Manteia

ENSMUSG00000045693

Mus musculus

Features

Gene ID:	ENSMUSG00000045693

Biological name :	Nlrp4e

Synonyms :	NACHT, LRR and PYD domains-containing protein 4E / Nlrp4e / Q66X19

Possible biological names infered from orthology :	NLR family pyrin domain containing 4 / NLRP4 / Q96MN2

Species:	Mus musculus

Chr. number:	7
Strand:	1
Band:	A3
Gene start:	23301192
Gene end:	23362277

Corresponding Affymetrix probe sets:	10550790 (MoGene1.0st) 10560746 (MoGene1.0st) 1457179_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000075794 NCBI entrez gene - 446099 See in Manteia. MGI - MGI:3056600 RefSeq - NM_001004194 RefSeq Peptide - NP_001004194 swissprot - Q66X19 Ensembl - ENSMUSG00000045693

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
FO704635.1	ENSDARG00000105141	Danio rerio
nlrb5	ENSDARG00000090699	Danio rerio
si:ch211-66k16.2	ENSDARG00000095634	Danio rerio
si:ch211-66k16.28	ENSDARG00000088423	Danio rerio
NLRP4	ENSG00000160505	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Nlrp4c / Q3TKR3 / NACHT, LRR and PYD domains-containing protein 4C / NLRP4* / Q96MN2* / NLR family pyrin domain containing 4*	ENSMUSG00000034690	89
Nlrp4a / Q8BU40 / NACHT, LRR and PYD domains-containing protein 4A / NLRP4* / Q96MN2* / NLR family pyrin domain containing 4*	ENSMUSG00000040601	76
Nlrp4f / NLRP4* / Q96MN2* / NLR family pyrin domain containing 4*	ENSMUSG00000032999	68
Nlrp4b / Q8C6J9 / Mus musculus NLR family, pyrin domain containing 4B (Nlrp4b), transcript variant 2, mRNA. / NLRP4* / Q96MN2* / NLR family pyrin domain containing 4*	ENSMUSG00000034087	55
Nlrp9c / Q66X01 / NACHT, LRR and PYD domains-containing protein 9C / NLRP9* / Q7RTR0* / NLR family pyrin domain containing 9*	ENSMUSG00000040614	33
Nlrp9b / Q66X22 / NACHT, LRR and PYD domains-containing protein 9B / NLRP9* / Q7RTR0* / NLR family pyrin domain containing 9*	ENSMUSG00000060508	33
Nlrp9a / NACHT, LRR and PYD domains-containing protein 9A isoform 3 / NLRP9* / Q7RTR0* / NLR family pyrin domain containing 9*	ENSMUSG00000054102	33
Nlrp3 / Q8R4B8 / NACHT, LRR and PYD domains-containing protein 3 / Q96P20* / NLR family pyrin domain containing 3*	ENSMUSG00000032691	31
E9Q5R7 / Nlrp12 / NACHT, LRR and PYD domains-containing protein 12 / P59046* / NLR family pyrin domain containing 12*	ENSMUSG00000078817	29
Nlrp14 / Q6B966 / NACHT, LRR and PYD domains-containing protein 14 / Q86W24* / NLR family pyrin domain containing 14*	ENSMUSG00000016626	28
Nlrp5 / Q9R1M5 / NACHT, LRR and PYD domains-containing protein 5 / P59047* / NLR family pyrin domain containing 5*	ENSMUSG00000015721	27
Nlrp2 / NLRP7* / Q8WX94* / Q9NX02* / NLR family pyrin domain containing 7* / NLR family pyrin domain containing 2*	ENSMUSG00000035177	25
Nlrp1a / Q2LKU9 / NACHT, LRR and PYD domains-containing protein 1a / NLRP1* / Q9C000* / NLR family pyrin domain containing 1*	ENSMUSG00000069830	23
A1Z198 / Nlrp1b / NACHT, LRR and PYD domains-containing protein 1b allele 2 / NLRP1* / Q9C000* / NLR family pyrin domain containing 1*	ENSMUSG00000070390	22
Nlrp6 / Q91WS2 / NACHT, LRR and PYD domains-containing protein 6 / P59044* / NLR family pyrin domain containing 6*	ENSMUSG00000038745	21
Nlrp10 / Q8CCN1 / NACHT, LRR and PYD domains-containing protein 10 / Q86W26* / NLR family pyrin domain containing 10*	ENSMUSG00000049709	15
Rnh1 / Q91VI7 / Ribonuclease inhibitor / P13489* / ribonuclease/angiogenin inhibitor 1*	ENSMUSG00000038650	11

Protein motifs (from Interpro)

Interpro ID	Name
IPR001611	Leucine-rich repeat
IPR004020	DAPIN domain
IPR007111	NACHT nucleoside triphosphatase
IPR011029	Death-like domain superfamily
IPR027417	P-loop containing nucleoside triphosphate hydrolase

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0006954	inflammatory response	IEA
biological_process	GO:0008150	biological_process	ND
molecular_function	GO:0000166	nucleotide binding	IEA
molecular_function	GO:0003674	molecular_function	ND
molecular_function	GO:0005515	protein binding	IEA
molecular_function	GO:0005524	ATP binding	IEA

Pathways (from Reactome)

Pathway description

Regulation of innate immune responses to cytosolic DNA

IRF3-mediated induction of type I IFN

Phenotype (from MGI, Zfin or HPO)

Phenotype

Definition

Genetic BG

No match

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

0 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr