ENSG00000160505


Homo sapiens

Features
Gene ID: ENSG00000160505
  
Biological name :NLRP4
  
Synonyms : NLR family pyrin domain containing 4 / NLRP4 / Q96MN2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: 1
Band: q13.43
Gene start: 55836578
Gene end: 55881854
  
Corresponding Affymetrix probe sets: 242334_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000301295
Ensembl peptide - ENSP00000465463
Ensembl peptide - ENSP00000468496
Ensembl peptide - ENSP00000468754
NCBI entrez gene - 147945     See in Manteia.
OMIM - 609645
RefSeq - XM_017026345
RefSeq - NM_134444
RefSeq - XM_017026344
RefSeq Peptide - NP_604393
swissprot - Q96MN2
swissprot - K7ESK5
swissprot - K7ES09
Ensembl - ENSG00000160505
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 FO704635.1ENSDARG00000105141Danio rerio
 nlrb5ENSDARG00000090699Danio rerio
 si:ch211-66k16.2ENSDARG00000095634Danio rerio
 si:ch211-66k16.28ENSDARG00000088423Danio rerio
 Nlrp4aENSMUSG00000040601Mus musculus
 Nlrp4bENSMUSG00000034087Mus musculus
 Nlrp4cENSMUSG00000034690Mus musculus
 Nlrp4eENSMUSG00000045693Mus musculus
 Nlrp4fENSMUSG00000032999Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
NLRP14 / Q86W24 / NLR family pyrin domain containing 14ENSG0000015807741
NLRP9 / Q7RTR0 / NLR family pyrin domain containing 9ENSG0000018579241
NLRP13 / Q86W25 / NLR family pyrin domain containing 13ENSG0000017357234
NLRP12 / P59046 / NLR family pyrin domain containing 12ENSG0000014240534
NLRP11 / P59045 / NLR family pyrin domain containing 11ENSG0000017987334
NLRP3 / Q96P20 / NLR family pyrin domain containing 3ENSG0000016271134
NLRP2 / Q9NX02 / NLR family pyrin domain containing 2ENSG0000002255633
NLRP5 / P59047 / NLR family pyrin domain containing 5ENSG0000017148733
NLRP7 / Q8WX94 / NLR family pyrin domain containing 7ENSG0000016763431
NLRP8 / Q86W28 / NLR family pyrin domain containing 8ENSG0000017970931
NLRP1 / Q9C000 / NLR family pyrin domain containing 1ENSG0000009159228
NLRP6 / P59044 / NLR family pyrin domain containing 6ENSG0000017488524
NLRP10 / Q86W26 / NLR family pyrin domain containing 10ENSG0000018226117
RNH1 / P13489 / ribonuclease/angiogenin inhibitor 1ENSG0000002319112


Protein motifs (from Interpro)
Interpro ID Name
 IPR001611  Leucine-rich repeat
 IPR004020  DAPIN domain
 IPR007111  NACHT nucleoside triphosphatase
 IPR011029  Death-like domain superfamily
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR032675  Leucine-rich repeat domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0032479 regulation of type I interferon production TAS
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005524 ATP binding IEA


Pathways (from Reactome)
Pathway description
IRF3 mediated activation of type 1 IFN
Regulation of innate immune responses to cytosolic DNA
IRF3-mediated induction of type I IFN


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000110042 DTX4 / Q9Y2E6 / deltex E3 ubiquitin ligase 4  / reaction / complex
 ENSG00000126456 IRF3 / Q14653 / interferon regulatory factor 3  / reaction / complex
 ENSG00000183735 TBK1 / Q9UHD2 / TANK binding kinase 1  / reaction / complex
 ENSG00000184584 Q86WV6 / TMEM173 / transmembrane protein 173  / reaction / complex
 ENSG00000124256 ZBP1 / Q9H171 / Z-DNA binding protein 1  / reaction / complex






 

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