ENSMUSG00000060508


Mus musculus

Features
Gene ID: ENSMUSG00000060508
  
Biological name :Nlrp9b
  
Synonyms : NACHT, LRR and PYD domains-containing protein 9B / Nlrp9b / Q66X22
  
Possible biological names infered from orthology : NLR family pyrin domain containing 9 / NLRP9 / Q7RTR0
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: A3
Gene start: 19991465
Gene end: 20073306
  
Corresponding Affymetrix probe sets: 10550749 (MoGene1.0st)   1457084_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000146427
Ensembl peptide - ENSMUSP00000072895
Ensembl peptide - ENSMUSP00000113762
Ensembl peptide - ENSMUSP00000115158
NCBI entrez gene - 243874     See in Manteia.
MGI - MGI:2675377
RefSeq - XM_011250565
RefSeq - XM_006539938
RefSeq - XM_006539939
RefSeq - XM_011250563
RefSeq - XM_011250564
RefSeq - NM_194058
RefSeq Peptide - NP_918947
swissprot - D3YWU2
swissprot - A0A140LHI6
swissprot - Q66X22
Ensembl - ENSMUSG00000060508
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 FO704635.1ENSDARG00000105141Danio rerio
 nlrb5ENSDARG00000090699Danio rerio
 si:ch211-66k16.2ENSDARG00000095634Danio rerio
 si:ch211-66k16.28ENSDARG00000088423Danio rerio
 NLRP9ENSG00000185792Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Nlrp9a / NACHT, LRR and PYD domains-containing protein 9A isoform 3 / NLRP9* / Q7RTR0* / NLR family pyrin domain containing 9*ENSMUSG0000005410272
Nlrp9c / Q66X01 / NACHT, LRR and PYD domains-containing protein 9C / NLRP9* / Q7RTR0* / NLR family pyrin domain containing 9*ENSMUSG0000004061471
Nlrp4c / Q3TKR3 / NACHT, LRR and PYD domains-containing protein 4C / NLRP4* / Q96MN2* / NLR family pyrin domain containing 4*ENSMUSG0000003469033
Nlrp4e / Q66X19 / NACHT, LRR and PYD domains-containing protein 4E / NLRP4* / Q96MN2* / NLR family pyrin domain containing 4*ENSMUSG0000004569332
Nlrp4a / Q8BU40 / NACHT, LRR and PYD domains-containing protein 4A / NLRP4* / Q96MN2* / NLR family pyrin domain containing 4*ENSMUSG0000004060132
Nlrp4f / NLRP4* / Q96MN2* / NLR family pyrin domain containing 4*ENSMUSG0000003299930
Nlrp3 / Q8R4B8 / NACHT, LRR and PYD domains-containing protein 3 / Q96P20* / NLR family pyrin domain containing 3*ENSMUSG0000003269129
E9Q5R7 / Nlrp12 / NACHT, LRR and PYD domains-containing protein 12 / P59046* / NLR family pyrin domain containing 12*ENSMUSG0000007881728
Nlrp14 / Q6B966 / NACHT, LRR and PYD domains-containing protein 14 / Q86W24* / NLR family pyrin domain containing 14*ENSMUSG0000001662627
Nlrp5 / Q9R1M5 / NACHT, LRR and PYD domains-containing protein 5 / P59047* / NLR family pyrin domain containing 5*ENSMUSG0000001572126
Nlrp4b / Q8C6J9 / Mus musculus NLR family, pyrin domain containing 4B (Nlrp4b), transcript variant 2, mRNA. / NLRP4* / Q96MN2* / NLR family pyrin domain containing 4*ENSMUSG0000003408725
Nlrp2 / NLRP7* / Q8WX94* / Q9NX02* / NLR family pyrin domain containing 7* / NLR family pyrin domain containing 2*ENSMUSG0000003517725
Nlrp6 / Q91WS2 / NACHT, LRR and PYD domains-containing protein 6 / P59044* / NLR family pyrin domain containing 6*ENSMUSG0000003874521
A1Z198 / Nlrp1b / NACHT, LRR and PYD domains-containing protein 1b allele 2 / NLRP1* / Q9C000* / NLR family pyrin domain containing 1*ENSMUSG0000007039020
Nlrp1a / Q2LKU9 / NACHT, LRR and PYD domains-containing protein 1a / NLRP1* / Q9C000* / NLR family pyrin domain containing 1*ENSMUSG0000006983020
Nlrp10 / Q8CCN1 / NACHT, LRR and PYD domains-containing protein 10 / Q86W26* / NLR family pyrin domain containing 10*ENSMUSG0000004970913
Rnh1 / Q91VI7 / Ribonuclease inhibitor / P13489* / ribonuclease/angiogenin inhibitor 1*ENSMUSG0000003865011


Protein motifs (from Interpro)
Interpro ID Name
 IPR000953  Chromo/chromo shadow domain
 IPR004020  DAPIN domain
 IPR007111  NACHT nucleoside triphosphatase
 IPR008251  Chromo shadow domain
 IPR011029  Death-like domain superfamily
 IPR016197  Chromo-like domain superfamily
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR032675  Leucine-rich repeat domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0032741 positive regulation of interleukin-18 production IMP
 biological_processGO:0045087 innate immune response IMP
 biological_processGO:0051607 defense response to virus IMP
 biological_processGO:0070269 pyroptosis IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0061702 inflammasome complex ISO
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003674 molecular_function ND
 molecular_functionGO:0005524 ATP binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
Show

Allelic Composition: Nek7tm1b(EUCOMM)Hmgu/Nek7tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Nek7tm1b(EUCOMM)Hmgu/J

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Nek7tm1b(EUCOMM)Hmgu/Nek7tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Nek7tm1b(EUCOMM)Hmgu/J

 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
Show

Allelic Composition: Nek7tm1b(EUCOMM)Hmgu/Nek7tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Nek7tm1b(EUCOMM)Hmgu/J

 MP:0005036 diarrhea "abnormally frequent discharge of semi-solid or fluid fecal matter from the bowel" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Prf1tm1Sdz/Prf1tm1Sdz,X/Yaa
Genetic Background: BXSB.B6-Prf1tm1Sdz/Dcr

 MP:0006043 decreased apoptosis "less than normal cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Prf1tm1Sdz/Prf1tm1Sdz,X/Yaa
Genetic Background: BXSB.B6-Prf1tm1Sdz/Dcr

 MP:0009791 increased susceptibility to viral infection induced morbidity/mortality "increased likelihood that an organism will display the expected moribund state caused by a viral invasion or from components of or toxins produced by a virus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Prf1tm1Sdz/Prf1tm1Sdz,X/Yaa
Genetic Background: BXSB.B6-Prf1tm1Sdz/Dcr

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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