ENSMUSG00000112039


Mus musculus

Features
Gene ID: ENSMUSG00000112039
  
Biological name :Gm5136
  
Synonyms : Gm5136 / predicted gene 5136 / Q7M757
  
Possible biological names infered from orthology : BRCA1/BRCA2-containing complex subunit 3 / BRCC3 / P46736
  
Species: Mus musculus
  
Chr. number: 10
Strand: -1
Band: D1
Gene start: 108698764
Gene end: 108700160
  
Corresponding Affymetrix probe sets: 10372338 (MoGene1.0st)   
  
Cross references: Ensembl peptide - ENSMUSP00000151516
NCBI entrez gene - 368203     See in Manteia.
MGI - MGI:3647286
RefSeq - NM_203660
RefSeq Peptide - NP_988991
swissprot - Q7M757
Ensembl - ENSMUSG00000112039
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 brcc3ENSDARG00000098242Danio rerio
 BRCC3ENSGALG00000005383Gallus gallus
 BRCC3ENSG00000185515Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Brcc3 / P46737 / Lys-63-specific deubiquitinase BRCC36 ENSMUSG0000003120185


Protein motifs (from Interpro)
Interpro ID Name
 IPR000555  JAB1/MPN/MOV34 metalloenzyme domain
 IPR033860  Brcc36 isopeptidase
 IPR037518  MPN domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006302 double-strand break repair ISS
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0008150 biological_process ND
 biological_processGO:0010212 response to ionizing radiation ISS
 biological_processGO:0045739 positive regulation of DNA repair ISS
 biological_processGO:0070536 protein K63-linked deubiquitination ISS
 biological_processGO:0070537 histone H2A K63-linked deubiquitination ISS
 biological_processGO:0072425 signal transduction involved in G2 DNA damage checkpoint ISS
 cellular_componentGO:0005575 cellular_component ND
 cellular_componentGO:0005634 nucleus ISS
 cellular_componentGO:0070531 BRCA1-A complex ISS
 cellular_componentGO:0070552 BRISC complex ISS
 molecular_functionGO:0003674 molecular_function ND
 molecular_functionGO:0004843 thiol-dependent ubiquitin-specific protease activity ISS
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008237 metallopeptidase activity ISS
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0031593 polyubiquitin modification-dependent protein binding ISS
 molecular_functionGO:0036459 thiol-dependent ubiquitinyl hydrolase activity ISS
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Metalloprotease DUBs
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Nonhomologous End-Joining (NHEJ)
G2/M DNA damage checkpoint


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000031820 Babam1 / Q3UI43 / BRISC and BRCA1-A complex member 1 / Q9NWV8* / AC010463.1*  / complex
 ENSMUSG00000032691 Nlrp3 / Q8R4B8 / NACHT, LRR and PYD domains-containing protein 3 / Q96P20* / NLR family pyrin domain containing 3*  / complex
 ENSMUSG00000052139 Babam2 / Q8K3W0 / BRISC and BRCA1-A complex member 2 / Q9NXR7*  / complex






 

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