MP:0000267 | abnormal cardiac development | "aberrant formation or incomplete differentiation of the heart" [MGI:cls, J:53370] |
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Allelic Composition: Dcntm1Ioz/Dcntm1Ioz Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
Allelic Composition: Becn1tm1Ebr/Becn1+,Tg(EIIa-cre)C5379Lmgd/? Genetic Background: involves: FVB/N
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MP:0000685 | abnormal immune system morphology | "morphological anomalies in the organs or cells associated with the development and formation of lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Mogtm1Reid/Mogtm1Reid Genetic Background: 129/Sv-Mogtm1Reid
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MP:0000913 | abnormal brain development | "malformed or incomplete differentiation of the brain" [MGI:cls, J:49840] |
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Allelic Composition: Dcntm1Ioz/Dcntm1Ioz Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
Allelic Composition: Becn1tm1Ebr/Becn1+,Tg(EIIa-cre)C5379Lmgd/? Genetic Background: involves: FVB/N
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MP:0001126 | abnormal ovary morphology | "malformed female reproductive gland containing the germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782] |
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Allelic Composition: Dcntm1Ioz/Dcntm1Ioz Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
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MP:0001127 | small ovary | "reduced size of the female reproductive gland containing the germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782] |
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Allelic Composition: Dcntm1Ioz/Dcntm1Ioz Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
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MP:0001698 | reduced embryo size | "smaller proportions of embryo compared to littermates" [J:61790] |
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Allelic Composition: Tnfsf4tm1Shr/Tnfsf4tm1Shr Genetic Background: involves: 129S4/SvJae
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MP:0001710 | absent amniotic folds | "failure of amnion to form involutions" [J:40594] |
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Allelic Composition: Tnfsf4tm1Shr/Tnfsf4tm1Shr Genetic Background: involves: 129S4/SvJae
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MP:0001730 | embryonic growth arrest | "the cessation of development beyond a particular stage" [J:17509] |
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Allelic Composition: Tnfsf4tm1Shr/Tnfsf4tm1Shr Genetic Background: involves: 129S4/SvJae
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MP:0002018 | malignant tumors | "higher than normal incidence of locally invasive, destructive and metastatic tumors " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:44427] |
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Allelic Composition: Becn1tm1Blev/Becn1+ Genetic Background: involves: 129X1/SvJ * C57BL/6J
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MP:0002020 | increased tumor incidence | "greater than average number of tumors, usually a specific type" [MGI:cls, J:34193] |
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Allelic Composition: Mogtm1Reid/Mogtm1Reid Genetic Background: 129/Sv-Mogtm1Reid
Allelic Composition: Becn1tm1Blev/Becn1+ Genetic Background: involves: 129X1/SvJ * C57BL/6J
Allelic Composition: Becn1tm1Htz/Becn1+ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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MP:0002023 | B cell derived lymphoma | "heterogeneous lymphoid tumors generally expressing one or more B-cell antigens or representing malignant transformations of B-lymphocytes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Becn1tm1Htz/Becn1+ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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MP:0002027 | lung adenocarcinoma | "malignant neoplasm of epithelial cells in the lung" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:18542] |
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Allelic Composition: Becn1tm1Blev/Becn1+ Genetic Background: involves: 129X1/SvJ * C57BL/6J
Allelic Composition: Becn1tm1Htz/Becn1+ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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MP:0002048 | lung adenoma | "benign epithelial neoplasm of the lung" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:57631] |
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Allelic Composition: Becn1tm1Blev/Becn1+ Genetic Background: involves: 129X1/SvJ * C57BL/6J
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MP:0002081 | perinatal lethality | "death anytime between E18.5 and postnatal day 1 " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Dcntm1Ioz/Dcntm1Ioz Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
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MP:0002083 | premature death | "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Mogtm1Reid/Mogtm1Reid Genetic Background: 129/Sv-Mogtm1Reid
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MP:0003037 | increased infarction size | "increased size of necrotic area from normal of the myocardium resulting from a sudden insufficiency of arterial or venous blood supply due to emboli, thrombi or mechanical factors" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, RGD:Rat Genome Database submission] |
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Allelic Composition: Gsk3btm1Grc/Gsk3b+ Genetic Background: involves: 129S6/SvEvTac
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MP:0003038 | decreased infarction size | "decreased size of necrotic area from normal of the myocardium resulting from a sudden insufficiency of arterial or venous blood supply due to emboli, thrombi or mechanical factors" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, RGD:Rat Genome Database submission] |
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Allelic Composition: Gsk3btm1Grc/Gsk3b+ Genetic Background: involves: 129S6/SvEvTac
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MP:0003331 | hepatocellular carcinoma | "malignant neoplasm arising from liver cells" [ncbi:Matthew Mailman, NCBI request] |
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Allelic Composition: Becn1tm1Blev/Becn1+ Genetic Background: involves: 129X1/SvJ * C57BL/6J
Allelic Composition: Becn1tm1Htz/Becn1+ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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MP:0004800 | decreased susceptibility to experimental autoimmune encephalomyelitis | "reduced likelihood that an organism will develop disease symptoms similar to human multiple sclerosis upon induction with antigens to Myelin Basic Protein (MBP), Proteolipid Protein (PLP), and/or Myelin Oligodendrocyte glycoprotein (MOG)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Stk11tm1.1Rdp/Stk11tm1.1Rdp Genetic Background: involves: 129S6/SvEvTac
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MP:0005029 | abnormal amnion | "malformed innermost layer of the extraembryonic membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator] |
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Allelic Composition: Tnfsf4tm1Shr/Tnfsf4tm1Shr Genetic Background: involves: 129S4/SvJae
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MP:0005095 | decreased T cell proliferation | "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7] |
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Allelic Composition: Stk11tm1.1Rdp/Stk11tm1.1Rdp Genetic Background: involves: 129S6/SvEvTac
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MP:0005463 | abnormal CD4+ T cell physiology | "anomalous response of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Stk11tm1.1Rdp/Stk11tm1.1Rdp Genetic Background: involves: 129S6/SvEvTac
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MP:0006413 | increased T cell apoptosis | "increase in the number of T cells undergoing programmed cell death" [MGI:brs "Beverly Richards-Smith, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Stk11tm1.1Rdp/Stk11tm1.1Rdp Genetic Background: involves: 129S6/SvEvTac
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MP:0008075 | decreased CD4-positive T cell number | "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Stk11tm1.1Rdp/Stk11tm1.1Rdp Genetic Background: involves: 129S6/SvEvTac
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MP:0008079 | decreased CD8-positive T cell number | "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Stk11tm1.1Rdp/Stk11tm1.1Rdp Genetic Background: involves: 129S6/SvEvTac
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MP:0008260 | abnormal autophagy | "abnormal catabolic process involving the degradation of a cell s own components through the lysosomal machinery" [MGI:honda "Hiraoki Onda, Mouse Genome Informatics Curator"] |
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Allelic Composition: Becn1tm1Blev/Becn1+ Genetic Background: involves: 129X1/SvJ * C57BL/6J
Allelic Composition: Becn1tm1Htz/Becn1tm1Htz Genetic Background: involves: 129P2/OlaHsd
Allelic Composition: Becn1tm1Blev/Becn1+,Tg(CAG-EGFP/Map1lc3b)53Nmz/0 Genetic Background: involves: 129X1/SvJ * C57BL/6J * C57BL/6NCrj
Allelic Composition: Becn1tm1Blev/Becn1+,Tg(CAG-EGFP/Map1lc3b)53Nmz/0 Genetic Background: involves: 129X1/SvJ * C57BL/6NCrj
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MP:0008481 | increased spleen germinal center number | "greater number of spleen secondary B follicles where rapid B-cell proliferation, somatic hypermutation, and selection for antigen binding occurs" [PMID:17495967] |
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Allelic Composition: Becn1tm1Blev/Becn1+ Genetic Background: involves: 129X1/SvJ * C57BL/6J
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MP:0008483 | increased spleen germinal center size | "greater size of spleen secondary B follicles where rapid B-cell proliferation, somatic hypermutation, and selection for antigen binding occurs" [PMID:17495967] |
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Allelic Composition: Becn1tm1Blev/Becn1+ Genetic Background: involves: 129X1/SvJ * C57BL/6J
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MP:0008714 | lung carcinoma | "a malignant neoplasm of the ling, arising from epithelial cells, usually glandular or squamous" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Becn1tm1Blev/Becn1+ Genetic Background: involves: 129X1/SvJ * C57BL/6J
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MP:0009317 | follicular lymphoma | "malignant lymphoma arising from lymphoid follicular B cells which may be small or large" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Becn1tm1Blev/Becn1+ Genetic Background: involves: 129X1/SvJ * C57BL/6J
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MP:0009321 | histiocytic sarcoma | |
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Allelic Composition: Becn1tm1Blev/Becn1+ Genetic Background: involves: 129X1/SvJ * C57BL/6J
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MP:0009361 | abnormal primordial ovarian follicle morphology | "any structural abnormality in the ovarian follicle in which the primary oocyte is surrounded by a single layer of flattened follicular cells; primordial follicles are indiscernible to the naked eye and develop to primary, secondary, and finally mature vesicular follicles" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Dcntm1Ioz/Dcntm1Ioz Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
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MP:0009503 | abnormal mammary gland duct morphology | "any structural anomaly of the canals that lead from the lobes of the mammary gland to the tip of the nipple and are responsible for carrying milk toward the nipple in a lactating female" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Becn1tm1Blev/Becn1+ Genetic Background: involves: 129X1/SvJ * C57BL/6J
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MP:0010286 | increased plasmacytoma incidence | "greater than the expected number of neoplastic plasma cells in bone or in one of the extramedullary sites occurring in a specific population in a given time period" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Becn1tm1Blev/Becn1+ Genetic Background: involves: 129X1/SvJ * C57BL/6J
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MP:0010299 | increased mammary gland tumor incidence | "greater than the expected number of neoplasms in the mammary gland, usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Becn1tm1Blev/Becn1+ Genetic Background: involves: 129X1/SvJ * C57BL/6J
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MP:0011091 | complete prenatal lethality | "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith] |
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Allelic Composition: Htr1btm1Rhn/Htr1b+,Tph1tm1Kry/Tph1+,Tg(Vil-cre)20Syr/0 Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2
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MP:0011096 | complete embryonic lethality before somite formation | "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith] |
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Allelic Composition: Becn1tm1Htz/Becn1tm1Htz Genetic Background: involves: 129P2/OlaHsd
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MP:0011108 | partial embryonic lethality during organogenesis | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith] |
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Allelic Composition: Dcntm1Ioz/Dcntm1Ioz Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
Allelic Composition: Becn1tm1Ebr/Becn1+,Tg(EIIa-cre)C5379Lmgd/? Genetic Background: involves: FVB/N
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MP:0011121 | decreased primordial ovarian follicle number | "fewer than normal numbers of the ovarian follicle in which the primary oocyte is surrounded by a single layer of flattened follicular cells; primordial follicles are indiscernible to the naked eye and develop to primary, secondary, and finally mature vesicular follicles" [MGI:csmith] |
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Allelic Composition: Dcntm1Ioz/Dcntm1Ioz Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
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MP:0012106 | impaired exercise endurance | "impaired performance during controlled physical activity" [MGI:smb] |
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Allelic Composition: Becn1tm1Blev/Becn1+,Tg(CAG-EGFP/Map1lc3b)53Nmz/0 Genetic Background: involves: 129X1/SvJ * C57BL/6NCrj
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MP:0012431 | increased lymphoma incidence | "greater than the expected number of neoplasms characterized by a proliferation of malignant lymphocytes in lymphoid tissue in a specific population in a given time period" [http://orcid.org/0000-0001-5208-3432, MGI:csmith] |
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Allelic Composition: Becn1tm1Blev/Becn1+ Genetic Background: involves: 129X1/SvJ * C57BL/6J
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MP:0013504 | increased embryonic tissue cell apoptosis | "increase in the timing or the number of cells in embryonic tissue undergoing programmed cell death" [MGI:csmith] |
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Allelic Composition: Becn1tm1Htz/Becn1tm1Htz Genetic Background: involves: 129P2/OlaHsd
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