ENSMUSG00000070390


Mus musculus

Features
Gene ID: ENSMUSG00000070390
  
Biological name :Nlrp1b
  
Synonyms : A1Z198 / NACHT, LRR and PYD domains-containing protein 1b allele 2 / Nlrp1b
  
Possible biological names infered from orthology : NLR family pyrin domain containing 1 / NLRP1 / Q9C000
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: B4
Gene start: 71153102
Gene end: 71230733
  
Corresponding Affymetrix probe sets: 10388065 (MoGene1.0st)   
  
Cross references: Ensembl peptide - ENSMUSP00000121155
Ensembl peptide - ENSMUSP00000091588
Ensembl peptide - ENSMUSP00000104154
Ensembl peptide - ENSMUSP00000104155
Ensembl peptide - ENSMUSP00000104156
NCBI entrez gene - 637515     See in Manteia.
MGI - MGI:3582959
RefSeq - NM_001040696
RefSeq - XM_006533907
RefSeq - NM_001162414
RefSeq - XM_017314698
RefSeq Peptide - NP_001035786
RefSeq Peptide - NP_001155886
swissprot - A1Z198
Ensembl - ENSMUSG00000070390
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 FO704635.1ENSDARG00000105141Danio rerio
 nlrb5ENSDARG00000090699Danio rerio
 si:ch211-66k16.2ENSDARG00000095634Danio rerio
 si:ch211-66k16.28ENSDARG00000088423Danio rerio
 NLRP1ENSG00000091592Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Nlrp1a / Q2LKU9 / NACHT, LRR and PYD domains-containing protein 1a / NLRP1* / Q9C000* / NLR family pyrin domain containing 1*ENSMUSG0000006983078
E9Q5R7 / Nlrp12 / NACHT, LRR and PYD domains-containing protein 12 / P59046* / NLR family pyrin domain containing 12*ENSMUSG0000007881722
Nlrp3 / Q8R4B8 / NACHT, LRR and PYD domains-containing protein 3 / Q96P20* / NLR family pyrin domain containing 3*ENSMUSG0000003269121
Nlrp4c / Q3TKR3 / NACHT, LRR and PYD domains-containing protein 4C / NLRP4* / Q96MN2* / NLR family pyrin domain containing 4*ENSMUSG0000003469019
Nlrp14 / Q6B966 / NACHT, LRR and PYD domains-containing protein 14 / Q86W24* / NLR family pyrin domain containing 14*ENSMUSG0000001662619
Nlrp5 / Q9R1M5 / NACHT, LRR and PYD domains-containing protein 5 / P59047* / NLR family pyrin domain containing 5*ENSMUSG0000001572118
Nlrp4e / Q66X19 / NACHT, LRR and PYD domains-containing protein 4E / NLRP4* / Q96MN2* / NLR family pyrin domain containing 4*ENSMUSG0000004569318
Nlrp4a / Q8BU40 / NACHT, LRR and PYD domains-containing protein 4A / NLRP4* / Q96MN2* / NLR family pyrin domain containing 4*ENSMUSG0000004060118
Nlrp6 / Q91WS2 / NACHT, LRR and PYD domains-containing protein 6 / P59044* / NLR family pyrin domain containing 6*ENSMUSG0000003874518
Nlrp4f / NLRP4* / Q96MN2* / NLR family pyrin domain containing 4*ENSMUSG0000003299918
Nlrp9b / Q66X22 / NACHT, LRR and PYD domains-containing protein 9B / NLRP9* / Q7RTR0* / NLR family pyrin domain containing 9*ENSMUSG0000006050817
Nlrp9a / NACHT, LRR and PYD domains-containing protein 9A isoform 3 / NLRP9* / Q7RTR0* / NLR family pyrin domain containing 9*ENSMUSG0000005410217
Nlrp2 / NLRP7* / Q8WX94* / Q9NX02* / NLR family pyrin domain containing 7* / NLR family pyrin domain containing 2*ENSMUSG0000003517716
Nlrp9c / Q66X01 / NACHT, LRR and PYD domains-containing protein 9C / NLRP9* / Q7RTR0* / NLR family pyrin domain containing 9*ENSMUSG0000004061416
Nlrp4b / Q8C6J9 / Mus musculus NLR family, pyrin domain containing 4B (Nlrp4b), transcript variant 2, mRNA. / NLRP4* / Q96MN2* / NLR family pyrin domain containing 4*ENSMUSG0000003408715
Nlrp10 / Q8CCN1 / NACHT, LRR and PYD domains-containing protein 10 / Q86W26* / NLR family pyrin domain containing 10*ENSMUSG0000004970914
Rnh1 / Q91VI7 / Ribonuclease inhibitor / P13489* / ribonuclease/angiogenin inhibitor 1*ENSMUSG000000386508


Protein motifs (from Interpro)
Interpro ID Name
 IPR001315  CARD domain
 IPR001611  Leucine-rich repeat
 IPR007111  NACHT nucleoside triphosphatase
 IPR011029  Death-like domain superfamily
 IPR025307  FIIND domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR033516  CARD8/ASC/NALP1, CARD domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process ISO
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0030163 protein catabolic process IMP
 biological_processGO:0032610 interleukin-1 alpha production IMP
 biological_processGO:0032611 interleukin-1 beta production IMP
 biological_processGO:0042981 regulation of apoptotic process IEA
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0051402 neuron apoptotic process ISO
 biological_processGO:0070269 pyroptosis IMP
 biological_processGO:1904784 NLRP1 inflammasome complex assembly ISO
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0061702 inflammasome complex IEA
 cellular_componentGO:0072558 NLRP1 inflammasome complex ISO
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005524 ATP binding ISO
 molecular_functionGO:0019899 enzyme binding ISO
 molecular_functionGO:0019904 protein domain specific binding ISO


Pathways (from Reactome)
Pathway description
The NLRP1 inflammasome


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Mysm1tm1a(KOMP)Wtsi/Mysm1+
Genetic Background: Not Specified

 MP:0005166 decreased susceptiblity to injury "less than the normal reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Mysm1tm1a(KOMP)Wtsi/Mysm1+
Genetic Background: Not Specified

 MP:0005571 decreased lactate dehydrogenase level "less than the normal concentration of this enzyme, which catalyzes the interconversion of lactate and pyruvate" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Mysm1tm1a(KOMP)Wtsi/Mysm1+
Genetic Background: Not Specified

 MP:0008655 decreased interleukin-1 alpha secretion "reduction in the production or release of an interleukin-1 subtype that occurs as a membrane-bound pro-protein form that is cleaved by proteases to form a secreted mature form; both membrane-bound and secreted forms of interleukin-1alpha are biologically active" [MESH:D12.644.276.374.465.501.300]
Show

Allelic Composition: Mysm1tm1a(KOMP)Wtsi/Mysm1+
Genetic Background: Not Specified

 MP:0008658 decreased interleukin-1 beta secretion "reduction in the production or release of an interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein on monocytes, macrophages and other cells; proteolytic processing of the precursor form by caspase 1 results in release of the active form of interleukin-1beta from the membrane" [MESH:D12.644.276.374.465.501.600]
Show

Allelic Composition: Mysm1tm1a(KOMP)Wtsi/Mysm1+
Genetic Background: Not Specified

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000069830 Nlrp1a / Q2LKU9 / NACHT, LRR and PYD domains-containing protein 1a / NLRP1* / Q9C000* / NLR family pyrin domain containing 1*  / -
 ENSMUSG00000070390 A1Z198 / Nlrp1b / NACHT, LRR and PYD domains-containing protein 1b allele 2 / NLRP1* / Q9C000* / NLR family pyrin domain containing 1*  / -
 ENSMUSG00000007659 Bcl2l1 / Q64373 / Mus musculus BCL2-like 1 (Bcl2l1), transcript variant 5, mRNA. / Q07817* / BCL2 like 1*  / complex / reaction
 ENSMUSG00000057329 Bcl2 / P10417 / Apoptosis regulator Bcl-2 / P10415* / BCL2, apoptosis regulator*  / reaction / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr