ENSMUSG00000049709


Mus musculus

Features
Gene ID: ENSMUSG00000049709
  
Biological name :Nlrp10
  
Synonyms : NACHT, LRR and PYD domains-containing protein 10 / Nlrp10 / Q8CCN1
  
Possible biological names infered from orthology : NLR family pyrin domain containing 10 / Q86W26
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: E3
Gene start: 108921852
Gene end: 108930178
  
Corresponding Affymetrix probe sets: 10566709 (MoGene1.0st)   1456211_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000050252
NCBI entrez gene - 244202     See in Manteia.
MGI - MGI:2444084
RefSeq - NM_175532
RefSeq Peptide - NP_780741
swissprot - Q6JGS9
swissprot - Q8CCN1
Ensembl - ENSMUSG00000049709
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 FO704635.1ENSDARG00000105141Danio rerio
 nlrb5ENSDARG00000090699Danio rerio
 si:ch211-66k16.2ENSDARG00000095634Danio rerio
 si:ch211-66k16.28ENSDARG00000088423Danio rerio
 NLRP10ENSG00000182261Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Nlrp3 / Q8R4B8 / NACHT, LRR and PYD domains-containing protein 3 / Q96P20* / NLR family pyrin domain containing 3*ENSMUSG0000003269130
E9Q5R7 / Nlrp12 / NACHT, LRR and PYD domains-containing protein 12 / P59046* / NLR family pyrin domain containing 12*ENSMUSG0000007881728
Nlrp6 / Q91WS2 / NACHT, LRR and PYD domains-containing protein 6 / P59044* / NLR family pyrin domain containing 6*ENSMUSG0000003874526
Nlrp1a / Q2LKU9 / NACHT, LRR and PYD domains-containing protein 1a / NLRP1* / Q9C000* / NLR family pyrin domain containing 1*ENSMUSG0000006983024
A1Z198 / Nlrp1b / NACHT, LRR and PYD domains-containing protein 1b allele 2 / NLRP1* / Q9C000* / NLR family pyrin domain containing 1*ENSMUSG0000007039024
Nlrp4c / Q3TKR3 / NACHT, LRR and PYD domains-containing protein 4C / NLRP4* / Q96MN2* / NLR family pyrin domain containing 4*ENSMUSG0000003469022
Nlrp4a / Q8BU40 / NACHT, LRR and PYD domains-containing protein 4A / NLRP4* / Q96MN2* / NLR family pyrin domain containing 4*ENSMUSG0000004060122
Nlrp4f / NLRP4* / Q96MN2* / NLR family pyrin domain containing 4*ENSMUSG0000003299921
Nlrp14 / Q6B966 / NACHT, LRR and PYD domains-containing protein 14 / Q86W24* / NLR family pyrin domain containing 14*ENSMUSG0000001662621
Nlrp4e / Q66X19 / NACHT, LRR and PYD domains-containing protein 4E / NLRP4* / Q96MN2* / NLR family pyrin domain containing 4*ENSMUSG0000004569321
Nlrp4b / Q8C6J9 / Mus musculus NLR family, pyrin domain containing 4B (Nlrp4b), transcript variant 2, mRNA. / NLRP4* / Q96MN2* / NLR family pyrin domain containing 4*ENSMUSG0000003408720
Nlrp9b / Q66X22 / NACHT, LRR and PYD domains-containing protein 9B / NLRP9* / Q7RTR0* / NLR family pyrin domain containing 9*ENSMUSG0000006050819
Nlrp2 / NLRP7* / Q8WX94* / Q9NX02* / NLR family pyrin domain containing 7* / NLR family pyrin domain containing 2*ENSMUSG0000003517719
Nlrp9a / NACHT, LRR and PYD domains-containing protein 9A isoform 3 / NLRP9* / Q7RTR0* / NLR family pyrin domain containing 9*ENSMUSG0000005410219
Nlrp9c / Q66X01 / NACHT, LRR and PYD domains-containing protein 9C / NLRP9* / Q7RTR0* / NLR family pyrin domain containing 9*ENSMUSG0000004061418
Nlrp5 / Q9R1M5 / NACHT, LRR and PYD domains-containing protein 5 / P59047* / NLR family pyrin domain containing 5*ENSMUSG0000001572118
Rnh1 / Q91VI7 / Ribonuclease inhibitor / P13489* / ribonuclease/angiogenin inhibitor 1*ENSMUSG000000386504


Protein motifs (from Interpro)
Interpro ID Name
 IPR004020  DAPIN domain
 IPR007111  NACHT nucleoside triphosphatase
 IPR011029  Death-like domain superfamily
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002250 adaptive immune response IEA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0002827 positive regulation of T-helper 1 type immune response IMP
 biological_processGO:0006952 defense response RCA
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0050717 positive regulation of interleukin-1 alpha secretion ISS
 biological_processGO:0050729 positive regulation of inflammatory response IMP
 biological_processGO:0050829 defense response to Gram-negative bacterium IEA
 biological_processGO:0050832 defense response to fungus IMP
 biological_processGO:1900426 positive regulation of defense response to bacterium IEA
 biological_processGO:2000318 positive regulation of T-helper 17 type immune response IMP
 biological_processGO:2000484 positive regulation of interleukin-8 secretion IEA
 biological_processGO:2000778 positive regulation of interleukin-6 secretion IEA
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0019897 extrinsic component of plasma membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003924 GTPase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016887 ATPase activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002376 abnormal dendritic cell physiology "failure or atypical function of the immunocompetent cells of the lymphoid and hemopoietic systems and skin, which function to process antigens and present them to T cells, thus stimulating cellular immunity" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:85808]
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Allelic Composition: Psen1tm3.1Shn/Psen1tm3.1Shn,Psen2tm1Haa/Psen2tm1Haa
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * CBA

 MP:0002420 abnormal adaptive immunity "anomaly in the function of the response of antigen-specific lymphocytes to antigen, including the development of immunological memory" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Psen1tm3.1Shn/Psen1tm3.1Shn,Psen2tm1Haa/Psen2tm1Haa
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * CBA

 MP:0004800 decreased susceptibility to experimental autoimmune encephalomyelitis "reduced likelihood that an organism will develop disease symptoms similar to human multiple sclerosis upon induction with antigens to Myelin Basic Protein (MBP), Proteolipid Protein (PLP), and/or Myelin Oligodendrocyte glycoprotein (MOG)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Psen1tm3.1Shn/Psen1tm3.1Shn,Psen2tm1Haa/Psen2tm1Haa
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * CBA

 MP:0005466 abnormal T helper 2 physiology "anomalous response of the subset of T helper cells that enhance humoral immunity and inhibit cell-mediated immune responses; these cells produce IL-4 and induce B cells to produce IgE and IgG1, while also supporting eosinophil and mast cell functions " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Psen1tm3.1Shn/Psen1tm3.1Shn,Psen2tm1Haa/Psen2tm1Haa
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * CBA

 MP:0008127 decreased dendritic cell number "reduction in the number of a cells of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation" [ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Psen1tm3.1Shn/Psen1tm3.1Shn,Psen2tm1Haa/Psen2tm1Haa
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * CBA

 MP:0008495 decreased IgG1 level "less than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Psen1tm3.1Shn/Psen1tm3.1Shn,Psen2tm1Haa/Psen2tm1Haa
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * CBA

 MP:0008567 decreased interferon-gamma secretion "reduction in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Psen1tm3.1Shn/Psen1tm3.1Shn,Psen2tm1Haa/Psen2tm1Haa
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * CBA

 MP:0008682 decreased interleukin-17 secretion "reduction in the production or release of a proinflammatory cytokine produced primarily by T-cells or their precursors" [MESH:D12.644.276.374.465.517]
Show

Allelic Composition: Psen1tm3.1Shn/Psen1tm3.1Shn,Psen2tm1Haa/Psen2tm1Haa
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * CBA

 MP:0008734 decreased susceptibility to endotoxin shock "less than the expected early reaction of the microcirculation to endotoxins such as LPS, characterized by movement of fluid and leukocytes from the blood into extravascular tissues and often resulting in death" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Psen1tm3.1Shn/Psen1tm3.1Shn,Psen2tm1Haa/Psen2tm1Haa
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * CBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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