ENSMUSG00000031537


Mus musculus

Features
Gene ID: ENSMUSG00000031537
  
Biological name :Ikbkb
  
Synonyms : Ikbkb / inhibitor of kappaB kinase beta
  
Possible biological names infered from orthology : inhibitor of nuclear factor kappa B kinase subunit beta / O14920
  
Species: Mus musculus
  
Chr. number: 8
Strand: -1
Band: A2
Gene start: 22659212
Gene end: 22706589
  
Corresponding Affymetrix probe sets: 10577560 (MoGene1.0st)   1426207_at (Mouse Genome 430 2.0 Array)   1426333_a_at (Mouse Genome 430 2.0 Array)   1432275_at (Mouse Genome 430 2.0 Array)   1445141_at (Mouse Genome 430 2.0 Array)   1454184_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000138378
Ensembl peptide - ENSMUSP00000120916
Ensembl peptide - ENSMUSP00000138156
Ensembl peptide - ENSMUSP00000033939
Ensembl peptide - ENSMUSP00000064235
Ensembl peptide - ENSMUSP00000120049
NCBI entrez gene - 16150     See in Manteia.
MGI - MGI:1338071
RefSeq - XM_006509023
RefSeq - NM_001159774
RefSeq - NM_010546
RefSeq - XM_006509019
RefSeq - XM_006509020
RefSeq - XM_006509021
RefSeq - XM_006509022
RefSeq Peptide - NP_001153246
RefSeq Peptide - NP_034676
swissprot - F6ULQ4
swissprot - Q3U141
swissprot - A0A0R4J0T4
swissprot - Q5D0E0
swissprot - F6XPL0
Ensembl - ENSMUSG00000031537
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ikbkbENSDARG00000079123Danio rerio
 IKBKBENSGALG00000031832Gallus gallus
 IKBKBENSG00000104365Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Chuk / conserved helix-loop-helix ubiquitous kinase / O15111*ENSMUSG0000002519949
Ulk1 / unc-51 like kinase 1 / O75385* / unc-51 like autophagy activating kinase 1*ENSMUSG0000002951220
Ulk2 / Q9QY01 / unc-51 like kinase 2 / Q8IYT8* / unc-51 like autophagy activating kinase 2*ENSMUSG0000000479820
Tbk1 / Q9WUN2 / TANK-binding kinase 1 / Q9UHD2*ENSMUSG0000002011519
Ikbke / Q9R0T8 / Inhibitor of nuclear factor kappa-B kinase subunit epsilon / Q14164*ENSMUSG0000004234919
Ulk3 / Q3U3Q1 / unc-51-like kinase 3 / Q6PHR2*ENSMUSG0000003230812


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR022007  I-kappa-kinase-beta NEMO binding domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007249 I-kappaB kinase/NF-kappaB signaling IEA
 biological_processGO:0007252 I-kappaB phosphorylation IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IEA
 biological_processGO:0030866 cortical actin cytoskeleton organization IEA
 biological_processGO:0033209 tumor necrosis factor-mediated signaling pathway IEA
 biological_processGO:0035509 negative regulation of myosin-light-chain-phosphatase activity IEA
 biological_processGO:0042325 regulation of phosphorylation IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity IEA
 biological_processGO:0070498 interleukin-1-mediated signaling pathway IEA
 biological_processGO:0071356 cellular response to tumor necrosis factor IEA
 biological_processGO:0072659 protein localization to plasma membrane IEA
 biological_processGO:1903140 regulation of establishment of endothelial barrier IEA
 biological_processGO:1903347 negative regulation of bicellular tight junction assembly IEA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008384 IkappaB kinase activity IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA
 molecular_functionGO:0097110 scaffold protein binding IEA


Pathways (from Reactome)
Pathway description
Activation of NF-kappaB in B cells
NOD1/2 Signaling Pathway
RIP-mediated NFkB activation via ZBP1
Downstream TCR signaling
p75NTR recruits signalling complexes
NF-kB is activated and signals survival
FCERI mediated NF-kB activation
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
Regulation of TNFR1 signaling
TNFR1-induced NFkappaB signaling pathway
CLEC7A (Dectin-1) signaling
MAP3K8 (TPL2)-dependent MAPK1/3 activation
Interleukin-1 signaling
TRAF6 mediated NF-kB activation
IRAK1 recruits IKK complex
IKK complex recruitment mediated by RIP1
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000511 abnormal intestinal mucosa morphology "structural or developmental anomalies of the mucous lining of the intestine; this consists of epithelium, lamina, propria, and a layer of smooth muscle cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Cdc7tm1Hmas/Cdc7tm1Hmas,Trp53tm2Mok/Trp53tm2Mok
Genetic Background: involves: 129S/Sv * C57BL/6

 MP:0000601 small liver "reduced size of the liver" [J:23170]
Show

Allelic Composition: Aqp1tm1Ask/Aqp1tm1Ask,Aqp7tm1.1Suc/Aqp7tm1.1Suc
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0000607 abnormal hepatocyte morphology "malformation of the main structural component of the liver; these are specialized epithelial cells normally organize into interconnected plates called lobules" [J:23170, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Igkctm1Cgn/Igkc+
Genetic Background: involves: C57BL/6

Allelic Composition: Ikbkbtm1Trk/Ikbkbtm1Trk
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0000608 dissociated hepatocytes "disorganization of cohesive hepatocyte structure" [J:23170]
Show

Allelic Composition: Aqp1tm1Ask/Aqp1tm1Ask,Aqp7tm1.1Suc/Aqp7tm1.1Suc
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0000611 jaundice "clinical manifestation of hyperbilirubinemia, with deposition of bile pigments in the skin, resulting in yellowish staining of the skin and mucous membranes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Csnk1etm1Asil/Csnk1etm1.1Asil
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000729 abnormal myogenesis "anomaly in embryonic formation of muscle cells or fibers" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Relatm1Yuo/Relatm1Yuo,Tnftm1Ljo/Tnftm1Ljo
Genetic Background: involves: 129S/SvEv * 129S1/SvEv

 MP:0000841 abnormal hindbrain morphology "malformed caudal region of the brain; includes cerebellum, pons and medulla oblongata" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:45302]
Show

Allelic Composition: Baxtm1Dlo/Baxtm1Dlo
Genetic Background: involves: 129P2/OlaHsd

 MP:0000929 open neural tube "incomplete invagination and fusion of the neuroepithelial layer in early development" [MGI:CLS, J:53370, J:62571]
Show

Allelic Composition: Baxtm1Dlo/Baxtm1Dlo
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Chuktm1Ver/Chuktm1Ver,Ikbkbtm1Ver/Ikbkbtm1Ver,Tnfrsf1atm1Mak/Tnfrsf1atm1Mak
Genetic Background: involves: 129/Sv * 129S4/SvJae * C57BL/6J

 MP:0000936 small telencephalic vesicles "reduced size of the paired diverticula of the telencephalon, from which the forebrain develops" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:49840]
Show

Allelic Composition: Baxtm1Dlo/Baxtm1Dlo
Genetic Background: involves: 129P2/OlaHsd

 MP:0000961 abnormal dorsal root ganglia morphology "malformed group of nerve cell bodies of each segmental nerve projecting from the spinal cord " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:60159]
Show

Allelic Composition: Baxtm1Dlo/Baxtm1Dlo
Genetic Background: involves: 129P2/OlaHsd

 MP:0001193 psoriasis "chronic skin lesions characterized by inflammation and silvery-scaly patches" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tg(KRT5-Nfkbia*)3Rto/0,Tg(Krt5-Tnfr1)#Rsab/0,Tnfrsf1atm1Mak/Tnfrsf1atm1Mak
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA

 MP:0001212 skin lesions "focal patches of inflammation on the skin" [J:30162]
Show

Allelic Composition: Ikbkbtm1Cgn/Ikbkbtm1Cgn,Il20ratm1Rsab/Il20ratm1Rsab,Tg(KRT14-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * DBA/2

Allelic Composition: Ikbkbtm1Cgn/Ikbkbtm1Cgn,Il22ra1tm1Rsab/Il22ra1tm1Rsab,Tg(KRT14-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * DBA/2

Allelic Composition: Ikbkbtm1Cgn/Ikbkbtm1Cgn,Tnfrsf1atm2Gkl/Tnfrsf1atm2Gkl,Tg(KRT14-cre)1Cgn/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * DBA/2

Allelic Composition: Ikbkbtm1Cgn/Ikbkbtm1Cgn,Il22tm1Jcrd/Il22tm1Jcrd,Tg(KRT14-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0001222 epidermal hyperplasia "increase in size of the epidermis due to increase in epidermal cell number" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]
Show

Allelic Composition: Ikbkbtm1Cgn/Ikbkbtm1Cgn,Il20ratm1Rsab/Il20ratm1Rsab,Tg(KRT14-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * DBA/2

Allelic Composition: Ikbkbtm1Cgn/Ikbkbtm1Cgn,Tnfrsf1atm2Gkl/Tnfrsf1atm2Gkl,Tg(KRT14-cre)1Cgn/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * DBA/2

 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
Show

Allelic Composition: Hprttm1a(EUCOMM)Hmgu/Hprttm1a(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Hprttm1a(EUCOMM)Hmgu/Ieg

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Hprttm1a(EUCOMM)Hmgu/Hprttm1a(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Hprttm1a(EUCOMM)Hmgu/Ieg

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Csnk1etm1Asil/Csnk1etm1.1Asil
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001800 abnormal humoral immune response "abnormal immune function mediated by antibodies" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Ikbkbtm1Cgn/Ikbkbtm1.1Cgn,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0001805 decreased IgG "less than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ahrtm1Yfk/Ahrtm1Yfk
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0001806 decreased IgM "less than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ikbkbtm2Mka/Ikbkbtm2Mka
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0002007 increased sensitivity to gamma-irradiation "increased incidence of cell death following high levels of gamma-irradiation" [J:51834]
Show

Allelic Composition: Psme3tm1Tchi/Psme3tm1Tchi
Genetic Background: involves: C57BL/6J * CBA

 MP:0002082 postnatal lethality "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Baxtm1Dlo/Baxtm1Dlo
Genetic Background: involves: 129P2/OlaHsd

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Csnk1etm1Asil/Csnk1etm1.1Asil
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Ikbkbtm1Cgn/Ikbkbtm1Cgn,Il20ratm1Rsab/Il20ratm1Rsab,Tg(KRT14-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Traf6tm1Ywc/Traf6tm1Ywc
Genetic Background: Not Specified

 MP:0002418 increased susceptibility to viral infection "greater likelihood that an organism will develop ill effects from a viral infection or from components of or toxins produced by a virus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: IkbkbM1Btlr/IkbkbM1Btlr
Genetic Background: C57BL/6J-IkbkbM1Btlr

 MP:0002459 abnormal B cell physiology "abnormal function of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Hmgcrtm2Ishi/Hmgcrtm2Ishi
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: IkbkbM1Btlr/IkbkbM1Btlr
Genetic Background: C57BL/6J-IkbkbM1Btlr

 MP:0002492 decreased IgE "less than normal immunoglobulin class E level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ikbkbtm1Cgn/Ikbkbtm1.1Cgn,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0002928 abnormal bile duct morphology "malformation of the channels that secrete bile from the liver to the gall bladder and intestines" [RGD:Rat Genome Database submission, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Csnk1etm1Asil/Csnk1etm1.1Asil
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002941 increased circulating alanine transaminase level "increased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Csnk1etm1Asil/Csnk1etm1.1Asil
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003051 curly tail "a loop or corkscrew-like curl in the tail" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Chuktm1Ver/Chuktm1Ver,Ikbkbtm1Ver/Ikbkbtm1Ver,Tnfrsf1atm1Mak/Tnfrsf1atm1Mak
Genetic Background: involves: 129/Sv * 129S4/SvJae * C57BL/6J

 MP:0003103 liver degeneration "deterioration of the liver due to injury or disease, often accompanied by loss of function" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91653]
Show

Allelic Composition: Igkctm1Cgn/Igkc+
Genetic Background: involves: C57BL/6

Allelic Composition: Ikbkbtm1Trk/Ikbkbtm1Trk
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Ikbkbtm1Ver/Ikbkbtm1Ver
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Chuktm1Ver/Chuktm1Ver,Ikbkbtm1Ver/Ikbkbtm1Ver
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0003288 intestinal edema "an accumulation of an excessive amount of serous fluid in the intestine or intestinal cells " [ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Cdc7tm1Hmas/Cdc7tm1Hmas,Trp53tm2Mok/Trp53tm2Mok
Genetic Background: involves: 129S/Sv * C57BL/6

 MP:0003799 impaired macrophage migration "defect in the ability of macrophages to move up a chemotactic gradient" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Chuktm1Lex/Chuktm1Lex,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEvBrd

 MP:0003887 increased hepatocyte apoptosis "increase in the number of hepatocytes undergoing programmed cell death" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ikbkbtm1Trk/Ikbkbtm1Trk
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Ikbkbtm1Ver/Ikbkbtm1Ver
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Chuktm1Ver/Chuktm1Ver,Ikbkbtm1Ver/Ikbkbtm1Ver
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0003888 liver hemorrhage "bleeding within the liver" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ikbkbtm1Ver/Ikbkbtm1Ver
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0004574 broad limb buds "increased anterior-posterior width of the mesenchymal outgrowth on the lateral trunk of the embryo that develops into the limbs" [MESH:National Library of Medicine_Medical Subject Headings]
Show

Allelic Composition: Chuktm1Ver/Chuktm1Ver,Ikbkbtm1Ver/Ikbkbtm1Ver,Tnfrsf1atm1Mak/Tnfrsf1atm1Mak
Genetic Background: involves: 129/Sv * 129S4/SvJae * C57BL/6J

 MP:0004838 abnormal neural fold elevation formation "any anomaly in the process by which the lateral borders of the neural plate begin to migrate upwards to form the neural folds, caused by the proliferation of the underlying mesoderm" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Chuktm1Ver/Chuktm1Ver,Ikbkbtm1Ver/Ikbkbtm1Ver
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0004947 skin inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ikbkbtm1Cgn/Ikbkbtm1Cgn,Il20ratm1Rsab/Il20ratm1Rsab,Tg(KRT14-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * DBA/2

Allelic Composition: Ikbkbtm1Cgn/Ikbkbtm1Cgn,Il22ra1tm1Rsab/Il22ra1tm1Rsab,Tg(KRT14-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * DBA/2

Allelic Composition: Ikbkbtm1Cgn/Ikbkbtm1Cgn,Tnfrsf1atm2Gkl/Tnfrsf1atm2Gkl,Tg(KRT14-cre)1Cgn/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * DBA/2

Allelic Composition: Ikbkbtm1Cgn/Ikbkbtm1Cgn,Tg(KRT14-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * DBA/2

Allelic Composition: Ikbkbtm1Cgn/Ikbkbtm1Cgn,Il22tm1Jcrd/Il22tm1Jcrd,Tg(KRT14-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0004974 decreased regulatory T cell number "reduced number of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Galctwi/Galctwi
Genetic Background: involves: C57BL/6J * CAST/EiJ * CE/J

 MP:0004978 decreased B-1 B cell number "reduced number of the subset of B cells found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ikbkbtm2Mka/Ikbkbtm2Mka
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ikbkbtm1Cgn/Ikbkbtm1.1Cgn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ikbkbtm2Cgn/Ikbkbtm2.1Cgn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ikbkbtm2Mka/Ikbkbtm2Mka
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ikbkbtm1.1Cgn/Ikbkbtm1.1Cgn
Genetic Background: involves: C57BL/6

 MP:0005025 response to infection "the body s reaction to invasion and multiplication of microorganisms in its tissues, or the body s reaction to components of or toxins produced by pathogenic mircroorganisms " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Hmgcrtm2Ishi/Hmgcrtm2Ishi
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0005087 reduced acute inflammation "less than the expected early reaction of the microcirculation, characterized by movement of fluid and leukocytes from the blood into extravascular tissues; initiated by injury, infection, or local immune response " [Pathology:ISBN 0-397-51047-0, J:74478]
Show

Allelic Composition: Cdc7tm1Hmas/Cdc7tm1Hmas,Trp53tm2Mok/Trp53tm2Mok
Genetic Background: involves: 129S/Sv * C57BL/6

 MP:0005093 impaired B cell proliferation "absent or reduced ability of B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ikbkbtm2Mka/Ikbkbtm2Mka
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0005150 cachexia "general weight loss and wasting occurring in the course of chronic disease" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Csnk1etm1Asil/Csnk1etm1.1Asil
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005154 increased B cell proliferation "greater than the normal response by B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ikbkbtm2.1Cgn/Ikbkbtm2.1Cgn
Genetic Background: involves: C57BL/6

 MP:0005164 abnormal response to injury "anomaly in the body s reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Cdc7tm1Hmas/Cdc7tm1Hmas,Trp53tm2Mok/Trp53tm2Mok
Genetic Background: involves: 129S/Sv * C57BL/6

 MP:0005344 increased circulating bilirubin level "greater than the normal concentration in the blood of this yellow heme breakdown product" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85204]
Show

Allelic Composition: Csnk1etm1Asil/Csnk1etm1.1Asil
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005415 intrahepatic cholestasis "impariment of bile flow due to injury to the hepatocytes, bile canaliculi, or the intrahepatic bile ducts" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Csnk1etm1Asil/Csnk1etm1.1Asil
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005584 abnormal enzyme/coenzyme activity "altered ability of any of these proteins, or their cofactors, to act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Crabp2tm1Ipc/Crabp2tm1Ipc
Genetic Background: either: (involves: 129S2/SvPas) or (involves: 129S2/SvPas * C57BL/6)

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ikbkbtm1Trk/Ikbkbtm1Trk
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Ikbkbtm1Ver/Ikbkbtm1Ver
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Chuktm1Ver/Chuktm1Ver,Ikbkbtm1Ver/Ikbkbtm1Ver
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0008050 decreased memory T cell number "reduced number of the set of long-lived T cells differentiated from T cells activated by a specific antigen encountered during a past immune response" [adiehl:Alex Diehl_MGI GO curator, Biology-Online.org:http://www.biology-online.org/, MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Galctwi/Galctwi
Genetic Background: involves: C57BL/6J * CAST/EiJ * CE/J

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ikbkbtm1.1Cgn/Ikbkbtm1.1Cgn
Genetic Background: involves: C57BL/6

Allelic Composition: Ikbkbtm1Cgn/Ikbkbtm1.1Cgn,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2

Allelic Composition: Ikbkbtm2Cgn/Ikbkbtm2.1Cgn,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2

Allelic Composition: Ikbkbtm2Cgn/Ikbkbtm2Cgn,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ikbkbtm1.1Cgn/Ikbkbtm1.1Cgn
Genetic Background: involves: C57BL/6

Allelic Composition: Ikbkbtm1Cgn/Ikbkbtm1.1Cgn,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2

Allelic Composition: Ikbkbtm2Cgn/Ikbkbtm2.1Cgn,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0008080 abnormal CD8-positive T cell differentiation "atypical production of or inability to produce the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hmgcrtm2Ishi/Hmgcrtm2Ishi
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: IkbkbM1Btlr/IkbkbM1Btlr
Genetic Background: C57BL/6J-IkbkbM1Btlr

 MP:0008083 decreased single-positive T cell number "reduced number of T cells bearing either CD4 or CD8 markers on their surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ikbkbtm1Cgn/Ikbkbtm1.1Cgn,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0008174 decreased follicular B cell number "reduced number of resting mature B cells with distinct phenotypic characteristics (CD23-positive, CD21-positive) found typically in the B cell follicle region of the spleen and lymph nodes" [CL:0000843, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ikbkbtm1Cgn/Ikbkbtm1.1Cgn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ikbkbtm2Cgn/Ikbkbtm2.1Cgn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008182 decreased marginal zone B cell number "reduced number of CD23-negative, CD21-positive B cells of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL" [CL:0000845, ISBN:0781735149]
Show

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ikbkbtm2Mka/Ikbkbtm2Mka
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ikbkbtm1Cgn/Ikbkbtm1.1Cgn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ikbkbtm2Cgn/Ikbkbtm2.1Cgn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008211 decreased mature B cell number "reduced number of the mature form of B cells, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149]
Show

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ikbkbtm1Cgn/Ikbkbtm1.1Cgn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ikbkbtm2Cgn/Ikbkbtm2.1Cgn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008215 decreased immature B cell number "reduced number of the cells of the B lymphocyte lineage that have undergone VDJ rearrangement of the heavy chain and V-J rearrangement of the light chain; these cells express IgM on the cell surface but have not yet been selected for self-reactivity" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ikbkbtm1Cgn/Ikbkbtm1.1Cgn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008217 abnormal B cell activation "any anomaly in the normal change in morphology and behavior of a mature or immature B cell during an immune response, resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific" [GO:0002312, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ikbkbtm2Mka/Ikbkbtm2Mka
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0008554 decreased circulating tumor necrosis factor level "reduction in the amount in the blood of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
Show

Allelic Composition: Cdc7tm1Hmas/Cdc7tm1Hmas,Trp53tm2Mok/Trp53tm2Mok
Genetic Background: involves: 129S/Sv * C57BL/6

 MP:0008706 decreased interleukin-6 secretion "reduction in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
Show

Allelic Composition: Traf6tm1Ywc/Traf6tm1Ywc
Genetic Background: Not Specified

Allelic Composition: Ikbkbtm2.1Cgn/Ikbkbtm2.1Cgn
Genetic Background: involves: C57BL/6

 MP:0008719 impaired neutrophil recruitment "reduced diffusion or accumulation of neutrophils in tissues or cells in response to a wide variety of substances released at the sites of inflammatory reactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cdc7tm1Hmas/Cdc7tm1Hmas,Trp53tm2Mok/Trp53tm2Mok
Genetic Background: involves: 129S/Sv * C57BL/6

Allelic Composition: Ikbkbtm1Lex/Ikbkbtm1Lex,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEvBrd

 MP:0008720 impaired neutrophil migration "defect in the ability of neutrophils to move along a chemotactic gradient" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ikbkbtm1Lex/Ikbkbtm1Lex,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEvBrd

 MP:0008735 increased susceptibility to endotoxin shock "more than the expected early reaction of the microcirculation to endotoxins such as LPS, characterized by movement of fluid and leukocytes from the blood into extravascular tissues and often resulting in death" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Csnk1etm1Asil/Csnk1etm1.1Asil
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008770 decreased survivor rate "a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Csnk1etm1Asil/Csnk1etm1.1Asil
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008782 increased B cell apoptosis "increase in the timing or the number of B cells undergoing programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ikbkbtm2Mka/Ikbkbtm2Mka
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0008885 increased enterocyte apoptosis "increase in the timing or the number of B cells undergoing programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Psme3tm1Tchi/Psme3tm1Tchi
Genetic Background: involves: C57BL/6J * CBA

 MP:0008991 abnormal bile canaliculus morphology "any structural anomaly of the intercellular channels that take up bile from hepatocytes and transport it to the bile ducts" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Csnk1etm1Asil/Csnk1etm1.1Asil
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009405 increased skeletal muscle fiber number "increased number of the skeletal muscle fibers, the large multinucleated cells that make up the skeletal muscles" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Relatm1Yuo/Relatm1Yuo,Tnftm1Ljo/Tnftm1Ljo
Genetic Background: involves: 129S/SvEv * 129S1/SvEv

 MP:0011080 increased macrophage apoptosis "greater incidence of cell death in macrophages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ikbkbtm2Mka/Ikbkbtm2Mka,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Ikbkbtm1Cgn/Ikbkbtm1Cgn,Il22tm1Jcrd/Il22tm1Jcrd,Tg(KRT14-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Traf6tm1Ywc/Traf6tm1Ywc
Genetic Background: Not Specified

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Igkctm1Cgn/Igkc+
Genetic Background: involves: C57BL/6

Allelic Composition: Ikbkbtm1Ver/Ikbkbtm1Ver
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Chuktm1Ver/Chuktm1Ver,Ikbkbtm1Ver/Ikbkbtm1Ver
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Ikbkbtm1Trk/Ikbkbtm1Trk
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Chuktm1Ver/Chuktm1Ver,Ikbkbtm1Ver/Ikbkbtm1Ver,Tnfrsf1atm1Mak/Tnfrsf1atm1Mak
Genetic Background: involves: 129/Sv * 129S4/SvJae * C57BL/6J

 MP:0011706 abnormal fibroblast migration "any anomaly of cell migration that is accomplished by extension and retraction of a fibroblast pseudopodium" [GO:0010761]
Show

Allelic Composition: Trp53tm1Ldo/Trp53+
Genetic Background: B6.129S7-Trp53tm1Ldo

 MP:0011708 decreased fibroblast cell migration "reduced frequency of or less rapid cell migration that is accomplished by extension and retraction of a fibroblast pseudopodium" [MGI:csmith]
Show

Allelic Composition: Trp53tm1Ldo/Trp53+
Genetic Background: B6.129S7-Trp53tm1Ldo

 MP:0012261 increased hindbrain apoptosis "increase in the number of cells of the hindbrain undergoing programmed cell death" [MGI:anna]
Show

Allelic Composition: Chuktm1Ver/Chuktm1Ver,Ikbkbtm1Ver/Ikbkbtm1Ver
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0012701 increased embryonic neuroepithelium apoptosis "increase in the number of cells of the embryonic neuroepithelium undergoing programmed cell death" [MGI:anna]
Show

Allelic Composition: Chuktm1Ver/Chuktm1Ver,Ikbkbtm1Ver/Ikbkbtm1Ver
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0013182 increased spinal cord apoptosis "increase in the number of cells of the neural tube undergoing programmed cell death" [MGI:anna]
Show

Allelic Composition: Chuktm1Ver/Chuktm1Ver,Ikbkbtm1Ver/Ikbkbtm1Ver
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0013501 increased fibroblast apoptosis "increase in the timing or the number of fibroblast cells undergoing programmed cell death" [MGI:csmith]
Show

Allelic Composition: Ikbkbtm1Trk/Ikbkbtm1Trk
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Ikbkbtm1.1Cgn/Ikbkbtm1.1Cgn
Genetic Background: involves: C57BL/6

Allelic Composition: Ikbkbtm1Ver/Ikbkbtm1Ver
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0020002 increased response to antigen "increased immune response after exposure to an antigen" [GOC:NV]
Show

Allelic Composition: Hmgcrtm2Ishi/Hmgcrtm2Ishi
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0020416 decreased fibroblast chemotaxis "reduction in the directed movement response of a fibroblast cell population guided by a specific chemical concentration gradient; movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis)" [mgi:anna, PMID:20231695]
Show

Allelic Composition: Trp53tm1Ldo/Trp53+
Genetic Background: B6.129S7-Trp53tm1Ldo

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr