ENSG00000022556


Homo sapiens

Features
Gene ID: ENSG00000022556
  
Biological name :NLRP2
  
Synonyms : NLR family pyrin domain containing 2 / NLRP2 / Q9NX02
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: 1
Band: q13.42
Gene start: 54953130
Gene end: 55001142
  
Corresponding Affymetrix probe sets: 221690_s_at (Human Genome U133 Plus 2.0 Array)   237489_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000442351
Ensembl peptide - ENSP00000465069
Ensembl peptide - ENSP00000466260
Ensembl peptide - ENSP00000466537
Ensembl peptide - ENSP00000467349
Ensembl peptide - ENSP00000469973
Ensembl peptide - ENSP00000263437
Ensembl peptide - ENSP00000344074
Ensembl peptide - ENSP00000375601
Ensembl peptide - ENSP00000402474
Ensembl peptide - ENSP00000409370
Ensembl peptide - ENSP00000440601
Ensembl peptide - ENSP00000441363
Ensembl peptide - ENSP00000443519
Ensembl peptide - ENSP00000445135
Ensembl peptide - ENSP00000445846
NCBI entrez gene - 55655     See in Manteia.
OMIM - 609364
RefSeq - NM_001348003
RefSeq - NM_017852
RefSeq - NM_001174082
RefSeq - NM_001174083
RefSeq - NM_001174081
RefSeq Peptide - NP_001334932
RefSeq Peptide - NP_060322
RefSeq Peptide - NP_001167553
RefSeq Peptide - NP_001167552
RefSeq Peptide - NP_001167554
swissprot - Q9NX02
swissprot - A0A0G2JLJ4
swissprot - F5GYZ4
swissprot - F5H5B1
swissprot - F5H7Q5
swissprot - H0YH35
swissprot - J3KN39
swissprot - K7EJ90
swissprot - K7ELX1
swissprot - K7EMK2
swissprot - K7EPE6
Ensembl - ENSG00000022556
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 FO704635.1ENSDARG00000105141Danio rerio
 nlrb5ENSDARG00000090699Danio rerio
 si:ch211-66k16.2ENSDARG00000095634Danio rerio
 si:ch211-66k16.28ENSDARG00000088423Danio rerio
 Nlrp2ENSMUSG00000035177Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
NLRP7 / Q8WX94 / NLR family pyrin domain containing 7ENSG0000016763462
NLRP14 / Q86W24 / NLR family pyrin domain containing 14ENSG0000015807735
NLRP3 / Q96P20 / NLR family pyrin domain containing 3ENSG0000016271131
NLRP12 / P59046 / NLR family pyrin domain containing 12ENSG0000014240531
NLRP4 / Q96MN2 / NLR family pyrin domain containing 4ENSG0000016050531
NLRP9 / Q7RTR0 / NLR family pyrin domain containing 9ENSG0000018579230
NLRP13 / Q86W25 / NLR family pyrin domain containing 13ENSG0000017357229
NLRP5 / P59047 / NLR family pyrin domain containing 5ENSG0000017148729
NLRP1 / Q9C000 / NLR family pyrin domain containing 1ENSG0000009159227
NLRP8 / Q86W28 / NLR family pyrin domain containing 8ENSG0000017970927
NLRP11 / P59045 / NLR family pyrin domain containing 11ENSG0000017987326
NLRP6 / P59044 / NLR family pyrin domain containing 6ENSG0000017488523
NLRP10 / Q86W26 / NLR family pyrin domain containing 10ENSG0000018226115
RNH1 / P13489 / ribonuclease/angiogenin inhibitor 1ENSG0000002319111


Protein motifs (from Interpro)
Interpro ID Name
 IPR001611  Leucine-rich repeat
 IPR004020  DAPIN domain
 IPR007111  NACHT nucleoside triphosphatase
 IPR011029  Death-like domain superfamily
 IPR011989  Armadillo-like helical
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR032675  Leucine-rich repeat domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0032088 negative regulation of NF-kappaB transcription factor activity IGI
 biological_processGO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process IDA
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0050718 positive regulation of interleukin-1 beta secretion IDA
 cellular_componentGO:0000784 nuclear chromosome, telomeric region IDA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005794 Golgi apparatus IDA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0032090 Pyrin domain binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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