ENSG00000124256


Homo sapiens

Features
Gene ID: ENSG00000124256
  
Biological name :ZBP1
  
Synonyms : Q9H171 / ZBP1 / Z-DNA binding protein 1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 20
Strand: -1
Band: q13.31
Gene start: 57603846
Gene end: 57620576
  
Corresponding Affymetrix probe sets: 208087_s_at (Human Genome U133 Plus 2.0 Array)   242020_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000360215
Ensembl peptide - ENSP00000379167
Ensembl peptide - ENSP00000404620
Ensembl peptide - ENSP00000440552
NCBI entrez gene - 81030     See in Manteia.
OMIM - 606750
RefSeq - XM_017028086
RefSeq - NM_001160417
RefSeq - NM_001160418
RefSeq - NM_001160419
RefSeq - NM_001323966
RefSeq - NM_030776
RefSeq - XM_011529057
RefSeq - XM_011529058
RefSeq Peptide - NP_001153889
RefSeq Peptide - NP_001153890
RefSeq Peptide - NP_110403
RefSeq Peptide - NP_001153891
RefSeq Peptide - NP_001310895
swissprot - Q9H171
swissprot - H0Y6D1
Ensembl - ENSG00000124256
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Zbp1ENSMUSG00000027514Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000607  Double-stranded RNA-specific adenosine deaminase (DRADA)
 IPR025735  RHIM domain
 IPR036388  Winged helix-like DNA-binding domain superfamily
 IPR036390  Winged helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0008150 biological_process ND
 biological_processGO:0032479 regulation of type I interferon production TAS
 biological_processGO:0032481 positive regulation of type I interferon production TAS
 biological_processGO:0045087 innate immune response IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005829 cytosol IDA
 molecular_functionGO:0003677 DNA binding IDA
 molecular_functionGO:0003692 left-handed Z-DNA binding NAS
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0003726 double-stranded RNA adenosine deaminase activity IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
ZBP1(DAI) mediated induction of type I IFNs
IRF3 mediated activation of type 1 IFN
RIP-mediated NFkB activation via ZBP1
Regulation of innate immune responses to cytosolic DNA


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000129465 RIPK3 / Q9Y572 / receptor interacting serine/threonine kinase 3  / reaction / complex
 ENSG00000137275 RIPK1 / Q13546 / receptor interacting serine/threonine kinase 1  / reaction / complex
 ENSG00000183735 TBK1 / Q9UHD2 / TANK binding kinase 1  / reaction / complex
 ENSG00000160505 NLRP4 / Q96MN2 / NLR family pyrin domain containing 4  / complex / reaction
 ENSG00000110042 DTX4 / Q9Y2E6 / deltex E3 ubiquitin ligase 4  / reaction / complex
 ENSG00000124256 ZBP1 / Q9H171 / Z-DNA binding protein 1  / complex / reaction
 ENSG00000126456 IRF3 / Q14653 / interferon regulatory factor 3  / complex / reaction






 

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