ENSMUSG00000057329


Mus musculus

Features
Gene ID: ENSMUSG00000057329
  
Biological name :Bcl2
  
Synonyms : Apoptosis regulator Bcl-2 / Bcl2 / P10417
  
Possible biological names infered from orthology : BCL2, apoptosis regulator / P10415
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: E2.1
Gene start: 106538178
Gene end: 106714274
  
Corresponding Affymetrix probe sets: 10357043 (MoGene1.0st)   1422938_at (Mouse Genome 430 2.0 Array)   1437122_at (Mouse Genome 430 2.0 Array)   1440770_at (Mouse Genome 430 2.0 Array)   1443837_x_at (Mouse Genome 430 2.0 Array)   1457687_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000108371
Ensembl peptide - ENSMUSP00000139856
NCBI entrez gene - 12043     See in Manteia.
MGI - MGI:88138
RefSeq - NM_177410
RefSeq - NM_009741
RefSeq Peptide - NP_033871
RefSeq Peptide - NP_803129
swissprot - P10417
swissprot - Q6NTH7
Ensembl - ENSMUSG00000057329
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 bcl2aENSDARG00000094704Danio rerio
 bcl2bENSDARG00000089109Danio rerio
 BCL2ENSGALG00000012885Gallus gallus
 BCL2ENSG00000171791Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Bcl2l1 / Q64373 / Mus musculus BCL2-like 1 (Bcl2l1), transcript variant 5, mRNA. / Q07817* / BCL2 like 1*ENSMUSG0000000765939
Bcl2l2 / P70345 / Bcl-2-like protein 2 / Q92843* / BCL2 like 2*ENSMUSG0000008968234
Bak1 / O08734 / Bcl-2 homologous antagonist/killer / Q16611* / BCL2 antagonist/killer 1*ENSMUSG0000005778915


Protein motifs (from Interpro)
Interpro ID Name
 IPR002475  Bcl2-like
 IPR003093  Apoptosis regulator, Bcl-2 protein, BH4
 IPR004725  Apoptosis regulator, Bcl-2/ BclX
 IPR013278  Apoptosis regulator, Bcl-2
 IPR020717  Apoptosis regulator, Bcl-2, BH1 motif, conserved site
 IPR020726  Apoptosis regulator, Bcl-2, BH2 motif, conserved site
 IPR020728  Apoptosis regulator, Bcl-2, BH3 motif, conserved site
 IPR020731  Apoptosis regulator, Bcl-2, BH4 motif, conserved site
 IPR026298  Blc2 family
 IPR036834  Blc2-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000209 protein polyubiquitination ISO
 biological_processGO:0000902 cell morphogenesis IMP
 biological_processGO:0001503 ossification IMP
 biological_processGO:0001541 ovarian follicle development IMP
 biological_processGO:0001656 metanephros development IMP
 biological_processGO:0001657 ureteric bud development IMP
 biological_processGO:0001658 branching involved in ureteric bud morphogenesis IGI
 biological_processGO:0001662 behavioral fear response IMP
 biological_processGO:0001776 leukocyte homeostasis IMP
 biological_processGO:0001782 B cell homeostasis IMP
 biological_processGO:0001822 kidney development IMP
 biological_processGO:0001836 release of cytochrome c from mitochondria IDA
 biological_processGO:0001952 regulation of cell-matrix adhesion IMP
 biological_processGO:0002260 lymphocyte homeostasis IMP
 biological_processGO:0002320 lymphoid progenitor cell differentiation IMP
 biological_processGO:0002326 B cell lineage commitment IMP
 biological_processGO:0002360 T cell lineage commitment IMP
 biological_processGO:0002520 immune system development IMP
 biological_processGO:0002931 response to ischemia IMP
 biological_processGO:0003014 renal system process IMP
 biological_processGO:0006470 protein dephosphorylation IDA
 biological_processGO:0006582 melanin metabolic process IMP
 biological_processGO:0006808 regulation of nitrogen utilization IGI
 biological_processGO:0006874 cellular calcium ion homeostasis IDA
 biological_processGO:0006915 apoptotic process ISO
 biological_processGO:0006974 cellular response to DNA damage stimulus ISO
 biological_processGO:0006979 response to oxidative stress IMP
 biological_processGO:0007015 actin filament organization IMP
 biological_processGO:0007409 axonogenesis IMP
 biological_processGO:0007569 cell aging IMP
 biological_processGO:0008283 cell proliferation IGI
 biological_processGO:0008284 positive regulation of cell proliferation IDA
 biological_processGO:0008285 negative regulation of cell proliferation IMP
 biological_processGO:0008584 male gonad development IGI
 biological_processGO:0008625 extrinsic apoptotic signaling pathway via death domain receptors ISO
 biological_processGO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage IBA
 biological_processGO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress IMP
 biological_processGO:0008637 apoptotic mitochondrial changes IDA
 biological_processGO:0009636 response to toxic substance ISO
 biological_processGO:0009791 post-embryonic development IMP
 biological_processGO:0009887 animal organ morphogenesis IMP
 biological_processGO:0010039 response to iron ion ISO
 biological_processGO:0010224 response to UV-B IMP
 biological_processGO:0010332 response to gamma radiation IMP
 biological_processGO:0010468 regulation of gene expression IMP
 biological_processGO:0010506 regulation of autophagy IMP
 biological_processGO:0010507 negative regulation of autophagy IMP
 biological_processGO:0010523 negative regulation of calcium ion transport into cytosol IGI
 biological_processGO:0010559 regulation of glycoprotein biosynthetic process IMP
 biological_processGO:0014031 mesenchymal cell development IMP
 biological_processGO:0014042 positive regulation of neuron maturation IMP
 biological_processGO:0014911 positive regulation of smooth muscle cell migration IMP
 biological_processGO:0018105 peptidyl-serine phosphorylation IDA
 biological_processGO:0018107 peptidyl-threonine phosphorylation IDA
 biological_processGO:0021747 cochlear nucleus development IMP
 biological_processGO:0022612 gland morphogenesis IMP
 biological_processGO:0022898 regulation of transmembrane transporter activity ISO
 biological_processGO:0030097 hemopoiesis IMP
 biological_processGO:0030183 B cell differentiation IMP
 biological_processGO:0030217 T cell differentiation IMP
 biological_processGO:0030279 negative regulation of ossification IMP
 biological_processGO:0030307 positive regulation of cell growth ISO
 biological_processGO:0030308 negative regulation of cell growth IMP
 biological_processGO:0030318 melanocyte differentiation IMP
 biological_processGO:0030336 negative regulation of cell migration IMP
 biological_processGO:0030890 positive regulation of B cell proliferation ISO
 biological_processGO:0031069 hair follicle morphogenesis IMP
 biological_processGO:0031103 axon regeneration IDA
 biological_processGO:0031647 regulation of protein stability IMP
 biological_processGO:0032469 endoplasmic reticulum calcium ion homeostasis IGI
 biological_processGO:0032835 glomerulus development IMP
 biological_processGO:0032848 negative regulation of cellular pH reduction ISO
 biological_processGO:0032880 regulation of protein localization IMP
 biological_processGO:0033033 negative regulation of myeloid cell apoptotic process IDA
 biological_processGO:0033077 T cell differentiation in thymus IMP
 biological_processGO:0033138 positive regulation of peptidyl-serine phosphorylation IGI
 biological_processGO:0033689 negative regulation of osteoblast proliferation IMP
 biological_processGO:0034097 response to cytokine ISO
 biological_processGO:0035094 response to nicotine ISO
 biological_processGO:0035265 organ growth IMP
 biological_processGO:0040007 growth IMP
 biological_processGO:0040018 positive regulation of multicellular organism growth IMP
 biological_processGO:0042100 B cell proliferation ISO
 biological_processGO:0042149 cellular response to glucose starvation IDA
 biological_processGO:0042493 response to drug ISO
 biological_processGO:0042542 response to hydrogen peroxide IMP
 biological_processGO:0042981 regulation of apoptotic process IGI
 biological_processGO:0043029 T cell homeostasis IMP
 biological_processGO:0043066 negative regulation of apoptotic process ISS
 biological_processGO:0043067 regulation of programmed cell death IGI
 biological_processGO:0043085 positive regulation of catalytic activity IMP
 biological_processGO:0043375 CD8-positive, alpha-beta T cell lineage commitment IMP
 biological_processGO:0043473 pigmentation IMP
 biological_processGO:0043496 regulation of protein homodimerization activity ISO
 biological_processGO:0043497 regulation of protein heterodimerization activity ISO
 biological_processGO:0043524 negative regulation of neuron apoptotic process ISO
 biological_processGO:0043583 ear development IMP
 biological_processGO:0045069 regulation of viral genome replication IDA
 biological_processGO:0045636 positive regulation of melanocyte differentiation IMP
 biological_processGO:0045930 negative regulation of mitotic cell cycle IDA
 biological_processGO:0046671 negative regulation of retinal cell programmed cell death IMP
 biological_processGO:0046902 regulation of mitochondrial membrane permeability IDA
 biological_processGO:0048041 focal adhesion assembly IMP
 biological_processGO:0048066 developmental pigmentation IMP
 biological_processGO:0048070 regulation of developmental pigmentation IGI
 biological_processGO:0048087 positive regulation of developmental pigmentation IMP
 biological_processGO:0048536 spleen development IMP
 biological_processGO:0048538 thymus development IMP
 biological_processGO:0048545 response to steroid hormone IMP
 biological_processGO:0048546 digestive tract morphogenesis IMP
 biological_processGO:0048589 developmental growth IMP
 biological_processGO:0048599 oocyte development IMP
 biological_processGO:0048743 positive regulation of skeletal muscle fiber development IMP
 biological_processGO:0048753 pigment granule organization IMP
 biological_processGO:0048873 homeostasis of number of cells within a tissue IMP
 biological_processGO:0050790 regulation of catalytic activity IMP
 biological_processGO:0050853 B cell receptor signaling pathway ISO
 biological_processGO:0051384 response to glucocorticoid IMP
 biological_processGO:0051402 neuron apoptotic process IMP
 biological_processGO:0051607 defense response to virus ISO
 biological_processGO:0051726 regulation of cell cycle IMP
 biological_processGO:0051881 regulation of mitochondrial membrane potential IDA
 biological_processGO:0051924 regulation of calcium ion transport ISO
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress ISS
 biological_processGO:0071310 cellular response to organic substance IDA
 biological_processGO:0071456 cellular response to hypoxia IDA
 biological_processGO:0072593 reactive oxygen species metabolic process IMP
 biological_processGO:0097192 extrinsic apoptotic signaling pathway in absence of ligand IGI
 biological_processGO:0098609 cell-cell adhesion IMP
 biological_processGO:2000134 negative regulation of G1/S transition of mitotic cell cycle IMP
 biological_processGO:2000378 negative regulation of reactive oxygen species metabolic process IMP
 biological_processGO:2000811 negative regulation of anoikis ISO
 biological_processGO:2001234 negative regulation of apoptotic signaling pathway ISO
 biological_processGO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand ISO
 biological_processGO:2001243 negative regulation of intrinsic apoptotic signaling pathway ISO
 cellular_componentGO:0005622 intracellular IDA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005737 cytoplasm ISO
 cellular_componentGO:0005739 mitochondrion ISO
 cellular_componentGO:0005741 mitochondrial outer membrane ISO
 cellular_componentGO:0005783 endoplasmic reticulum ISO
 cellular_componentGO:0005789 endoplasmic reticulum membrane IDA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0016020 membrane ISO
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031965 nuclear membrane IEA
 cellular_componentGO:0031966 mitochondrial membrane IDA
 cellular_componentGO:0032991 protein-containing complex IEA
 cellular_componentGO:0043209 myelin sheath IDA
 cellular_componentGO:0046930 pore complex ISO
 molecular_functionGO:0002020 protease binding ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding IPI
 molecular_functionGO:0015267 channel activity ISO
 molecular_functionGO:0016248 channel inhibitor activity ISO
 molecular_functionGO:0019903 protein phosphatase binding IDA
 molecular_functionGO:0031625 ubiquitin protein ligase binding ISO
 molecular_functionGO:0042802 identical protein binding ISO
 molecular_functionGO:0042803 protein homodimerization activity IBA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity ISO
 molecular_functionGO:0051434 BH3 domain binding ISO
 molecular_functionGO:0051721 protein phosphatase 2A binding IDA


Pathways (from Reactome)
Pathway description
Activation of BAD and translocation to mitochondria
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
The NLRP1 inflammasome


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000018 small ears "outer ears of a smaller than normal size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Baxtm1Sjk/Bax+,Bcl2l1tm1Mam/Bcl2l1tm1Mam
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6

Allelic Composition: Bcl2tm1Sjk/Bcl2tm1Sjk
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Bcl2tm1Tsu/Bcl2tm1Tsu
Genetic Background: involves: 129P2/OlaHsd * ICR

 MP:0000187 abnormal triglyceride level "anomalous concentration of this molecule, glycerol esterified at each of its three hydroxyl groups by a fatty acid; triglyceride is an important molecule for storage of fatty acids in adipose tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Becn1tm1Blev/Becn1+,Tg(CAG-EGFP/Map1lc3b)53Nmz/0
Genetic Background: involves: 129X1/SvJ * C57BL/6NCrj

 MP:0000188 abnormal circulating glucose level "anomalous concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Becn1tm1Blev/Becn1+,Tg(CAG-EGFP/Map1lc3b)53Nmz/0
Genetic Background: involves: 129X1/SvJ * C57BL/6NCrj

 MP:0000218 increased WBC count "greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Bcl2tm1Dlo/Bcl2tm1Dlo,Bcl2l11tm3.1Boui/Bcl2l11tm3.1Boui
Genetic Background: B6.Cg-Bcl2tm1Dlo Bcl2l11tm3.1Boui

Allelic Composition: Bcl2tm1Dlo/Bcl2tm1Dlo,Bcl2l11tm1.1Boui/Bcl2l11tm2.1Boui
Genetic Background: B6.Cg-Bcl2tm1Dlo Bcl2l11tm1.1Boui/Bcl2l11tm2.1Boui

Allelic Composition: Bcl2tm1Dlo/Bcl2tm1Dlo,Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast
Genetic Background: B6.Cg-Bcl2tm1Dlo Bcl2l11tm1.1Ast

Allelic Composition: Bcl2tm1Dlo/Bcl2tm1Dlo,Bcl2l11tm1.1Ast/Bcl2l11+
Genetic Background: B6.Cg-Bcl2tm1Dlo Bcl2l11tm1.1Ast

 MP:0000371 diluted coat color "a coat color that appears lighter in intensity or paler than normal" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Bcl2tm1Dlo/Bcl2tm1Dlo,Bcl2l11tm1.1Ast/Bcl2l11+
Genetic Background: B6.129-Bcl2tm1Dlo Bcl2l11tm1.1Ast

Allelic Composition: Bcl2drn/Bcl2drn
Genetic Background: either: C57BL/6-Bcl2drn or (involves: C57BL/6JApb * CBA)

Allelic Composition: Bcl2tm1Dlo/Bcl2tm1Dlo,Bcl2l11tm1.1Boui/Bcl2l11tm1.1Boui
Genetic Background: B6.Cg-Bcl2tm1Dlo Bcl2l11tm1.1Boui

Allelic Composition: Bcl2tm1Dlo/Bcl2tm1Dlo,Bcl2l11tm2.1Boui/Bcl2l11tm2.1Boui
Genetic Background: B6.Cg-Bcl2tm1Dlo Bcl2l11tm2.1Boui

 MP:0000372 irregular coat pigmentation "uneven coloration of the hair" [J:65030]
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Allelic Composition: Bcl2drn/Bcl2drn
Genetic Background: either: C57BL/6-Bcl2drn or (involves: C57BL/6JApb * CBA)

 MP:0000394 absent melanin granules in hair follicle "missing pigment polymers in the hair follicles" [J:18378]
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Allelic Composition: Bcl2tm1Dlo/Bcl2tm1Dlo,Bcl2l11tm1.1Ast/Bcl2l11+
Genetic Background: B6.129-Bcl2tm1Dlo Bcl2l11tm1.1Ast

Allelic Composition: Bcl2tm1Tsu/Bcl2tm1Tsu
Genetic Background: involves: 129P2/OlaHsd * ICR

 MP:0000445 short snout "reduced length of the anterior facial part of the muzzle" [J:53370]
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Allelic Composition: Bcl2tm1Sjk/Bcl2tm1Sjk
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0000496 abnormal small intestine morphology "structural or developmental anomalies of the intestinum tenue " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Bcl2tm1Tsu/Bcl2tm1Tsu
Genetic Background: involves: 129P2/OlaHsd * ICR

 MP:0000521 abnormal kidney cortex "anomalous structure or development of the outer area of the kidney, which contains the glomerular capillaries and the capsula glomeruli that enclose it " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Baxtm1Sjk/Bax+,Bcl2l1tm1Mam/Bcl2l1tm1Mam
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6

 MP:0000522 cysts in kidney cortex "abnormal membranous sacs appearing in the renal lobules, tubules and glomeruli" [J:50844]
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Allelic Composition: Bcl2tm1Sjk/Bcl2tm1Sjk
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0000527 abnormal kidney development "anomalous differentiation of the paired organs responsible for urine secretion" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Baxtm1Sjk/Bax+,Bcl2l1tm1Mam/Bcl2l1tm1Mam
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6

Allelic Composition: Bcl2tm1Dlo/Bcl2tm1Dlo
Genetic Background: B6.129P2-Bcl2tm1Dlo

 MP:0000528 delayed kidney development "late onset of the induction and/or differentiation of the kidney" [J:18048]
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Allelic Composition: Bcl2tm1Sjk/Bcl2tm1Sjk
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0000530 abnormal kidney vasculature "malformation or malfunctioning of the blood vessel network of the organ of excretion" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc]
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Allelic Composition: Baxtm1Sjk/Bax+,Bcl2l1tm1Mam/Bcl2l1tm1Mam
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6

 MP:0000689 abnormal spleen morphology "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]
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Allelic Composition: Bcl2tm1Sjk/Bcl2tm1Sjk
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Bcl2tm2.1Lbox/Bcl2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

Allelic Composition: Bcl2tm2.1Lbox/Bcl2tm2.1Lbox
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0000692 small spleen "decreased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Bcl2tm1Sjk/Bcl2tm1Sjk
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Bcl2tm1Tsu/Bcl2tm1Tsu
Genetic Background: involves: 129P2/OlaHsd * ICR

 MP:0000702 enlarged lymph nodes "lymph nodes of increased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Bcl2tm2.1Lbox/Bcl2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

Allelic Composition: Bcl2tm2.1Lbox/Bcl2tm2.1Lbox
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0000703 abnormal thymus morphology "anomalous structure or development of the primary lymphoid organ; required for immune system development" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55400]
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Allelic Composition: Bcl2tm1Sjk/Bcl2tm1Sjk
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0000706 small thymus "reduced size of the thymus" [J:36561, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:31167]
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Allelic Composition: Bcl2tm1Sjk/Bcl2tm1Sjk
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Bcl2tm1Tsu/Bcl2tm1Tsu
Genetic Background: involves: 129P2/OlaHsd * ICR

 MP:0000715 decreased thymocyte number "fewer than expected number of precursors to T cells; these cells are lymphoid cells found in the thymus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Baxtm1Sjk/Bax+,Bcl2l1tm1Mam/Bcl2l1tm1Mam
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6

 MP:0000909 abnormal facial motor nucleus morphology "malformation or disorganization of the group of motor neurons residing in the pons that innervate the muscles of facial expression" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Bcl2tm1Mpin/Bcl2tm1Mpin
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0000938 motor neuron degeneration "retrogressive impairment of function or destruction of the cells that innervate an effector (muscle or glandular) tissue" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Bcl2tm1Mpin/Bcl2tm1Mpin
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0000966 reduced sensory neuron number "fewer than normal numbers of cells that innervate an effector (muscle or glandular) tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
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Allelic Composition: Bcl2tm1Mpin/Bcl2tm1Mpin
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001011 abnormal superior cervical ganglion morphology "malformation or absence of the group of neurons that is the largest of the sympathetic trunk; normally lies at the base of the skull and innervates the head and neck" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Bcl2tm1Mpin/Bcl2tm1Mpin
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001025 abnormal sympathetic neuron morphology "malformation or anomalous development of any of the neurons of the part of the autonomic nervous system that innervates smooth muscle, cardiac muscle and glands and mediates the body s response to stressful situations" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Bcl2tm1Mpin/Bcl2tm1Mpin
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Baxtm1Sjk/Bax+,Bcl2l1tm1Mam/Bcl2l1tm1Mam
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6

Allelic Composition: Bcl2tm1Dlo/Bcl2tm1Dlo
Genetic Background: B6.129P2-Bcl2tm1Dlo

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Baxtm1Sjk/Bax+,Bcl2l1tm1Mam/Bcl2l1tm1Mam
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6

Allelic Composition: Bcl2tm1Sjk/Bcl2tm1Sjk
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Bcl2tm1Mpin/Bcl2tm1Mpin
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Bcl2tm1Dlo/Bcl2tm1Dlo
Genetic Background: B6.129P2-Bcl2tm1Dlo

Allelic Composition: Bcl2tm1Dlo/Bcl2tm1Dlo,Biktm1Ast/Biktm1Ast
Genetic Background: B6.Cg-Bcl2tm1Dlo Biktm1Ast

Allelic Composition: Bcl2tm1Tsu/Bcl2tm1Tsu
Genetic Background: involves: 129P2/OlaHsd * ICR

 MP:0001330 abnormal optic nerve morphology "malformation, misprojection or atrophy in the second cranial nerve which is responsible for conveying visual information from the retina to the brain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Bcl2tm1Mpin/Bcl2tm1Mpin
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001560 abnormal circulating insulin level "anomalous blood concentration of this polypeptide hormone, secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Becn1tm1Blev/Becn1+,Tg(CAG-EGFP/Map1lc3b)53Nmz/0
Genetic Background: involves: 129X1/SvJ * C57BL/6NCrj

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Bcl2tm1Sjk/Bcl2tm1Sjk
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Bcl2tm1Tsu/Bcl2tm1Tsu
Genetic Background: involves: 129P2/OlaHsd * ICR

Allelic Composition: Bcl2tm1Dlo/Bcl2tm1Dlo,Bcl2l11tm3.1Boui/Bcl2l11tm3.1Boui
Genetic Background: B6.Cg-Bcl2tm1Dlo Bcl2l11tm3.1Boui

 MP:0001824 abnormal thymic involution "premature or late decline in thymic function normally associated with advancing age" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Bcl2tm1Sjk/Bcl2tm1Sjk
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002023 B cell derived lymphoma "heterogeneous lymphoid tumors generally expressing one or more B-cell antigens or representing malignant transformations of B-lymphocytes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Bcl2tm2.1Lbox/Bcl2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

Allelic Composition: Bcl2tm2.1Lbox/Bcl2tm2.1Lbox
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0002048 lung adenoma "benign epithelial neoplasm of the lung" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:57631]
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Allelic Composition: Skitm1Cco/Ski+
Genetic Background: involves: 129P2/OlaHsd * Black Swiss

Allelic Composition: Bcl2tm1Mpin/Bcl2+,Tg(SFTPC-RAF1-BxB)1Urr/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

Allelic Composition: Bcl2tm1Mpin/Bcl2tm1Mpin,Tg(SFTPC-RAF1-BxB)1Urr/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

 MP:0002052 decreased tumor incidence "less than the expected number of abnormal growths in a specific population" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Sod1tm1Cep/Sod1tm1Cep
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0002075 abnormal coat color "irregular or unusual pigmentation pattern of the hair in relation to control animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Baxtm1Sjk/Bax+,Bcl2l1tm1Mam/Bcl2l1tm1Mam
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6

Allelic Composition: Bcl2tm1Dlo/Bcl2tm1Dlo,Bcl2l11tm1.1Ast/Bcl2l11+
Genetic Background: B6.129-Bcl2tm1Dlo Bcl2l11tm1.1Ast

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Becn1tm1Blev/Becn1+,Tg(CAG-EGFP/Map1lc3b)53Nmz/0
Genetic Background: involves: 129X1/SvJ * C57BL/6NCrj

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Bcl2tm1Sjk/Bcl2tm1Sjk
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Bcl2tm1Mpin/Bcl2tm1Mpin
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Bcl2tm1Dlo/Bcl2tm1Dlo
Genetic Background: B6.129P2-Bcl2tm1Dlo

Allelic Composition: Bcl2tm1Dlo/Bcl2tm1Dlo,Biktm1Ast/Biktm1Ast
Genetic Background: B6.Cg-Bcl2tm1Dlo Biktm1Ast

Allelic Composition: Bcl2tm1Tsu/Bcl2tm1Tsu
Genetic Background: involves: 129P2/OlaHsd * ICR

Allelic Composition: Bcl2tm1Dlo/Bcl2tm1Dlo,Bcl2l11tm3.1Boui/Bcl2l11tm3.1Boui
Genetic Background: B6.Cg-Bcl2tm1Dlo Bcl2l11tm3.1Boui

Allelic Composition: Bcl2tm2.1Lbox/Bcl2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

Allelic Composition: Bcl2tm2.1Lbox/Bcl2tm2.1Lbox
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0002135 abnormal kidney morphology "abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Baxtm1Sjk/Bax+,Bcl2l1tm1Mam/Bcl2l1tm1Mam
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6

Allelic Composition: Bcl2tm1Tsu/Bcl2tm1Tsu
Genetic Background: involves: 129P2/OlaHsd * ICR

 MP:0002144 abnormal B lymphocyte development "atypical production of or inability to produce mature B cells, and/or accumulation of B cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Bmpertm2Ysas/Bmpertm2Ysas
Genetic Background: involves: C57BL/6 * CBA

 MP:0002145 abnormal T lymphocyte development "atypical production of or inability to produce mature T cells, and/or accumulation of T cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Baxtm1Sjk/Bax+,Bcl2l1tm1Mam/Bcl2l1tm1Mam
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6

 MP:0002356 abnormal spleen red pulp morphology "anomalous structure of the area of the spleen that screens and eliminates defective or foreign cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology:ISBN 0-397-51047-0]
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Allelic Composition: Bcl2tm1Sjk/Bcl2tm1Sjk
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002357 abnormal spleen white pulp morphology "anomalous structure or formation of the splenic area consisting of lymph nodules and diffuse lymphatic tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Bcl2tm1Sjk/Bcl2tm1Sjk
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002432 abnormal CD4+ T cell morphology/development "anomalous structure, differentiation, or number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Bcl2tm1Sjk/Bcl2tm1Sjk
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002444 abnormal T cell physiology "anomalous response of T lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Bcl2tm1Tsu/Bcl2tm1Tsu
Genetic Background: involves: 129P2/OlaHsd * ICR

 MP:0002459 abnormal B cell physiology "abnormal function of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Bcl2tm2.1Lbox/Bcl2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

Allelic Composition: Bcl2tm2.1Lbox/Bcl2tm2.1Lbox
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0002619 abnormal lymphocyte morphology/development "anomalous structure, differentiation, or number of the white blood cells formed in the body s lymphoid tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Bcl2tm1Tsu/Bcl2tm1Tsu
Genetic Background: involves: 129P2/OlaHsd * ICR

 MP:0002705 dilated renal tubules "enlarged lumens of the loops of Henle and/or collecting ducts of the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Baxtm1Sjk/Bax+,Bcl2l1tm1Mam/Bcl2l1tm1Mam
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6

 MP:0002722 abnormal immune system organ morphology "anomalous structure/organization or development of lymphoid organs" [cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: Bcl2tm1Sjk/Bcl2tm1Sjk
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002792 abnormal retinal vascularization "malformation or disorganization of the blood vessels supplying the retina" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Bcl2tm1Sjk/Bcl2tm1Sjk
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002955 increased compensatory renal growth "increased additional growth of a kidney upon removal of the other kidney through surgery or disease" [RGD:Rat Genome Database submission]
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Allelic Composition: Bcl2tm1Sjk/Bcl2tm1Sjk
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002989 small kidney "reduced physical bulk one or both of the organs responsible for urine secretion" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Baxtm1Sjk/Bax+,Bcl2l1tm1Mam/Bcl2l1tm1Mam
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6

Allelic Composition: Bcl2tm1Sjk/Bcl2tm1Sjk
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0003014 abnormal kidney medulla morphology "anomalous structure of the inner portion of the kidney consisting of the renal pyramids" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:88636, smb:Susan M. Bello , Mouse Genome Informatics Curator]
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Allelic Composition: Baxtm1Sjk/Bax+,Bcl2l1tm1Mam/Bcl2l1tm1Mam
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6

 MP:0003068 enlarged kidney "larger than average size of the kidney" [J:86005, pvb:Pierre Vanden Borre, Mouse Genome Informatics Curator]
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Allelic Composition: Bcl2tm1Sjk/Bcl2tm1Sjk
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0003132 increased number of pre-B cells "greater number of progenitor cells that form the B cell component of the immune system" [J:91592, Immunobiology, The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Bcl2tm2.1Lbox/Bcl2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

Allelic Composition: Bcl2tm2.1Lbox/Bcl2tm2.1Lbox
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0003446 renal hypoplasia "decreased cell number in the kidney leading to reduced size" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Baxtm1Sjk/Bax+,Bcl2l1tm1Mam/Bcl2l1tm1Mam
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6

Allelic Composition: Bcl2tm1Sjk/Bcl2tm1Sjk
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0003566 abnormal cell adhesion "altered ability of a cell to adhere to another cell or to a non-cellular component of the environment" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Bcl2tm1Sjk/Bcl2tm1Sjk
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0003606 kidney failure "cessation of renal function" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Baxtm1Sjk/Bax+,Bcl2l1tm1Mam/Bcl2l1tm1Mam
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6

Allelic Composition: Bcl2tm1Sjk/Bcl2tm1Sjk
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0003643 spleen atrophy "wasting of the spleen resulting in reduced size" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Bcl2tm1Dlo/Bcl2tm1Dlo
Genetic Background: B6.129P2-Bcl2tm1Dlo

Allelic Composition: Bcl2tm1Tsu/Bcl2tm1Tsu
Genetic Background: involves: 129P2/OlaHsd * ICR

 MP:0003644 thymus atrophy "wasting of the thymus resulting in reduced size " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Bcl2tm1Tsu/Bcl2tm1Tsu
Genetic Background: involves: 129P2/OlaHsd * ICR

 MP:0003675 kidney cysts "abnormal membranous sacs in any portion of the pair of organs responsible for urine secretion" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Bcl2tm1Sjk/Bcl2tm1Sjk
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Bcl2tm1Dlo/Bcl2tm1Dlo
Genetic Background: B6.129P2-Bcl2tm1Dlo

 MP:0003719 abnormal pericyte morphology "malformation in the connective tissue cells that occurs around capillaries or other small blood vessels " [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Bcl2tm1Sjk/Bcl2tm1Sjk
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0003918 decreased kidney weight "reduced heft of the organs responsible for urine secretion" [RGD:Rat Genome Database submission]
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Allelic Composition: Baxtm1Sjk/Bax+,Bcl2l1tm1Mam/Bcl2l1tm1Mam
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6

Allelic Composition: Bcl2tm1Sjk/Bcl2tm1Sjk
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0003945 abnormal lymphocyte physiology "abnormal function of any of the white blood cells that includes B cells, T cells, and NK cells " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Bcl2tm1Dlo/Bcl2tm1Dlo,Bcl2l11tm1.1Ast/Bcl2l11+
Genetic Background: B6.129-Bcl2tm1Dlo Bcl2l11tm1.1Ast

Allelic Composition: Bcl2tm1Dlo/Bcl2tm1Dlo
Genetic Background: B6.129P2-Bcl2tm1Dlo

Allelic Composition: Bcl2tm1Dlo/Bcl2tm1Dlo,Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast
Genetic Background: B6.129-Bcl2tm1Dlo Bcl2l11tm1.1Ast

Allelic Composition: Bcl2tm1Dlo/Bcl2tm1Dlo,Biktm1Ast/Biktm1Ast
Genetic Background: B6.Cg-Bcl2tm1Dlo Biktm1Ast

 MP:0004381 abnormal hair follicle melanocyte morphology "any structural anomaly of the cells that produce pigment in the hair follicles" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Bcl2tm1Dlo/Bcl2tm1Dlo,Bcl2l11tm1.1Ast/Bcl2l11+
Genetic Background: B6.129-Bcl2tm1Dlo Bcl2l11tm1.1Ast

 MP:0004505 decreased renal glomerulus number "reduced number of the capillary loops of the kidney that normally function as a filtration unit" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Baxtm1Sjk/Bax+,Bcl2l1tm1Mam/Bcl2l1tm1Mam
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6

Allelic Composition: Bcl2tm1Sjk/Bcl2tm1Sjk
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Bcl2tm1Tsu/Bcl2tm1Tsu
Genetic Background: involves: 129P2/OlaHsd * ICR

 MP:0004805 absent oocytes "absence of mature germ cells in the female" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bcl2tm1Sjk/Bcl2tm1Sjk
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0004841 abnormal small intestine crypts of Lieberkuhn morphology "any structural anomaly in the tubular intestinal glands found in the mucosal membranes of the small intestine" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Bcl2tm1Tsu/Bcl2tm1Tsu
Genetic Background: involves: 129P2/OlaHsd * ICR

 MP:0004893 decreased adiponectin level "reduced concentration of a protein hormone that regulates glucose homeostasis and metabolism of lipids; it is normally produced by adipose tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Becn1tm1Blev/Becn1+,Tg(CAG-EGFP/Map1lc3b)53Nmz/0
Genetic Background: involves: 129X1/SvJ * C57BL/6NCrj

 MP:0004936 abnormal ureteric bud branching morphogenesis "partial or complete failure of the ureteric bud to repeatedly divide into lobules during development of the kidney" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Baxtm1Sjk/Bax+,Bcl2l1tm1Mam/Bcl2l1tm1Mam
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6

 MP:0004952 increased spleen weight "greater than average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bcl2tm1Dlo/Bcl2tm1Dlo,Bcl2l11tm3.1Boui/Bcl2l11tm3.1Boui
Genetic Background: B6.Cg-Bcl2tm1Dlo Bcl2l11tm3.1Boui

Allelic Composition: Bcl2tm1Dlo/Bcl2tm1Dlo,Bcl2l11tm1.1Boui/Bcl2l11tm2.1Boui
Genetic Background: B6.Cg-Bcl2tm1Dlo Bcl2l11tm1.1Boui/Bcl2l11tm2.1Boui

Allelic Composition: Bcl2tm1Dlo/Bcl2tm1Dlo,Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast
Genetic Background: B6.Cg-Bcl2tm1Dlo Bcl2l11tm1.1Ast

Allelic Composition: Bcl2tm1Dlo/Bcl2tm1Dlo,Bcl2l11tm1.1Ast/Bcl2l11+
Genetic Background: B6.Cg-Bcl2tm1Dlo Bcl2l11tm1.1Ast

 MP:0004953 decreased spleen weight "reduction in the average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bcl2tm1Dlo/Bcl2tm1Dlo
Genetic Background: B6.129P2-Bcl2tm1Dlo

 MP:0004969 pale kidney "kidney lacks normal reddish coloration; often occurs with a bloodless or reduced vasculature condition" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Baxtm1Sjk/Bax+,Bcl2l1tm1Mam/Bcl2l1tm1Mam
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6

Allelic Composition: Bcl2tm1Sjk/Bcl2tm1Sjk
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Bcl2tm1Tsu/Bcl2tm1Tsu
Genetic Background: involves: 129P2/OlaHsd * ICR

 MP:0005010 abnormal CD8+ T cell morphology/development "anomalous structure, formation, or numbers of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Bcl2tm1Sjk/Bcl2tm1Sjk
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0005014 increased B cell number "greater than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Bcl2tm2.1Lbox/Bcl2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

Allelic Composition: Bcl2tm2.1Lbox/Bcl2tm2.1Lbox
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0005016 decreased lymphocyte number "fewer than normal white blood cell numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Baxtm1Sjk/Bax+,Bcl2l1tm1Mam/Bcl2l1tm1Mam
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6

Allelic Composition: Bcl2tm1Sjk/Bcl2tm1Sjk
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Bcl2tm1Sjk/Bcl2tm1Sjk
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Bcl2tm1Lbox/Bcl2tm1Lbox
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Bcl2tm1Sjk/Bcl2tm1Sjk
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0005090 increased double-negative T cells count "greater than expected numbers of the subset of T cells found in the thymus that express neither CD4 nor CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Bcl2tm1Sjk/Bcl2tm1Sjk
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0005092 decreased double-positive T cell count "less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Bcl2tm1Sjk/Bcl2tm1Sjk
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0005093 impaired B cell proliferation "absent or reduced ability of B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Bcl2tm1Lbox/Bcl2tm1Lbox
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0005150 cachexia "general weight loss and wasting occurring in the course of chronic disease" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Bcl2tm1Sjk/Bcl2tm1Sjk
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0005264 glomerulosclerosis "hyaline deposits or scarring within the renal glomeruli, often occurring with renal arteriosclerosis or diabetes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Baxtm1Sjk/Bax+,Bcl2l1tm1Mam/Bcl2l1tm1Mam
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6

 MP:0005278 abnormal cholesterol homeostasis "anomaly in the state of equilibrium in the body of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:71350]
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Allelic Composition: Becn1tm1Blev/Becn1+,Tg(CAG-EGFP/Map1lc3b)53Nmz/0
Genetic Background: involves: 129X1/SvJ * C57BL/6NCrj

 MP:0005288 abnormal oxygen consumption "deviation from the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Becn1tm1Blev/Becn1+,Tg(CAG-EGFP/Map1lc3b)53Nmz/0
Genetic Background: involves: 129X1/SvJ * C57BL/6NCrj

 MP:0005291 abnormal glucose tolerance "deviation from the normal response to oral consumption or intravenous injection of specified amounts of glucose; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Becn1tm1Blev/Becn1+,Tg(CAG-EGFP/Map1lc3b)53Nmz/0
Genetic Background: involves: 129X1/SvJ * C57BL/6NCrj

 MP:0005325 abnormal glomerulus "anomalous structure of the capillary loops of the kidney that normally function as a filtration unit" [J:57971, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Baxtm1Sjk/Bax+,Bcl2l1tm1Mam/Bcl2l1tm1Mam
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6

Allelic Composition: Bcl2tm1Sjk/Bcl2tm1Sjk
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0005326 abnormal podocytes "anomalous structure of the foot processes of the epithelial cells of the glomerulus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:57971]
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Allelic Composition: Baxtm1Sjk/Bax+,Bcl2l1tm1Mam/Bcl2l1tm1Mam
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6

 MP:0005338 atherosclerotic lesions "thickening and loss of elasticity of arterial walls, involving lipid deposition and thickening of intimal layers within arteries" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Apoetm1Bres/Apoetm1Bres,Bcl2tm1Irt/Bcl2tm1Irt,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005408 hypopigmentation "dilution of the pigment in the body" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Bcl2tm1Sjk/Bcl2tm1Sjk
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Bcl2tm1Tsu/Bcl2tm1Tsu
Genetic Background: involves: 129P2/OlaHsd * ICR

 MP:0005457 abnormal percent body fat "more or less fat, relative to the norm, as a percentage of total body weight" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Becn1tm1Blev/Becn1+,Tg(CAG-EGFP/Map1lc3b)53Nmz/0
Genetic Background: involves: 129X1/SvJ * C57BL/6NCrj

 MP:0005460 abnormal leukopoiesis "anomalous process of generating white blood cells (leukocytes) from the pluripotent hematopoietic stem cells of the bone marrow; two significant pathways generate various types of leukocytes: myelopoiesis, in which leukocytes in the blood are derived from myeloid stem cells, and lymphopoiesis, in which leukocytes of the lymphatic system (lymphocytes) are generated from lymphoid stem cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Bcl2tm1Dlo/Bcl2tm1Dlo
Genetic Background: B6.129P2-Bcl2tm1Dlo

Allelic Composition: Bcl2tm1Dlo/Bcl2tm1Dlo,Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast
Genetic Background: B6.129-Bcl2tm1Dlo Bcl2l11tm1.1Ast

 MP:0005553 increased circulating creatinine level "greater than the normal blood concentration of this product of creatine catabolism; abnormal levels indicative of renal dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Bcl2tm1Sjk/Bcl2tm1Sjk
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Bcl2tm1Mpin/Bcl2tm1Mpin
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0005565 increased blood urea nitrogen level "high circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Bcl2tm1Sjk/Bcl2tm1Sjk
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Bcl2tm1Mpin/Bcl2tm1Mpin
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0005669 increased circulating leptin level "greater than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
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Allelic Composition: Becn1tm1Blev/Becn1+,Tg(CAG-EGFP/Map1lc3b)53Nmz/0
Genetic Background: involves: 129X1/SvJ * C57BL/6NCrj

 MP:0006057 decreased vascular endothelial cell number "less than normal number of cells lining the vasculature" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Bcl2tm1Sjk/Bcl2tm1Sjk
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0006405 abnormal L3 dorsal root ganglion morphology "any structural anomaly of the group of nerve cell bodies located on the dorsal spinal roots within the vertebral column at the level of the third lumbar vertebra" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Bcl2tm1Mpin/Bcl2tm1Mpin
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0006413 increased T cell apoptosis "increase in the number of T cells undergoing programmed cell death" [MGI:brs "Beverly Richards-Smith, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Bcl2tm1Sjk/Bcl2tm1Sjk
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Bcl2tm1Dlo/Bcl2tm1Dlo,Bcl2l11tm1.1Ast/Bcl2l11+
Genetic Background: B6.129-Bcl2tm1Dlo Bcl2l11tm1.1Ast

Allelic Composition: Bcl2tm1Dlo/Bcl2tm1Dlo
Genetic Background: B6.129P2-Bcl2tm1Dlo

Allelic Composition: Bcl2tm1Dlo/Bcl2tm1Dlo,Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast
Genetic Background: B6.129-Bcl2tm1Dlo Bcl2l11tm1.1Ast

 MP:0008067 retinal ganglion cell degeneration "degeneration or loss of ganglion neurons located in the innermost nuclear layer of the retina of that receive visual information from photoreceptors via various intermediate cells such as bipolar cells, amacrine cells, and horizontal cells; axons from these cells form the optic nerve and connect mainly to the lateral geniculate nucleus (LGN) and to the suprachiasmatic nucleus in the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bcl2tm1Mpin/Bcl2tm1Mpin
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Baxtm1Sjk/Bax+,Bcl2l1tm1Mam/Bcl2l1tm1Mam
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6

 MP:0008108 abnormal small intestinal villus morphology "any structural anomaly of the tiny hair-like projections that protrude from the inside of the small intestine that contain blood vessels that capture digested nutrients that are absorbed through the intestinal wall; the villi increase the absorptive surface area of the small intestine by approximately 30-fold" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Bcl2tm1Tsu/Bcl2tm1Tsu
Genetic Background: involves: 129P2/OlaHsd * ICR

 MP:0008140 podocyte foot process effacement "thinning of the footlike extension of podocytes that interdigitate with one another to form the walls of the glomerular capillaries" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Baxtm1Sjk/Bax+,Bcl2l1tm1Mam/Bcl2l1tm1Mam
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6

 MP:0008209 decreased pre-B cell number "reduced number of the cells in the B lymphocyte lineage that have undergone VDJ rearrangement of the immunoglobulin heavy chain and are in the process of V-J rearrangement of the light chain: these cells express mu heavy chain on the cell surface" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
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Allelic Composition: Baxtm1Sjk/Bax+,Bcl2l1tm1Mam/Bcl2l1tm1Mam
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6

Allelic Composition: Bcl2tm1Lbox/Bcl2tm1Lbox
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0008210 increased mature B cell number "greater number of the mature form of B cells, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149]
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Allelic Composition: Bcl2tm2.1Lbox/Bcl2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

Allelic Composition: Bcl2tm2.1Lbox/Bcl2tm2.1Lbox
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0008211 decreased mature B cell number "reduced number of the mature form of B cells, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149]
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Allelic Composition: Baxtm1Sjk/Bax+,Bcl2l1tm1Mam/Bcl2l1tm1Mam
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6

Allelic Composition: Bcl2tm1Lbox/Bcl2tm1Lbox
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0008214 increased immature B cell number "greater number of the cells of the B lymphocyte lineage that have undergone VDJ rearrangement of the heavy chain and V-J rearrangement of the light chain; these cells express IgM on the cell surface but have not yet been selected for self-reactivity" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bcl2tm2.1Lbox/Bcl2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

Allelic Composition: Bcl2tm2.1Lbox/Bcl2tm2.1Lbox
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0008215 decreased immature B cell number "reduced number of the cells of the B lymphocyte lineage that have undergone VDJ rearrangement of the heavy chain and V-J rearrangement of the light chain; these cells express IgM on the cell surface but have not yet been selected for self-reactivity" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bcl2tm1Lbox/Bcl2tm1Lbox
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0008217 abnormal B cell activation "any anomaly in the normal change in morphology and behavior of a mature or immature B cell during an immune response, resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific" [GO:0002312, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bcl2tm1Lbox/Bcl2tm1Lbox
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0008260 abnormal autophagy "abnormal catabolic process involving the degradation of a cell s own components through the lysosomal machinery" [MGI:honda "Hiraoki Onda, Mouse Genome Informatics Curator"]
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Allelic Composition: Becn1tm1Blev/Becn1+,Tg(CAG-EGFP/Map1lc3b)53Nmz/0
Genetic Background: involves: 129X1/SvJ * C57BL/6NCrj

 MP:0008479 decreased spleen white pulp amount "reduction in the quantity of the parenchymatous tissue of the spleen that surrounds splenic blood vessels, consists of compact masses of lymphatic cells and is where foreign material removed from the blood is used to initiate an immune reaction that results in the production of antibodies" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bcl2tm1Dlo/Bcl2tm1Dlo
Genetic Background: B6.129P2-Bcl2tm1Dlo

 MP:0008528 polycystic kidney "the development of innumerable cysts in the kidneys filled with fluid replacing much of the mass of the kidneys leading to reduction in kidney function and frequently kidney failure" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Baxtm1Sjk/Bax+,Bcl2l1tm1Mam/Bcl2l1tm1Mam
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6

Allelic Composition: Bcl2tm1Sjk/Bcl2tm1Sjk
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Bcl2tm1Mpin/Bcl2tm1Mpin
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Bcl2tm1Dlo/Bcl2tm1Dlo
Genetic Background: B6.129P2-Bcl2tm1Dlo

Allelic Composition: Bcl2tm1Dlo/Bcl2tm1Dlo,Biktm1Ast/Biktm1Ast
Genetic Background: B6.Cg-Bcl2tm1Dlo Biktm1Ast

Allelic Composition: Bcl2tm1Tsu/Bcl2tm1Tsu
Genetic Background: involves: 129P2/OlaHsd * ICR

Allelic Composition: Bcl2tm1Dlo/Bcl2tm1Dlo,Bcl2l11tm3.1Boui/Bcl2l11tm3.1Boui
Genetic Background: B6.Cg-Bcl2tm1Dlo Bcl2l11tm3.1Boui

 MP:0008782 increased B cell apoptosis "increase in the timing or the number of B cells undergoing programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bcl2tm1Dlo/Bcl2tm1Dlo
Genetic Background: B6.129P2-Bcl2tm1Dlo

Allelic Composition: Bcl2tm1Lbox/Bcl2tm1Lbox
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0008783 decreased B cell apoptosis "reduction in the timing or the number of B cells undergoing programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bcl2tm1Dlo/Bcl2tm1Dlo,Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast
Genetic Background: B6.129-Bcl2tm1Dlo Bcl2l11tm1.1Ast

 MP:0008961 abnormal basal metabolism "any anomaly in heat production of an organism at the lowest level of cell chemistry in an inactive, awake, and fasting state" [MESH:E01.370.374.750.100]
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Allelic Composition: Becn1tm1Blev/Becn1+,Tg(CAG-EGFP/Map1lc3b)53Nmz/0
Genetic Background: involves: 129X1/SvJ * C57BL/6NCrj

 MP:0008962 abnormal carbon dioxide production "deviation from the normal rate at which carbon dioxide leaves the blood and enters the alveolar gas" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Becn1tm1Blev/Becn1+,Tg(CAG-EGFP/Map1lc3b)53Nmz/0
Genetic Background: involves: 129X1/SvJ * C57BL/6NCrj

 MP:0009050 dilated proximal convoluted tubules "stretched or widened aperture of the luminal space of the convoluted portion of the duct system of the nephron that extends from the renal glomerular capsule in the kidney cortex into the kidney medulla where it joins the loop of Henle" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Bcl2tm1Sjk/Bcl2tm1Sjk
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Bcl2tm1Tsu/Bcl2tm1Tsu
Genetic Background: involves: 129P2/OlaHsd * ICR

 MP:0009051 dilated distal convoluted tubules "stretched or widened aperture of the luminal space of the convoluted portion of the duct system of the nephron between the ascending portion of the loop of Henle and the collecting duct system in the kidney cortex" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Bcl2tm1Sjk/Bcl2tm1Sjk
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Bcl2tm1Tsu/Bcl2tm1Tsu
Genetic Background: involves: 129P2/OlaHsd * ICR

 MP:0009317 follicular lymphoma "malignant lymphoma arising from lymphoid follicular B cells which may be small or large" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Bcl2tm2.1Lbox/Bcl2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

Allelic Composition: Bcl2tm2.1Lbox/Bcl2tm2.1Lbox
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0009322 increased splenocyte apoptosis "increase in the number of spleen cells undergoing programmed cell death" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Bcl2tm1Dlo/Bcl2tm1Dlo
Genetic Background: B6.129P2-Bcl2tm1Dlo

 MP:0009341 decreased splenocyte apoptosis "reduction in the number of spleen cells undergoing programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bcl2tm1Dlo/Bcl2tm1Dlo,Bcl2l11tm3.1Boui/Bcl2l11tm3.1Boui
Genetic Background: B6.Cg-Bcl2tm1Dlo Bcl2l11tm3.1Boui

 MP:0009361 abnormal primordial ovarian follicle morphology "any structural abnormality in the ovarian follicle in which the primary oocyte is surrounded by a single layer of flattened follicular cells; primordial follicles are indiscernible to the naked eye and develop to primary, secondary, and finally mature vesicular follicles" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Bcl2tm1Sjk/Bcl2tm1Sjk
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0009409 abnormal skeletal muscle fiber type ratio "deviation from the standard ratios of fiber types in a given skeletal muscle compared to control samples" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fkbp4tm1Shou/Fkbp4tm1Shou
Genetic Background: either: (involves: 129S/SvEv) or (involves: 129S/SvEv * C57BL/6J)

 MP:0009640 abnormal renal tubule epithelium morphology "any structural anomaly of the cellular avascular layer of the renal tubule luminar surfaces" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Baxtm1Sjk/Bax+,Bcl2l1tm1Mam/Bcl2l1tm1Mam
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6

Allelic Composition: Bcl2tm1Sjk/Bcl2tm1Sjk
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0009641 kidney degeneration "a retrogressive impairment of function or destruction of either or both of the two excretory organs that filter wastes (especially urea) from the blood and excrete them and water in urine" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Baxtm1Sjk/Bax+,Bcl2l1tm1Mam/Bcl2l1tm1Mam
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6

 MP:0009660 abnormal induced retinal neovascularization "any anomaly in the response to conditions which induce the pathological growth of vessels into the retina" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Bcl2tm1Sjk/Bcl2tm1Sjk
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0010979 small ureteric bud "reduced size of the epithelial swelling on the Wolffian duct that elongates to invade the adjacent metanephric mesenchyme" [PMID:19828308]
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Allelic Composition: Baxtm1Sjk/Bax+,Bcl2l1tm1Mam/Bcl2l1tm1Mam
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6

 MP:0010982 abnormal ureteric bud elongation "any anomaly in the process in which a ureteric bud grows along its axis" [GO:0060677]
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Allelic Composition: Baxtm1Sjk/Bax+,Bcl2l1tm1Mam/Bcl2l1tm1Mam
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6

 MP:0010984 abnormal metanephric mesenchyme morphology "any structural anomaly of the embryonic connective tissue made up of loosely aggregated mesenchymal cells, supported by interlaminar jelly, in the developing metanephros; interactions between the ureteric bud and the metanephric mesenchyme leads to the initiation of outgrowth and repetitive branching of the UB that ultimately generates the definitive renal collecting system and induces formation of renal vesicles from the mesenchyme tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:19828308]
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Allelic Composition: Bcl2tm1Sjk/Bcl2tm1Sjk
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0010985 abnormal kidney mesenchyme morphology "any structural anomaly of the embryonic connective tissue made up of loosely aggregated mesenchymal cells, supported by interlaminar jelly, in the developing kidney" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bcl2tm1Dlo/Bcl2tm1Dlo
Genetic Background: B6.129P2-Bcl2tm1Dlo

 MP:0011080 increased macrophage apoptosis "greater incidence of cell death in macrophages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tymptm1Mihi/Tymptm1Mihi,Upp1tm1Gp/Upp1tm1Gp
Genetic Background: involves: 129 * 129X1/SvJ * C57BL/6J

Allelic Composition: Apoetm1Bres/Apoetm1Bres,Bcl2tm1Irt/Bcl2tm1Irt,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Baxtm1Sjk/Bax+,Bcl2l1tm1Mam/Bcl2l1tm1Mam
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6

Allelic Composition: Bcl2tm1Sjk/Bcl2tm1Sjk
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Bcl2tm1Tsu/Bcl2tm1Tsu
Genetic Background: involves: 129P2/OlaHsd * ICR

 MP:0011290 decreased nephron number "reduction in the total number of filtering units of the kidney" [MGI:anna]
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Allelic Composition: Baxtm1Sjk/Bax+,Bcl2l1tm1Mam/Bcl2l1tm1Mam
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6

Allelic Composition: Bcl2tm1Sjk/Bcl2tm1Sjk
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Bcl2tm1Dlo/Bcl2tm1Dlo
Genetic Background: B6.129P2-Bcl2tm1Dlo

 MP:0011294 renal glomerulus hypertrophy "increase in the bulk size of the capillary loops of the kidney that normally function as a filtration unit, due to cell enlargement" [MGI:anna]
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Allelic Composition: Baxtm1Sjk/Bax+,Bcl2l1tm1Mam/Bcl2l1tm1Mam
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6

 MP:0011307 kidney medulla cysts "abnormal membranous sacs appearing in the inner portion of the kidney which consists of the renal pyramids" [MGI:anna]
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Allelic Composition: Bcl2tm1Sjk/Bcl2tm1Sjk
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0011334 abnormal nephrogenic zone morphology "any structural anomaly in the region found at the periphery of the developing metanephros within which the metanephric mesenchyme aggregates around the tips of the ureteric tree to form the nephrons; in rodents including mice, this region normally disappears within the first postnatal week when nephrogenesis ceases and only mature nephrons are present; in humans, it is lost by 36 weeks of gestation" [PMID:17452023]
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Allelic Composition: Baxtm1Sjk/Bax+,Bcl2l1tm1Mam/Bcl2l1tm1Mam
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6

Allelic Composition: Bcl2tm1Sjk/Bcl2tm1Sjk
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Bcl2tm1Dlo/Bcl2tm1Dlo
Genetic Background: B6.129P2-Bcl2tm1Dlo

 MP:0011353 expanded mesangial matrix "increase in the amount of mesangial matrix present in the basement membrane surrounding the glomerular capillaries that also contain the intraglomerular mesangial cells" [MGI:csmith]
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Allelic Composition: Baxtm1Sjk/Bax+,Bcl2l1tm1Mam/Bcl2l1tm1Mam
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6

 MP:0011365 small metanephros "reduced size of the primordium of the permanent kidney, which develops later than and caudal to the mesonephros, from the mesonephric duct and nephrogenic cord" [MGI:anna]
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Allelic Composition: Bcl2tm1Sjk/Bcl2tm1Sjk
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Bcl2tm1Dlo/Bcl2tm1Dlo
Genetic Background: B6.129P2-Bcl2tm1Dlo

 MP:0011368 increased kidney apoptosis "increase in the number of cells of the kidney undergoing programmed cell death" [MGI:anna]
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Allelic Composition: Baxtm1Sjk/Bax+,Bcl2l1tm1Mam/Bcl2l1tm1Mam
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6

Allelic Composition: Bcl2tm1Sjk/Bcl2tm1Sjk
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0011369 increased renal glomerulus apoptosis "increase in the number of cells of the kidney glomerulus undergoing programmed cell death" [MGI:anna]
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Allelic Composition: Baxtm1Sjk/Bax+,Bcl2l1tm1Mam/Bcl2l1tm1Mam
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6

 MP:0011376 abnormal kidney corticomedullary boundary morphology "any structural anomaly of the region demarcating the renal medulla from the surrounding cortex; end-stage renal failure may be associated with loss of the normal corticomedullary boundary" [MGI:anna]
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Allelic Composition: Baxtm1Sjk/Bax+,Bcl2l1tm1Mam/Bcl2l1tm1Mam
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6

 MP:0011386 increased metanephric mesenchyme apoptosis "increase in the number of cells of the metanephric mesenchyme (MM) undergoing programmed cell death; usually due to failure of MM cells to interact with the ureteric bud (UB) tips after UB invasion" [MGI:anna]
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Allelic Composition: Bcl2tm1Sjk/Bcl2tm1Sjk
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0011408 renal tubule hypertrophy "increase in the bulk size of the loop of Henle, the proximal convoluted tubule or the distal convoluted tubule, due to cell enlargement" [MGI:anna]
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Allelic Composition: Baxtm1Sjk/Bax+,Bcl2l1tm1Mam/Bcl2l1tm1Mam
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6

 MP:0011425 abnormal kidney interstitium morphology "any structural anomaly of the kidney region located between the nephrons, ureteric epithelia (ureteric tips, trunk and collecting duct system) and renal vasculature, and composed of renal support cells, including fibroblasts and macrophages, and mesenchymal stroma or interstitial cells; the renal vasculature lies within the renal interstitium but is not a part of it; various conditions can lead to scarring (fibrosis) and congestion of this area, which can cause kidney dysfunction and failure" [MGI:anna]
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Allelic Composition: Bcl2tm1Sjk/Bcl2tm1Sjk
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0011430 mesangiolysis "an injurious glomerular process that affects primarily the mesangium, starting with loosening and detachment of its matrix and progressing to dissolution/attenuation with degeneration of mesangial cells; mesangial cells may show only edema and vacuolization, or may undergo severe degeneration and necrosis" [MGI:anna]
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Allelic Composition: Baxtm1Sjk/Bax+,Bcl2l1tm1Mam/Bcl2l1tm1Mam
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6

 MP:0011440 increased kidney cell proliferation "increase in the expansion rate of any kidney cell population by cell division" [MGI:anna]
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Allelic Composition: Bcl2tm1Sjk/Bcl2tm1Sjk
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0011453 abnormal glomerular capillary endothelium morphology "any structural anomaly of the thin, extremely flattened layer of cells that line the interior surface of glomerular capillaries and is densely perforated by large transcellular pores (aka fenestrae or fenestrations) that, unlike those of other fenestrated capillaries, are generally thought to lack diaphragms" [MGI:anna]
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Allelic Composition: Baxtm1Sjk/Bax+,Bcl2l1tm1Mam/Bcl2l1tm1Mam
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6

 MP:0011457 abnormal metanephric ureteric bud development "any anomaly in the development of the portion of the ureteric bud tube that contributes to the morphogenesis of the metanephros" [GO:0035502]
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Allelic Composition: Bcl2tm1Sjk/Bcl2tm1Sjk
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0011483 renal glomerular synechia "presence of adhesions (synechiae) between the Bowman s capsule and the glomerular tuft; may develop when areas of glomerular capillary basement membrane denuded of visceral epithelial cells come in contact with the parietal epithelium of Bowman s capsule" [MGI:anna]
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Allelic Composition: Baxtm1Sjk/Bax+,Bcl2l1tm1Mam/Bcl2l1tm1Mam
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6

 MP:0011498 abnormal glomerular capsule parietal layer morphology "any structural anomaly of the outer layer of the glomerular capsule composed of a single layer of simple squamous epithelium" [MGI:anna]
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Allelic Composition: Baxtm1Sjk/Bax+,Bcl2l1tm1Mam/Bcl2l1tm1Mam
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6

 MP:0011500 decreased glomerular capsule space "reduced volume of the luminal region between the glomerular capsule visceral and parietal layers, into which filtrate enters after passing through the filtration barrier from the glomerular capillaries" [MGI:csmith]
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Allelic Composition: Baxtm1Sjk/Bax+,Bcl2l1tm1Mam/Bcl2l1tm1Mam
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6

 MP:0011502 parietal capsular epithelium metaplasia "a metaplastic change or transformation of the single layer of the parietal epithelium of Bowman s capsule from the normal structural appearance of simple squamous epithelium to a cuboidal or low columnar epithelium; also referred to as a prominent parietal epithelium" [MGI:anna]
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Allelic Composition: Bcl2tm1Sjk/Bcl2tm1Sjk
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0011871 podocyte hypertrophy "increase in the bulk size of the modified epithelial cell of the visceral layer of the Bowman capsule in the renal corpuscle, due to cell enlargement" [MGI:anna]
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Allelic Composition: Baxtm1Sjk/Bax+,Bcl2l1tm1Mam/Bcl2l1tm1Mam
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6

 MP:0012106 impaired exercise endurance "impaired performance during controlled physical activity" [MGI:smb]
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Allelic Composition: Becn1tm1Blev/Becn1+,Tg(CAG-EGFP/Map1lc3b)53Nmz/0
Genetic Background: involves: 129X1/SvJ * C57BL/6NCrj

 MP:0014082 decreased small intestinal villus height "decreased height of the tiny hair-like projections which protrude from the inside of the small intestine and contain blood vessels that capture digested nutrients that are absorbed through the intestinal wall; usually accompanied by crypt elongation or hyperplasia" [MGI:Anna, PMID:16679353]
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Allelic Composition: Bcl2tm1Tsu/Bcl2tm1Tsu
Genetic Background: involves: 129P2/OlaHsd * ICR

 MP:0020084 short ears "reduced length of the ears" [GOC:NV]
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Allelic Composition: Bcl2tm1Dlo/Bcl2tm1Dlo
Genetic Background: B6.129P2-Bcl2tm1Dlo

 MP:0030022 decreased muscle cell glucose uptake "reduced ability of muscle cells to take in glucose" [MGI:anna]
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Allelic Composition: Becn1tm1Blev/Becn1+,Tg(CAG-EGFP/Map1lc3b)53Nmz/0
Genetic Background: involves: 129X1/SvJ * C57BL/6NCrj

 MP:0030188 round snout "appearance of the anterior facial part of the face or muzzle containing the oral and nasal regions is more circular than usual" [MGI:anna]
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Allelic Composition: Baxtm1Sjk/Bax+,Bcl2l1tm1Mam/Bcl2l1tm1Mam
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6

Allelic Composition: Bcl2tm1Sjk/Bcl2tm1Sjk
Genetic Background: involves: 129S2/SvPas * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000004446 Bid / P70444 / BH3-interacting domain death agonist BH3-interacting domain death agonist p15 BH3-interacting domain death agonist p13 BH3-interacting domain death agonist p11 / P55957* / BH...  / reaction / complex
 ENSMUSG00000027381 O54918 / Bcl2l11 / Bcl-2-like protein 11 / O43521* / BCL2 like 11*  / complex / reaction
 ENSMUSG00000024959 Bad / Q61337 / Bcl2-associated agonist of cell death / Q92934*  / complex / reaction
 ENSMUSG00000069830 Nlrp1a / Q2LKU9 / NACHT, LRR and PYD domains-containing protein 1a / NLRP1* / Q9C000* / NLR family pyrin domain containing 1*  / complex / reaction
 ENSMUSG00000070390 A1Z198 / Nlrp1b / NACHT, LRR and PYD domains-containing protein 1b allele 2 / NLRP1* / Q9C000* / NLR family pyrin domain containing 1*  / complex / reaction
 ENSMUSG00000040093 Bmf / Mus musculus BCL2 modifying factor (Bmf), transcript variant 3, mRNA. / Q96LC9* / Bcl2 modifying factor*  / complex / reaction






 

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