ENSMUSG00000069830


Mus musculus

Features
Gene ID: ENSMUSG00000069830
  
Biological name :Nlrp1a
  
Synonyms : NACHT, LRR and PYD domains-containing protein 1a / Nlrp1a / Q2LKU9
  
Possible biological names infered from orthology : NLR family pyrin domain containing 1 / NLRP1 / Q9C000
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: B4
Gene start: 71092236
Gene end: 71144704
  
Corresponding Affymetrix probe sets: 10388047 (MoGene1.0st)   
  
Cross references: Ensembl peptide - ENSMUSP00000038186
Ensembl peptide - ENSMUSP00000104158
NCBI entrez gene - 195046     See in Manteia.
MGI - MGI:2684861
RefSeq - XM_017314355
RefSeq - NM_001004142
RefSeq - XM_017314354
RefSeq Peptide - NP_001004142
swissprot - Q2LKU9
Ensembl - ENSMUSG00000069830
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 FO704635.1ENSDARG00000105141Danio rerio
 nlrb5ENSDARG00000090699Danio rerio
 si:ch211-66k16.2ENSDARG00000095634Danio rerio
 si:ch211-66k16.28ENSDARG00000088423Danio rerio
 NLRP1ENSG00000091592Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
A1Z198 / Nlrp1b / NACHT, LRR and PYD domains-containing protein 1b allele 2 / NLRP1* / Q9C000* / NLR family pyrin domain containing 1*ENSMUSG0000007039078
E9Q5R7 / Nlrp12 / NACHT, LRR and PYD domains-containing protein 12 / P59046* / NLR family pyrin domain containing 12*ENSMUSG0000007881723
Nlrp3 / Q8R4B8 / NACHT, LRR and PYD domains-containing protein 3 / Q96P20* / NLR family pyrin domain containing 3*ENSMUSG0000003269122
Nlrp4c / Q3TKR3 / NACHT, LRR and PYD domains-containing protein 4C / NLRP4* / Q96MN2* / NLR family pyrin domain containing 4*ENSMUSG0000003469020
Nlrp14 / Q6B966 / NACHT, LRR and PYD domains-containing protein 14 / Q86W24* / NLR family pyrin domain containing 14*ENSMUSG0000001662620
Nlrp5 / Q9R1M5 / NACHT, LRR and PYD domains-containing protein 5 / P59047* / NLR family pyrin domain containing 5*ENSMUSG0000001572119
Nlrp4e / Q66X19 / NACHT, LRR and PYD domains-containing protein 4E / NLRP4* / Q96MN2* / NLR family pyrin domain containing 4*ENSMUSG0000004569319
Nlrp4a / Q8BU40 / NACHT, LRR and PYD domains-containing protein 4A / NLRP4* / Q96MN2* / NLR family pyrin domain containing 4*ENSMUSG0000004060119
Nlrp6 / Q91WS2 / NACHT, LRR and PYD domains-containing protein 6 / P59044* / NLR family pyrin domain containing 6*ENSMUSG0000003874518
Nlrp4f / NLRP4* / Q96MN2* / NLR family pyrin domain containing 4*ENSMUSG0000003299918
Nlrp9b / Q66X22 / NACHT, LRR and PYD domains-containing protein 9B / NLRP9* / Q7RTR0* / NLR family pyrin domain containing 9*ENSMUSG0000006050817
Nlrp2 / NLRP7* / Q8WX94* / Q9NX02* / NLR family pyrin domain containing 7* / NLR family pyrin domain containing 2*ENSMUSG0000003517717
Nlrp9a / NACHT, LRR and PYD domains-containing protein 9A isoform 3 / NLRP9* / Q7RTR0* / NLR family pyrin domain containing 9*ENSMUSG0000005410217
Nlrp9c / Q66X01 / NACHT, LRR and PYD domains-containing protein 9C / NLRP9* / Q7RTR0* / NLR family pyrin domain containing 9*ENSMUSG0000004061416
Nlrp4b / Q8C6J9 / Mus musculus NLR family, pyrin domain containing 4B (Nlrp4b), transcript variant 2, mRNA. / NLRP4* / Q96MN2* / NLR family pyrin domain containing 4*ENSMUSG0000003408715
Nlrp10 / Q8CCN1 / NACHT, LRR and PYD domains-containing protein 10 / Q86W26* / NLR family pyrin domain containing 10*ENSMUSG0000004970913
Rnh1 / Q91VI7 / Ribonuclease inhibitor / P13489* / ribonuclease/angiogenin inhibitor 1*ENSMUSG000000386508


Protein motifs (from Interpro)
Interpro ID Name
 IPR001315  CARD domain
 IPR001611  Leucine-rich repeat
 IPR007111  NACHT nucleoside triphosphatase
 IPR011029  Death-like domain superfamily
 IPR025307  FIIND domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR033516  CARD8/ASC/NALP1, CARD domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process ISS
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0032495 response to muramyl dipeptide IDA
 biological_processGO:0042742 defense response to bacterium IDA
 biological_processGO:0042981 regulation of apoptotic process IEA
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0050718 positive regulation of interleukin-1 beta secretion IDA
 biological_processGO:0051402 neuron apoptotic process ISS
 biological_processGO:0097300 programmed necrotic cell death IDA
 cellular_componentGO:0005634 nucleus ISS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0061702 inflammasome complex IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding ISS
 molecular_functionGO:0019899 enzyme binding ISS


Pathways (from Reactome)
Pathway description
The NLRP1 inflammasome


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000217 abnormal white blood cell count "anomalies in the number of leukocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Cd3etm1.1Geno/Cd3etm1.1Geno,Tg(TcrAND)53Hed/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0000219 increased neutrophil count "greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Nlrp1aNeut1/Nlrp1aNeut1
Genetic Background: C.B6-Nlrp1aNeut1

Allelic Composition: Il1atm1Yiw/Il1atm1Yiw,Nlrp1aNeut1/Nlrp1aNeut1
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Nlrp1aNeut1/Nlrp1aNeut1,Pycardtm1Vmd/Pycardtm1Vmd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Il18tm1Aki/Il18tm1Aki,Nlrp1aNeut1/Nlrp1aNeut1
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd3etm1Mal/Cd3etm1Mal,Nlrp1aNeut1/Nlrp1aNeut1
Genetic Background: involves: C57BL/6

 MP:0000223 decreased monocyte count "fewer than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cd3etm1.1Geno/Cd3etm1.1Geno,Tg(TcrAND)53Hed/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Nlrp1aNeut1/Nlrp1aNeut1
Genetic Background: C.B6-Nlrp1aNeut1

 MP:0001845 abnormal inflammatory response "aberrant reaction of the microcirculation characterized by movement of fluid and leukocytes from the blood into extravascular tissues" [Pathology:ISBN 0-397-51047-0]
Show

Allelic Composition: Il1r1tm1Roml/Il1r1tm1Roml,Nlrp1aNeut1/Nlrp1aNeut1
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Nlrp1aNeut1/Nlrp1aNeut1,Pycardtm1Vmd/Pycardtm1Vmd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Il18tm1Aki/Il18tm1Aki,Nlrp1aNeut1/Nlrp1aNeut1
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001846 increased inflammatory response "greater than expected response to injury, infection, or insult " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Nr5a1tm2.1Hain/Nr5a1tm2.1Hain
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Nlrp1aNeut1/Nlrp1aNeut1
Genetic Background: C.B6-Nlrp1aNeut1

 MP:0001847 brain inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the brain" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Il18tm1Aki/Il18tm1Aki,Nlrp1aNeut1/Nlrp1aNeut1
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001856 myocarditis "inflammation of the heart walls" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Nr5a1tm2.1Hain/Nr5a1tm2.1Hain
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Nlrp1aNeut1/Nlrp1aNeut1
Genetic Background: C.B6-Nlrp1aNeut1

Allelic Composition: Il18tm1Aki/Il18tm1Aki,Nlrp1aNeut1/Nlrp1aNeut1
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001860 liver inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Nr5a1tm2.1Hain/Nr5a1tm2.1Hain
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Nlrp1aNeut1/Nlrp1aNeut1
Genetic Background: C.B6-Nlrp1aNeut1

 MP:0001861 lung inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Nr5a1tm2.1Hain/Nr5a1tm2.1Hain
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Nlrp1aNeut1/Nlrp1aNeut1
Genetic Background: C.B6-Nlrp1aNeut1

 MP:0001869 pancreas inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the pancreas " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Nr5a1tm2.1Hain/Nr5a1tm2.1Hain
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Nlrp1aNeut1/Nlrp1aNeut1
Genetic Background: C.B6-Nlrp1aNeut1

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nr5a1tm2.1Hain/Nr5a1tm2.1Hain
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Il18tm1Aki/Il18tm1Aki,Nlrp1aNeut1/Nlrp1aNeut1
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002418 increased susceptibility to viral infection "greater likelihood that an organism will develop ill effects from a viral infection or from components of or toxins produced by a virus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cd3etm1.1Geno/Cd3etm1.1Geno,Tg(TcrAND)53Hed/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0003179 decreased platelet count "fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, hdene:Howard Dene , Mouse Genome Informatics Curator, J:93052]
Show

Allelic Composition: Il1r1tm1Roml/Il1r1tm1Roml,Nlrp1aNeut1/Nlrp1aNeut1
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0003884 decreased macrophage count "fewer than the normal numbers of macrophages" [acv:Alicia Valenzuela, Genetic Resources Curator]
Show

Allelic Composition: Nlrp1aNeut1/Nlrp1aNeut1
Genetic Background: C.B6-Nlrp1aNeut1

 MP:0004947 skin inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd3etm1Mal/Cd3etm1Mal,Nlrp1aNeut1/Nlrp1aNeut1
Genetic Background: involves: C57BL/6

 MP:0005012 decreased eosinophil count "fewer than normal eosinophil numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Il1r1tm1Roml/Il1r1tm1Roml,Nlrp1aNeut1/Nlrp1aNeut1
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0005016 decreased lymphocyte number "fewer than normal white blood cell numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Nlrp1aNeut1/Nlrp1aNeut1
Genetic Background: C.B6-Nlrp1aNeut1

Allelic Composition: Il1r1tm1Roml/Il1r1tm1Roml,Nlrp1aNeut1/Nlrp1aNeut1
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0005460 abnormal leukopoiesis "anomalous process of generating white blood cells (leukocytes) from the pluripotent hematopoietic stem cells of the bone marrow; two significant pathways generate various types of leukocytes: myelopoiesis, in which leukocytes in the blood are derived from myeloid stem cells, and lymphopoiesis, in which leukocytes of the lymphatic system (lymphocytes) are generated from lymphoid stem cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Il1r1tm1Roml/Il1r1tm1Roml,Nlrp1aNeut1/Nlrp1aNeut1
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0006082 CNS inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the brain and/or spinal cord" [smb:Susan M Bello, Mouse Genome Informatics Curator, ncbi:NCBI request]
Show

Allelic Composition: Nr5a1tm2.1Hain/Nr5a1tm2.1Hain
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Nlrp1aNeut1/Nlrp1aNeut1
Genetic Background: C.B6-Nlrp1aNeut1

 MP:0008635 increased circulating interleukin-18 level "increase in the amount in the blood of a cytokine which enhances the cytotoxic activity of NK cells and cytotoxic T-cells and appears to play a role both as neuroimmunomodulator and in the induction of mucosal immunity" [MESH:D12.644.276.374.465.518]
Show

Allelic Composition: Il1atm1Yiw/Il1atm1Yiw,Nlrp1aNeut1/Nlrp1aNeut1
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009766 increased sensitivity to xenobiotic induced morbidity/mortality "decrease in the amount of a foreign compound required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Il1r1tm1Roml/Il1r1tm1Roml,Nlrp1aNeut1/Nlrp1aNeut1
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0009787 increased susceptibility to infection induced morbidity/mortality "increased likelihood that an organism will display the expected moribund state caused by a pathogenic invasion or from components of or toxins produced by pathogens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd3etm1Mal/Cd3etm1Mal,Nlrp1aNeut1/Nlrp1aNeut1
Genetic Background: involves: C57BL/6

 MP:0011078 increased macrophage cytokine production "greater production of macrophage-derived cytokine(s) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nlrp1aNeut1/Nlrp1aNeut1
Genetic Background: C.B6-Nlrp1aNeut1

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000057329 Bcl2 / P10417 / Apoptosis regulator Bcl-2 / P10415* / BCL2, apoptosis regulator*  / complex / reaction
 ENSMUSG00000007659 Bcl2l1 / Q64373 / Mus musculus BCL2-like 1 (Bcl2l1), transcript variant 5, mRNA. / Q07817* / BCL2 like 1*  / reaction / complex
 ENSMUSG00000070390 A1Z198 / Nlrp1b / NACHT, LRR and PYD domains-containing protein 1b allele 2 / NLRP1* / Q9C000* / NLR family pyrin domain containing 1*  / -
 ENSMUSG00000069830 Nlrp1a / Q2LKU9 / NACHT, LRR and PYD domains-containing protein 1a / NLRP1* / Q9C000* / NLR family pyrin domain containing 1*  / -






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr