ENSMUSG00000020115


Mus musculus

Features
Gene ID: ENSMUSG00000020115
  
Biological name :Tbk1
  
Synonyms : Q9WUN2 / TANK-binding kinase 1 / Tbk1
  
Possible biological names infered from orthology : Q9UHD2
  
Species: Mus musculus
  
Chr. number: 10
Strand: -1
Band: D2
Gene start: 121546455
Gene end: 121586787
  
Corresponding Affymetrix probe sets: 10372853 (MoGene1.0st)   1422469_at (Mouse Genome 430 2.0 Array)   1445571_at (Mouse Genome 430 2.0 Array)   1460315_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000020316
Ensembl peptide - ENSMUSP00000151935
Ensembl peptide - ENSMUSP00000151440
NCBI entrez gene - 56480     See in Manteia.
MGI - MGI:1929658
RefSeq - NM_019786
RefSeq Peptide - NP_062760
swissprot - A0A1W2P835
swissprot - A0A1W2P6W7
swissprot - A1L361
swissprot - Q9WUN2
Ensembl - ENSMUSG00000020115
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tbk1ENSDARG00000103095Danio rerio
 TBK1ENSGALG00000009840Gallus gallus
 TBK1ENSG00000183735Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ikbke / Q9R0T8 / Inhibitor of nuclear factor kappa-B kinase subunit epsilon / Q14164*ENSMUSG0000004234946
Ikbkb / inhibitor of kappaB kinase beta / O14920* / inhibitor of nuclear factor kappa B kinase subunit beta*ENSMUSG0000003153720
Chuk / conserved helix-loop-helix ubiquitous kinase / O15111*ENSMUSG0000002519918
Ulk1 / unc-51 like kinase 1 / O75385* / unc-51 like autophagy activating kinase 1*ENSMUSG0000002951217
Ulk2 / Q9QY01 / unc-51 like kinase 2 / Q8IYT8* / unc-51 like autophagy activating kinase 2*ENSMUSG0000000479817
Ulk3 / Q3U3Q1 / unc-51-like kinase 3 / Q6PHR2*ENSMUSG0000003230812


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002218 activation of innate immune response IMP
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0010629 negative regulation of gene expression IMP
 biological_processGO:0016239 positive regulation of macroautophagy ISO
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IDA
 biological_processGO:0018107 peptidyl-threonine phosphorylation ISO
 biological_processGO:0032727 positive regulation of interferon-alpha production ISO
 biological_processGO:0032728 positive regulation of interferon-beta production ISO
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IEA
 biological_processGO:0044565 dendritic cell proliferation IGI
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0045359 positive regulation of interferon-beta biosynthetic process IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0050830 defense response to Gram-positive bacterium IMP
 biological_processGO:0051607 defense response to virus IEA
 biological_processGO:1904417 positive regulation of xenophagy IMP
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0016235 aggresome IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003676 nucleic acid binding IDA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0051219 phosphoprotein binding ISO


Pathways (from Reactome)
Pathway description
Regulation of innate immune responses to cytosolic DNA
STAT6-mediated induction of chemokines
IRF3-mediated induction of type I IFN
Interleukin-37 signaling
Negative regulators of DDX58/IFIH1 signaling
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000220 increased monocyte count "greater than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Tbk1tm1.1Lex/Tbk1tm1.1Lex
Genetic Background: involves: 129S4/SvJae * 129S5/SvEvBrd

 MP:0000416 sparse fur "fur that is significantly less dense" [J:46854]
Show

Allelic Composition: Tbk1tm1.1Lex/Tbk1tm1.1Lex
Genetic Background: involves: 129S4/SvJae * 129S5/SvEvBrd

 MP:0000688 lymphoid hyperplasia "increased cell number in lymphatic tissues" [J:62478]
Show

Allelic Composition: Tbk1tm1.1Lex/Tbk1tm1.1Lex
Genetic Background: involves: 129S4/SvJae * 129S5/SvEvBrd

 MP:0001214 skin hyperplasia "increased cell number in the skin; usually results in thick skin" [J:47225]
Show

Allelic Composition: Tbk1tm1.1Lex/Tbk1tm1.1Lex
Genetic Background: involves: 129S4/SvJae * 129S5/SvEvBrd

 MP:0001242 hyperkeratosis "increased depth of the corneal layer of the epidermis; thickening of the horny layer of the epidermis" [J:1133]
Show

Allelic Composition: Tbk1tm1.1Lex/Tbk1tm1.1Lex
Genetic Background: involves: 129S4/SvJae * 129S5/SvEvBrd

 MP:0001511 disheveled coat "coat that looks generally unkempt" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Tbk1tm1.1Lex/Tbk1tm1.1Lex
Genetic Background: involves: 129S4/SvJae * 129S5/SvEvBrd

 MP:0001786 skin edema "accumulation of an excessive amount of fluid in the skin" [J:65039]
Show

Allelic Composition: Tbk1tm1.1Lex/Tbk1tm1.1Lex
Genetic Background: involves: 129S4/SvJae * 129S5/SvEvBrd

 MP:0001805 decreased IgG "less than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Tcf3tm1Wein/Tcf3tm3Zhu
Genetic Background: involves: 129/Sv * 129S4/SvJaeSor * C57BL/6

 MP:0001845 abnormal inflammatory response "aberrant reaction of the microcirculation characterized by movement of fluid and leukocytes from the blood into extravascular tissues" [Pathology:ISBN 0-397-51047-0]
Show

Allelic Composition: Ctsgtm2.1(PML/RARA)Ley/Ctsg+
Genetic Background: involves: 129 * 129X1/SvJ * C57BL/6

Allelic Composition: Tbk1tm1.1Lex/Tbk1tm1.1Lex
Genetic Background: involves: 129S4/SvJae * 129S5/SvEvBrd

 MP:0002060 abnormal skin morphology "malformation or atypical structure of the membranous protective covering of the body" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:56777]
Show

Allelic Composition: Ctsgtm2.1(PML/RARA)Ley/Ctsg+
Genetic Background: involves: 129 * 129X1/SvJ * C57BL/6

 MP:0002136 abnormal kidney physiology "altered ability or inability to excrete urine, not due to anatomical defect" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Dnah11b2b1775Clo/Dnah11b2b1775Clo
Genetic Background: C57BL/6J-Dnah11b2b1775Clo

 MP:0002144 abnormal B lymphocyte development "atypical production of or inability to produce mature B cells, and/or accumulation of B cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tbk1tm1Arte/Tbk1tm1Arte,Map3k14tm1Rds/Map3k14tm1Rds,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129/SvEv * 129P2/OlaHsd * C57BL/6

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Pax7tm1.1(rtTA)Sjl/Pax7tm1.1(rtTA)Sjl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002459 abnormal B cell physiology "abnormal function of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Dnah11b2b1775Clo/Dnah11b2b1775Clo
Genetic Background: C57BL/6J-Dnah11b2b1775Clo

 MP:0002490 abnormal circulating immunoglobulin concentration "deviation from the normal levels of glycoproteins present in the blood and other tissue, often functioning as antibodies" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Map3k14tm1Rds/Map3k14tm1Rds
Genetic Background: involves: 129/Sv

 MP:0002494 increased IgM "greater than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Tbk1tm1Arte/Tbk1tm1Arte,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129/SvEv * 129P2/OlaHsd * C57BL/6

 MP:0002495 increased IgA "greater than normal immunoglobulin class A level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Tbk1tm1.1Lex/Tbk1tm1.1Lex
Genetic Background: involves: 129S4/SvJae * 129S5/SvEvBrd

Allelic Composition: Tbk1tm1Arte/Tbk1tm1Arte,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129/SvEv * 129P2/OlaHsd * C57BL/6

 MP:0002607 decreased basophil count "lower than average number of basophils as measured by the percent of the total number of leukocytes" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, MPD:Mouse Phenome Database]
Show

Allelic Composition: Ctsgtm2.1(PML/RARA)Ley/Ctsg+
Genetic Background: involves: 129 * 129X1/SvJ * C57BL/6

 MP:0002962 increased protein excretion "greater than the normal amount of serum proteins voided by the kidneys" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Tbk1tm1Arte/Tbk1tm1Arte,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129/SvEv * 129P2/OlaHsd * C57BL/6

 MP:0003009 abnormal cytokine secretion "impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tbk1tm1.1Lex/Tbk1tm1.1Lex
Genetic Background: involves: 129S4/SvJae * 129S5/SvEvBrd

 MP:0003103 liver degeneration "deterioration of the liver due to injury or disease, often accompanied by loss of function" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91653]
Show

Allelic Composition: Ptpn11tm1Bgn/Ptpn11+
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0003717 pallor "an unnatural paleness to the skin, generally attributable to anemia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Ptpn11tm1Bgn/Ptpn11+
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0003888 liver hemorrhage "bleeding within the liver" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ptpn11tm1Bgn/Ptpn11+
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0004762 increased anti-double stranded DNA antibody level "increase in the level of antibodies that recognize double stranded DNA" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tbk1tm1Arte/Tbk1tm1Arte,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129/SvEv * 129P2/OlaHsd * C57BL/6

 MP:0004794 increased anti-nuclear antigen antibody level "elevated level of antibodies to nuclear antigens present in the sera" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tbk1tm1Arte/Tbk1tm1Arte,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129/SvEv * 129P2/OlaHsd * C57BL/6

 MP:0004816 abnormal class switch recombination "anomaly in the rearrangement of the heavy chain genes of differentiating B cells such that the initially encoded heavy chain IgM molecule is altered to one encoding IgG, IgA or IgE; normally, this allows the body to produce antibodies with different effector functions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tbk1tm1Arte/Tbk1tm1Arte,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129/SvEv * 129P2/OlaHsd * C57BL/6

 MP:0004947 skin inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tbk1tm1.1Lex/Tbk1tm1.1Lex
Genetic Background: involves: 129S4/SvJae * 129S5/SvEvBrd

 MP:0004952 increased spleen weight "greater than average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tbk1tm1.1Lex/Tbk1tm1.1Lex
Genetic Background: involves: 129S4/SvJae * 129S5/SvEvBrd

 MP:0004971 dermal hyperplasia "overdevelopment or increased size, usually due an increased number of cells in the dermal layer of the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tbk1tm1.1Lex/Tbk1tm1.1Lex
Genetic Background: involves: 129S4/SvJae * 129S5/SvEvBrd

 MP:0005012 decreased eosinophil count "fewer than normal eosinophil numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ctsgtm2.1(PML/RARA)Ley/Ctsg+
Genetic Background: involves: 129 * 129X1/SvJ * C57BL/6

 MP:0005078 abnormal cytotoxic T cell physiology "impaired function of the subset of CD8+ T lymphocytes capable of directly killing appropriately targeted cells " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Tbk1tm1Aki/Tbk1tm1Aki,Tnftm1Sek/Tnftm1Sek
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0005079 defective cytotoxic T cell cytolysis "impaired ability of these cells to destroy or dissolve targeted cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:6692]
Show

Allelic Composition: Tbk1tm1Aki/Tbk1tm1Aki,Tnftm1Sek/Tnftm1Sek
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0005553 increased circulating creatinine level "greater than the normal blood concentration of this product of creatine catabolism; abnormal levels indicative of renal dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Tbk1tm1Arte/Tbk1tm1Arte,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129/SvEv * 129P2/OlaHsd * C57BL/6

 MP:0005565 increased blood urea nitrogen level "high circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Tbk1tm1Arte/Tbk1tm1Arte,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129/SvEv * 129P2/OlaHsd * C57BL/6

 MP:0008039 increased NK T cell number "greater number of the distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repertoire of variable region gene segments" [GO:0001865]
Show

Allelic Composition: Tbk1tm1.1Lex/Tbk1tm1.1Lex
Genetic Background: involves: 129S4/SvJae * 129S5/SvEvBrd

 MP:0008040 decreased NK T cell number "reduced number of the distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repertoire of variable region gene segments" [GO:0001865]
Show

Allelic Composition: Tbk1tm1.1Lex/Tbk1tm1.1Lex
Genetic Background: involves: 129S4/SvJae * 129S5/SvEvBrd

 MP:0008210 increased mature B cell number "greater number of the mature form of B cells, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149]
Show

Allelic Composition: Tbk1tm1Arte/Tbk1tm1Arte,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129/SvEv * 129P2/OlaHsd * C57BL/6

 MP:0008495 decreased IgG1 level "less than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tbk1tm1Aki/Tbk1tm1Aki,Tnftm1Sek/Tnftm1Sek
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0008496 decreased IgG2a level "less than normal immunoglobulin class G2a level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tbk1tm1Aki/Tbk1tm1Aki,Tnftm1Sek/Tnftm1Sek
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0008553 increased circulating tumor necrosis factor level "greater amount in the blood of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
Show

Allelic Composition: Tbk1tm1.1Lex/Tbk1tm1.1Lex
Genetic Background: involves: 129S4/SvJae * 129S5/SvEvBrd

 MP:0008555 abnormal interferon secretion "anomaly in the production or release of proteins secreted by vertebrate cells in response to a wide variety of inducers; they confer resistance against many different viruses, inhibit proliferation of normal and malignant cells, impede multiplication of intracellular parasites, enhance macrophage and granulocyte phagocytosis, augment natural killer cell activity, and show several other immunomodulatory functions" [MESH:D12.644.276.374.440]
Show

Allelic Composition: Pax7tm1.1(rtTA)Sjl/Pax7tm1.1(rtTA)Sjl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008560 increased tumor necrosis factor secretion "increase in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
Show

Allelic Composition: Tbk1tm1.1Lex/Tbk1tm1.1Lex
Genetic Background: involves: 129S4/SvJae * 129S5/SvEvBrd

 MP:0008565 decreased interferon-beta secretion "reduction in the production or release of one of the type I interferons produced by fibroblasts in response to stimulation by live or inactivated virus or by double-stranded RNA with antiviral, antiproliferative, and immunomodulating activity" [MESH:D12.644.276.374.440.890.275]
Show

Allelic Composition: Tbk1tm1.1Lex/Tbk1tm1.1Lex
Genetic Background: involves: 129S4/SvJae * 129S5/SvEvBrd

 MP:0008567 decreased interferon-gamma secretion "reduction in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
Show

Allelic Composition: Tbk1tm1Aki/Tbk1tm1Aki,Tnftm1Sek/Tnftm1Sek
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0008593 increased circulating interleukin-10 level "increase in the amount in the blood of a cytokine produced by a variety of cell types, including T-cells, monocytes, dendritic cells and epithelial cells that exerts a variety of effects on immunoregulation and inflammation" [MESH:D12.644.276.374.465.510]
Show

Allelic Composition: Tbk1tm1.1Lex/Tbk1tm1.1Lex
Genetic Background: involves: 129S4/SvJae * 129S5/SvEvBrd

 MP:0008596 increased circulating interleukin-6 level "increase in the amount in the blood of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
Show

Allelic Composition: Tbk1tm1.1Lex/Tbk1tm1.1Lex
Genetic Background: involves: 129S4/SvJae * 129S5/SvEvBrd

 MP:0008641 increased circulating interleukin-1 beta level "increased in the amount in the blood of an interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein on monocytes, macrophages and other cells; proteolytic processing of the precursor form by caspase 1 results in release of the active form of interleukin-1beta from the membrane" [MESH:D12.644.276.374.465.501.600]
Show

Allelic Composition: Tbk1tm1.1Lex/Tbk1tm1.1Lex
Genetic Background: involves: 129S4/SvJae * 129S5/SvEvBrd

 MP:0008705 increased interleukin-6 secretion "increase in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
Show

Allelic Composition: Tbk1tm1.1Lex/Tbk1tm1.1Lex
Genetic Background: involves: 129S4/SvJae * 129S5/SvEvBrd

 MP:0008713 abnormal cytokine level "deviation from the normal levels of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tbk1tm1.1Lex/Tbk1tm1.1Lex
Genetic Background: involves: 129S4/SvJae * 129S5/SvEvBrd

 MP:0008735 increased susceptibility to endotoxin shock "more than the expected early reaction of the microcirculation to endotoxins such as LPS, characterized by movement of fluid and leukocytes from the blood into extravascular tissues and often resulting in death" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tbk1tm1.1Lex/Tbk1tm1.1Lex
Genetic Background: involves: 129S4/SvJae * 129S5/SvEvBrd

 MP:0008858 abnormal hair cycle anagen phase "anomaly in the growth phase of the hair cycle" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tbk1tm1.1Lex/Tbk1tm1.1Lex
Genetic Background: involves: 129S4/SvJae * 129S5/SvEvBrd

 MP:0009788 increased susceptibility to bacterial infection induced morbidity/mortality "increased likelihood that an organism will display the expected moribund state caused by a bacterial invasion or from components of or toxins produced by bacteria" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tbk1tm1.1Lex/Tbk1tm1.1Lex
Genetic Background: involves: 129S4/SvJae * 129S5/SvEvBrd

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Tbk1tm1.1Lex/Tbk1tm1.1Lex
Genetic Background: involves: 129S4/SvJae * 129S5/SvEvBrd

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Pax7tm1.1(rtTA)Sjl/Pax7tm1.1(rtTA)Sjl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Ptpn11tm1Bgn/Ptpn11+
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Tbk1tm1Aki/Tbk1tm1Aki
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Tbk1tm1.1Lex/Tbk1tm1.1Lex
Genetic Background: involves: 129S4/SvJae * 129S5/SvEvBrd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000003184 Irf3 / P70671 / interferon regulatory factor 3 / Q14653*  / reaction / complex
 ENSMUSG00000039005 Tlr4 / Q9QUK6 / toll-like receptor 4 / O00206*  / reaction / complex
 ENSMUSG00000021277 Traf3 / Q60803 / TNF receptor-associated factor 3 / Q13114*  / reaction / complex
 ENSMUSG00000042349 Ikbke / Q9R0T8 / Inhibitor of nuclear factor kappa-B kinase subunit epsilon / Q14164*  / reaction / complex
 ENSMUSG00000002147 Stat6 / P52633 / Signal transducer and transcription activator 6 / P42226* / signal transducer and activator of transcription 6*  / complex / reaction
 ENSMUSG00000064289 Tank / P70347 / Mus musculus TRAF family member-associated Nf-kappa B activator (Tank), transcript variant 4, mRNA. / Q92844* / TRAF family member associated NFKB activator*  / complex / reaction
 ENSMUSG00000025498 Irf7 / P70434 / interferon regulatory factor 7 / Q92985*  / reaction / complex
 ENSMUSG00000051439 Cd14 / P10810 / Monocyte differentiation antigen CD14 / P08571* / CD14 molecule*  / reaction / complex
 ENSMUSG00000025779 Ly96 / Q9JHF9 / lymphocyte antigen 96 / Q9Y6Y9*  / reaction / complex
 ENSMUSG00000020115 Tbk1 / Q9WUN2 / TANK-binding kinase 1 / Q9UHD2*  / complex / reaction
 ENSMUSG00000024349 Q3TBT3 / Tmem173 / Stimulator of interferons protein / Q86WV6* / transmembrane protein 173*  / complex / reaction
 ENSMUSG00000027514 Zbp1 / Q9QY24 / Z-DNA binding protein 1 / Q9H171*  / reaction / complex
 ENSMUSG00000056130 Q8BJQ4 / Ticam2 / TIR domain-containing adapter molecule 2 / Q86XR7* / toll like receptor adaptor molecule 2*  / reaction / complex
 ENSMUSG00000047123 Q80UF7 / Ticam1 / TIR domain-containing adapter molecule 1 / Q8IUC6* / toll like receptor adaptor molecule 1*  / complex / reaction
 ENSMUSG00000019850 Q60769 / Tnfaip3 / tumor necrosis factor, alpha-induced protein 3 / P21580* / TNF alpha induced protein 3*  / complex / reaction
 ENSMUSG00000039982 Dtx4 / Q6PDK8 / E3 ubiquitin-protein ligase DTX4 / Q9Y2E6* / deltex E3 ubiquitin ligase 4*  / complex / reaction
 ENSMUSG00000004535 Q3UKC1 / Tax1bp1 / Tax1-binding / Q86VP1* / Tax1 binding protein 1*  / complex / reaction






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr