ENSMUSG00000004798


Mus musculus

Features
Gene ID: ENSMUSG00000004798
  
Biological name :Ulk2
  
Synonyms : Q9QY01 / Ulk2 / unc-51 like kinase 2
  
Possible biological names infered from orthology : Q8IYT8 / unc-51 like autophagy activating kinase 2
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: B2
Gene start: 61775649
Gene end: 61855073
  
Corresponding Affymetrix probe sets: 10386789 (MoGene1.0st)   1417846_at (Mouse Genome 430 2.0 Array)   1417847_at (Mouse Genome 430 2.0 Array)   1439591_at (Mouse Genome 430 2.0 Array)   1448858_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000004920
NCBI entrez gene - 29869     See in Manteia.
MGI - MGI:1352758
RefSeq - XM_006533509
RefSeq - NM_013881
RefSeq - XM_006533508
RefSeq Peptide - NP_038909
swissprot - Q9QY01
Ensembl - ENSMUSG00000004798
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ulk2ENSDARG00000097205Danio rerio
 ULK2ENSGALG00000004727Gallus gallus
 ULK2ENSG00000083290Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ulk1 / unc-51 like kinase 1 / O75385* / unc-51 like autophagy activating kinase 1*ENSMUSG0000002951254
Ulk3 / Q3U3Q1 / unc-51-like kinase 3 / Q6PHR2*ENSMUSG0000003230815
Ikbkb / inhibitor of kappaB kinase beta / O14920* / inhibitor of nuclear factor kappa B kinase subunit beta*ENSMUSG0000003153715
Chuk / conserved helix-loop-helix ubiquitous kinase / O15111*ENSMUSG0000002519915
Ikbke / Q9R0T8 / Inhibitor of nuclear factor kappa-B kinase subunit epsilon / Q14164*ENSMUSG0000004234913
Tbk1 / Q9WUN2 / TANK-binding kinase 1 / Q9UHD2*ENSMUSG0000002011512


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR016237  Serine/threonine-protein kinase, Ulk1/Ulk2
 IPR017441  Protein kinase, ATP binding site
 IPR022708  Serine/threonine-protein kinase, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006914 autophagy IMP
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0007409 axonogenesis IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0042594 response to starvation IDA
 biological_processGO:0046777 protein autophosphorylation IEA
 biological_processGO:0048671 negative regulation of collateral sprouting IMP
 biological_processGO:0048675 axon extension IMP
 biological_processGO:0075044 autophagy of host cells involved in interaction with symbiont IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030659 cytoplasmic vesicle membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0034045 phagophore assembly site membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001363 increased anxiety-related response "when compared to controls, subjects exhibit more responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:49752, J:53060]
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Allelic Composition: Casp9tm1Flv/Casp9tm1Flv
Genetic Background: B6.129S1-Casp9tm1Flv

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Kcnn2bc-9J/Kcnn2bc-9J
Genetic Background: C57BL/6J-bc9J/GrsrJ

Allelic Composition: Ulk2tm1Thsn/Ulk2tm1Thsn
Genetic Background: B6.129-Ulk2tm1Thsn

 MP:0010166 increased response to stress-induced hyperthermia "greater increase or faster than expected increase in core body termperature in response to stress or anticipatory anxiety" [PMID:18722480]
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Allelic Composition: Casp9tm1Flv/Casp9tm1Flv
Genetic Background: B6.129S1-Casp9tm1Flv

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Kcnn2bc-9J/Kcnn2bc-9J
Genetic Background: C57BL/6J-bc9J/GrsrJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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