ENSMUSG00000029512


Mus musculus

Features
Gene ID: ENSMUSG00000029512
  
Biological name :Ulk1
  
Synonyms : Ulk1 / unc-51 like kinase 1
  
Possible biological names infered from orthology : O75385 / unc-51 like autophagy activating kinase 1
  
Species: Mus musculus
  
Chr. number: 5
Strand: -1
Band: F
Gene start: 110784488
Gene end: 110810097
  
Corresponding Affymetrix probe sets: 10532472 (MoGene1.0st)   1416504_at (Mouse Genome 430 2.0 Array)   1448370_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000143308
Ensembl peptide - ENSMUSP00000143536
Ensembl peptide - ENSMUSP00000143380
Ensembl peptide - ENSMUSP00000031490
NCBI entrez gene - 22241     See in Manteia.
MGI - MGI:1270126
RefSeq - XM_006534851
RefSeq - XM_011249420
RefSeq - XM_011249419
RefSeq - NM_001347394
RefSeq - NM_009469
RefSeq Peptide - NP_001334323
RefSeq Peptide - NP_033495
swissprot - Q6PB82
swissprot - A0A0R4J0B3
swissprot - A0A0G2JFU2
swissprot - A0A0G2JG09
Ensembl - ENSMUSG00000029512
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ulk1aENSDARG00000062518Danio rerio
 ulk1bENSDARG00000074481Danio rerio
 ULK1ENSGALG00000002403Gallus gallus
 ULK1ENSG00000177169Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ulk2 / Q9QY01 / unc-51 like kinase 2 / Q8IYT8* / unc-51 like autophagy activating kinase 2*ENSMUSG0000000479853
Ulk3 / Q3U3Q1 / unc-51-like kinase 3 / Q6PHR2*ENSMUSG0000003230815
Ikbkb / inhibitor of kappaB kinase beta / O14920* / inhibitor of nuclear factor kappa B kinase subunit beta*ENSMUSG0000003153715
Ikbke / Q9R0T8 / Inhibitor of nuclear factor kappa-B kinase subunit epsilon / Q14164*ENSMUSG0000004234914
Chuk / conserved helix-loop-helix ubiquitous kinase / O15111*ENSMUSG0000002519913
Tbk1 / Q9WUN2 / TANK-binding kinase 1 / Q9UHD2*ENSMUSG0000002011511


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR016237  Serine/threonine-protein kinase, Ulk1/Ulk2
 IPR017441  Protein kinase, ATP binding site
 IPR022708  Serine/threonine-protein kinase, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006914 autophagy IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007409 axonogenesis IEA
 biological_processGO:0008104 protein localization IEA
 biological_processGO:0016236 macroautophagy IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IEA
 biological_processGO:0018107 peptidyl-threonine phosphorylation IEA
 biological_processGO:0031102 neuron projection regeneration IEA
 biological_processGO:0031175 neuron projection development IEA
 biological_processGO:0031333 negative regulation of protein complex assembly IEA
 biological_processGO:0046777 protein autophosphorylation IEA
 biological_processGO:0075044 autophagy of host cells involved in interaction with symbiont IEA
 biological_processGO:2000786 positive regulation of autophagosome assembly IEA
 cellular_componentGO:0005776 autophagosome IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0032045 guanyl-nucleotide exchange factor complex IEA
 cellular_componentGO:0034045 phagophore assembly site membrane IEA
 cellular_componentGO:0097629 extrinsic component of omegasome membrane IEA
 cellular_componentGO:0097632 extrinsic component of phagophore assembly site membrane IEA
 cellular_componentGO:0097635 extrinsic component of autophagosome membrane IEA
 cellular_componentGO:1990316 Atg1/ULK1 kinase complex IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0017137 Rab GTPase binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0044877 protein-containing complex binding IEA
 molecular_functionGO:0051020 GTPase binding IEA


Pathways (from Reactome)
Pathway description
Macroautophagy
TBC/RABGAPs
RAB GEFs exchange GTP for GDP on RABs
Receptor Mediated Mitophagy


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000245 abnormal erythropoiesis "atypical process of red blood cell formation" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Tbx4tm1.1Kng/Tbx4+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * DBA/2

 MP:0002424 abnormal reticulocyte morphology/development "anomalous structure, formation, or numbers of immature erthrocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Tbx4tm1.1Kng/Tbx4+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * DBA/2

 MP:0002447 abnormal erythrocyte morphology "structural anomaly of the cells in the blood that carry oxygen, red blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tbx4tm1.1Kng/Tbx4+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * DBA/2

 MP:0002590 increased mean corpuscular volume "greater than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Tbx4tm1.1Kng/Tbx4+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * DBA/2

 MP:0002640 reticulocytosis "an increase in the number of reticulocytes in the blood" [J:78271, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: Tbx4tm1.1Kng/Tbx4+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * DBA/2

 MP:0004952 increased spleen weight "greater than average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tbx4tm1.1Kng/Tbx4+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * DBA/2

 MP:0005641 increased mean corpuscular hemoglobin concentration "greater than the normal Hgb/Hct; the average hemoglobin concentration in a given volume of packed red cells, calculated from the hemoglobin therein and the hematocrit, in erythrocyte indices" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:8936]
Show

Allelic Composition: Tbx4tm1.1Kng/Tbx4+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * DBA/2

 MP:0006035 abnormal mitochondrial morphology "anomalous structure of the mitochondria" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Tbx4tm1.1Kng/Tbx4+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * DBA/2

 MP:0008260 abnormal autophagy "abnormal catabolic process involving the degradation of a cell s own components through the lysosomal machinery" [MGI:honda "Hiraoki Onda, Mouse Genome Informatics Curator"]
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Allelic Composition: Tbx4tm1.1Kng/Tbx4+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * DBA/2

 MP:0010067 increased red blood cell distribution width "higher than normal coefficient of variance (reference range) of the red blood cell volume for an organism" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", NCI:C64800 "NCI Thesaurus (Code C64800)"]
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Allelic Composition: Tbx4tm1.1Kng/Tbx4+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * DBA/2

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Kcnn2bc-9J/Kcnn2bc-9J
Genetic Background: C57BL/6J-bc9J/GrsrJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000004771 P62492 / Rab11a / RAB11A, member RAS oncogene family / P62491*  / reaction / complex
 ENSMUSG00000025907 Q9ESK9 / Rb1cc1 / RB1-inducible coiled-coil protein 1 / Q8TDY2* / RB1 inducible coiled-coil 1*  / complex
 ENSMUSG00000029513 Prkab1 / Q9R078 / protein kinase, AMP-activated, beta 1 non-catalytic subunit / Q9Y478* / protein kinase AMP-activated non-catalytic subunit beta 1*  / complex / reaction
 ENSMUSG00000028945 Rheb / Q921J2 / Ras homolog enriched in brain / Q15382* / Ras homolog, mTORC1 binding*  / complex / reaction
 ENSMUSG00000028944 Prkag2 / Q91WG5 / protein kinase, AMP-activated, gamma 2 non-catalytic subunit / Q9UGJ0* / protein kinase AMP-activated non-catalytic subunit gamma 2*  / reaction / complex
 ENSMUSG00000028518 Prkaa2 / Q8BRK8 / protein kinase, AMP-activated, alpha 2 catalytic subunit / P54646* / protein kinase AMP-activated catalytic subunit alpha 2*  / reaction / complex
 ENSMUSG00000028278 Rragd / Ras-related GTP binding D / Q9NQL2*  / complex / reaction
 ENSMUSG00000037526 Atg14 / Q8CDJ3 / Beclin 1-associated autophagy-related key regulator / Q6ZNE5* / autophagy related 14*  / reaction
 ENSMUSG00000028991 Mtor / Q9JLN9 / Serine/threonine-protein kinase mTOR / P42345* / mechanistic target of rapamycin kinase*  / complex / reaction
 ENSMUSG00000047789 Q8BGD6 / Slc38a9 / Sodium-coupled neutral amino acid transporter 9 / Q8NBW4* / solute carrier family 38 member 9*  / reaction / complex
 ENSMUSG00000067713 O54950 / Prkag1 / protein kinase, AMP-activated, gamma 1 non-catalytic subunit / P54619* / protein kinase AMP-activated non-catalytic subunit gamma 1*  / reaction / complex
 ENSMUSG00000041658 Rragb / Q6NTA4 / Ras-related GTP-binding protein B / Q5VZM2* / Ras related GTP binding B*  / reaction / complex
 ENSMUSG00000035086 Becn1 / O88597 / Beclin-1 Beclin-1-C 35 kDa Beclin-1-C 37 kDa / Q14457* / beclin 1*  / reaction
 ENSMUSG00000028646 Rragc / Q99K70 / Ras-related GTP-binding protein C / Q9HB90* / Ras related GTP binding C*  / complex / reaction
 ENSMUSG00000070934 Rraga / Q80X95 / Ras-related GTP-binding protein A / Q7L523* / Ras related GTP binding A*  / reaction / complex
 ENSMUSG00000020483 Dynll2 / Q9D0M5 / Dynein light chain 2, cytoplasmic / Q96FJ2* / dynein light chain LC8-type 2*  / reaction
 ENSMUSG00000036661 A2RT67 / Dennd3 / DENN domain-containing protein 3 / A2RUS2* / DENN domain containing 3*  / reaction
 ENSMUSG00000037204 Atg101 / Q9D8Z6 / Autophagy-related protein 101 / Q9BSB4* / autophagy related 101*  / complex
 ENSMUSG00000064063 BC048507 / cDNA sequence BC048507 / DYNLL1* / P63167* / dynein light chain LC8-type 1*  / reaction
 ENSMUSG00000050697 Prkaa1 / Q5EG47 / protein kinase, AMP-activated, alpha 1 catalytic subunit / Q13131* / protein kinase AMP-activated catalytic subunit alpha 1*  / reaction / complex
 ENSMUSG00000040506 A2AH22 / Ambra1 / Activating molecule in BECN1-regulated autophagy protein 1 / Q9C0C7* / autophagy and beclin 1 regulator 1*  / reaction
 ENSMUSG00000038205 Prkab2 / Q6PAM0 / protein kinase, AMP-activated, beta 2 non-catalytic subunit / O43741* / protein kinase AMP-activated non-catalytic subunit beta 2*  / reaction / complex
 ENSMUSG00000032571 Pik3r4 / Q8VD65 / Phosphoinositide 3-kinase regulatory subunit 4 / Q99570*  / reaction
 ENSMUSG00000006542 Prkag3 / Q8BGM7 / protein kinase, AMP-activated, gamma 3 non-catatlytic subunit / Q9UGI9* / protein kinase AMP-activated non-catalytic subunit gamma 3*  / reaction / complex
 ENSMUSG00000024142 Mlst8 / Q9DCJ1 / Target of rapamycin complex subunit LST8 / Q9BVC4* / MTOR associated protein, LST8 homolog*  / reaction / complex
 ENSMUSG00000027244 Atg13 / Q91YI1 / Mus musculus autophagy related 13 (Atg13), transcript variant 4, mRNA. / O75143* / autophagy related 13*  / complex
 ENSMUSG00000033628 Pik3c3 / Q6PF93 / Phosphatidylinositol 3-kinase catalytic subunit type 3 / Q8NEB9*  / reaction
 ENSMUSG00000025040 Fundc1 / Q9DB70 / FUN14 domain-containing protein 1 / Q8IVP5* / FUN14 domain containing 1*  / reaction
 ENSMUSG00000077450 P46638 / Rab11b / RAB11B, member RAS oncogene family / Q15907*  / complex / reaction






 

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