ENSMUSG00000027514


Mus musculus

Features
Gene ID: ENSMUSG00000027514
  
Biological name :Zbp1
  
Synonyms : Q9QY24 / Zbp1 / Z-DNA binding protein 1
  
Possible biological names infered from orthology : Q9H171
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: H3
Gene start: 173206612
Gene end: 173218923
  
Corresponding Affymetrix probe sets: 10490150 (MoGene1.0st)   1419604_at (Mouse Genome 430 2.0 Array)   1429947_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000029018
Ensembl peptide - ENSMUSP00000104744
NCBI entrez gene - 58203     See in Manteia.
MGI - MGI:1927449
RefSeq - NM_001139519
RefSeq - NM_021394
RefSeq Peptide - NP_001132991
RefSeq Peptide - NP_067369
swissprot - Q9QY24
swissprot - A2APF7
Ensembl - ENSMUSG00000027514
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ZBP1ENSG00000124256Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000607  Double-stranded RNA-specific adenosine deaminase (DRADA)
 IPR025735  RHIM domain
 IPR036388  Winged helix-like DNA-binding domain superfamily
 IPR036390  Winged helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0016032 viral process IEA
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0051607 defense response to virus IEA
 biological_processGO:0060340 positive regulation of type I interferon-mediated signaling pathway IMP
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005737 cytoplasm ISO
 cellular_componentGO:0005829 cytosol TAS
 molecular_functionGO:0003677 DNA binding ISO
 molecular_functionGO:0003692 left-handed Z-DNA binding IDA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0003726 double-stranded RNA adenosine deaminase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0042802 identical protein binding ISO


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002418 increased susceptibility to viral infection "greater likelihood that an organism will develop ill effects from a viral infection or from components of or toxins produced by a virus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Arl8btm1Kkon/Arl8btm1Kkon,Tg(Ttr-cre)1Hadj/0
Genetic Background: involves: C57BL/6J * C57BL/6N * CBA/J

 MP:0012555 decreased cell death "decreased occurrence of the cessation of function at the cellular level" [http://orcid.org/0000-0001-5208-3432]
Show

Allelic Composition: Arl8btm1Kkon/Arl8btm1Kkon,Tg(Ttr-cre)1Hadj/0
Genetic Background: involves: C57BL/6J * C57BL/6N * CBA/J

 MP:0013293 embryonic lethality prior to tooth bud stage "death prior to the appearance of tooth buds (Mus: E12-E12.5)" [MGI:smb]
Show

Allelic Composition: Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+,Ripk3tm1Arte/Ripk3tm1Arte
Genetic Background: involves: C57BL/6NTac

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000003184 Irf3 / P70671 / interferon regulatory factor 3 / Q14653*  / complex / reaction
 ENSMUSG00000020115 Tbk1 / Q9WUN2 / TANK-binding kinase 1 / Q9UHD2*  / reaction / complex
 ENSMUSG00000027514 Zbp1 / Q9QY24 / Z-DNA binding protein 1 / Q9H171*  / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr