ENSMUSG00000032691


Mus musculus

Features
Gene ID: ENSMUSG00000032691
  
Biological name :Nlrp3
  
Synonyms : NACHT, LRR and PYD domains-containing protein 3 / Nlrp3 / Q8R4B8
  
Possible biological names infered from orthology : NLR family pyrin domain containing 3 / Q96P20
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: B1.3
Gene start: 59541568
Gene end: 59566956
  
Corresponding Affymetrix probe sets: 10376513 (MoGene1.0st)   1425412_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000078440
Ensembl peptide - ENSMUSP00000098707
Ensembl peptide - ENSMUSP00000114231
NCBI entrez gene - 216799     See in Manteia.
MGI - MGI:2653833
RefSeq - XM_006532858
RefSeq - NM_145827
RefSeq - XM_006532857
RefSeq Peptide - NP_665826
swissprot - Q8R4B8
swissprot - Q5SXI6
Ensembl - ENSMUSG00000032691
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 FO704635.1ENSDARG00000105141Danio rerio
 nlrb5ENSDARG00000090699Danio rerio
 si:ch211-66k16.2ENSDARG00000095634Danio rerio
 si:ch211-66k16.28ENSDARG00000088423Danio rerio
 NLRP3ENSG00000162711Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
E9Q5R7 / Nlrp12 / NACHT, LRR and PYD domains-containing protein 12 / P59046* / NLR family pyrin domain containing 12*ENSMUSG0000007881745
Nlrp4a / Q8BU40 / NACHT, LRR and PYD domains-containing protein 4A / NLRP4* / Q96MN2* / NLR family pyrin domain containing 4*ENSMUSG0000004060130
Nlrp4c / Q3TKR3 / NACHT, LRR and PYD domains-containing protein 4C / NLRP4* / Q96MN2* / NLR family pyrin domain containing 4*ENSMUSG0000003469029
Nlrp14 / Q6B966 / NACHT, LRR and PYD domains-containing protein 14 / Q86W24* / NLR family pyrin domain containing 14*ENSMUSG0000001662629
Nlrp6 / Q91WS2 / NACHT, LRR and PYD domains-containing protein 6 / P59044* / NLR family pyrin domain containing 6*ENSMUSG0000003874529
Nlrp4e / Q66X19 / NACHT, LRR and PYD domains-containing protein 4E / NLRP4* / Q96MN2* / NLR family pyrin domain containing 4*ENSMUSG0000004569329
Nlrp9a / NACHT, LRR and PYD domains-containing protein 9A isoform 3 / NLRP9* / Q7RTR0* / NLR family pyrin domain containing 9*ENSMUSG0000005410228
Nlrp4f / NLRP4* / Q96MN2* / NLR family pyrin domain containing 4*ENSMUSG0000003299928
Nlrp2 / NLRP7* / Q8WX94* / Q9NX02* / NLR family pyrin domain containing 7* / NLR family pyrin domain containing 2*ENSMUSG0000003517728
Nlrp9b / Q66X22 / NACHT, LRR and PYD domains-containing protein 9B / NLRP9* / Q7RTR0* / NLR family pyrin domain containing 9*ENSMUSG0000006050828
Nlrp9c / Q66X01 / NACHT, LRR and PYD domains-containing protein 9C / NLRP9* / Q7RTR0* / NLR family pyrin domain containing 9*ENSMUSG0000004061427
Nlrp5 / Q9R1M5 / NACHT, LRR and PYD domains-containing protein 5 / P59047* / NLR family pyrin domain containing 5*ENSMUSG0000001572127
Nlrp1a / Q2LKU9 / NACHT, LRR and PYD domains-containing protein 1a / NLRP1* / Q9C000* / NLR family pyrin domain containing 1*ENSMUSG0000006983025
A1Z198 / Nlrp1b / NACHT, LRR and PYD domains-containing protein 1b allele 2 / NLRP1* / Q9C000* / NLR family pyrin domain containing 1*ENSMUSG0000007039024
Nlrp4b / Q8C6J9 / Mus musculus NLR family, pyrin domain containing 4B (Nlrp4b), transcript variant 2, mRNA. / NLRP4* / Q96MN2* / NLR family pyrin domain containing 4*ENSMUSG0000003408724
Nlrp10 / Q8CCN1 / NACHT, LRR and PYD domains-containing protein 10 / Q86W26* / NLR family pyrin domain containing 10*ENSMUSG0000004970920
Rnh1 / Q91VI7 / Ribonuclease inhibitor / P13489* / ribonuclease/angiogenin inhibitor 1*ENSMUSG0000003865013


Protein motifs (from Interpro)
Interpro ID Name
 IPR001611  Leucine-rich repeat
 IPR004020  DAPIN domain
 IPR007111  NACHT nucleoside triphosphatase
 IPR011029  Death-like domain superfamily
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR029495  NACHT-associated domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002374 cytokine secretion involved in immune response IMP
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0002674 negative regulation of acute inflammatory response IEA
 biological_processGO:0002830 positive regulation of type 2 immune response IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process IMP
 biological_processGO:0006954 inflammatory response ISS
 biological_processGO:0032088 negative regulation of NF-kappaB transcription factor activity IEA
 biological_processGO:0032611 interleukin-1 beta production IMP
 biological_processGO:0032621 interleukin-18 production IMP
 biological_processGO:0032736 positive regulation of interleukin-13 production IMP
 biological_processGO:0032753 positive regulation of interleukin-4 production IDA
 biological_processGO:0032754 positive regulation of interleukin-5 production IMP
 biological_processGO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process IEA
 biological_processGO:0044546 NLRP3 inflammasome complex assembly IMP
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0045630 positive regulation of T-helper 2 cell differentiation IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0050701 interleukin-1 secretion IMP
 biological_processGO:0050713 negative regulation of interleukin-1 beta secretion IEA
 biological_processGO:0050718 positive regulation of interleukin-1 beta secretion IEA
 biological_processGO:0050727 regulation of inflammatory response IMP
 biological_processGO:0050728 negative regulation of inflammatory response IEA
 biological_processGO:0050830 defense response to Gram-positive bacterium IMP
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity IEA
 biological_processGO:0051607 defense response to virus IMP
 biological_processGO:0071222 cellular response to lipopolysaccharide IEA
 biological_processGO:0071224 cellular response to peptidoglycan IMP
 biological_processGO:2000321 positive regulation of T-helper 17 cell differentiation IMP
 biological_processGO:2000553 positive regulation of T-helper 2 cell cytokine production IMP
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0061702 inflammasome complex IEA
 cellular_componentGO:0072559 NLRP3 inflammasome complex IMP
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008134 transcription factor binding IDA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IDA


Pathways (from Reactome)
Pathway description
Metalloprotease DUBs
The NLRP3 inflammasome


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
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Allelic Composition: Nlrp3tm3.1Hhf/Nlrp3+
Genetic Background: involves: 129

 MP:0000065 abnormal bone marrow cavities "absence or abnormal size or shape of the medullary cavities of the bones" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61295]
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Allelic Composition: Ptentm1Hwu/Pten+,Tg(Nkx2-1-cre)2Sand/0
Genetic Background: B6.Cg-Ptentm1Hwu Tg(Nkx2-1-cre)2Sand

 MP:0000130 abnormal cancellous bone morphology "structural anomaly of bone that has a latticelike or spongy structure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ptentm1Hwu/Pten+,Tg(Nkx2-1-cre)2Sand/0
Genetic Background: B6.Cg-Ptentm1Hwu Tg(Nkx2-1-cre)2Sand

 MP:0000131 abnormal long bone epiphysis morphology "the head of a developing long bone that is separated from the shaft by the epiphyseal plate" [J:61509]
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Allelic Composition: Nlrp3tm3.1Hhf/Nlrp3+
Genetic Background: involves: 129

 MP:0000135 reduced cortical bone thickness "thinner than normal superficial layer of compact bone " [J:61509]
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Allelic Composition: Nlrp3tm3.1Hhf/Nlrp3+
Genetic Background: involves: 129

 MP:0000165 abnormal hypertrophic chondrocyte zone "anomaly of the cartilage cell matrix layer " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58795]
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Allelic Composition: Nlrp3tm3.1Hhf/Nlrp3+
Genetic Background: involves: 129

 MP:0000167 reduced chondrocyte numbers "fewer than normal numbers of nondividing cartilage cells" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:61509]
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Allelic Composition: Nlrp3tm3.1Hhf/Nlrp3+
Genetic Background: involves: 129

 MP:0000218 increased WBC count "greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Neurod1tm1Mjts/Neurod1tm1Mjts,Neurod6tm1Kan/Neurod6tm1Kan
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6J

Allelic Composition: Nlrp3tm1Hhf/Nlrp3+,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

Allelic Composition: Nlrp3tm1Wstr/Nlrp3+
Genetic Background: involves: C57BL/6

 MP:0000219 increased neutrophil count "greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Neurod1tm1Mjts/Neurod1tm1Mjts,Neurod6tm1Kan/Neurod6tm1Kan
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6J

Allelic Composition: Nlrp3tm1Hhf/Nlrp3+,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

Allelic Composition: Nlrp3tm3.1Hhf/Nlrp3+
Genetic Background: involves: 129

 MP:0000220 increased monocyte count "greater than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nlrp3tm3.1Hhf/Nlrp3+
Genetic Background: involves: 129

 MP:0000322 increased granulocyte number "greater than expected number of leukocytes that have abundant granules in the cytoplasm: basophils, neutrophils, or eosinophils" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nlrp3tm3.1Hhf/Nlrp3+
Genetic Background: involves: 129

 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ptentm1Hwu/Pten+,Tg(Nkx2-1-cre)2Sand/0
Genetic Background: B6.Cg-Ptentm1Hwu Tg(Nkx2-1-cre)2Sand

 MP:0000477 abnormal intestine morphology "malformation of the digestive tube passing from the stomach to the anus" [J:48968]
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Allelic Composition: Neurod1tm1Mjts/Neurod1tm1Mjts,Neurod6tm1Kan/Neurod6tm1Kan
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6J

Allelic Composition: Nlrp3tm1Hhf/Nlrp3+,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0000559 abnormal femur morphology "structural anomaly of the long bone of the thigh" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Nlrp3tm3.1Hhf/Nlrp3+
Genetic Background: involves: 129

 MP:0000599 enlarged liver "larger than average size of the liver" [J:65146]
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Allelic Composition: Neurog3tm1(cre/ERT)Ggu/Neurog3tm1.1(cre/ERT)Ggu,Tg(Pdx1-cre/Esr1*)1Mga/0
Genetic Background: involves: 129S6/SvEvTac

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nlrp3tm1Wstr/Nlrp3+
Genetic Background: involves: C57BL/6

 MP:0000702 enlarged lymph nodes "lymph nodes of increased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nlrp3tm1Wstr/Nlrp3+
Genetic Background: involves: C57BL/6

 MP:0001190 reddish skin "skin has a more intense ruddy appearance than normal, often due to capillary congestion" [J:65038]
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Allelic Composition: Neurod1tm1Mjts/Neurod1tm1Mjts,Neurod6tm1Kan/Neurod6tm1Kan
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6J

Allelic Composition: Nlrp3tm1Hhf/Nlrp3+,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

Allelic Composition: Nlrp3tm1Hhf/Nlrp3+,Rag1tm1Mom/Rag1tm1Mom,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0001192 scaly skin "skin covered with shedding scales or flakes" [J:65146]
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Allelic Composition: Neurod1tm1Mjts/Neurod1tm1Mjts,Neurod6tm1Kan/Neurod6tm1Kan
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6J

Allelic Composition: Nlrp3tm1Hhf/Nlrp3+,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

Allelic Composition: Nlrp3tm1Hhf/Nlrp3+,Rag1tm1Mom/Rag1tm1Mom,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0001194 dermatitis "inflammation of the skin" [J:65146]
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Allelic Composition: Neurog3tm1(cre/ERT)Ggu/Neurog3tm1.1(cre/ERT)Ggu,Tg(Pdx1-cre/Esr1*)1Mga/0
Genetic Background: involves: 129S6/SvEvTac

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Mefvtm5.1(MEFV)Chae/Mefvtm5.1(MEFV)Chae,Pycardtm1Tno/Pycardtm1Tno
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

Allelic Composition: Nlrp3tm3.1Hhf/Nlrp3+
Genetic Background: involves: 129

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Nlrp3tm3.1Hhf/Nlrp3+
Genetic Background: involves: 129

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Neurog3tm1(cre/ERT)Ggu/Neurog3tm1.1(cre/ERT)Ggu,Tg(Pdx1-cre/Esr1*)1Mga/0
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Nlrp3tm3.1Hhf/Nlrp3+
Genetic Background: involves: 129

 MP:0001829 increased activated T cell number "greater than normal numbers of effector T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nlrp3tm1Wstr/Nlrp3+
Genetic Background: involves: C57BL/6

 MP:0001846 increased inflammatory response "greater than expected response to injury, infection, or insult " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Neurod1tm1Mjts/Neurod1tm1Mjts,Neurod6tm1Kan/Neurod6tm1Kan
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6J

Allelic Composition: Nlrp3tm1Hhf/Nlrp3+,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

Allelic Composition: Nlrp3tm1Flv/Nlrp3tm1Hhf,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Mefvtm5.1(MEFV)Chae/Mefvtm5.1(MEFV)Chae,Nlrp3tm1Tsc/Nlrp3tm1Tsc
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Nlrp3tm3.1Hhf/Nlrp3+
Genetic Background: involves: 129

 MP:0001847 brain inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the brain" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Nlrp3tm3.1Hhf/Nlrp3+
Genetic Background: involves: 129

 MP:0001921 reduced fertility "diminished ability to produce live offspring" [J:65030]
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Allelic Composition: Neurog3tm1(cre/ERT)Ggu/Neurog3tm1.1(cre/ERT)Ggu,Tg(Pdx1-cre/Esr1*)1Mga/0
Genetic Background: involves: 129S6/SvEvTac

 MP:0002113 abnormal skeleton development "anomalous differentiation or remodeling of bone tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ptentm1Hwu/Pten+,Tg(Nkx2-1-cre)2Sand/0
Genetic Background: B6.Cg-Ptentm1Hwu Tg(Nkx2-1-cre)2Sand

 MP:0002135 abnormal kidney morphology "abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Neurod1tm1Mjts/Neurod1tm1Mjts,Neurod6tm1Kan/Neurod6tm1Kan
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6J

Allelic Composition: Nlrp3tm1Hhf/Nlrp3+,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nlrp3tm1Hhf/Nlrp3+,Rag1tm1Mom/Rag1tm1Mom,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

Allelic Composition: Nlrp3tm3Hhf/Nlrp3tm3Hhf
Genetic Background: B6N.129-Nlrp3tm3Hhf

 MP:0002339 abnormal lymph node morphology "anomalous structure, size, or celluarity of the oval or bean shaped bodies located along the lymphatic system" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Neurog3tm1(cre/ERT)Ggu/Neurog3tm1.1(cre/ERT)Ggu,Tg(Pdx1-cre/Esr1*)1Mga/0
Genetic Background: involves: 129S6/SvEvTac

 MP:0002356 abnormal spleen red pulp morphology "anomalous structure of the area of the spleen that screens and eliminates defective or foreign cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology:ISBN 0-397-51047-0]
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Allelic Composition: Nlrp3tm1Wstr/Nlrp3+
Genetic Background: involves: C57BL/6

 MP:0002376 abnormal dendritic cell physiology "failure or atypical function of the immunocompetent cells of the lymphoid and hemopoietic systems and skin, which function to process antigens and present them to T cells, thus stimulating cellular immunity" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:85808]
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Allelic Composition: Nlrp3tm1Hhf/Nlrp3+,Tg(CAG-cre/Esr1*)5Amc/?
Genetic Background: involves: 129/Sv * C57BL/6 * CBA

Allelic Composition: Nlrp3tm2Hhf/Nlrp3+,Tg(CAG-cre/Esr1*)5Amc/?
Genetic Background: involves: 129/Sv * C57BL/6 * CBA

Allelic Composition: Nlrp3tm1Wstr/Nlrp3+
Genetic Background: involves: C57BL/6

 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nlrp3tm1Flv/Nlrp3tm1Flv,Slc11a1s/Slc11a1s
Genetic Background: B6.129S5-Nlrp3tm1Flv

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Arhgef1tm1.1Rmt/Arhgef1tm1.1Rmt
Genetic Background: C57BL/6-Arhgef1tm1.1Rmt

Allelic Composition: Nlrp3tm1Hhf/Nlrp3+,Tg(CAG-cre/Esr1*)5Amc/?
Genetic Background: involves: 129/Sv * C57BL/6 * CBA

Allelic Composition: Nlrp3tm2Hhf/Nlrp3+,Tg(CAG-cre/Esr1*)5Amc/?
Genetic Background: involves: 129/Sv * C57BL/6 * CBA

Allelic Composition: Nlrp3tm1Wstr/Nlrp3+
Genetic Background: involves: C57BL/6

 MP:0002455 abnormal dendritic cell antigen presentation "impairment of these specialized cells to process and present antigen to T lymphoytes" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Nlrp3tm1Hhf/Nlrp3+,Tg(CAG-cre/Esr1*)5Amc/?
Genetic Background: involves: 129/Sv * C57BL/6 * CBA

 MP:0002499 chronic inflammation "persistent inflammatory response, often caused by persistent infection or during an autoimmune response" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Neurog3tm1(cre/ERT)Ggu/Neurog3tm1.1(cre/ERT)Ggu,Tg(Pdx1-cre/Esr1*)1Mga/0
Genetic Background: involves: 129S6/SvEvTac

 MP:0002875 decreased erythrocyte count "reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nlrp3tm3.1Hhf/Nlrp3+
Genetic Background: involves: 129

 MP:0002933 joint inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the joints" [RGD:Rat Genome Database submission]
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Allelic Composition: Nlrp3tm3.1Hhf/Nlrp3+
Genetic Background: involves: 129

 MP:0003009 abnormal cytokine secretion "impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator]
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Allelic Composition: Mdm2tm1Glo/Mdm2+,Mdm4Gt(VICTR20)7Lex/Mdm4+,Trp53tm1Wahl/Trp53tm1Wahl
Genetic Background: involves: 129S5/SvEvBrd * 129S7/SvEvBrd * C57BL/6

 MP:0003409 decreased width of hypertrophic chondrocyte zone "decreased width of cartilage cell matrix layer " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Nlrp3tm3.1Hhf/Nlrp3+
Genetic Background: involves: 129

 MP:0003815 nude "having no hair at some time during or throughout lifespan, generally referring to primary genetic hairlessness" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Neurod1tm1Mjts/Neurod1tm1Mjts,Neurod6tm1Kan/Neurod6tm1Kan
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6J

Allelic Composition: Nlrp3tm1Hhf/Nlrp3+,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0004016 decreased bone mass "a reduction in the total amount of bone tissue contained in the skeleton" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Nlrp3tm3.1Hhf/Nlrp3+
Genetic Background: involves: 129

 MP:0004762 increased anti-double stranded DNA antibody level "increase in the level of antibodies that recognize double stranded DNA" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Nlrp3tm1Wstr/Nlrp3+
Genetic Background: involves: C57BL/6

 MP:0004800 decreased susceptibility to experimental autoimmune encephalomyelitis "reduced likelihood that an organism will develop disease symptoms similar to human multiple sclerosis upon induction with antigens to Myelin Basic Protein (MBP), Proteolipid Protein (PLP), and/or Myelin Oligodendrocyte glycoprotein (MOG)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cftrtm1Unc/Cftrtm1Unc,Tg(FABPCFTR)1Jaw/0,Tg(Scgb1a1-Scnn1b)6608Bouc/0
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6 * FVB/N

 MP:0004947 skin inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nlrp3tm1Hhf/Nlrp3+,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

Allelic Composition: Nlrp3tm2Hhf/Nlrp3+,Tg(CAG-cre/Esr1*)5Amc/?
Genetic Background: involves: 129/Sv * C57BL/6 * CBA

Allelic Composition: Il1r1tm1Roml/Il1r1tm1Roml,Nlrp3tm1Hhf/Nlrp3+,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129 * C57BL/6

 MP:0004984 increased osteoclast cell number "greater than average number of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nlrp3tm3.1Hhf/Nlrp3+
Genetic Background: involves: 129

 MP:0004992 increased bone resorption "greater than average amount of degradation of the organic and inorganic phases of bone by absorption, usually by the abnormal function or number of osteoclasts" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nlrp3tm3.1Hhf/Nlrp3+
Genetic Background: involves: 129

 MP:0005013 increased lymphocyte number "greater than normal white blood cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nlrp3tm3.1Hhf/Nlrp3+
Genetic Background: involves: 129

 MP:0005016 decreased lymphocyte number "fewer than normal white blood cell numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nlrp3tm3.1Hhf/Nlrp3+
Genetic Background: involves: 129

 MP:0005025 response to infection "the body s reaction to invasion and multiplication of microorganisms in its tissues, or the body s reaction to components of or toxins produced by pathogenic mircroorganisms " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mdm2tm1Glo/Mdm2+,Mdm4Gt(VICTR20)7Lex/Mdm4+,Trp53tm1Wahl/Trp53tm1Wahl
Genetic Background: involves: 129S5/SvEvBrd * 129S7/SvEvBrd * C57BL/6

 MP:0005190 osteomyelitis "bone inflammation" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Nlrp3tm3.1Hhf/Nlrp3+
Genetic Background: involves: 129

 MP:0005505 increased platelet count "greater than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Neurod1tm1Mjts/Neurod1tm1Mjts,Neurod6tm1Kan/Neurod6tm1Kan
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6J

Allelic Composition: Nlrp3tm1Hhf/Nlrp3+,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

Allelic Composition: Nlrp3tm3.1Hhf/Nlrp3+
Genetic Background: involves: 129

 MP:0005571 decreased lactate dehydrogenase level "less than the normal concentration of this enzyme, which catalyzes the interconversion of lactate and pyruvate" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mysm1tm1a(KOMP)Wtsi/Mysm1+
Genetic Background: Not Specified

 MP:0005616 decreased susceptibility to type IV hypersensitivity reaction "less likelihood of or resistance to developing an antigen-elicited cellular immune reaction that results in tissue damage, but does not require Ab participation; the response is seen at the area of contact" [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Arhgef1tm1.1Rmt/Arhgef1tm1.1Rmt
Genetic Background: C57BL/6-Arhgef1tm1.1Rmt

 MP:0005617 increased susceptibility to type IV hypersensitivity reaction "greater likelihood of developing an antigen-elicited cellular immune reaction that results in tissue damage, but does not require Ab participation; the response is seen at the area of contact " [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nlrp3tm1Wstr/Nlrp3+
Genetic Background: involves: C57BL/6

 MP:0006397 disorganized long bone epiphyseal plate "a lack of the regular arrangement of the cells or zones of the epiphyseal plate" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Nlrp3tm3.1Hhf/Nlrp3+
Genetic Background: involves: 129

 MP:0008070 absent T cells "absence of the lymphocytes that are responsible for cell-mediated immunity and immune system regulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nlrp3tm1Hhf/Nlrp3+,Rag1tm1Mom/Rag1tm1Mom,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0008071 absent B cells "absence of lymphocytes that expresses membrane-bound antibody, and differentiate into antibody-secreting plasma cells and memory cells upon interaction with antigen; B cells are the primary lymphocyte responsible for humoral immunity, and are most effective against extracellular pathogens" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nlrp3tm1Hhf/Nlrp3+,Rag1tm1Mom/Rag1tm1Mom,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0008073 abnormal CD4-positive T cell number "anomaly in the number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nlrp3tm1Wstr/Nlrp3+
Genetic Background: involves: C57BL/6

 MP:0008086 increased T-helper 1 cell number "greater number of the subset of the type of T-helper cell whose cytokine production favors cellular immune responses and delayed type hypersensitivity" [CL:0000545, ISBN:0781735149]
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Allelic Composition: Nlrp3tm1Wstr/Nlrp3+
Genetic Background: involves: C57BL/6

 MP:0008396 abnormal osteoclast differentiation "atypical production of or inability to produce bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nlrp3tm3.1Hhf/Nlrp3+
Genetic Background: involves: 129

 MP:0008489 postnatal slow weight gain "the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Neurod1tm1Mjts/Neurod1tm1Mjts,Neurod6tm1Kan/Neurod6tm1Kan
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6J

Allelic Composition: Nlrp3tm1Hhf/Nlrp3+,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

Allelic Composition: Nlrp3tm1Hhf/Nlrp3+,Tg(CAG-cre/Esr1*)5Amc/?
Genetic Background: involves: 129/Sv * C57BL/6 * CBA

Allelic Composition: Nlrp3tm2Hhf/Nlrp3+,Tg(CAG-cre/Esr1*)5Amc/?
Genetic Background: involves: 129/Sv * C57BL/6 * CBA

Allelic Composition: Nlrp3tm1Hhf/Nlrp3+,Rag1tm1Mom/Rag1tm1Mom,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

Allelic Composition: Nlrp3tm1Wstr/Nlrp3+
Genetic Background: involves: C57BL/6

 MP:0008539 decreased susceptibility to induced colitis "decreased severity or induction threshold of colitis upon treatment of an organism with intestinal inflammation agents such as dextran sodium sulfate (DSS)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Atad1tm1.1Vdaw/Atad1tm1.1Vdaw
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

 MP:0008553 increased circulating tumor necrosis factor level "greater amount in the blood of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
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Allelic Composition: Nlrp3tm1Hhf/Nlrp3+,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

Allelic Composition: Nlrp3tm3.1Hhf/Nlrp3+
Genetic Background: involves: 129

 MP:0008566 increased interferon-gamma secretion "increase in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Nlrp3tm3.1Hhf/Nlrp3+
Genetic Background: involves: 129

 MP:0008596 increased circulating interleukin-6 level "increase in the amount in the blood of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
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Allelic Composition: Nlrp3tm1Hhf/Nlrp3+,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

Allelic Composition: Nlrp3tm3.1Hhf/Nlrp3+
Genetic Background: involves: 129

 MP:0008602 increased circulating interleukin-4 level "increase in the amount in the blood of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]
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Allelic Composition: Nlrp3tm3.1Hhf/Nlrp3+
Genetic Background: involves: 129

 MP:0008608 increased circulating interleukin-13 level "increase in the amount in the blood of a cytokine synthesized by T-cells that produces proliferation, immunoglobulin isotype switching, and immunoglobulin production by immature B-cells, and appears to play a role in regulating inflammatory and immune responses" [MESH:D12.644.276.374.465.513]
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Allelic Composition: Nlrp3tm3.1Hhf/Nlrp3+
Genetic Background: involves: 129

 MP:0008623 increased circulating interleukin-3 level "increase in the amount in the blood of a multilineage cell growth factor secreted by lymphocytes, epithelial cells and astrocytes which stimulates clonal proliferation and differentiation of various types of blood and tissue cells" [MESH:D12.644.276.374.410.240.400]
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Allelic Composition: Nlrp3tm3.1Hhf/Nlrp3+
Genetic Background: involves: 129

 MP:0008627 decreased circulating interleukin-5 level "reduction in the amount in the blood of a cytokine that promotes differentiation and activation of eosinophils; it also triggers activated B-cells to differentiate into immunoglobulin-secreting cells" [MESH:D12.644.276.374.465.505]
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Allelic Composition: Nlrp3tm3.1Hhf/Nlrp3+
Genetic Background: involves: 129

 MP:0008629 increased circulating interleukin-9 level "increase in the amount in the blood of a multifunctional cytokine secreted by primarily by activated TH2 cells that may play a role as a regulator of allergic inflammation, and has been shown to enhance the growth and differentiation of mast cells, and can act on a variety of other immune cells" [MESH:D12.644.276.374.465.509]
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Allelic Composition: Nlrp3tm3.1Hhf/Nlrp3+
Genetic Background: involves: 129

 MP:0008635 increased circulating interleukin-18 level "increase in the amount in the blood of a cytokine which enhances the cytotoxic activity of NK cells and cytotoxic T-cells and appears to play a role both as neuroimmunomodulator and in the induction of mucosal immunity" [MESH:D12.644.276.374.465.518]
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Allelic Composition: Nlrp3tm1Hhf/Nlrp3+,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

Allelic Composition: Nlrp3tm3.1Hhf/Nlrp3+
Genetic Background: involves: 129

 MP:0008636 decreased circulating interleukin-18 level "reduction in the amount in the blood of a cytokine which enhances the cytotoxic activity of NK cells and cytotoxic T-cells and appears to play a role both as neuroimmunomodulator and in the induction of mucosal immunity" [MESH:D12.644.276.374.465.518]
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Allelic Composition: Arhgef1tm1.1Rmt/Arhgef1tm1.1Rmt
Genetic Background: C57BL/6-Arhgef1tm1.1Rmt

Allelic Composition: Nlrp3tm1Vmd/Nlrp3tm1Vmd
Genetic Background: B6.B6N-Nlrp3tm1Vmd

 MP:0008641 increased circulating interleukin-1 beta level "increased in the amount in the blood of an interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein on monocytes, macrophages and other cells; proteolytic processing of the precursor form by caspase 1 results in release of the active form of interleukin-1beta from the membrane" [MESH:D12.644.276.374.465.501.600]
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Allelic Composition: Nlrp3tm1Hhf/Nlrp3+,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

Allelic Composition: Nlrp3tm3.1Hhf/Nlrp3+
Genetic Background: involves: 129

 MP:0008642 decreased circulating interleukin-1 beta level "reduction in the amount in the blood of an interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein on monocytes, macrophages and other cells; proteolytic processing of the precursor form by caspase 1 results in release of the active form of interleukin-1beta from the membrane" [MESH:D12.644.276.374.465.501.600]
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Allelic Composition: Arhgef1tm1.1Rmt/Arhgef1tm1.1Rmt
Genetic Background: C57BL/6-Arhgef1tm1.1Rmt

Allelic Composition: Nlrp3tm1Vmd/Nlrp3tm1Vmd
Genetic Background: B6.B6N-Nlrp3tm1Vmd

 MP:0008648 decreased circulating interleukin-12b level "reduction in the amount in the blood of the p40 cytokine subunit that is a component of both interleukin-12 and interleukin-23" [MESH:D12.644.276.374.465.512.500]
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Allelic Composition: Nlrp3tm3.1Hhf/Nlrp3+
Genetic Background: involves: 129

 MP:0008656 abnormal interleukin-1 beta secretion "anomaly in the production or release of an interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein on monocytes, macrophages and other cells; proteolytic processing of the precursor form by caspase 1 results in release of the active form of interleukin-1beta from the membrane" [MESH:D12.644.276.374.465.501.600]
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Allelic Composition: PrkcbM1Btlr/PrkcbM1Btlr
Genetic Background: C57BL/6J-PrkcbM1Btlr

Allelic Composition: Nlrp3m3Btlr/?
Genetic Background: C57BL/6J-Nlrp3m3Btlr

 MP:0008657 increased interleukin-1 beta secretion "increase in the production or release of an interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein on monocytes, macrophages and other cells; proteolytic processing of the precursor form by caspase 1 results in release of the active form of interleukin-1beta from the membrane" [MESH:D12.644.276.374.465.501.600]
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Allelic Composition: Nlrp3tm1Wstr/Nlrp3+
Genetic Background: involves: C57BL/6

Allelic Composition: Mefvtm5.1(MEFV)Chae/Mefvtm5.1(MEFV)Chae,Nlrp3tm1Tsc/Nlrp3tm1Tsc
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Nlrp3tm3.1Hhf/Nlrp3+
Genetic Background: involves: 129

 MP:0008658 decreased interleukin-1 beta secretion "reduction in the production or release of an interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein on monocytes, macrophages and other cells; proteolytic processing of the precursor form by caspase 1 results in release of the active form of interleukin-1beta from the membrane" [MESH:D12.644.276.374.465.501.600]
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Allelic Composition: Zbtb17tm1Cksn/Zbtb17tm1.1Cksn,Krt14tm1(cre)Wbm/Krt14+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

Allelic Composition: Nlrp3m1Btlr/Nlrp3m1Btlr
Genetic Background: C57BL/6J-Nlrp3m1Btlr

Allelic Composition: Nlrp3tm1Flv/Nlrp3tm1Flv
Genetic Background: B6.129S5-Nlrp3tm1Flv

Allelic Composition: Nlrp3m4Btlr/Nlrp3m4Btlr
Genetic Background: involves: C57BL/6J

Allelic Composition: Nlrp3tm1Tsc/Nlrp3tm1Tsc
Genetic Background: involves: C57BL/6

Allelic Composition: Nlrc4tm1Vmd/Nlrc4tm1Vmd,Nlrp3tm1Vmd/Nlrp3tm1Vmd
Genetic Background: C57BL/6-Nlrp3tm1Vmd Nlrc4tm1Vmd

Allelic Composition: Nlrp3tm1Bhk/Nlrp3tm1Bhk
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Nlrp3m5Btlr/Nlrp3m5Btlr
Genetic Background: C57BL/6J-Nlrp3m5Btlr

Allelic Composition: Nlrp3m5Btlr/Nlrp3+
Genetic Background: C57BL/6J-Nlrp3m5Btlr

Allelic Composition: Nlrp3tm1Vmd/Nlrp3tm1Vmd
Genetic Background: B6.B6N-Nlrp3tm1Vmd

Allelic Composition: Nlrp3M6Btlr/Nlrp3+
Genetic Background: C57BL/6J-Nlrp3M6Btlr

Allelic Composition: Nlrp3M7Btlr/Nlrp3M7Btlr
Genetic Background: C57BL/6J-Nlrp3M7Btlr

Allelic Composition: Nlrp3M7Btlr/Nlrp3+
Genetic Background: C57BL/6J-Nlrp3M7Btlr

Allelic Composition: Nlrp3M8Btlr/Nlrp3M8Btlr
Genetic Background: C57BL/6J-Nlrp3M8Btlr

Allelic Composition: Nlrp3M8Btlr/Nlrp3+
Genetic Background: C57BL/6J-Nlrp3M8Btlr

Allelic Composition: Nlrp3M9Btlr/Nlrp3M9Btlr
Genetic Background: C57BL/6J-Nlrp3M9Btlr

Allelic Composition: Nlrp3M9Btlr/Nlrp3+
Genetic Background: C57BL/6J-Nlrp3M9Btlr

Allelic Composition: Nlrp3M10Btlr/Nlrp3M10Btlr
Genetic Background: C57BL/6J-Nlrp3M10Btlr

Allelic Composition: Nlrp3M10Btlr/Nlrp3+
Genetic Background: C57BL/6J-Nlrp3M10Btlr

Allelic Composition: Nlrp3M11Btlr/Nlrp3M11Btlr
Genetic Background: C57BL/6J-Nlrp3M11Btlr

 MP:0008681 increased interleukin-17 secretion "increase in the production or release of a proinflammatory cytokine produced primarily by T-cells or their precursors" [MESH:D12.644.276.374.465.517]
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Allelic Composition: Nlrp3tm1Wstr/Nlrp3+
Genetic Background: involves: C57BL/6

 MP:0008684 increased interleukin-18 secretion "increase in the production or release of a cytokine which enhances the cytotoxic activity of NK cells and cytotoxic T-cells and appears to play a role both as neuroimmunomodulator and in the induction of mucosal immunity" [MESH:D12.644.276.374.465.518]
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Allelic Composition: Nlrp3tm1Wstr/Nlrp3+
Genetic Background: involves: C57BL/6

 MP:0008734 decreased susceptibility to endotoxin shock "less than the expected early reaction of the microcirculation to endotoxins such as LPS, characterized by movement of fluid and leukocytes from the blood into extravascular tissues and often resulting in death" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Mdm2tm1Glo/Mdm2+,Mdm4Gt(VICTR20)7Lex/Mdm4+,Trp53tm1Wahl/Trp53tm1Wahl
Genetic Background: involves: 129S5/SvEvBrd * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Nlrp3tm1Flv/Nlrp3tm1Flv
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

Allelic Composition: Nlrp3tm1Vmd/Nlrp3tm1Vmd
Genetic Background: B6.B6N-Nlrp3tm1Vmd

 MP:0008770 decreased survivor rate "a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Nlrp3tm1Wstr/Nlrp3+
Genetic Background: involves: C57BL/6

 MP:0009278 abnormal bone marrow cell physiology "any functional anomaly of any of the cells found in the blood" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Nlrp3tm1Wstr/Nlrp3+
Genetic Background: involves: C57BL/6

Allelic Composition: Nlrp3tm3.1Hhf/Nlrp3+
Genetic Background: involves: 129

 MP:0009346 decreased cancellous bone thickness "thinner than normal bone with a lattice-like or spongy structure" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Nlrp3tm3.1Hhf/Nlrp3+
Genetic Background: involves: 129

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Nlrp3tm1Flv/Nlrp3tm1Flv,Slc11a1s/Slc11a1s
Genetic Background: B6.129S5-Nlrp3tm1Flv

 MP:0009780 abnormal chondrocyte physiology "any functional anomaly of nondividing cartilage cells" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Nlrp3tm3.1Hhf/Nlrp3+
Genetic Background: involves: 129

 MP:0010209 abnormal circulating chemokine level "deviation from the normal levels of any of the class of pro-inflammatory cytokines that attract and activate leukocytes in the circulation" [MESH:D12.644.276.374.200, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nlrp3tm1Hhf/Nlrp3+,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

Allelic Composition: Nlrp3tm3.1Hhf/Nlrp3+
Genetic Background: involves: 129

 MP:0010210 abnormal circulating cytokine level "deviation from the normal levels in the blood of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nlrp3tm1Hhf/Nlrp3+,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0010869 decreased bone trabecula number "decreased number of intersecting plates and spicules in cancellous bone which form a meshwork of intercommunicating spaces filled with blood vessels and marrow; in mature bone, the trabeculae are aligned in parallel with the lines of major compressive or tensile force" [http://www.dorlands.com/ "Dorland s Illustrated Medical Dictionary, 31st edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nlrp3tm3.1Hhf/Nlrp3+
Genetic Background: involves: 129

 MP:0010873 decreased trabecular bone mass "reduced total amount of trabecular bone tissue contained in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nlrp3tm3.1Hhf/Nlrp3+
Genetic Background: involves: 129

 MP:0010968 decreased compact bone area "reduction in the total amount of cross-sectional area of compact bone tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nlrp3tm3.1Hhf/Nlrp3+
Genetic Background: involves: 129

 MP:0011072 abnormal macrophage cytokine production "any anomaly in the appearance of macrophage-derived cytokine(s) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels" [GO:0010934]
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Allelic Composition: Nlrp3M7Btlr/Nlrp3M7Btlr
Genetic Background: C57BL/6J-Nlrp3M7Btlr

Allelic Composition: Nlrp3M7Btlr/Nlrp3+
Genetic Background: C57BL/6J-Nlrp3M7Btlr

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Neurod1tm1Mjts/Neurod1tm1Mjts,Neurod6tm1Kan/Neurod6tm1Kan
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6J

Allelic Composition: Nlrp3tm1Hhf/Nlrp3+,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

Allelic Composition: Nlrp3tm1Hhf/Nlrp3+,Rag1tm1Mom/Rag1tm1Mom,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

Allelic Composition: Nlrp3tm1Flv/Nlrp3tm1Hhf,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Nlrp3tm3.1Hhf/Nlrp3+
Genetic Background: involves: 129

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Nlrp3tm1Hhf/Nlrp3+,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000031820 Babam1 / Q3UI43 / BRISC and BRCA1-A complex member 1 / Q9NWV8* / AC010463.1*  / complex
 ENSMUSG00000023944 P11499 / Hsp90ab1 / Heat shock protein HSP 90-beta / P08238* / heat shock protein 90 alpha family class B member 1*  / reaction / complex
 ENSMUSG00000022024 Sugt1 / Q9CX34 / SGT1 homolog, MIS12 kinetochore complex assembly cochaperone / Q9Y2Z0*  / reaction / complex
 ENSMUSG00000052139 Babam2 / Q8K3W0 / BRISC and BRCA1-A complex member 2 / Q9NXR7*  / complex
 ENSMUSG00000038393 Txnip / Q8BG60 / thioredoxin interacting protein / Q9H3M7*  / reaction / complex
 ENSMUSG00000112039 Gm5136 / Q7M757 / predicted gene 5136 / BRCC3* / P46736* / BRCA1/BRCA2-containing complex subunit 3*  / complex






 

1 s.

 
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© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr