ENSG00000174885


Homo sapiens

Features
Gene ID: ENSG00000174885
  
Biological name :NLRP6
  
Synonyms : NLR family pyrin domain containing 6 / NLRP6 / P59044
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: 1
Band: p15.5
Gene start: 278365
Gene end: 285359
  
Corresponding Affymetrix probe sets: 1552932_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000309767
Ensembl peptide - ENSP00000433617
NCBI entrez gene - 171389     See in Manteia.
OMIM - 609650
RefSeq - XM_017017253
RefSeq - NM_001276700
RefSeq - NM_138329
RefSeq - XM_011519931
RefSeq Peptide - NP_001263629
RefSeq Peptide - NP_612202
swissprot - P59044
Ensembl - ENSG00000174885
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 FO704635.1ENSDARG00000105141Danio rerio
 nlrb5ENSDARG00000090699Danio rerio
 si:ch211-66k16.2ENSDARG00000095634Danio rerio
 si:ch211-66k16.28ENSDARG00000088423Danio rerio
 Nlrp6ENSMUSG00000038745Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
NLRP12 / P59046 / NLR family pyrin domain containing 12ENSG0000014240533
NLRP3 / Q96P20 / NLR family pyrin domain containing 3ENSG0000016271133
NLRP7 / Q8WX94 / NLR family pyrin domain containing 7ENSG0000016763429
NLRP1 / Q9C000 / NLR family pyrin domain containing 1ENSG0000009159228
NLRP14 / Q86W24 / NLR family pyrin domain containing 14ENSG0000015807727
NLRP4 / Q96MN2 / NLR family pyrin domain containing 4ENSG0000016050527
NLRP2 / Q9NX02 / NLR family pyrin domain containing 2ENSG0000002255627
NLRP9 / Q7RTR0 / NLR family pyrin domain containing 9ENSG0000018579226
NLRP5 / P59047 / NLR family pyrin domain containing 5ENSG0000017148726
NLRP13 / Q86W25 / NLR family pyrin domain containing 13ENSG0000017357225
NLRP8 / Q86W28 / NLR family pyrin domain containing 8ENSG0000017970924
NLRP11 / P59045 / NLR family pyrin domain containing 11ENSG0000017987322
NLRP10 / Q86W26 / NLR family pyrin domain containing 10ENSG0000018226120
RNH1 / P13489 / ribonuclease/angiogenin inhibitor 1ENSG000000231917


Protein motifs (from Interpro)
Interpro ID Name
 IPR004020  DAPIN domain
 IPR007111  NACHT nucleoside triphosphatase
 IPR011029  Death-like domain superfamily
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0002862 negative regulation of inflammatory response to antigenic stimulus IEA
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0009617 response to bacterium IEA
 biological_processGO:0010506 regulation of autophagy IEA
 biological_processGO:0034122 negative regulation of toll-like receptor signaling pathway IEA
 biological_processGO:0042060 wound healing IEA
 biological_processGO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling IEA
 biological_processGO:0043409 negative regulation of MAPK cascade IEA
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0050727 regulation of inflammatory response IEA
 biological_processGO:0050777 negative regulation of immune response IEA
 biological_processGO:0070255 regulation of mucus secretion IEA
 biological_processGO:0070373 negative regulation of ERK1 and ERK2 cascade IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031965 nuclear membrane IEA
 cellular_componentGO:0061702 inflammasome complex IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005000 vasopressin receptor activity ISS
 molecular_functionGO:0005524 ATP binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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