 3*  / reaction
 ENSMUSG00000067713 O54950 / Prkag1 / protein kinase, AMP-activated, gamma 1 non-catalytic subunit / P54619* / protein kinase AMP-activated non-catalytic subunit gamma 1*  / reaction






 

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